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dihydrofolate_reductase_motif-containing_protein
Euk-VirPandoravirus_inopinatum
dihydrofolate_reductase_motif-containing_protein__YP_009119044__Pandoravirus_inopinatum__1605721
Identity
- Accession:
- YP_009119044 ↗
- Protein ID:
- dihydrofolate_reductase_motif-containing_protein
- Kingdom:
- euk
Quality
67.1
mean pLDDT
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 42-164
Domain cluster:
representative
CATH (26)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4n5qA00 | 1.25.40.20 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Ankyrin repeat-containing domain | 0.68 | 45.0 | 3.56e-01 | 95.9% | 33.3% |
| 1h6gA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.64 | 44.0 | 4.45e-01 | 94.3% | 69.4% |
| 3bqoA00 | 1.25.40.210 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Telomere repeat-binding factor, dimerisation domain | 0.62 | 37.0 | 3.12e-01 | 100.0% | 35.1% |
| 5z2mB00 | 1.25.40.20 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Ankyrin repeat-containing domain | 0.61 | 36.0 | 3.53e-01 | 95.1% | 51.8% |
| 2mabA00 | 1.10.10.1350 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Spidroin domain, C-terminal domain | 0.57 | 40.0 | 4.28e-01 | 93.5% | 82.6% |
| 6pnjL00 | 1.20.1240.10 | Mainly Alpha › Up-down Bundle › Photosystem 1 Reaction Centre Subunit Xi; Chain: L; › Photosystem I PsaL, reaction centre subunit XI | 0.57 | 44.0 | 4.07e-01 | 86.2% | 64.1% |
| 4ymuD00 | 1.10.3720.10 | Mainly Alpha › Orthogonal Bundle › MetI-like fold › MetI-like | 0.56 | 45.0 | 3.78e-01 | 87.8% | 91.2% |
| 6lumD01 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.56 | 40.0 | 4.01e-01 | 95.1% | 72.8% |
| 4bmoA00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.54 | 45.0 | 3.46e-01 | 91.9% | 52.8% |
| 3dzaA01 | 1.20.120.1940 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YfdX protein domain | 0.53 | 36.0 | 3.69e-01 | 89.4% | 70.9% |
| 2wtvA02 | 1.10.510.10 | Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 | 0.53 | 47.0 | 4.20e-01 | 96.7% | 90.6% |
| 3vhlA02 | 1.20.58.740 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › DOCK DHR2 domain, lobe C | 0.53 | 45.0 | 4.60e-01 | 95.9% | 97.5% |
| 4iu9B02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.52 | 41.0 | 3.45e-01 | 82.9% | 75.4% |
| 6vg3B02 | 1.10.510.10 | Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 | 0.52 | 46.0 | 3.99e-01 | 96.7% | 92.1% |
| 6kzdA02 | 1.10.510.10 | Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 | 0.52 | 46.0 | 4.06e-01 | 96.7% | 92.8% |
| 1hh8A00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.52 | 36.0 | 3.14e-01 | 95.1% | 45.3% |
| 2wglA00 | 1.10.4190.10 | Mainly Alpha › Orthogonal Bundle › Urease accessory protein UreF › Urease accessory protein UreF | 0.52 | 41.0 | 3.56e-01 | 87.0% | 83.3% |
| 1fx8A00 | 1.20.1080.10 | Mainly Alpha › Up-down Bundle › Glycerol uptake facilitator protein › Glycerol uptake facilitator protein. | 0.52 | 46.0 | 3.60e-01 | 96.7% | 91.7% |
| 4itjB02 | 1.10.510.10 | Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 | 0.51 | 45.0 | 3.94e-01 | 96.7% | 89.9% |
| 3kmuA02 | 1.10.510.10 | Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 | 0.51 | 43.0 | 3.87e-01 | 93.5% | 89.4% |
| 3uqcD02 | 1.10.510.10 | Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 | 0.51 | 44.0 | 4.16e-01 | 95.9% | 88.9% |
| 3qthB00 | 1.20.120.450 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain | 0.51 | 39.0 | 3.58e-01 | 81.3% | 86.6% |
| 1gg1A00 | 3.20.20.70 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I | 0.50 | 39.0 | 2.83e-01 | 93.5% | 29.5% |
| 2amlB01 | 3.40.50.10490 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1 | 0.50 | 41.0 | 3.49e-01 | 90.2% | 68.5% |
| 1wolA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.50 | 34.0 | 3.42e-01 | 96.7% | 68.9% |
| 7fhyB01 | 1.50.10.100 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › Chondroitin AC/alginate lyase | 0.50 | 40.0 | 3.07e-01 | 97.6% | 36.4% |
ECOD (26)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3612163 | 4177.1.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like | 0.61 | 51.0 | 4.05e-01 | 88.6% | 70.6% |
| 3729412 | 109.3.1.96 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › Ank+Ank_2+Ank_4 | 0.59 | 39.0 | 3.31e-01 | 98.4% | 40.5% |
| 3358048 | 109.4.1.843 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › EFR3_ARM | 0.58 | 46.0 | 3.05e-01 | 99.2% | 20.6% |
| 3972975 | 3758.2.1.0 ↗ | alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB | 0.56 | 46.0 | 4.08e-01 | 87.8% | 82.8% |
| 3419156 | 5059.1.1.1 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA | 0.56 | 49.0 | 3.68e-01 | 100.0% | 77.9% |
| 4887929 | 5064.1.1.1 ↗ | alpha bundles › Photosystem I reaction center subunit XI, PsaL › Photosystem I reaction center subunit XI, PsaL › Photosystem I reaction center subunit XI, PsaL › PsaL | 0.56 | 44.0 | 4.05e-01 | 86.2% | 64.0% |
| 4961707 | 1075.3.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC importer transmembrane domain fold › Type I ABC importer transmembrane domain fold › BPD_transp_1 | 0.55 | 47.0 | 3.59e-01 | 91.1% | 78.6% |
| 4277308 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.55 | 43.0 | 3.18e-01 | 84.6% | 75.2% |
| 5081075 | 1076.1.1.1 ↗ | alpha bundles › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › Rce1-like | 0.55 | 41.0 | 3.14e-01 | 78.0% | 82.1% |
| 3483468 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.55 | 43.0 | 3.34e-01 | 83.7% | 80.7% |
| 4304766 | 6155.1.1.2 ↗ | alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop | 0.54 | 31.0 | 2.99e-01 | 71.5% | 47.1% |
| 3503452 | 5050.1.1.31 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › SLC52_ribofla_tr | 0.54 | 42.0 | 3.85e-01 | 81.3% | 89.4% |
| 4411218 | 172.2.1.1 ↗ | alpha complex topology › Citrate synthase-like › Urease accessory protein ureF › Urease accessory protein ureF › UreF | 0.54 | 42.0 | 3.55e-01 | 85.4% | 77.8% |
| 3214280 | 109.25.1.1 ↗ | alpha superhelices › Repetitive alpha hairpins › GPCR-autoproteolysis inducing domain subdomain A › GPCR-autoproteolysis inducing domain subdomain A › GAIN | 0.53 | 43.0 | 4.40e-01 | 95.9% | 88.3% |
| 3483218 | 109.24.1.2 ↗ | alpha superhelices › Repetitive alpha hairpins › Helical domain in dedicator of cytokinesis protein 9 › Helical domain in dedicator of cytokinesis protein 9 › DHR-2_Lobe_C | 0.53 | 47.0 | 4.47e-01 | 97.6% | 94.5% |
| 3226292 | 5050.1.1.6 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › OATP | 0.53 | 41.0 | 3.17e-01 | 79.7% | 79.6% |
| 3824122 | 5059.1.1.1 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA | 0.53 | 46.0 | 3.41e-01 | 98.4% | 72.2% |
| 4026169 | 5050.1.1.28 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › BT1 | 0.53 | 43.0 | 3.69e-01 | 86.2% | 80.0% |
| 5023880 | 3745.1.1.1 ↗ | alpha bundles › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Na_Ca_ex | 0.53 | 47.0 | 3.51e-01 | 99.2% | 86.9% |
| 5041648 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.52 | 40.0 | 3.50e-01 | 81.3% | 70.5% |
| 3420043 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.52 | 40.0 | 3.64e-01 | 82.9% | 62.5% |
| 4946483 | 133.2.1.1 ↗ | alpha bundles › DH domain-like › Methenyltetrahydrofolate cyclohydrolase-like › Methenyltetrahydrofolate cyclohydrolase-like › FTCD_C | 0.51 | 44.0 | 3.89e-01 | 96.7% | 82.2% |
| 3786025 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.51 | 37.0 | 3.09e-01 | 75.6% | 77.7% |
| 3247005 | 620.1.1.0 ↗ | alpha bundles › YfiT-like putative metal-dependent hydrolases › YfiT-like putative metal-dependent hydrolases › YfiT-like putative metal-dependent hydrolases | 0.51 | 41.0 | 3.91e-01 | 95.9% | 72.3% |
| 3274428 | 5050.1.1.5 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Folate_carrier | 0.50 | 39.0 | 3.33e-01 | 82.1% | 65.9% |
| 3968139 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.50 | 40.0 | 3.35e-01 | 85.4% | 70.0% |
D2
medium
residues 165-238