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dihydrofolate_reductase_motif-containing_protein
Euk-VirPandoravirus_inopinatum
dihydrofolate_reductase_motif-containing_protein__YP_009119717__Pandoravirus_inopinatum__1605721
Identity
- Accession:
- YP_009119717 ↗
- Protein ID:
- dihydrofolate_reductase_motif-containing_protein
- Kingdom:
- euk
Quality
70.7
mean pLDDT
Cluster
View cluster (7 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 7-167
Domain cluster:
rep: dihydrofolate_reductase__YP_009119754__Pandoravirus_inopinatum__1605721__D21-210
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00186.25 best | DHFR_1 | 53.4 | 3.50e-14 | 99.4% | 92.5% |
CATH (69)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1vdrA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.81 | 74.0 | 7.57e-01 | 100.0% | 98.7% |
| 2w9hA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 74.0 | 7.50e-01 | 100.0% | 98.7% |
| 5eccA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 73.0 | 7.39e-01 | 100.0% | 98.7% |
| 3nzbX00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 76.0 | 6.86e-01 | 100.0% | 96.1% |
| 1j3jB00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 75.0 | 6.70e-01 | 100.0% | 94.0% |
| 1ao8A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 74.0 | 7.47e-01 | 99.4% | 98.1% |
| 1dhiA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 74.0 | 7.47e-01 | 100.0% | 99.4% |
| 1bozA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.78 | 74.0 | 7.04e-01 | 100.0% | 97.3% |
| 2p4gA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 73.0 | 6.20e-01 | 100.0% | 91.1% |
| 3ix9A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 74.0 | 7.32e-01 | 100.0% | 97.0% |
| 1juvA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 73.0 | 6.81e-01 | 100.0% | 100.0% |
| 3zpgA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 72.0 | 6.49e-01 | 100.0% | 93.5% |
| 1cz3B00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 73.0 | 7.20e-01 | 100.0% | 95.8% |
| 2b3zA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.77 | 72.0 | 6.37e-01 | 100.0% | 93.8% |
| 3vcoA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.76 | 72.0 | 6.91e-01 | 100.0% | 98.4% |
| 2hxvA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.76 | 72.0 | 6.65e-01 | 100.0% | 98.5% |
| 2aznA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.76 | 71.0 | 6.36e-01 | 100.0% | 96.8% |
| 1aoeA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.76 | 72.0 | 6.72e-01 | 100.0% | 96.9% |
| 6pf8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.76 | 72.0 | 6.96e-01 | 100.0% | 97.7% |
| 3ky8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.74 | 69.0 | 6.75e-01 | 100.0% | 99.4% |
| 2g6vA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.74 | 70.0 | 6.19e-01 | 100.0% | 93.7% |
| 2gd9A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.64 | 59.0 | 5.83e-01 | 99.4% | 99.4% |
| 1pgjA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.62 | 46.0 | 4.36e-01 | 75.2% | 96.2% |
| 6g80B01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 51.0 | 4.63e-01 | 90.1% | 91.0% |
| 3busB00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.61 | 51.0 | 4.50e-01 | 90.7% | 98.8% |
| 1ej6A04 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.60 | 50.0 | 4.50e-01 | 90.7% | 95.7% |
| 3g7uA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.60 | 43.0 | 4.19e-01 | 73.9% | 96.7% |
| 3bkxA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.60 | 49.0 | 4.19e-01 | 88.8% | 92.7% |
| 4pneA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.60 | 50.0 | 4.26e-01 | 90.7% | 90.4% |
| 1tltA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.59 | 41.0 | 4.71e-01 | 76.4% | 95.8% |
| 4gc5A01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 50.0 | 4.48e-01 | 90.7% | 86.9% |
| 4idcA02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.59 | 40.0 | 4.61e-01 | 73.9% | 95.7% |
| 1t57A00 | 3.40.1380.20 | Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain | 0.59 | 46.0 | 4.41e-01 | 81.4% | 98.9% |
| 2gs9A01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 49.0 | 4.57e-01 | 90.1% | 99.5% |
| 2k4mA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 46.0 | 4.71e-01 | 88.8% | 86.3% |
| 5fcdA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 49.0 | 4.38e-01 | 90.1% | 100.0% |
| 1l3iA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 48.0 | 4.65e-01 | 90.1% | 93.5% |
| 2yxdA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 48.0 | 4.67e-01 | 89.4% | 93.3% |
| 3qhaA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.58 | 42.0 | 4.25e-01 | 74.5% | 100.0% |
| 3e05B00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 48.0 | 4.57e-01 | 90.7% | 91.7% |
| 1zq9A01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 48.0 | 4.68e-01 | 90.7% | 97.2% |
| 2qmxA01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.57 | 32.0 | 4.08e-01 | 100.0% | 96.7% |
| 1uwvA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 49.0 | 4.57e-01 | 95.0% | 86.5% |
| 4pg4A01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.57 | 43.0 | 4.36e-01 | 77.6% | 97.5% |
| 2uyyA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.56 | 42.0 | 4.21e-01 | 78.3% | 99.4% |
| 4eexA02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.56 | 45.0 | 4.80e-01 | 88.2% | 97.1% |
| 2dr3A00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.56 | 50.0 | 4.42e-01 | 96.9% | 89.2% |
| 5je8B01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.56 | 42.0 | 4.17e-01 | 77.0% | 100.0% |
| 3htxD03 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 48.0 | 4.36e-01 | 95.0% | 91.4% |
| 4c4aA03 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 44.0 | 4.65e-01 | 88.2% | 92.4% |
| 2pjdA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 46.0 | 4.70e-01 | 89.4% | 92.9% |
| 3q87B00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 47.0 | 4.69e-01 | 91.3% | 96.3% |
| 3tmaA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 46.0 | 4.48e-01 | 90.7% | 93.8% |
| 2qmwA01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.55 | 32.0 | 4.05e-01 | 99.4% | 98.9% |
| 2b25A02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 46.0 | 4.47e-01 | 90.7% | 93.4% |
| 1kolA02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.54 | 45.0 | 4.46e-01 | 87.0% | 97.0% |
| 1vbfA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.54 | 45.0 | 4.05e-01 | 88.8% | 65.6% |
| 1x19A02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.54 | 45.0 | 4.57e-01 | 91.3% | 100.0% |
| 1dl5A01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.54 | 45.0 | 4.21e-01 | 90.7% | 77.1% |
| 4qttB00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.54 | 44.0 | 4.38e-01 | 90.7% | 96.6% |
| 1e0tA01 | 3.40.1380.20 | Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain | 0.53 | 37.0 | 4.14e-01 | 90.1% | 92.7% |
| 3p04A00 | 3.30.110.150 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › SepF-like protein | 0.53 | 24.0 | 3.29e-01 | 100.0% | 87.0% |
| 2ek0A00 | 3.30.110.20 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Alba-like domain | 0.52 | 28.0 | 3.64e-01 | 98.8% | 93.3% |
| 4a8jA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.51 | 45.0 | 3.82e-01 | 96.9% | 85.9% |
| 3bdvA00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.51 | 41.0 | 3.89e-01 | 83.2% | 95.8% |
| 2xheA01 | 3.40.50.2060 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Sec1/Munc18 (SM) protein, domain 1 | 0.51 | 38.0 | 4.19e-01 | 86.3% | 96.1% |
| 4nh0B01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.51 | 44.0 | 3.63e-01 | 96.3% | 70.9% |
| 2a3nA01 | 3.40.50.10490 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1 | 0.51 | 36.0 | 3.67e-01 | 79.5% | 72.8% |
| 2d9iA00 | 3.30.1370.110 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › | 0.50 | 28.0 | 3.47e-01 | 100.0% | 88.5% |
ECOD (81)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4563316 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.84 | 76.0 | 7.57e-01 | 100.0% | 92.1% |
| 4209889 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.82 | 69.0 | 7.24e-01 | 100.0% | 97.2% |
| 4315799 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.81 | 77.0 | 7.47e-01 | 100.0% | 98.3% |
| 3963884 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.80 | 75.0 | 7.54e-01 | 100.0% | 98.8% |
| 4624802 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 76.0 | 7.59e-01 | 100.0% | 98.8% |
| 169540 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 75.0 | 7.42e-01 | 100.0% | 95.8% |
| 4228699 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 75.0 | 6.92e-01 | 100.0% | 100.0% |
| 5030442 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.79 | 75.0 | 7.39e-01 | 100.0% | 98.8% |
| 3263045 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 75.0 | 6.89e-01 | 100.0% | 94.0% |
| 4183099 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 75.0 | 7.21e-01 | 100.0% | 93.3% |
| 4295510 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 73.0 | 7.37e-01 | 100.0% | 98.1% |
| 4965070 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.78 | 75.0 | 7.27e-01 | 100.0% | 92.6% |
| 4652224 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.78 | 75.0 | 7.46e-01 | 100.0% | 98.2% |
| 4392683 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.78 | 74.0 | 7.41e-01 | 100.0% | 97.6% |
| 4279950 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.78 | 74.0 | 7.37e-01 | 100.0% | 97.6% |
| 2847460 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.77 | 68.0 | 6.97e-01 | 100.0% | 95.5% |
| 163852 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.77 | 73.0 | 6.20e-01 | 100.0% | 91.1% |
| 137968 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.77 | 74.0 | 7.32e-01 | 100.0% | 97.0% |
| 2831687 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.77 | 72.0 | 7.03e-01 | 100.0% | 90.8% |
| 10266 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.77 | 73.0 | 6.81e-01 | 100.0% | 100.0% |
| 4123104 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.77 | 72.0 | 7.22e-01 | 100.0% | 97.6% |
| 2580403 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.77 | 62.0 | 6.00e-01 | 85.7% | 76.6% |
| 4262258 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.76 | 72.0 | 6.34e-01 | 100.0% | 93.8% |
| 10273 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.76 | 72.0 | 6.65e-01 | 100.0% | 98.5% |
| 4992215 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.76 | 72.0 | 6.44e-01 | 100.0% | 97.2% |
| 5009586 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.76 | 71.0 | 6.48e-01 | 100.0% | 97.6% |
| 2503171 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.76 | 72.0 | 6.93e-01 | 100.0% | 96.1% |
| 4816241 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.75 | 60.0 | 5.87e-01 | 82.6% | 98.9% |
| 1764169 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.74 | 69.0 | 5.94e-01 | 100.0% | 87.4% |
| 3385448 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.74 | 68.0 | 6.88e-01 | 100.0% | 97.5% |
| 137569 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.74 | 69.0 | 6.70e-01 | 100.0% | 97.7% |
| 3839944 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.74 | 70.0 | 6.74e-01 | 100.0% | 92.7% |
| 3284365 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.74 | 69.0 | 6.49e-01 | 100.0% | 97.4% |
| 3740375 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.73 | 69.0 | 6.46e-01 | 100.0% | 99.5% |
| 3278543 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 68.0 | 6.45e-01 | 100.0% | 97.9% |
| 4980571 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 67.0 | 6.01e-01 | 100.0% | 98.2% |
| 1841334 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.70 | 61.0 | 6.39e-01 | 100.0% | 98.0% |
| 4200076 | 7550.1.1.0 ↗ | a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain | 0.66 | 39.0 | 4.90e-01 | 73.3% | 98.9% |
| 160146 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.64 | 59.0 | 5.75e-01 | 100.0% | 94.4% |
| 4636840 | 2003.1.5.8 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Ubie_methyltran | 0.61 | 51.0 | 4.46e-01 | 90.7% | 91.8% |
| 4992208 | 2003.1.5.81 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 | 0.60 | 50.0 | 4.37e-01 | 91.3% | 90.8% |
| 1498308 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.59 | 50.0 | 4.27e-01 | 90.7% | 92.4% |
| 5075492 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.59 | 49.0 | 4.63e-01 | 91.3% | 92.5% |
| 3507294 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.58 | 44.0 | 4.79e-01 | 100.0% | 95.6% |
| 4336917 | 2003.1.5.179 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PF30636 | 0.58 | 48.0 | 4.51e-01 | 88.8% | 89.2% |
| 1903993 | 2003.1.5.179 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PF30636 | 0.58 | 48.0 | 4.66e-01 | 89.4% | 92.8% |
| 5076036 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.57 | 45.0 | 4.39e-01 | 83.9% | 94.4% |
| 5076582 | 2003.1.12.1 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › UDPG/MGDP dehydrogenase C-terminal domain › UDPG_MGDP_dh_C | 0.57 | 46.0 | 4.73e-01 | 84.5% | 100.0% |
| 4991604 | 7523.1.1.5 ↗ | a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › PDT | 0.57 | 33.0 | 3.86e-01 | 100.0% | 81.8% |
| 3307502 | 2003.1.5.6 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltr_RsmB-F | 0.57 | 47.0 | 4.04e-01 | 90.1% | 75.1% |
| 4512937 | 2003.1.5.25 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › GidB | 0.57 | 47.0 | 4.36e-01 | 90.1% | 81.0% |
| 5025127 | 2004.1.1.791 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › GvpD_bR2 | 0.57 | 50.0 | 4.47e-01 | 96.3% | 93.9% |
| 4964947 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.56 | 47.0 | 4.52e-01 | 91.3% | 91.6% |
| 4980782 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.56 | 47.0 | 4.40e-01 | 90.7% | 95.6% |
| 4538622 | 2003.1.5.179 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PF30636 | 0.56 | 47.0 | 4.37e-01 | 89.4% | 87.5% |
| 3315603 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.56 | 46.0 | 4.31e-01 | 90.1% | 85.9% |
| 4989544 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.56 | 47.0 | 4.30e-01 | 90.7% | 99.0% |
| None | — | 0.56 | 47.0 | 4.51e-01 | 90.1% | 93.5% | |
| 5025539 | 2003.1.5.179 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PF30636 | 0.56 | 46.0 | 4.34e-01 | 89.4% | 87.0% |
| 4027219 | 247.1.1.0 ↗ | a+b four layers › Metallo-hydrolase/oxidoreductase › Metallo-hydrolase/oxidoreductase › Metallo-hydrolase/oxidoreductase | 0.56 | 48.0 | 3.44e-01 | 95.0% | 36.8% |
| 4318151 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.56 | 46.0 | 3.86e-01 | 90.1% | 88.9% |
| 4988836 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.55 | 48.0 | 4.87e-01 | 94.4% | 97.4% |
| None | — | 0.55 | 46.0 | 4.10e-01 | 90.1% | 83.4% | |
| 4993932 | 7545.1.1.1 ↗ | a/b three-layered sandwiches › YchN-like › YchN-like › YchN-like › DsrE | 0.55 | 34.0 | 4.13e-01 | 83.2% | 100.0% |
| 5065426 | 7558.1.1.3 ↗ | a/b three-layered sandwiches › Glycerol-3-phosphate (1)-acyltransferase › Glycerol-3-phosphate (1)-acyltransferase › Glycerol-3-phosphate (1)-acyltransferase › Lip_A_acyltrans | 0.55 | 40.0 | 3.41e-01 | 75.2% | 71.5% |
| 3516136 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.55 | 46.0 | 4.01e-01 | 91.3% | 92.7% |
| 3968398 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.55 | 46.0 | 4.20e-01 | 92.5% | 90.0% |
| 3241616 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.54 | 45.0 | 3.84e-01 | 91.3% | 90.7% |
| 3921925 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.54 | 45.0 | 4.07e-01 | 91.3% | 91.3% |
| 3975836 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.54 | 45.0 | 4.11e-01 | 92.5% | 87.3% |
| 3817455 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.53 | 44.0 | 3.78e-01 | 91.3% | 93.9% |
| 4999838 | 2003.1.1.50 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › DUF364 | 0.53 | 45.0 | 4.55e-01 | 90.1% | 100.0% |
| 3307924 | 2003.1.5.165 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11, Methyltransf_23 | 0.53 | 45.0 | 3.96e-01 | 91.3% | 92.5% |
| 4084494 | 2003.1.1.33 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › DXP_reductoisom | 0.53 | 46.0 | 4.66e-01 | 99.4% | 95.2% |
| 3520384 | 213.1.1.6 ↗ | a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › ODC_AZ | 0.53 | 29.0 | 3.42e-01 | 100.0% | 78.1% |
| 3277078 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.52 | 45.0 | 3.97e-01 | 95.7% | 98.0% |
| 4944454 | 2004.1.1.194 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C_2 | 0.52 | 46.0 | 4.44e-01 | 100.0% | 98.9% |
| 5011282 | 2004.1.1.76 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DUF87 | 0.52 | 47.0 | 3.61e-01 | 100.0% | 81.6% |
| 3253301 | 207.1.1.0 ↗ | beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats | 0.51 | 38.0 | 2.86e-01 | 76.4% | 59.1% |
| 3893733 | 7514.1.1.3 ↗ | a/b three-layered sandwiches › Ferredoxin reductase-like, C-terminal NADP-linked domain › Ferredoxin reductase-like, C-terminal NADP-linked domain › Ferredoxin reductase-like, C-terminal NADP-linked domain › NAD_binding_6 | 0.51 | 40.0 | 3.98e-01 | 82.6% | 87.3% |
| 3298833 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.51 | 45.0 | 4.08e-01 | 100.0% | 98.7% |