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dihydrofolate_reductase
Euk-VirPhaeocystis_globosa_virus
dihydrofolate_reductase__YP_008052579__Phaeocystis_globosa_virus__251749
Identity
- Accession:
- YP_008052579 ↗
- Protein ID:
- dihydrofolate_reductase
- Kingdom:
- euk
Quality
82.2
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Megaviricetes›
Algavirales›
Phycodnaviridae›
Prymnesiovirus›
Phaeocystis_globosa_virus
TaxID: 251749
Cluster
View cluster (29 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-40_120-173
Domain cluster:
rep: putative_dihydrofolate_reductase__YP_009259384__Short-finned_eel_ranavirus__638660__D1-10_34-47_130-189
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00186.25 best | DHFR_1 | 31.3 | 2.20e-07 | 58.5% | 30.8% |
| PF00186.25 | DHFR_1 | 39.2 | 8.00e-10 | 45.7% | 23.9% |
CATH (36)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1j3jB00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.90 | 85.0 | 6.26e-01 | 100.0% | 95.4% |
| 3ix9A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.89 | 85.0 | 6.84e-01 | 100.0% | 98.8% |
| 6pf8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.89 | 85.0 | 6.65e-01 | 100.0% | 99.4% |
| 1bozA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.89 | 84.0 | 6.52e-01 | 100.0% | 98.9% |
| 3nzbX00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.88 | 84.0 | 6.27e-01 | 100.0% | 97.6% |
| 2w9hA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.88 | 83.0 | 6.79e-01 | 98.9% | 100.0% |
| 1ao8A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.88 | 81.0 | 6.61e-01 | 97.9% | 99.4% |
| 3k2hA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.88 | 84.0 | 6.45e-01 | 100.0% | 95.7% |
| 4eckA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 82.0 | 6.42e-01 | 100.0% | 100.0% |
| 1vdrA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 81.0 | 6.63e-01 | 98.9% | 100.0% |
| 5eccA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 81.0 | 6.64e-01 | 100.0% | 100.0% |
| 1dhiA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.84 | 78.0 | 6.40e-01 | 98.9% | 100.0% |
| 2aznA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.81 | 76.0 | 5.61e-01 | 100.0% | 98.2% |
| 4xt6A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 75.0 | 5.43e-01 | 100.0% | 89.5% |
| 1cz3B00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 75.0 | 6.05e-01 | 100.0% | 97.6% |
| 2b3zA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 74.0 | 5.46e-01 | 100.0% | 95.1% |
| 2hxvA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 73.0 | 5.64e-01 | 100.0% | 100.0% |
| 3zpgA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 74.0 | 5.49e-01 | 100.0% | 94.9% |
| 3vcoA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.78 | 72.0 | 5.68e-01 | 100.0% | 98.9% |
| 2g6vA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 72.0 | 5.36e-01 | 100.0% | 95.0% |
| 3jtwA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 72.0 | 5.73e-01 | 100.0% | 99.4% |
| 3ky8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 70.0 | 5.62e-01 | 97.9% | 100.0% |
| 2gd9A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.76 | 68.0 | 5.54e-01 | 96.8% | 100.0% |
| 3kgyA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.76 | 70.0 | 5.25e-01 | 100.0% | 96.8% |
| 2xw7A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.76 | 69.0 | 5.58e-01 | 100.0% | 97.7% |
| 3iv6A01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.64 | 50.0 | 3.95e-01 | 84.0% | 94.8% |
| 3gnlA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 45.0 | 3.70e-01 | 100.0% | 45.5% |
| 3h2bB00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 45.0 | 3.63e-01 | 87.2% | 97.4% |
| 3fpfA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 44.0 | 3.27e-01 | 89.4% | 79.9% |
| 5tvfD00 | 3.60.90.10 | Alpha Beta › 4-Layer Sandwich › S-adenosylmethionine decarboxylase › S-adenosylmethionine decarboxylase | 0.55 | 43.0 | 3.10e-01 | 84.0% | 98.9% |
| 2xswB00 | 3.60.10.10 | Alpha Beta › 4-Layer Sandwich › Deoxyribonuclease I; Chain A › Endonuclease/exonuclease/phosphatase | 0.54 | 45.0 | 3.02e-01 | 100.0% | 25.2% |
| 2h00B00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.53 | 40.0 | 3.16e-01 | 81.9% | 87.6% |
| 3fn2A00 | 3.30.2200.10 | Alpha Beta › 2-Layer Sandwich › histidine kinase doma clostridium symbiosum atcc 14940 › histidine kinase doma clostridium symbiosum atcc 14940 | 0.51 | 39.0 | 3.88e-01 | 80.9% | 90.7% |
| 3jamD02 | 3.30.1140.32 | Alpha Beta › 2-Layer Sandwich › Ribosomal protein S3 C-terminal domain › Ribosomal protein S3, C-terminal domain | 0.50 | 36.0 | 3.26e-01 | 75.5% | 63.9% |
| 1cjwA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.50 | 38.0 | 3.27e-01 | 84.0% | 89.2% |
| 4m3sA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.50 | 38.0 | 3.25e-01 | 80.9% | 88.7% |
ECOD (60)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3900511 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.91 | 87.0 | 6.74e-01 | 100.0% | 98.9% |
| 4667474 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 84.0 | 6.55e-01 | 97.9% | 100.0% |
| 4228699 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 83.0 | 6.26e-01 | 96.8% | 100.0% |
| 4392834 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 85.0 | 6.18e-01 | 100.0% | 97.4% |
| 4115051 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 85.0 | 6.08e-01 | 100.0% | 96.2% |
| 3360231 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 86.0 | 6.25e-01 | 100.0% | 81.8% |
| 4279950 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.90 | 85.0 | 6.79e-01 | 98.9% | 98.8% |
| 4624802 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 85.0 | 6.81e-01 | 98.9% | 99.4% |
| 169540 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 85.0 | 6.84e-01 | 100.0% | 97.0% |
| 3581890 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 85.0 | 6.46e-01 | 100.0% | 97.9% |
| 4965070 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 85.0 | 6.68e-01 | 100.0% | 93.7% |
| 4402042 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 84.0 | 6.53e-01 | 100.0% | 99.5% |
| 2503171 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.89 | 85.0 | 6.60e-01 | 100.0% | 97.8% |
| 3913441 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 84.0 | 6.44e-01 | 100.0% | 97.9% |
| 185430 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 84.0 | 6.47e-01 | 100.0% | 96.2% |
| 4183099 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 84.0 | 6.54e-01 | 100.0% | 95.0% |
| 4276639 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.88 | 83.0 | 6.63e-01 | 100.0% | 95.3% |
| 4652224 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 83.0 | 6.67e-01 | 100.0% | 99.4% |
| 3232633 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 81.0 | 6.32e-01 | 98.9% | 99.5% |
| 3963884 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 81.0 | 6.59e-01 | 97.9% | 99.4% |
| 5029141 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.83 | 78.0 | 6.18e-01 | 100.0% | 96.6% |
| 5030442 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.82 | 75.0 | 6.07e-01 | 98.9% | 100.0% |
| 4123104 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.80 | 75.0 | 6.10e-01 | 100.0% | 99.4% |
| 1764169 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.80 | 75.0 | 5.38e-01 | 100.0% | 88.2% |
| 3289265 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.80 | 73.0 | 5.83e-01 | 98.9% | 100.0% |
| 5063695 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 73.0 | 5.68e-01 | 98.9% | 97.9% |
| 235716 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 74.0 | 5.57e-01 | 100.0% | 99.5% |
| 5058063 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 73.0 | 5.87e-01 | 100.0% | 99.4% |
| 3289701 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 73.0 | 5.48e-01 | 100.0% | 99.1% |
| 3278932 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.78 | 72.0 | 5.64e-01 | 100.0% | 99.5% |
| 3282759 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.78 | 72.0 | 5.70e-01 | 100.0% | 99.5% |
| 3974710 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.78 | 72.0 | 5.79e-01 | 100.0% | 98.3% |
| 137569 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.78 | 71.0 | 5.72e-01 | 100.0% | 99.4% |
| 163314 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.77 | 72.0 | 5.38e-01 | 100.0% | 96.3% |
| 136641 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.77 | 72.0 | 5.73e-01 | 100.0% | 99.4% |
| 3286316 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.77 | 71.0 | 5.58e-01 | 100.0% | 98.9% |
| 3282327 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.77 | 71.0 | 5.50e-01 | 100.0% | 99.5% |
| 160146 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.76 | 69.0 | 5.57e-01 | 98.9% | 95.5% |
| 5073892 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.76 | 69.0 | 5.46e-01 | 100.0% | 98.4% |
| 4949256 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.75 | 70.0 | 5.21e-01 | 100.0% | 99.1% |
| 3590464 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.75 | 69.0 | 5.56e-01 | 100.0% | 99.4% |
| 3278543 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.74 | 68.0 | 5.34e-01 | 100.0% | 99.5% |
| 3839944 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.74 | 68.0 | 5.43e-01 | 100.0% | 94.4% |
| 3277763 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 67.0 | 5.31e-01 | 100.0% | 99.5% |
| 3430689 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.73 | 66.0 | 5.09e-01 | 98.9% | 99.0% |
| 5034207 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.57 | 42.0 | 3.32e-01 | 77.7% | 93.3% |
| 3869055 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.56 | 33.0 | 3.36e-01 | 95.7% | 60.0% |
| 3678575 | 304.8.1.45 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant | 0.56 | 32.0 | 4.13e-01 | 96.8% | 98.2% |
| 4001929 | 246.3.1.3 ↗ | a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › Exo_endo_phos_2 | 0.56 | 39.0 | 3.03e-01 | 73.4% | 88.3% |
| 5021005 | 2003.1.5.27 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › NAS | 0.56 | 45.0 | 3.29e-01 | 90.4% | 77.2% |
| 4436750 | 2003.1.5.27 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › NAS | 0.55 | 45.0 | 3.29e-01 | 89.4% | 72.5% |
| 1503818 | 2003.1.5.27 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › NAS | 0.55 | 44.0 | 3.28e-01 | 89.4% | 79.6% |
| 4934161 | 3110.1.1.2 ↗ | a/b three-layered sandwiches › STT3/PglB/AglB core domain › STT3/PglB/AglB core domain › STT3/PglB/AglB core domain › STT3-PglB_core | 0.55 | 50.0 | 3.89e-01 | 100.0% | 91.0% |
| 5050977 | 328.5.1.1 ↗ | a+b two layers › IF3-like › SirA-like › SirA-like › TusA | 0.55 | 43.0 | 4.56e-01 | 100.0% | 94.0% |
| 3592716 | 2003.1.5.5 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0020 | 0.52 | 44.0 | 3.20e-01 | 100.0% | 68.4% |
| 4098347 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.52 | 37.0 | 2.34e-01 | 73.4% | 35.3% |
| 3237258 | 2003.1.5.119 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_22 | 0.51 | 46.0 | 3.48e-01 | 100.0% | 64.2% |
| 1141903 | 3488.1.1.0 ↗ | a+b three layers › Putative sensor histidine kinase domain › Putative sensor histidine kinase domain › Putative sensor histidine kinase domain | 0.51 | 39.0 | 3.88e-01 | 80.9% | 90.7% |
| 3791182 | 213.1.1.1 ↗ | a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 | 0.50 | 40.0 | 3.16e-01 | 85.1% | 75.3% |
| None | — | 0.50 | 44.0 | 3.18e-01 | 100.0% | 65.9% |
D2
medium
residues 41-119
Domain cluster:
rep: IMGVR_UViG_3300017956_004020-3300017956-Ga0181580_100249958__D38-113
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00186.25 best | DHFR_1 | 49.8 | 4.20e-13 | 100.0% | 44.0% |
CATH (62)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1j3jB00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 80.0 | 5.62e-01 | 100.0% | 36.1% |
| 1cz3B00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 76.0 | 5.82e-01 | 100.0% | 44.6% |
| 2w9hA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.86 | 70.0 | 5.45e-01 | 100.0% | 43.3% |
| 3ix9A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.85 | 74.0 | 5.66e-01 | 100.0% | 44.0% |
| 6pf8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.85 | 78.0 | 5.84e-01 | 100.0% | 43.8% |
| 3k2hA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.85 | 77.0 | 5.66e-01 | 100.0% | 40.6% |
| 1dhiA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.85 | 71.0 | 5.49e-01 | 100.0% | 44.0% |
| 5eccA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.84 | 71.0 | 5.56e-01 | 100.0% | 45.9% |
| 1bozA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 78.0 | 5.73e-01 | 100.0% | 43.5% |
| 1ao8A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 72.0 | 5.61e-01 | 100.0% | 45.7% |
| 3nzbX00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.82 | 77.0 | 5.51e-01 | 100.0% | 40.8% |
| 3vcoA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.82 | 77.0 | 5.69e-01 | 100.0% | 43.7% |
| 3jtwA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 71.0 | 5.40e-01 | 100.0% | 46.0% |
| 3ky8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 70.0 | 5.37e-01 | 100.0% | 46.6% |
| 2hxvA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.75 | 68.0 | 5.02e-01 | 100.0% | 54.0% |
| 2xw7A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.73 | 66.0 | 5.07e-01 | 100.0% | 45.7% |
| 2ayxA01 | 3.40.50.10970 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.71 | 50.0 | 4.41e-01 | 78.5% | 50.9% |
| 7oo1A02 | 3.40.1380.20 | Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain | 0.68 | 57.0 | 5.03e-01 | 92.4% | 80.5% |
| 2czrA01 | 3.40.1350.70 | Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 › TBP-interacting protein, N-terminal domain | 0.68 | 49.0 | 4.41e-01 | 77.2% | 55.7% |
| 1ej0A00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.66 | 57.0 | 4.47e-01 | 100.0% | 55.0% |
| 1kyqB01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.66 | 57.0 | 4.70e-01 | 100.0% | 76.5% |
| 2iyeA01 | 3.40.50.1000 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HAD superfamily/HAD-like | 0.65 | 56.0 | 4.58e-01 | 98.7% | 59.9% |
| 1e0tA01 | 3.40.1380.20 | Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain | 0.65 | 56.0 | 4.88e-01 | 96.2% | 78.0% |
| 3plnA03 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.65 | 53.0 | 4.27e-01 | 98.7% | 46.1% |
| 2r6hA02 | 3.40.50.80 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module | 0.65 | 55.0 | 4.90e-01 | 97.5% | 96.6% |
| 1xmxA02 | 3.40.1350.10 | Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 › | 0.64 | 47.0 | 3.87e-01 | 78.5% | 55.7% |
| 4fflA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.63 | 55.0 | 5.25e-01 | 100.0% | 87.2% |
| 3pp8A02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.63 | 54.0 | 4.18e-01 | 100.0% | 41.5% |
| 8ajjA01 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.63 | 52.0 | 4.60e-01 | 89.9% | 82.5% |
| 4yrbA00 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.63 | 55.0 | 4.13e-01 | 100.0% | 47.6% |
| 3ddmA02 | 3.20.20.120 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Enolase-like C-terminal domain | 0.63 | 49.0 | 3.60e-01 | 87.3% | 81.5% |
| 3cgxA00 | 3.90.550.10 | Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A | 0.63 | 55.0 | 4.03e-01 | 100.0% | 69.6% |
| 2x0dA02 | 3.40.50.2000 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; | 0.63 | 55.0 | 4.34e-01 | 100.0% | 88.8% |
| 3lp8A01 | 3.40.50.20 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.63 | 53.0 | 5.15e-01 | 98.7% | 87.0% |
| 1xdiA02 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.62 | 50.0 | 4.41e-01 | 88.6% | 79.0% |
| 4fe7A01 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.62 | 45.0 | 3.90e-01 | 77.2% | 84.8% |
| 4p7oB00 | 3.20.20.80 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases | 0.61 | 48.0 | 3.24e-01 | 88.6% | 93.6% |
| 4gx0B04 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.61 | 53.0 | 4.56e-01 | 100.0% | 61.1% |
| 1vkzA01 | 3.40.50.20 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.61 | 49.0 | 4.99e-01 | 97.5% | 90.9% |
| 1gsoA01 | 3.40.50.20 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.61 | 52.0 | 4.95e-01 | 98.7% | 87.2% |
| 2px7A00 | 3.90.550.10 | Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A | 0.61 | 53.0 | 4.02e-01 | 100.0% | 82.3% |
| 4ft4A02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 52.0 | 3.45e-01 | 100.0% | 50.5% |
| 3fetA00 | 3.40.50.620 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs | 0.60 | 52.0 | 4.18e-01 | 100.0% | 95.2% |
| 3gpiA00 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.60 | 50.0 | 3.60e-01 | 98.7% | 48.7% |
| 3qy9B01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.60 | 48.0 | 4.06e-01 | 100.0% | 51.5% |
| 1pjqA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.60 | 52.0 | 4.68e-01 | 100.0% | 72.3% |
| 4gu5B01 | 3.40.50.620 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs | 0.60 | 51.0 | 4.36e-01 | 100.0% | 87.6% |
| 3ghyA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.59 | 53.0 | 3.98e-01 | 100.0% | 68.9% |
| 2x0kA01 | 3.40.50.620 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs | 0.59 | 52.0 | 4.00e-01 | 100.0% | 65.6% |
| 4qlaB00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.59 | 50.0 | 3.31e-01 | 100.0% | 24.5% |
| 6gnaA02 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.59 | 47.0 | 4.31e-01 | 88.6% | 72.9% |
| 1ve3A00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 50.0 | 3.73e-01 | 100.0% | 41.5% |
| 4m7oA01 | 3.40.50.1980 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase molybdenum iron protein domain | 0.57 | 48.0 | 4.25e-01 | 97.5% | 61.6% |
| 3uwpA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 48.0 | 3.60e-01 | 100.0% | 43.6% |
| 2pbzA01 | 3.40.50.20 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.56 | 48.0 | 4.79e-01 | 97.5% | 96.3% |
| 4oo3A01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.56 | 48.0 | 4.02e-01 | 100.0% | 67.6% |
| 5j83B01 | 3.50.30.80 | Alpha Beta › 3-Layer(bba) Sandwich › Glucose Oxidase; domain 1 › IlvD/EDD C-terminal domain-like | 0.55 | 48.0 | 3.86e-01 | 100.0% | 75.9% |
| 1r0sA02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.54 | 42.0 | 3.65e-01 | 87.3% | 84.8% |
| 3iv3A00 | 3.20.20.70 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I | 0.54 | 41.0 | 2.83e-01 | 84.8% | 72.0% |
| 3gjzA02 | 3.50.30.60 | Alpha Beta › 3-Layer(bba) Sandwich › Glucose Oxidase; domain 1 › LD-carboxypeptidase A C-terminal domain-like | 0.53 | 38.0 | 3.00e-01 | 74.7% | 46.7% |
| 4aw9A00 | 3.40.50.1460 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.51 | 43.0 | 3.14e-01 | 100.0% | 65.0% |
| 3w1hA02 | 3.40.640.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) | 0.51 | 43.0 | 3.05e-01 | 100.0% | 28.9% |
ECOD (75)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 169540 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.87 | 74.0 | 5.63e-01 | 100.0% | 42.8% |
| 4276639 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.86 | 74.0 | 5.60e-01 | 100.0% | 42.4% |
| 137968 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 74.0 | 5.66e-01 | 100.0% | 44.0% |
| 4624802 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 75.0 | 5.75e-01 | 100.0% | 45.4% |
| 2503171 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 77.0 | 5.77e-01 | 100.0% | 43.0% |
| 3232633 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 80.0 | 5.86e-01 | 100.0% | 43.8% |
| 4228699 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 76.0 | 5.46e-01 | 100.0% | 37.5% |
| 1841334 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 71.0 | 5.61e-01 | 100.0% | 47.0% |
| 2580403 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.85 | 71.0 | 5.33e-01 | 100.0% | 40.0% |
| 4402042 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.83 | 78.0 | 5.76e-01 | 100.0% | 43.8% |
| 3913441 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.83 | 78.0 | 5.70e-01 | 100.0% | 42.6% |
| 10268 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.82 | 77.0 | 5.49e-01 | 100.0% | 40.8% |
| 3900511 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.81 | 75.0 | 5.60e-01 | 100.0% | 43.8% |
| 2831687 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.81 | 68.0 | 5.12e-01 | 100.0% | 40.5% |
| 4392683 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 73.0 | 5.65e-01 | 100.0% | 47.9% |
| 3974710 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 72.0 | 5.51e-01 | 100.0% | 45.1% |
| 4315799 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.77 | 68.0 | 5.22e-01 | 100.0% | 43.4% |
| 137569 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.77 | 70.0 | 5.34e-01 | 100.0% | 45.8% |
| 3590464 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.76 | 70.0 | 5.33e-01 | 100.0% | 46.2% |
| 3278932 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.75 | 68.0 | 5.10e-01 | 100.0% | 50.3% |
| 3278543 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.74 | 67.0 | 5.00e-01 | 100.0% | 51.6% |
| 4295510 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.71 | 62.0 | 4.94e-01 | 100.0% | 48.1% |
| 3701544 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.70 | 63.0 | 4.44e-01 | 100.0% | 42.8% |
| None | — | 0.68 | 61.0 | 4.18e-01 | 100.0% | 61.1% | |
| 4275183 | 2003.1.1.82 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Slo-like_RCK | 0.68 | 60.0 | 4.73e-01 | 100.0% | 55.3% |
| 4075097 | 2003.1.5.15 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › FtsJ | 0.68 | 59.0 | 4.52e-01 | 100.0% | 49.2% |
| 3203469 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.67 | 59.0 | 4.61e-01 | 100.0% | 61.1% |
| 5079944 | 7512.1.1.51 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_trans_4_2 | 0.66 | 59.0 | 4.68e-01 | 100.0% | 79.4% |
| 3972696 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.66 | 57.0 | 5.03e-01 | 100.0% | 66.1% |
| 4477959 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.65 | 57.0 | 4.84e-01 | 100.0% | 61.5% |
| 2527184 | 7518.1.1.1 ↗ | a/b three-layered sandwiches › PK C-terminal domain-like › PK C-terminal domain-like › PK C-terminal domain-like › PK_C | 0.65 | 57.0 | 4.74e-01 | 97.5% | 76.4% |
| 4135725 | 2003.1.10.4 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain › GARS_N | 0.65 | 56.0 | 5.00e-01 | 98.7% | 82.6% |
| 5062144 | 2003.1.1.52 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › RmlD_sub_bind | 0.65 | 59.0 | 3.93e-01 | 100.0% | 33.0% |
| 3693854 | 2003.1.1.53 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NmrA | 0.65 | 57.0 | 3.86e-01 | 98.7% | 39.7% |
| 3692389 | 2003.1.1.53 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NmrA | 0.65 | 57.0 | 3.87e-01 | 100.0% | 29.2% |
| 3381864 | 7512.1.1.33 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_transf_41 | 0.65 | 56.0 | 3.98e-01 | 98.7% | 58.1% |
| 4930662 | 7518.1.1.6 ↗ | a/b three-layered sandwiches › PK C-terminal domain-like › PK C-terminal domain-like › PK C-terminal domain-like › DacZ_A | 0.65 | 54.0 | 4.77e-01 | 92.4% | 76.5% |
| 2596039 | 2003.1.1.28 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › TrkA_N | 0.64 | 57.0 | 4.86e-01 | 100.0% | 66.9% |
| 4417233 | 7514.1.1.8 ↗ | a/b three-layered sandwiches › Ferredoxin reductase-like, C-terminal NADP-linked domain › Ferredoxin reductase-like, C-terminal NADP-linked domain › Ferredoxin reductase-like, C-terminal NADP-linked domain › DHODB_Fe-S_bind | 0.64 | 56.0 | 4.48e-01 | 100.0% | 56.2% |
| 5020238 | 2003.1.10.21 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain › PylC-like_N | 0.64 | 55.0 | 4.82e-01 | 100.0% | 65.6% |
| 4959153 | 7518.1.1.6 ↗ | a/b three-layered sandwiches › PK C-terminal domain-like › PK C-terminal domain-like › PK C-terminal domain-like › DacZ_A | 0.64 | 54.0 | 4.71e-01 | 96.2% | 77.6% |
| 3225471 | 2003.1.10.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain | 0.63 | 55.0 | 5.06e-01 | 100.0% | 86.7% |
| 2120643 | 2003.1.1.28 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › TrkA_N | 0.63 | 54.0 | 5.20e-01 | 100.0% | 84.8% |
| 4288654 | 2008.1.1.7 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › ERCC4 | 0.63 | 46.0 | 3.88e-01 | 79.7% | 69.7% |
| 1716670 | 7512.1.1.43 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › WsaF_C | 0.63 | 55.0 | 4.27e-01 | 100.0% | 83.8% |
| 4451990 | 7512.1.1.82 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › DUF188 | 0.63 | 55.0 | 4.53e-01 | 98.7% | 56.6% |
| 4945425 | 2003.1.10.33 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain › GARS_A | 0.63 | 54.0 | 5.16e-01 | 100.0% | 83.2% |
| 4044568 | 2006.1.4.17 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › DUF188 | 0.62 | 54.0 | 4.46e-01 | 97.5% | 55.9% |
| 4222519 | 7512.1.1.82 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › DUF188 | 0.62 | 54.0 | 4.45e-01 | 97.5% | 55.9% |
| 4471935 | 2006.1.4.17 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › DUF188 | 0.62 | 54.0 | 4.43e-01 | 98.7% | 54.7% |
| 1680489 | 2003.1.5.83 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltrans_Mon_2nd | 0.62 | 53.0 | 3.73e-01 | 100.0% | 41.4% |
| 3349539 | 2003.1.5.31 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › GRAS | 0.62 | 53.0 | 3.48e-01 | 100.0% | 33.3% |
| 5057875 | 7516.1.1.79 ↗ | a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glyco_trans_2_3 | 0.62 | 54.0 | 3.65e-01 | 98.7% | 55.8% |
| 3966867 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.61 | 52.0 | 4.59e-01 | 98.7% | 83.2% |
| 4262034 | 7512.1.1.80 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Gtf3_C | 0.61 | 53.0 | 4.18e-01 | 100.0% | 82.2% |
| 3352395 | 300.1.1.1 ↗ | a+b three layers › Phospholipase D/nuclease › Phospholipase D/nuclease › Phospholipase D/nuclease › PLDc | 0.61 | 45.0 | 3.06e-01 | 78.5% | 72.5% |
| 5072707 | 2003.1.10.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain | 0.61 | 52.0 | 4.60e-01 | 100.0% | 76.8% |
| 4960251 | 2008.1.1.16 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Mrr_cat | 0.61 | 44.0 | 3.73e-01 | 75.9% | 60.2% |
| 4513258 | 2006.1.4.17 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › DUF188 | 0.61 | 53.0 | 4.28e-01 | 97.5% | 52.6% |
| 5038618 | 2003.1.5.1 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › DNA_methylase | 0.61 | 52.0 | 3.61e-01 | 100.0% | 34.2% |
| 3587038 | 2003.1.2.24 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain › Pyr_redox_2 | 0.60 | 48.0 | 4.29e-01 | 88.6% | 81.7% |
| 4966921 | 2003.1.10.34 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain › ATP-grasp_3 | 0.60 | 50.0 | 4.83e-01 | 97.5% | 95.8% |
| 5005450 | 2003.1.10.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain | 0.60 | 51.0 | 4.86e-01 | 98.7% | 94.7% |
| 4981730 | 2003.2.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Formate dehydrogenase/DMSO reductase, domains 2 and 3 › Formate dehydrogenase/DMSO reductase, domains 2 and 3 | 0.60 | 51.0 | 4.63e-01 | 100.0% | 93.0% |
| 4888550 | 2007.1.3.0 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like | 0.59 | 42.0 | 4.46e-01 | 77.2% | 95.5% |
| 3291388 | 323.1.1.3 ↗ | a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding | 0.59 | 40.0 | 3.51e-01 | 88.6% | 44.8% |
| 4108859 | 2003.1.2.30 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain › Pyr_redox_3 | 0.59 | 48.0 | 4.07e-01 | 89.9% | 80.0% |
| 3190180 | 2005.1.1.38 ↗ | a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › CTU2 | 0.58 | 49.0 | 3.24e-01 | 100.0% | 78.2% |
| 4441101 | 2007.2.1.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › Flavoproteins › Flavodoxin_2 | 0.58 | 42.0 | 3.17e-01 | 78.5% | 85.5% |
| 4102088 | 2006.1.6.0 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › vWA-like | 0.58 | 48.0 | 3.66e-01 | 97.5% | 90.7% |
| 4662945 | 7512.1.1.0 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase | 0.58 | 49.0 | 3.86e-01 | 98.7% | 50.3% |
| 4938025 | 7516.1.1.0 ↗ | a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases | 0.56 | 49.0 | 3.42e-01 | 97.5% | 53.5% |
| 3829808 | 300.1.1.16 ↗ | a+b three layers › Phospholipase D/nuclease › Phospholipase D/nuclease › Phospholipase D/nuclease › PLDc, PLDc_2 | 0.55 | 46.0 | 2.81e-01 | 98.7% | 73.2% |
| 4958602 | 2007.15.1.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › N-deoxyribosyltransferase › N-deoxyribosyltransferase › Nuc_deoxyrib_tr | 0.54 | 46.0 | 3.90e-01 | 98.7% | 56.4% |
| 3234945 | 2006.1.6.1 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › vWA-like › VWA | 0.51 | 42.0 | 3.29e-01 | 100.0% | 80.5% |