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dihydrofolate_reductase_motif-containing_protein
Euk-VirPandoravirus_inopinatum
dihydrofolate_reductase_motif-containing_protein__YP_009119751__Pandoravirus_inopinatum__1605721
Identity
- Accession:
- YP_009119751 ↗
- Protein ID:
- dihydrofolate_reductase_motif-containing_protein
- Kingdom:
- euk
Quality
70.5
mean pLDDT
Cluster
View cluster (7 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 3-198
Domain cluster:
rep: dihydrofolate_reductase__YP_009119754__Pandoravirus_inopinatum__1605721__D21-210
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00186.25 best | DHFR_1 | 29.2 | 9.60e-07 | 70.9% | 39.6% |
CATH (51)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1vdrA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.83 | 65.0 | 7.20e-01 | 90.8% | 100.0% |
| 1ao8A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.82 | 66.0 | 7.28e-01 | 90.8% | 100.0% |
| 2w9hA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.82 | 64.0 | 7.14e-01 | 90.8% | 100.0% |
| 1dhiA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.82 | 65.0 | 7.16e-01 | 90.8% | 100.0% |
| 5eccA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 62.0 | 6.93e-01 | 91.3% | 100.0% |
| 1cz3B00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 65.0 | 7.01e-01 | 92.3% | 98.8% |
| 3ix9A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 65.0 | 7.01e-01 | 92.9% | 100.0% |
| 3nzbX00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.75 | 67.0 | 6.61e-01 | 92.9% | 99.0% |
| 1juvA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.74 | 64.0 | 6.45e-01 | 89.8% | 100.0% |
| 6pf8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.74 | 64.0 | 6.73e-01 | 91.8% | 100.0% |
| 4eckA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.73 | 64.0 | 6.76e-01 | 91.8% | 100.0% |
| 1bozA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.73 | 65.0 | 6.71e-01 | 92.3% | 100.0% |
| 3zpgA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.73 | 65.0 | 6.29e-01 | 92.3% | 97.7% |
| 2b3zA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.73 | 65.0 | 6.14e-01 | 92.3% | 97.3% |
| 2g6vA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.73 | 65.0 | 6.18e-01 | 92.3% | 98.6% |
| 1j3jB00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.73 | 65.0 | 6.29e-01 | 93.4% | 99.5% |
| 2xw7A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.73 | 62.0 | 6.54e-01 | 93.4% | 99.4% |
| 2hxvA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.72 | 63.0 | 6.31e-01 | 91.3% | 100.0% |
| 2aznA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.72 | 64.0 | 6.15e-01 | 92.9% | 99.5% |
| 3k2hA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.72 | 64.0 | 6.58e-01 | 92.9% | 97.3% |
| 2p4gA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.72 | 64.0 | 5.88e-01 | 93.9% | 93.5% |
| 1aoeA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.71 | 63.0 | 6.44e-01 | 92.3% | 99.5% |
| 4xt6A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.71 | 63.0 | 5.82e-01 | 92.3% | 90.3% |
| 3kgyA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.70 | 61.0 | 5.91e-01 | 92.3% | 97.7% |
| 2gd9A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.64 | 52.0 | 5.63e-01 | 89.8% | 100.0% |
| 4bucA03 | 3.90.190.20 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Mur ligase, C-terminal domain | 0.61 | 37.0 | 4.49e-01 | 92.9% | 91.4% |
| 4powA02 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.60 | 35.0 | 4.38e-01 | 72.4% | 93.3% |
| 5dzsB02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.60 | 39.0 | 4.64e-01 | 83.2% | 96.2% |
| 3qtgA03 | 3.40.1380.20 | Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain | 0.59 | 32.0 | 4.12e-01 | 83.2% | 89.6% |
| 4eexA02 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.59 | 40.0 | 4.59e-01 | 83.7% | 94.3% |
| 2gs9A01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 45.0 | 4.54e-01 | 82.7% | 100.0% |
| 1earA02 | 3.30.70.790 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › UreE, C-terminal domain | 0.58 | 17.0 | 2.81e-01 | 96.4% | 68.1% |
| 2pjdA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.57 | 42.0 | 4.62e-01 | 85.2% | 96.2% |
| 4pneA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 44.0 | 4.01e-01 | 83.2% | 87.8% |
| 1s12A00 | 3.30.70.1490 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Cysteine protease Prp | 0.56 | 22.0 | 3.12e-01 | 92.9% | 73.4% |
| 3rhzA02 | 3.40.50.2000 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; | 0.55 | 40.0 | 4.41e-01 | 99.5% | 93.6% |
| 3douA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 44.0 | 4.63e-01 | 83.7% | 97.1% |
| 1e0tA01 | 3.40.1380.20 | Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain | 0.55 | 33.0 | 4.00e-01 | 82.7% | 92.7% |
| 1zq9A01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 44.0 | 4.54e-01 | 84.2% | 97.8% |
| 1t57A00 | 3.40.1380.20 | Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain | 0.54 | 38.0 | 3.93e-01 | 71.4% | 98.4% |
| 1suiA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.54 | 44.0 | 4.23e-01 | 87.8% | 99.6% |
| 2y23A01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.53 | 21.0 | 2.81e-01 | 92.9% | 64.4% |
| 5cm2Z00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.53 | 41.0 | 4.23e-01 | 80.1% | 98.4% |
| 3ihtA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.53 | 40.0 | 4.33e-01 | 84.7% | 94.5% |
| 4cu2A00 | 3.40.50.12090 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.53 | 23.0 | 3.34e-01 | 90.3% | 93.8% |
| 3e05B00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.53 | 41.0 | 4.22e-01 | 82.7% | 89.6% |
| 1l3iA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.52 | 41.0 | 4.26e-01 | 82.1% | 93.0% |
| 5dx9A01 | 3.30.70.1020 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Trehalose-6-phosphate phosphatase related protein; domain 2 | 0.52 | 21.0 | 3.30e-01 | 89.3% | 97.2% |
| 6z6fA01 | 3.40.800.20 | Alpha Beta › 3-Layer(aba) Sandwich › Arginase; Chain A › Histone deacetylase domain | 0.52 | 44.0 | 3.57e-01 | 90.8% | 92.2% |
| 2v3aA02 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.51 | 33.0 | 3.89e-01 | 73.5% | 92.6% |
| 3lkbA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.50 | 39.0 | 4.18e-01 | 80.1% | 93.4% |
ECOD (82)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4563316 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.82 | 64.0 | 7.00e-01 | 92.9% | 95.8% |
| 2847460 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.82 | 62.0 | 6.96e-01 | 91.8% | 98.1% |
| 4624802 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.81 | 66.0 | 7.24e-01 | 91.3% | 100.0% |
| 3963884 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.81 | 65.0 | 7.14e-01 | 90.8% | 100.0% |
| 169540 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.81 | 66.0 | 7.14e-01 | 92.9% | 98.8% |
| 2831687 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.80 | 65.0 | 6.90e-01 | 92.3% | 93.6% |
| 2580403 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.80 | 55.0 | 5.85e-01 | 78.6% | 78.3% |
| 4209889 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.79 | 57.0 | 6.63e-01 | 91.3% | 99.3% |
| 4392683 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 65.0 | 7.06e-01 | 91.8% | 100.0% |
| 4279950 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 65.0 | 7.04e-01 | 91.8% | 100.0% |
| 4965070 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 65.0 | 6.89e-01 | 92.3% | 94.9% |
| 4295510 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 63.0 | 6.93e-01 | 91.8% | 100.0% |
| 4652224 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 64.0 | 7.01e-01 | 91.8% | 100.0% |
| 4123104 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 65.0 | 7.04e-01 | 91.8% | 100.0% |
| 137968 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 65.0 | 7.01e-01 | 92.9% | 100.0% |
| 4276639 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 64.0 | 6.89e-01 | 92.9% | 97.1% |
| 4315799 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.77 | 66.0 | 7.00e-01 | 91.3% | 100.0% |
| 4183099 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.76 | 66.0 | 6.87e-01 | 93.9% | 97.8% |
| 3385448 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.76 | 60.0 | 6.62e-01 | 91.3% | 99.4% |
| 5030442 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.75 | 63.0 | 6.79e-01 | 90.8% | 100.0% |
| 3263045 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.75 | 66.0 | 6.62e-01 | 91.8% | 96.0% |
| 4663296 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.74 | 66.0 | 6.38e-01 | 93.4% | 100.0% |
| 3974710 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.74 | 64.0 | 6.72e-01 | 92.9% | 100.0% |
| 10266 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.74 | 64.0 | 6.45e-01 | 89.8% | 100.0% |
| 235716 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 65.0 | 6.38e-01 | 91.8% | 100.0% |
| 2503171 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.73 | 64.0 | 6.70e-01 | 92.3% | 98.9% |
| 136031 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.73 | 65.0 | 6.27e-01 | 91.8% | 100.0% |
| 4238819 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 66.0 | 6.30e-01 | 93.4% | 99.5% |
| 4577003 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 66.0 | 6.41e-01 | 93.9% | 100.0% |
| 3432837 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 65.0 | 6.15e-01 | 92.9% | 94.8% |
| 4946280 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 65.0 | 6.20e-01 | 92.3% | 100.0% |
| 163314 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 65.0 | 6.21e-01 | 92.3% | 100.0% |
| 4968801 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 65.0 | 6.09e-01 | 92.3% | 92.2% |
| 3182252 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 65.0 | 5.73e-01 | 92.9% | 91.1% |
| 4228699 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.73 | 63.0 | 6.29e-01 | 89.8% | 100.0% |
| 5063695 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 64.0 | 6.56e-01 | 91.8% | 98.9% |
| 5029141 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 61.0 | 6.48e-01 | 92.9% | 98.3% |
| 4262258 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.73 | 65.0 | 6.14e-01 | 92.9% | 98.2% |
| 4033392 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 64.0 | 6.29e-01 | 92.3% | 99.5% |
| 5001085 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 66.0 | 6.14e-01 | 94.9% | 95.7% |
| 1841334 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.72 | 53.0 | 6.12e-01 | 91.3% | 99.3% |
| 4487226 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 65.0 | 5.90e-01 | 93.9% | 90.4% |
| 5015705 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 63.0 | 5.98e-01 | 91.8% | 94.8% |
| 3953555 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 64.0 | 6.52e-01 | 92.3% | 99.5% |
| 10273 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 63.0 | 6.31e-01 | 91.3% | 100.0% |
| 4992215 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 64.0 | 6.20e-01 | 92.9% | 100.0% |
| 5062001 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 64.0 | 5.97e-01 | 93.9% | 95.4% |
| 5048917 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 63.0 | 6.07e-01 | 91.8% | 99.1% |
| 5058063 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.72 | 61.0 | 6.46e-01 | 92.3% | 100.0% |
| 1764169 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.71 | 63.0 | 5.80e-01 | 92.3% | 89.0% |
| 185430 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.71 | 64.0 | 6.57e-01 | 92.9% | 97.8% |
| 2389059 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.71 | 66.0 | 6.10e-01 | 96.9% | 96.2% |
| 5009586 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.71 | 62.0 | 6.09e-01 | 91.3% | 99.0% |
| 3277763 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.70 | 62.0 | 6.38e-01 | 91.8% | 100.0% |
| 3740375 | 7501.1.1.0 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases | 0.70 | 61.0 | 6.17e-01 | 90.8% | 100.0% |
| 3284365 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.70 | 62.0 | 6.26e-01 | 92.3% | 100.0% |
| 5073892 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.70 | 62.0 | 6.33e-01 | 92.9% | 100.0% |
| 3279668 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.69 | 61.0 | 6.27e-01 | 91.3% | 100.0% |
| 3278543 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.69 | 61.0 | 6.28e-01 | 92.9% | 100.0% |
| 160146 | 7501.1.1.2 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › RibD_C | 0.64 | 54.0 | 5.69e-01 | 91.8% | 97.2% |
| 3959323 | 2003.1.1.31 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › CbiJ | 0.61 | 37.0 | 4.57e-01 | 70.4% | 97.5% |
| 3950320 | 2003.1.5.80 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_24 | 0.59 | 50.0 | 4.70e-01 | 90.3% | 90.6% |
| 4999660 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.59 | 45.0 | 4.24e-01 | 80.1% | 88.9% |
| 4988836 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.58 | 44.0 | 4.85e-01 | 80.6% | 100.0% |
| 4980782 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.58 | 45.0 | 4.47e-01 | 81.6% | 95.1% |
| 4046970 | 2003.1.5.68 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › MTS_N | 0.58 | 43.0 | 4.73e-01 | 85.2% | 95.6% |
| 5010205 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.57 | 46.0 | 4.64e-01 | 83.7% | 95.9% |
| 3958608 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.57 | 45.0 | 4.39e-01 | 82.7% | 95.8% |
| 5056775 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.56 | 45.0 | 4.39e-01 | 83.7% | 99.1% |
| 5075492 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.56 | 45.0 | 4.48e-01 | 83.7% | 93.5% |
| 3375545 | 7518.1.1.0 ↗ | a/b three-layered sandwiches › PK C-terminal domain-like › PK C-terminal domain-like › PK C-terminal domain-like | 0.56 | 34.0 | 4.18e-01 | 83.2% | 94.4% |
| None | — | 0.55 | 43.0 | 4.13e-01 | 89.3% | 72.3% | |
| 3516136 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.54 | 43.0 | 3.98e-01 | 82.7% | 90.7% |
| 4241513 | 2003.1.5.20 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › MethyltransfD12 | 0.53 | 42.0 | 3.68e-01 | 82.7% | 92.2% |
| 3975836 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.53 | 42.0 | 4.07e-01 | 83.2% | 87.7% |
| 4089899 | 304.120.1.6 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI › ThiI_fer | 0.53 | 19.0 | 3.08e-01 | 95.9% | 84.0% |
| 4026112 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.53 | 43.0 | 4.06e-01 | 85.7% | 94.9% |
| 4966697 | 4955.1.1.0 ↗ | a+b two layers › permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit › permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit › permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit | 0.53 | 22.0 | 3.26e-01 | 91.8% | 90.0% |
| 4565833 | 2007.2.5.1 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › Rhodanese/Cell cycle control phosphatase › Rhodanese | 0.53 | 29.0 | 3.81e-01 | 86.2% | 99.0% |
| 3315603 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.52 | 41.0 | 4.09e-01 | 82.7% | 86.3% |
| 4221724 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.51 | 41.0 | 3.71e-01 | 84.2% | 61.9% |
| 4502645 | 7514.1.1.1 ↗ | a/b three-layered sandwiches › Ferredoxin reductase-like, C-terminal NADP-linked domain › Ferredoxin reductase-like, C-terminal NADP-linked domain › Ferredoxin reductase-like, C-terminal NADP-linked domain › NAD_binding_1 | 0.50 | 35.0 | 3.92e-01 | 95.9% | 94.4% |