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dihydrofolate_reductase-thymidylate_synthase
Euk-VirLausannevirus
dihydrofolate_reductase-thymidylate_synthase__YP_004347389__Lausannevirus__999883
Identity
- Accession:
- YP_004347389 ↗
- Protein ID:
- dihydrofolate_reductase-thymidylate_synthase
- Kingdom:
- euk
Quality
92.0
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Megaviricetes›
Pimascovirales›
Marseilleviridae›
Losannavirus›
Lausannevirus
TaxID: 999883
Cluster
View cluster (13 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 4-157
Domain cluster:
rep: dihydrofolate_reductase__YP_009119754__Pandoravirus_inopinatum__1605721__D21-210
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00186.25 best | DHFR_1 | 118.3 | 3.70e-34 | 98.7% | 82.4% |
D2
medium
residues 158-200_340-354_379-446
Domain cluster:
rep: thymidylate_synthase__YP_009342120__Lymphocystis_disease_virus_Sa__1898060__D1-35_226-286
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00303.25 best | Thymidylat_synt | 54.4 | 1.50e-14 | 61.1% | 28.3% |
CATH (6)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3egyX00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.94 | 88.0 | 6.87e-01 | 96.8% | 99.6% |
| 1bo7A00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.93 | 90.0 | 6.38e-01 | 99.2% | 100.0% |
| 1bkpA00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.90 | 86.0 | 6.42e-01 | 100.0% | 100.0% |
| 1tisA00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.87 | 81.0 | 6.03e-01 | 98.4% | 100.0% |
| 3v8hC00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.79 | 66.0 | 4.88e-01 | 86.5% | 100.0% |
| 1b5eA00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.59 | 53.0 | 4.21e-01 | 96.0% | 97.1% |
ECOD (20)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4151800 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.96 | 92.0 | 6.61e-01 | 98.4% | 100.0% |
| 3479792 | 266.1.1.0 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase | 0.96 | 92.0 | 6.57e-01 | 98.4% | 92.6% |
| 4664958 | 266.1.1.0 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase | 0.96 | 91.0 | 6.82e-01 | 97.6% | 100.0% |
| 4228846 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.95 | 90.0 | 6.37e-01 | 97.6% | 100.0% |
| 3203076 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.95 | 93.0 | 6.49e-01 | 100.0% | 99.4% |
| 2540892 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.95 | 92.0 | 6.47e-01 | 100.0% | 87.8% |
| 3164619 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.94 | 89.0 | 6.55e-01 | 97.6% | 100.0% |
| 5059575 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.94 | 88.0 | 6.40e-01 | 96.0% | 100.0% |
| 4108234 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.94 | 90.0 | 6.36e-01 | 98.4% | 99.7% |
| 4937005 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.93 | 89.0 | 6.19e-01 | 97.6% | 100.0% |
| 3944795 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.93 | 88.0 | 6.05e-01 | 97.6% | 99.2% |
| 4225236 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.93 | 89.0 | 6.59e-01 | 100.0% | 100.0% |
| 1900468 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.93 | 88.0 | 6.55e-01 | 99.2% | 99.3% |
| 4599962 | 266.1.1.0 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase | 0.90 | 86.0 | 6.39e-01 | 99.2% | 99.3% |
| 4086625 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.90 | 85.0 | 6.27e-01 | 98.4% | 99.3% |
| 3824671 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.88 | 76.0 | 5.62e-01 | 88.9% | 92.5% |
| 2028021 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.81 | 73.0 | 5.26e-01 | 94.4% | 97.5% |
| 5068964 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.69 | 60.0 | 4.44e-01 | 91.3% | 93.1% |
| 4976145 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.56 | 53.0 | 4.24e-01 | 99.2% | 95.6% |
| 3435804 | 3016.1.1.3 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › Aminotran_5 | 0.52 | 38.0 | 2.60e-01 | 77.0% | 83.4% |
D3
medium
residues 212-339
Domain cluster:
rep: thymidylate_synthase__YP_006347622__European_catfish_virus__84739__D66-177
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00303.25 best | Thymidylat_synt | 112.9 | 2.10e-32 | 100.0% | 39.2% |