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coronavirus_nsp11
Euk-VirInfectious_bronchitis_virus
coronavirus_nsp11__NP_740631__Infectious_bronchitis_virus__11120
Identity
- Accession:
- NP_740631 ↗
- Protein ID:
- coronavirus_nsp11
- Kingdom:
- euk
Quality
86.1
mean pLDDT
Taxonomy
Orthornavirae›
Pisuviricota›
Pisoniviricetes›
Nidovirales›
Coronaviridae›
Gammacoronavirus›
Infectious_bronchitis_virus
TaxID: 11120
Cluster
View cluster (23 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 299-519
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06471.20 best | CoV_ExoN | 315.9 | 6.90e-94 | 100.0% | 41.9% |
CATH (31)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2zfuA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.66 | 42.0 | 4.89e-01 | 92.3% | 86.3% |
| 3ihtA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.63 | 45.0 | 5.24e-01 | 94.6% | 98.8% |
| 1w4rA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.63 | 36.0 | 4.58e-01 | 88.7% | 93.2% |
| 2h1qA02 | 3.40.50.11590 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.62 | 35.0 | 4.61e-01 | 89.6% | 100.0% |
| 2zw9B01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.62 | 58.0 | 4.93e-01 | 97.7% | 81.0% |
| 2qe6A00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 55.0 | 5.17e-01 | 95.0% | 83.1% |
| 3bxoA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 44.0 | 4.94e-01 | 94.6% | 93.2% |
| 2orwB01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.60 | 34.0 | 4.30e-01 | 88.7% | 92.9% |
| 4f3nA00 | 3.40.50.12710 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.60 | 54.0 | 4.51e-01 | 96.8% | 83.7% |
| 3hnrA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 48.0 | 5.16e-01 | 95.0% | 97.4% |
| 1usgA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.59 | 36.0 | 4.44e-01 | 91.4% | 94.4% |
| 1mjfB02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 47.0 | 4.82e-01 | 98.2% | 86.6% |
| 1wznA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 44.0 | 4.77e-01 | 94.6% | 92.0% |
| 8c9vA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 43.0 | 4.76e-01 | 93.7% | 93.9% |
| 3htxD03 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 51.0 | 5.12e-01 | 94.6% | 92.8% |
| 3d02A02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.57 | 37.0 | 4.43e-01 | 92.3% | 95.4% |
| 3gbvA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.56 | 36.0 | 4.34e-01 | 91.9% | 95.3% |
| 5bq3A02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.56 | 37.0 | 4.34e-01 | 92.3% | 94.8% |
| 4rkrD02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.56 | 36.0 | 4.42e-01 | 92.3% | 100.0% |
| 4evqA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.55 | 37.0 | 4.34e-01 | 83.3% | 94.9% |
| 4xr9B02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.54 | 37.0 | 3.88e-01 | 92.8% | 74.6% |
| 1rjgA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.54 | 48.0 | 4.32e-01 | 94.1% | 79.0% |
| 4wzzA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.53 | 36.0 | 4.18e-01 | 91.4% | 93.7% |
| 3td9A02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.53 | 36.0 | 4.29e-01 | 81.9% | 99.3% |
| 2po3A01 | 3.40.640.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) | 0.53 | 38.0 | 3.87e-01 | 95.5% | 74.5% |
| 4rxtA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.52 | 37.0 | 4.27e-01 | 90.5% | 100.0% |
| 2p9jB00 | 3.40.50.1000 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HAD superfamily/HAD-like | 0.52 | 34.0 | 3.84e-01 | 95.9% | 87.0% |
| 1gq2A02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.51 | 42.0 | 3.75e-01 | 84.6% | 83.0% |
| 3nv9A02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.51 | 41.0 | 3.73e-01 | 84.2% | 86.1% |
| 2z67A00 | 3.40.640.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) | 0.51 | 43.0 | 3.41e-01 | 89.1% | 45.7% |
| 1qz9A02 | 3.40.640.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) | 0.50 | 43.0 | 4.05e-01 | 89.1% | 77.8% |
ECOD (29)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1567479 | 2003.1.5.57 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › CoV_ExoN | 0.95 | 90.0 | 8.92e-01 | 100.0% | 94.7% |
| 4998506 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.64 | 52.0 | 5.52e-01 | 95.0% | 93.0% |
| None | — | 0.63 | 41.0 | 4.19e-01 | 94.6% | 65.0% | |
| 136182 | 2003.1.5.77 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_17 | 0.63 | 45.0 | 5.24e-01 | 94.6% | 98.8% |
| 5013653 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.62 | 49.0 | 5.27e-01 | 93.2% | 94.2% |
| 5067350 | 7518.1.1.0 ↗ | a/b three-layered sandwiches › PK C-terminal domain-like › PK C-terminal domain-like › PK C-terminal domain-like | 0.61 | 29.0 | 4.17e-01 | 89.6% | 95.2% |
| 3743216 | 2003.1.5.120 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Bmt2 | 0.61 | 45.0 | 4.23e-01 | 94.1% | 62.6% |
| 3286078 | 2003.1.5.35 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › LCM | 0.61 | 54.0 | 5.14e-01 | 93.7% | 83.1% |
| 3975836 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.60 | 49.0 | 5.00e-01 | 94.6% | 85.5% |
| 3959323 | 2003.1.1.31 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › CbiJ | 0.60 | 32.0 | 4.20e-01 | 87.3% | 93.3% |
| 5083094 | 2003.1.5.81 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 | 0.60 | 53.0 | 5.12e-01 | 93.7% | 94.8% |
| 4975041 | 2003.1.5.35 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › LCM | 0.60 | 53.0 | 5.00e-01 | 94.1% | 79.1% |
| 3308212 | 2003.1.5.115 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_29 | 0.59 | 44.0 | 3.94e-01 | 94.1% | 56.3% |
| 3717094 | 2004.1.1.28 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › TK | 0.59 | 38.0 | 3.82e-01 | 90.0% | 62.2% |
| 4948203 | 2003.1.5.35 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › LCM | 0.59 | 55.0 | 4.96e-01 | 97.7% | 79.5% |
| 4980047 | 2003.1.5.35 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › LCM | 0.59 | 53.0 | 4.94e-01 | 94.6% | 80.0% |
| 3961850 | 2003.1.5.79 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23 | 0.59 | 51.0 | 5.01e-01 | 91.9% | 95.8% |
| 3381087 | 2003.1.5.115 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_29 | 0.57 | 43.0 | 3.79e-01 | 94.1% | 54.0% |
| 4973581 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.56 | 51.0 | 4.67e-01 | 97.3% | 86.7% |
| 1841334 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.56 | 29.0 | 3.50e-01 | 94.1% | 73.8% |
| 3292011 | 2003.1.5.154 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_29, Methyltransf_11 | 0.53 | 44.0 | 3.39e-01 | 94.6% | 39.8% |
| 3838126 | 2003.1.5.46 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › MTS | 0.52 | 44.0 | 4.71e-01 | 92.8% | 99.0% |
| 3876664 | 2003.1.5.120 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Bmt2 | 0.52 | 46.0 | 4.16e-01 | 94.1% | 71.5% |
| 3295485 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.52 | 48.0 | 4.19e-01 | 99.1% | 92.6% |
| 3409414 | 2003.1.5.120 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Bmt2 | 0.51 | 46.0 | 4.17e-01 | 95.0% | 73.2% |
| 3893467 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.51 | 46.0 | 4.07e-01 | 94.6% | 72.9% |
| 3332187 | 2003.1.5.13 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Spermine_synth | 0.51 | 48.0 | 4.32e-01 | 99.5% | 74.2% |
| 3278200 | 2007.1.2.10 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3 | 0.51 | 35.0 | 4.11e-01 | 91.9% | 100.0% |
| 3697902 | 2003.1.5.120 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Bmt2 | 0.51 | 45.0 | 4.06e-01 | 94.6% | 88.0% |
D2
medium
residues 1-65_123-133
D3
medium
residues 66-85_168-248
Domain cluster:
rep: putative_coronavirus_nsp11__NP_835354__Human_coronavirus_229E__11137__D77-87_158-249
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06471.20 best | CoV_ExoN | 122.8 | 2.40e-35 | 80.2% | 15.7% |
D4
medium
residues 86-122_134-167
Domain cluster:
rep: ExoN__YP_009924421__Rabbit_coronavirus_HKU14__1160968__D90-156
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06471.20 best | CoV_ExoN | 93.0 | 2.40e-26 | 100.0% | 15.9% |
CATH (10)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4qozB02 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.73 | 67.0 | 4.63e-01 | 100.0% | 36.9% |
| 5dk5A01 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.72 | 64.0 | 4.64e-01 | 100.0% | 41.7% |
| 4okeA00 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.65 | 58.0 | 4.45e-01 | 100.0% | 45.6% |
| 2k2jA00 | 2.30.29.30 | Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) | 0.56 | 41.0 | 3.55e-01 | 80.3% | 90.6% |
| 2druA01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.55 | 36.0 | 3.13e-01 | 76.1% | 45.6% |
| 4ky9P00 | 3.40.930.10 | Alpha Beta › 3-Layer(aba) Sandwich › Mannitol-specific EII; Chain A › Mannitol-specific EII; Chain A | 0.55 | 47.0 | 3.19e-01 | 98.6% | 53.5% |
| 2p4tA00 | 2.30.30.60 | Mainly Beta › Roll › SH3 type barrels. › | 0.52 | 26.0 | 2.83e-01 | 80.3% | 51.7% |
| 2atpD00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.52 | 36.0 | 3.16e-01 | 74.6% | 50.9% |
| 1neuA00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.51 | 37.0 | 3.17e-01 | 77.5% | 48.7% |
| 2bhvB01 | 2.40.128.260 | Mainly Beta › Beta Barrel › Lipocalin › Type IV secretion system, VirB10/TraB/TrbI | 0.50 | 43.0 | 3.37e-01 | 100.0% | 59.6% |
ECOD (12)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4882792 | 2003.1.5.57 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › CoV_ExoN | 0.98 | 95.0 | 5.98e-01 | 100.0% | 28.7% |
| 185107 | 2484.1.1.13 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_T | 0.72 | 65.0 | 4.26e-01 | 100.0% | 28.0% |
| 4992318 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.58 | 30.0 | 2.74e-01 | 91.5% | 34.7% |
| 3252809 | 220.1.1.1 ↗ | beta barrels › PH domain-like › PH domain-like › PH domain-like › PH | 0.54 | 39.0 | 3.31e-01 | 78.9% | 69.2% |
| 4175069 | 11.1.1.99 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › V-set | 0.53 | 38.0 | 2.82e-01 | 76.1% | 32.4% |
| 3533080 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.53 | 38.0 | 3.08e-01 | 76.1% | 40.7% |
| 3536240 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.52 | 37.0 | 3.03e-01 | 76.1% | 43.7% |
| 3914849 | 11.1.1.99 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › V-set | 0.51 | 35.0 | 3.07e-01 | 77.5% | 47.6% |
| 3546858 | 11.1.1.852 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › PF28276 | 0.51 | 36.0 | 2.93e-01 | 76.1% | 44.3% |
| 3882734 | 11.1.1.99 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › V-set | 0.51 | 36.0 | 3.22e-01 | 76.1% | 52.4% |
| 4308473 | 10.12.1.41 ↗ | beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix › CsiD | 0.51 | 40.0 | 2.70e-01 | 90.1% | 27.1% |
| 3875508 | 11.1.1.99 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › V-set | 0.50 | 37.0 | 3.07e-01 | 78.9% | 46.2% |