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dihydrofolate_reductase-thymidylate_synthase
Euk-VirNoumeavirus
dihydrofolate_reductase-thymidylate_synthase__YP_009345185__Noumeavirus__1955558
Identity
- Accession:
- YP_009345185 ↗
- Protein ID:
- dihydrofolate_reductase-thymidylate_synthase
- Kingdom:
- euk
Quality
90.9
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Megaviricetes›
Pimascovirales›
Marseilleviridae›
Marseillevirus›
Noumeavirus
TaxID: 1955558
Cluster
View cluster (13 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 2-152
Domain cluster:
rep: dihydrofolate_reductase__YP_009119754__Pandoravirus_inopinatum__1605721__D21-210
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00186.25 best | DHFR_1 | 115.4 | 2.80e-33 | 98.7% | 81.1% |
CATH (69)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3k2hA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.92 | 89.0 | 8.11e-01 | 100.0% | 94.1% |
| 1j3jB00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.91 | 88.0 | 7.61e-01 | 100.0% | 93.5% |
| 3nzbX00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.91 | 88.0 | 7.75e-01 | 100.0% | 95.1% |
| 1bozA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.91 | 88.0 | 8.08e-01 | 100.0% | 96.2% |
| 3ix9A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.91 | 88.0 | 8.52e-01 | 100.0% | 95.8% |
| 6pf8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.90 | 87.0 | 8.19e-01 | 100.0% | 96.6% |
| 2w9hA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.90 | 88.0 | 8.67e-01 | 100.0% | 97.5% |
| 1ao8A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.89 | 86.0 | 8.39e-01 | 100.0% | 98.1% |
| 5eccA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.89 | 86.0 | 8.54e-01 | 100.0% | 96.8% |
| 1dhiA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.89 | 85.0 | 8.40e-01 | 100.0% | 97.5% |
| 1aoeA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.87 | 83.0 | 7.58e-01 | 100.0% | 95.8% |
| 1juvA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.87 | 83.0 | 7.47e-01 | 98.7% | 97.9% |
| 1vdrA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 83.0 | 8.18e-01 | 100.0% | 97.5% |
| 3vcoA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 82.0 | 7.59e-01 | 100.0% | 96.2% |
| 3kgyA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.85 | 81.0 | 7.02e-01 | 100.0% | 94.5% |
| 2h2qB01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.84 | 81.0 | 7.07e-01 | 100.0% | 87.7% |
| 3ky8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.84 | 79.0 | 7.48e-01 | 99.3% | 97.7% |
| 3jtwA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 79.0 | 7.44e-01 | 100.0% | 96.6% |
| 2xw7A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 78.0 | 7.41e-01 | 100.0% | 95.4% |
| 2g6vA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 79.0 | 6.76e-01 | 100.0% | 92.8% |
| 4ha7B00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.76 | 72.0 | 6.41e-01 | 100.0% | 86.3% |
| 1ej6A04 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.64 | 53.0 | 4.63e-01 | 89.4% | 96.5% |
| 2uyoA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.63 | 54.0 | 4.46e-01 | 93.4% | 99.6% |
| 3l8dA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.63 | 52.0 | 4.80e-01 | 91.4% | 99.0% |
| 6jp6D01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.63 | 54.0 | 4.73e-01 | 92.7% | 83.9% |
| 4rv9A02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.62 | 52.0 | 4.81e-01 | 91.4% | 93.5% |
| 3mw8A02 | 3.40.50.10090 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.62 | 45.0 | 5.05e-01 | 75.5% | 99.2% |
| 4hh4C01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.62 | 53.0 | 4.88e-01 | 92.7% | 87.2% |
| 3dliA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.62 | 52.0 | 4.66e-01 | 92.7% | 98.2% |
| 4e4yA00 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.62 | 46.0 | 3.91e-01 | 76.8% | 95.0% |
| 2gs9A01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 52.0 | 4.74e-01 | 92.1% | 100.0% |
| 3douA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 52.0 | 5.01e-01 | 92.1% | 97.7% |
| 3busB00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 52.0 | 4.46e-01 | 92.1% | 99.6% |
| 1ej0A00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 52.0 | 4.93e-01 | 92.1% | 97.8% |
| 1nv8A02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 52.0 | 4.76e-01 | 92.1% | 91.9% |
| 2bzgA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 53.0 | 4.69e-01 | 96.7% | 99.1% |
| 3fzgA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 52.0 | 4.79e-01 | 93.4% | 87.2% |
| 2h1qA02 | 3.40.50.11590 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.60 | 46.0 | 5.06e-01 | 86.1% | 100.0% |
| 1y8cA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.60 | 52.0 | 4.85e-01 | 93.4% | 92.5% |
| 3plnA03 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.60 | 47.0 | 4.75e-01 | 83.4% | 98.1% |
| 3c3pA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.60 | 53.0 | 4.85e-01 | 97.4% | 98.0% |
| 1sc6A02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.60 | 50.0 | 4.80e-01 | 89.4% | 95.4% |
| 2fpoC00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 51.0 | 4.82e-01 | 93.4% | 88.4% |
| 3cggA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 49.0 | 4.61e-01 | 89.4% | 88.7% |
| 1t57A00 | 3.40.1380.20 | Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain | 0.59 | 47.0 | 4.40e-01 | 83.4% | 98.9% |
| 4necC01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 50.0 | 4.49e-01 | 93.4% | 90.9% |
| 3lccA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 52.0 | 4.67e-01 | 98.0% | 95.4% |
| 1wznA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 50.0 | 4.72e-01 | 93.4% | 91.5% |
| 3lcvB02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 49.0 | 4.51e-01 | 91.4% | 81.7% |
| 2o57A02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 50.0 | 4.90e-01 | 92.7% | 98.2% |
| 2a35A00 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.59 | 43.0 | 3.92e-01 | 76.8% | 96.6% |
| 5tx7A02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.58 | 49.0 | 4.55e-01 | 90.1% | 96.8% |
| 4pneA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 50.0 | 4.23e-01 | 96.0% | 97.8% |
| 4gvlA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.58 | 42.0 | 4.46e-01 | 76.2% | 83.8% |
| 4dmgA03 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 49.0 | 4.39e-01 | 92.7% | 90.5% |
| 3ccfA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 49.0 | 4.23e-01 | 92.7% | 100.0% |
| 3oj0A00 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.57 | 45.0 | 4.71e-01 | 83.4% | 93.5% |
| 2i6gB00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 47.0 | 4.34e-01 | 90.7% | 91.5% |
| 2jjqA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 49.0 | 4.58e-01 | 96.0% | 92.2% |
| 3merA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 45.0 | 4.39e-01 | 86.8% | 98.8% |
| 3d4gE03 | 2.60.40.3210 | Mainly Beta › Sandwich › Immunoglobulin-like › Zona pellucida, ZP-N domain | 0.56 | 22.0 | 2.65e-01 | 99.3% | 53.5% |
| 6gnaA02 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.55 | 34.0 | 3.99e-01 | 82.1% | 86.0% |
| 4oqpA00 | 3.40.50.1360 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.55 | 47.0 | 4.02e-01 | 95.4% | 90.9% |
| 6ewjB01 | 3.40.640.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) | 0.54 | 47.0 | 3.93e-01 | 94.0% | 69.3% |
| 3rhzA02 | 3.40.50.2000 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; | 0.54 | 41.0 | 4.08e-01 | 78.8% | 87.9% |
| 2c81A01 | 3.40.640.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) | 0.53 | 45.0 | 3.81e-01 | 91.4% | 75.4% |
| 1yksA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.51 | 41.0 | 3.94e-01 | 88.1% | 82.2% |
| 2v3aA02 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.51 | 39.0 | 4.13e-01 | 80.8% | 100.0% |
| 2cduA02 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.50 | 37.0 | 3.78e-01 | 77.5% | 86.8% |
ECOD (83)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4667474 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 89.0 | 8.31e-01 | 100.0% | 98.3% |
| 3963884 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 89.0 | 8.67e-01 | 98.7% | 96.2% |
| 4276639 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 90.0 | 8.53e-01 | 100.0% | 92.9% |
| 3360231 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 89.0 | 7.64e-01 | 100.0% | 79.5% |
| 4392834 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 89.0 | 7.49e-01 | 100.0% | 95.2% |
| 4624802 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 89.0 | 8.66e-01 | 100.0% | 96.9% |
| 4652224 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.92 | 89.0 | 8.62e-01 | 100.0% | 96.3% |
| 185430 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 88.0 | 8.11e-01 | 100.0% | 94.1% |
| 4563316 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 88.0 | 8.49e-01 | 100.0% | 90.9% |
| 137968 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 88.0 | 8.52e-01 | 100.0% | 95.8% |
| 169540 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 89.0 | 8.52e-01 | 100.0% | 94.0% |
| 3913441 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 88.0 | 8.00e-01 | 100.0% | 95.3% |
| 4115051 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 88.0 | 7.30e-01 | 100.0% | 94.6% |
| 4402042 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 88.0 | 8.06e-01 | 100.0% | 96.8% |
| 4228699 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 86.0 | 7.70e-01 | 98.7% | 98.0% |
| 4279950 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 88.0 | 8.47e-01 | 100.0% | 96.4% |
| 4392683 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 88.0 | 8.46e-01 | 100.0% | 96.4% |
| 2831687 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 87.0 | 8.27e-01 | 100.0% | 89.6% |
| 3263045 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 87.0 | 7.76e-01 | 100.0% | 94.0% |
| 4183099 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 87.0 | 8.10e-01 | 100.0% | 92.2% |
| 3900511 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 86.0 | 7.96e-01 | 100.0% | 96.2% |
| 4315799 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 87.0 | 8.17e-01 | 100.0% | 97.1% |
| 4965070 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 86.0 | 8.13e-01 | 100.0% | 90.9% |
| 2580403 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 76.0 | 7.13e-01 | 87.4% | 78.3% |
| 4295510 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 85.0 | 8.35e-01 | 100.0% | 96.2% |
| 10266 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 83.0 | 7.47e-01 | 98.7% | 97.9% |
| 3974710 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.87 | 83.0 | 7.83e-01 | 100.0% | 95.4% |
| 4123104 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 83.0 | 8.02e-01 | 100.0% | 96.4% |
| 2847460 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 81.0 | 8.04e-01 | 100.0% | 95.5% |
| 3278932 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.85 | 80.0 | 7.36e-01 | 100.0% | 96.8% |
| 3282759 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.84 | 80.0 | 7.44e-01 | 100.0% | 96.7% |
| 5063695 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.84 | 80.0 | 7.28e-01 | 99.3% | 95.3% |
| 136641 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.83 | 79.0 | 7.44e-01 | 100.0% | 96.6% |
| 4209889 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.82 | 74.0 | 7.56e-01 | 100.0% | 97.2% |
| 3279668 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.82 | 77.0 | 7.12e-01 | 99.3% | 96.8% |
| 3278543 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.81 | 76.0 | 7.01e-01 | 100.0% | 96.8% |
| 3839944 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 75.0 | 7.05e-01 | 100.0% | 91.6% |
| 1841334 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.75 | 69.0 | 6.97e-01 | 100.0% | 96.0% |
| 3740375 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.71 | 66.0 | 6.05e-01 | 100.0% | 97.9% |
| 4948203 | 2003.1.5.35 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › LCM | 0.66 | 54.0 | 4.37e-01 | 86.8% | 78.5% |
| 4980047 | 2003.1.5.35 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › LCM | 0.65 | 55.0 | 4.57e-01 | 92.1% | 98.9% |
| 3286078 | 2003.1.5.35 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › LCM | 0.65 | 54.0 | 4.61e-01 | 91.4% | 100.0% |
| 4975041 | 2003.1.5.35 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › LCM | 0.65 | 55.0 | 4.61e-01 | 93.4% | 96.6% |
| 3970075 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.64 | 54.0 | 4.85e-01 | 92.7% | 95.8% |
| 4936542 | 2003.1.5.33 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0146 | 0.63 | 52.0 | 5.49e-01 | 90.7% | 100.0% |
| 4986416 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.63 | 53.0 | 4.60e-01 | 92.7% | 94.3% |
| 4099044 | 2003.1.5.67 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_12 | 0.63 | 53.0 | 4.78e-01 | 92.1% | 94.8% |
| 5041207 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.63 | 52.0 | 5.08e-01 | 90.7% | 98.8% |
| 3990242 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.63 | 52.0 | 4.09e-01 | 90.7% | 81.5% |
| 5064874 | 2003.1.5.79 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23 | 0.63 | 52.0 | 4.61e-01 | 90.1% | 92.0% |
| 4323773 | 2003.1.5.51 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › TPMT | 0.62 | 53.0 | 4.70e-01 | 92.7% | 93.3% |
| 5078688 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.62 | 53.0 | 4.75e-01 | 92.1% | 84.3% |
| 3666556 | 2003.1.5.2 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › RrnaAD | 0.62 | 53.0 | 4.52e-01 | 93.4% | 90.0% |
| 4075097 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.62 | 53.0 | 4.87e-01 | 92.1% | 89.6% |
| 4451549 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.62 | 53.0 | 4.74e-01 | 92.1% | 84.2% |
| 5024560 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.62 | 52.0 | 4.83e-01 | 92.1% | 90.8% |
| 362489 | 2003.1.5.81 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 | 0.61 | 52.0 | 4.49e-01 | 92.7% | 90.2% |
| 4998315 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.61 | 52.0 | 4.73e-01 | 92.7% | 91.2% |
| 9393 | 2003.1.5.151 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23, Methyltransf_25 | 0.61 | 52.0 | 4.45e-01 | 92.7% | 96.7% |
| 3805409 | 2003.1.5.202 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › TPMT, Methyltransf_25 | 0.60 | 51.0 | 4.58e-01 | 93.4% | 82.7% |
| 3972696 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.60 | 42.0 | 4.76e-01 | 82.8% | 94.8% |
| 4318151 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.60 | 50.0 | 4.12e-01 | 92.1% | 89.6% |
| 4989805 | 328.5.1.0 ↗ | a+b two layers › IF3-like › SirA-like › SirA-like | 0.60 | 28.0 | 3.95e-01 | 100.0% | 94.3% |
| None | — | 0.59 | 53.0 | 4.04e-01 | 97.4% | 98.0% | |
| 3195679 | 2003.1.5.63 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › CARME | 0.59 | 50.0 | 3.72e-01 | 92.7% | 66.8% |
| 3960615 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.59 | 48.0 | 4.56e-01 | 88.7% | 98.9% |
| 4533168 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.59 | 50.0 | 4.51e-01 | 91.4% | 82.4% |
| 3715749 | 2003.1.5.63 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › CARME | 0.59 | 52.0 | 3.92e-01 | 96.7% | 93.3% |
| 3307924 | 2003.1.5.165 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11, Methyltransf_23 | 0.59 | 49.0 | 4.29e-01 | 92.1% | 92.1% |
| 4037133 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.59 | 49.0 | 4.50e-01 | 91.4% | 86.8% |
| 3952314 | 2003.1.5.155 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › RrnaAD, Methyltransf_25 | 0.58 | 50.0 | 4.79e-01 | 93.4% | 91.4% |
| 4962328 | 2003.1.5.81 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 | 0.58 | 49.0 | 4.56e-01 | 92.1% | 90.8% |
| 3803649 | 2003.1.1.37 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C | 0.58 | 44.0 | 4.18e-01 | 79.5% | 88.0% |
| 4936070 | 2003.1.5.5 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0020 | 0.58 | 50.0 | 4.65e-01 | 92.7% | 91.5% |
| 4962546 | 2003.1.5.33 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0146 | 0.58 | 46.0 | 4.80e-01 | 90.1% | 92.1% |
| None | — | 0.57 | 50.0 | 3.86e-01 | 96.0% | 92.0% | |
| 4939667 | 2003.1.5.5 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0020 | 0.57 | 49.0 | 4.52e-01 | 92.7% | 86.2% |
| 4012886 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.57 | 48.0 | 4.67e-01 | 91.4% | 84.1% |
| 5051695 | 2003.1.1.50 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › DUF364 | 0.57 | 49.0 | 4.88e-01 | 94.7% | 100.0% |
| 4988628 | 328.5.1.6 ↗ | a+b two layers › IF3-like › SirA-like › SirA-like › DUF2249 | 0.56 | 25.0 | 3.71e-01 | 99.3% | 96.9% |
| 4956949 | 328.5.1.1 ↗ | a+b two layers › IF3-like › SirA-like › SirA-like › TusA | 0.54 | 27.0 | 3.63e-01 | 100.0% | 93.2% |
| 5017354 | 2003.1.1.50 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › DUF364 | 0.53 | 47.0 | 4.62e-01 | 95.4% | 100.0% |
| 5030524 | 7514.1.1.1 ↗ | a/b three-layered sandwiches › Ferredoxin reductase-like, C-terminal NADP-linked domain › Ferredoxin reductase-like, C-terminal NADP-linked domain › Ferredoxin reductase-like, C-terminal NADP-linked domain › NAD_binding_1 | 0.53 | 43.0 | 4.31e-01 | 87.4% | 82.5% |
D2
medium
residues 153-205_332-432
Domain cluster:
rep: NC_048821.1__YP_009853457.1__HWC77_gp105__00105__D1-80_280-380
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00303.25 best | Thymidylat_synt | 99.4 | 2.80e-28 | 66.2% | 37.0% |
| PF00303.25 | Thymidylat_synt | 34.0 | 2.40e-08 | 33.8% | 17.7% |
D3
medium
residues 206-331
Domain cluster:
rep: thymidylate_synthase__YP_006347622__European_catfish_virus__84739__D66-177
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00303.25 best | Thymidylat_synt | 112.6 | 2.50e-32 | 100.0% | 39.2% |