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dihydrofolate_reductase_motif-containing_protein

Euk-Vir

Pandoravirus_inopinatum

dihydrofolate_reductase_motif-containing_protein__YP_009119897__Pandoravirus_inopinatum__1605721

Identity

Accession:
YP_009119897 ↗
Protein ID:
dihydrofolate_reductase_motif-containing_protein
Kingdom:
euk

Quality

61.5 mean pLDDT

Taxonomy

TaxID: 1605721

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 78-208
PDB
Domain cluster: representative
CATH (34)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2fupA00 1.20.58.300 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › FlgN-like 0.72 55.0 5.58e-01 80.2% 96.9%
3ro3A00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.67 38.0 3.55e-01 100.0% 45.3%
4yvoA00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.65 38.0 3.96e-01 100.0% 62.2%
4etrB00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.64 37.0 3.87e-01 80.9% 59.8%
6tkyA03 1.20.58.740 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › DOCK DHR2 domain, lobe C 0.62 50.0 5.19e-01 100.0% 91.8%
3r2qA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.59 43.0 4.61e-01 100.0% 87.6%
1fioA00 1.20.58.70 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.59 51.0 4.58e-01 96.2% 88.4%
3qc1A01 1.25.40.540 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › TAP42-like family 0.57 44.0 4.22e-01 100.0% 71.5%
6wb9201 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.56 36.0 2.81e-01 96.2% 28.0%
3on4D00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.56 49.0 4.33e-01 94.7% 93.0%
2o7tA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.55 47.0 4.24e-01 93.1% 69.7%
2ix5A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.55 42.0 4.00e-01 80.9% 78.1%
3himA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.54 48.0 4.22e-01 95.4% 70.5%
3dcfA02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.54 46.0 4.51e-01 90.8% 90.8%
4x28C03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.54 41.0 4.04e-01 80.9% 83.9%
2x64A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.54 39.0 4.13e-01 100.0% 87.6%
8hk0B03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.54 41.0 4.09e-01 80.9% 81.2%
2jbwA01 1.20.1440.110 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › acylaminoacyl peptidase 0.53 36.0 3.98e-01 90.8% 86.4%
4q5nA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.53 41.0 4.33e-01 100.0% 95.5%
2or0A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.53 37.0 3.30e-01 80.9% 50.5%
5figA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.53 36.0 4.02e-01 80.9% 91.0%
2cmrA00 1.20.58.1860 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.53 44.0 3.95e-01 100.0% 64.1%
1rx0A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.52 40.0 3.77e-01 80.9% 78.7%
3rkgA02 1.20.58.340 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region 0.51 39.0 3.61e-01 79.4% 84.8%
1qoyA00 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.51 46.0 3.50e-01 98.5% 94.7%
2oezA02 1.10.3900.10 Mainly Alpha › Orthogonal Bundle › YacF-like › YacF-like 0.51 39.0 3.67e-01 80.9% 92.6%
1k3kA00 1.10.437.10 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like 0.51 35.0 3.41e-01 87.0% 62.3%
1sgmA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.51 44.0 3.93e-01 95.4% 94.0%
2z1qB04 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.50 39.0 3.86e-01 80.9% 80.9%
5k7fA02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.50 43.0 4.25e-01 92.4% 92.8%
2eh3A02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.50 43.0 4.44e-01 93.9% 100.0%
5af7B03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.50 38.0 3.72e-01 80.9% 76.4%
2wbiB03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.50 38.0 3.62e-01 80.9% 74.1%
7e4gA01 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.50 35.0 3.09e-01 80.9% 47.7%
ECOD (35)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4874432 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.69 39.0 4.02e-01 100.0% 56.6%
3232658 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.66 36.0 3.66e-01 75.6% 53.1%
3618609 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.62 37.0 3.74e-01 79.4% 57.7%
4654652 633.21.1.23 alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › CD20 0.61 43.0 4.28e-01 89.3% 67.9%
3453205 633.21.1.0 alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 0.61 42.0 4.18e-01 90.1% 66.4%
3765032 633.23.1.34 alpha bundles › Bromodomain-like › Claudin › Claudin › CD20 0.61 42.0 4.09e-01 70.2% 73.8%
3762118 633.21.1.23 alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › CD20 0.60 41.0 3.86e-01 70.2% 68.5%
3616490 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.60 42.0 4.01e-01 73.3% 62.7%
3655114 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.59 40.0 3.96e-01 100.0% 64.3%
3585215 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.59 53.0 4.26e-01 100.0% 78.1%
3791 603.1.1.1 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin 0.59 51.0 4.58e-01 96.2% 88.4%
3592900 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.57 44.0 3.61e-01 95.4% 42.8%
3228302 601.1.2.0 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.57 37.0 3.91e-01 79.4% 71.7%
5055533 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.57 40.0 3.94e-01 98.5% 67.1%
3248267 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.56 38.0 3.71e-01 79.4% 62.1%
3929825 633.21.1.0 alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 0.56 38.0 3.92e-01 90.1% 74.2%
3781754 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.56 50.0 3.92e-01 98.5% 63.9%
5024802 3543.1.1.14 alpha complex topology › Acid-activated urea channel › Acid-activated urea channel › Acid-activated urea channel › DUF981 0.56 41.0 3.73e-01 100.0% 54.5%
4027027 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.55 45.0 4.02e-01 92.4% 61.0%
3408394 5001.1.1.0 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.55 45.0 3.58e-01 89.3% 71.2%
2818706 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.54 47.0 3.99e-01 100.0% 72.2%
3179886 1079.1.1.12 alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › GDT1 0.54 37.0 3.37e-01 70.2% 70.3%
3236694 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.53 39.0 3.85e-01 75.6% 75.0%
3927605 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.53 48.0 3.70e-01 100.0% 56.0%
3291550 191.1.1.49 alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_13_2 0.53 46.0 4.46e-01 94.7% 91.7%
3503768 633.21.1.0 alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 0.53 38.0 3.67e-01 79.4% 65.3%
3237547 150.1.1.31 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Tweety 0.52 41.0 3.37e-01 84.7% 84.4%
5002084 5001.1.1.0 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.52 43.0 3.53e-01 89.3% 61.6%
3536637 633.23.1.22 alpha bundles › Bromodomain-like › Claudin › Claudin › MARVEL 0.52 39.0 3.83e-01 89.3% 72.0%
3611626 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.51 45.0 3.81e-01 100.0% 77.0%
3601705 4121.1.1.0 a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like 0.51 46.0 3.43e-01 100.0% 55.8%
3866648 174.1.1.43 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › CD20 0.50 37.0 3.51e-01 81.7% 62.5%
4602773 611.9.1.4 alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N 0.50 35.0 3.49e-01 70.2% 78.5%
2321875 633.6.1.5 alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA-dh_C 0.50 39.0 3.85e-01 80.9% 80.3%
3399533 174.1.1.1 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin 0.50 39.0 3.70e-01 99.2% 69.0%
D2 medium residues 209-295
PDB
Domain cluster: representative
CATH (18)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2i2xB01 1.10.1240.10 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain 0.66 48.0 4.64e-01 98.9% 67.0%
1sxjE03 1.20.272.10 Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › 0.65 50.0 4.90e-01 83.9% 96.9%
2dlaA01 1.20.930.50 Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › 0.65 54.0 4.38e-01 89.7% 65.0%
3qnmA02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.64 36.0 3.60e-01 73.6% 52.2%
2gnoA03 1.20.272.10 Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › 0.63 48.0 4.69e-01 83.9% 94.0%
2j0wA02 1.20.120.1320 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartokinase, catalytic domain 0.63 44.0 4.39e-01 87.4% 69.9%
2ra1A03 1.20.58.770 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.60 39.0 4.45e-01 100.0% 92.1%
4mcwA02 1.10.3210.10 Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 0.59 38.0 2.93e-01 86.2% 29.0%
1a7eA00 1.20.120.50 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like 0.58 44.0 4.04e-01 82.8% 91.5%
2xguB00 1.10.375.10 Mainly Alpha › Orthogonal Bundle › Human Immunodeficiency Virus Type 1 Capsid Protein › Human Immunodeficiency Virus Type 1 Capsid Protein 0.55 45.0 3.90e-01 89.7% 86.6%
2qupA00 1.20.120.490 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hypothetical protein TM1646-like domain 0.54 43.0 3.89e-01 86.2% 68.1%
1vctA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.54 44.0 4.11e-01 88.5% 87.2%
2i10B02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.53 43.0 3.89e-01 89.7% 80.8%
2lsgA00 1.20.58.1280 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › DNA repair protein Rev1, C-terminal domain 0.53 37.0 3.64e-01 98.9% 67.0%
1st6A04 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.52 39.0 3.56e-01 79.3% 85.5%
3axjB02 1.20.58.200 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 0.51 41.0 4.16e-01 100.0% 87.1%
7fhyB01 1.50.10.100 Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › Chondroitin AC/alginate lyase 0.51 43.0 3.00e-01 93.1% 89.3%
4pkwA02 1.10.2030.10 Mainly Alpha › Orthogonal Bundle › Anthrax toxin lethal factor, domain 3, chain A › Anthrax toxin lethal factor, domain 3, chain A 0.50 26.0 2.99e-01 82.8% 68.3%
ECOD (9)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3673343 138.1.1.0 alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain 0.65 51.0 4.85e-01 86.2% 99.0%
4571267 1079.1.1.13 alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Mntp 0.59 49.0 3.86e-01 89.7% 77.5%
3775164 109.4.1.1871 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DNA_pol_phi, PF26720 0.57 41.0 2.69e-01 100.0% 16.9%
3239453 601.1.2.1 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Vinculin 0.57 45.0 3.93e-01 86.2% 60.0%
3781341 3955.1.1.1 alpha arrays › Sir2 N-terminal domain › Sir2 N-terminal domain › Sir2 N-terminal domain › DUF592 0.56 44.0 4.59e-01 87.4% 98.8%
3583810 601.1.1.0 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.56 44.0 3.98e-01 87.4% 94.4%
4238557 1188.1.1.3 alpha bundles › ZIP zinc transporter › ZIP zinc transporter › ZIP zinc transporter › Mntp 0.53 41.0 3.30e-01 85.1% 71.7%
3743077 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.52 41.0 3.63e-01 83.9% 76.0%
5033158 7064.1.1.0 alpha bundles › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 0.51 43.0 3.66e-01 95.4% 81.3%
D3 medium residues 296-369
PDB