←Back to structures

dihydrofolate_reductase

Euk-Vir

Pandoravirus_inopinatum

dihydrofolate_reductase__YP_009119516__Pandoravirus_inopinatum__1605721

Identity

Accession:
YP_009119516 ↗
Protein ID:
dihydrofolate_reductase
Kingdom:
euk

Quality

70.5 mean pLDDT

Taxonomy

Pandoravirus› Pandoravirus_inopinatum

TaxID: 1605721

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 55-97
PDB
Domain cluster: representative
CATH (16)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2qaiB00 3.40.50.10580 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › ATPase, V1 complex, subunit F 0.71 59.0 4.77e-01 100.0% 51.6%
4xglA01 3.40.50.11980 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.68 50.0 3.54e-01 83.7% 30.6%
1vkpB00 3.75.10.10 Alpha Beta › 5-stranded Propeller › L-arginine/glycine Amidinotransferase; Chain A › L-arginine/glycine Amidinotransferase; Chain A 0.64 53.0 3.17e-01 100.0% 14.3%
5lx1A00 3.20.20.140 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Metal-dependent hydrolases 0.60 48.0 2.88e-01 100.0% 12.3%
4g1vA03 3.40.50.80 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module 0.59 48.0 3.51e-01 100.0% 37.5%
1uxtA01 3.40.605.10 Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 0.56 43.0 2.76e-01 97.7% 15.0%
3rc3A04 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.55 44.0 3.20e-01 100.0% 29.0%
2cu2A00 3.90.550.10 Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A 0.54 46.0 2.77e-01 100.0% 20.0%
1jqbA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.54 42.0 3.17e-01 100.0% 47.8%
4eyeA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.54 41.0 3.06e-01 100.0% 39.1%
1z5zB01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.52 41.0 2.99e-01 100.0% 56.1%
2r7kA01 3.40.50.20 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.51 36.0 2.94e-01 86.0% 39.6%
1pswA01 3.40.50.2000 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; 0.51 39.0 2.95e-01 100.0% 30.8%
2i5qA02 3.20.20.120 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Enolase-like C-terminal domain 0.51 39.0 2.62e-01 100.0% 19.1%
2pd2A00 3.40.1260.10 Alpha Beta › 3-Layer(aba) Sandwich › Hypothetical Protein Ychn; Chain: A, › DsrEFH-like 0.51 39.0 3.11e-01 95.3% 73.1%
1hskA02 3.30.43.10 Alpha Beta › 2-Layer Sandwich › Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 › Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 0.50 35.0 2.95e-01 79.1% 93.2%
ECOD (17)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4100434 2007.24.1.1 ↗ a/b three-layered sandwiches › Flavodoxin-like › AtpF-like › AtpF-like › ATP-synt_F 0.72 61.0 4.75e-01 100.0% 47.0%
5072390 7510.1.1.0 ↗ a/b three-layered sandwiches › Isocitrate/Isopropylmalate dehydrogenase-like › Isocitrate/Isopropylmalate dehydrogenase-like › Isocitrate/Isopropylmalate dehydrogenase-like 0.67 54.0 3.90e-01 95.3% 34.3%
4954716 7563.1.1.2 ↗ a/b three-layered sandwiches › MCP/YpsA-related › MCP/YpsA-related › MCP/YpsA-related › Lysine_decarbox 0.64 50.0 3.52e-01 100.0% 29.1%
5032016 2006.1.4.2 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › PIN 0.63 46.0 3.55e-01 83.7% 34.5%
3547333 2484.1.1.104 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_1 0.60 48.0 3.21e-01 97.7% 23.8%
3978151 7512.1.1.7 ↗ a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_transf_9 0.60 47.0 3.46e-01 100.0% 30.3%
3505358 2003.1.5.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.58 46.0 2.92e-01 97.7% 76.4%
4999177 300.1.1.6 ↗ a+b three layers › Phospholipase D/nuclease › Phospholipase D/nuclease › Phospholipase D/nuclease › Regulator_TrmB 0.58 46.0 3.26e-01 100.0% 29.4%
5073762 2002.1.1.0 ↗ a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels 0.57 45.0 2.71e-01 100.0% 32.8%
3197097 2003.1.5.67 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_12 0.57 45.0 2.83e-01 100.0% 14.9%
4419934 4126.1.1.6 ↗ a/b three-layered sandwiches › beta-carbonic anhydrase-like › beta-carbonic anhydrase › beta-carbonic anhydrase › DabA 0.55 42.0 2.74e-01 88.4% 86.0%
4947512 2003.1.10.10 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain › DUF1246 0.53 39.0 3.14e-01 93.0% 60.9%
5064013 7516.1.1.24 ↗ a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › NTP_transf_3 0.52 43.0 2.92e-01 100.0% 30.3%
3753120 2484.1.1.104 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_1 0.52 42.0 2.75e-01 100.0% 18.7%
3443934 207.1.1.60 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › LRR_1,LRRNT_2,LRR_8 0.51 39.0 2.50e-01 95.3% 23.9%
4218810 323.1.1.0 ↗ a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases 0.51 38.0 2.73e-01 100.0% 25.6%
3805460 7512.1.1.77 ↗ a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_transf_N 0.50 36.0 2.38e-01 86.0% 20.8%