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dsRNA-binding_PKR_inhibitor
Euk-VirEptesipox_virus
dsRNA-binding_PKR_inhibitor__YP_009407988__Eptesipox_virus__1329402
Identity
- Accession:
- YP_009407988 ↗
- Protein ID:
- dsRNA-binding_PKR_inhibitor
- Kingdom:
- euk
Quality
49.4
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Pokkesviricetes›
Chitovirales›
Poxviridae›
Vespertilionpoxvirus›
Eptesipox_virus
TaxID: 1329402
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 5-74
D2
high
residues 136-237
Domain cluster:
representative
CATH (24)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2rs7A01 | 3.30.160.20 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › | 0.79 | 55.0 | 6.45e-01 | 79.4% | 100.0% |
| 4ibnA01 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.72 | 52.0 | 4.19e-01 | 92.2% | 40.4% |
| 7a0hA02 | 3.90.1150.210 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › F-actin capping protein, beta subunit | 0.65 | 49.0 | 4.13e-01 | 80.4% | 80.5% |
| 4e19A00 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.64 | 40.0 | 3.71e-01 | 93.1% | 48.1% |
| 2vqeE01 | 3.30.160.20 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › | 0.62 | 35.0 | 4.18e-01 | 89.2% | 87.5% |
| 2xzmE01 | 3.30.160.20 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › | 0.61 | 48.0 | 4.65e-01 | 84.3% | 92.2% |
| 7clyA01 | 2.60.40.150 | Mainly Beta › Sandwich › Immunoglobulin-like › C2 domain | 0.60 | 43.0 | 3.65e-01 | 75.5% | 85.8% |
| 4akrA02 | 3.90.1150.210 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › F-actin capping protein, beta subunit | 0.58 | 44.0 | 3.93e-01 | 80.4% | 82.3% |
| 2w3sB04 | 3.30.365.10 | Alpha Beta › 2-Layer Sandwich › Aldehyde Oxidoreductase; domain 4 › Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain | 0.57 | 40.0 | 3.18e-01 | 72.5% | 62.3% |
| 5bkaE01 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.55 | 39.0 | 3.66e-01 | 74.5% | 63.6% |
| 2cc3A00 | 3.10.450.230 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › VirB8 protein | 0.55 | 38.0 | 3.47e-01 | 72.5% | 62.5% |
| 1rm6D04 | 3.30.365.10 | Alpha Beta › 2-Layer Sandwich › Aldehyde Oxidoreductase; domain 4 › Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain | 0.54 | 38.0 | 2.87e-01 | 72.5% | 48.7% |
| 3liuA02 | 2.60.40.3690 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.53 | 38.0 | 3.10e-01 | 76.5% | 90.6% |
| 4jf8A00 | 3.10.450.230 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › VirB8 protein | 0.52 | 36.0 | 3.30e-01 | 72.5% | 62.5% |
| 6pl6B01 | 3.40.710.10 | Alpha Beta › 3-Layer(aba) Sandwich › Beta-lactamase › DD-peptidase/beta-lactamase superfamily | 0.52 | 47.0 | 3.22e-01 | 100.0% | 89.3% |
| 4o3vA00 | 3.10.450.230 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › VirB8 protein | 0.52 | 38.0 | 3.45e-01 | 77.5% | 61.6% |
| 7rd0A02 | 3.40.710.10 | Alpha Beta › 3-Layer(aba) Sandwich › Beta-lactamase › DD-peptidase/beta-lactamase superfamily | 0.52 | 46.0 | 3.25e-01 | 99.0% | 93.5% |
| 6rtqA00 | 2.40.128.30 | Mainly Beta › Beta Barrel › Lipocalin › Avidin-like | 0.52 | 37.0 | 3.44e-01 | 75.5% | 78.9% |
| 1bf5A02 | 2.60.40.630 | Mainly Beta › Sandwich › Immunoglobulin-like › STAT transcription factor, DNA-binding domain | 0.51 | 39.0 | 3.51e-01 | 81.4% | 98.6% |
| 1yqzA03 | 3.30.390.30 | Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › FAD/NAD-linked reductase, C-terminal dimerisation domain | 0.51 | 36.0 | 3.55e-01 | 79.4% | 68.5% |
| 2ichA01 | 2.40.370.10 | Mainly Beta › Beta Barrel › AttH-like fold › AttH-like domain | 0.51 | 39.0 | 3.28e-01 | 81.4% | 62.0% |
| 3cu3A00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.51 | 39.0 | 3.44e-01 | 88.2% | 53.1% |
| 5o16B00 | 3.10.129.110 | Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Polyketide synthase dehydratase | 0.51 | 38.0 | 2.81e-01 | 79.4% | 66.9% |
| 3soyA00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.50 | 36.0 | 3.30e-01 | 76.5% | 59.9% |
ECOD (54)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3710326 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.84 | 60.0 | 6.53e-01 | 81.4% | 88.2% |
| 3499841 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.83 | 61.0 | 6.53e-01 | 81.4% | 86.7% |
| 3819309 | 330.1.1.5 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › DND1_DSRM | 0.82 | 63.0 | 6.91e-01 | 83.3% | 96.5% |
| 3596525 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.81 | 63.0 | 5.75e-01 | 81.4% | 91.5% |
| 3216163 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.80 | 62.0 | 6.44e-01 | 80.4% | 87.4% |
| 3596299 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.79 | 62.0 | 6.14e-01 | 81.4% | 92.4% |
| 3244569 | 330.1.1.1 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm | 0.78 | 60.0 | 6.61e-01 | 83.3% | 96.5% |
| 4026006 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.75 | 53.0 | 5.90e-01 | 80.4% | 93.8% |
| 4960250 | 330.2.1.5 ↗ | a+b two layers › dsRBD-like › Ribosome binding protein Y (YfiA homologue) › Ribosome binding protein Y (YfiA homologue) › PF29181 | 0.74 | 55.0 | 5.57e-01 | 80.4% | 78.0% |
| 5066042 | 330.2.1.5 ↗ | a+b two layers › dsRBD-like › Ribosome binding protein Y (YfiA homologue) › Ribosome binding protein Y (YfiA homologue) › PF29181 | 0.74 | 53.0 | 5.55e-01 | 80.4% | 80.0% |
| 5008315 | 330.2.1.5 ↗ | a+b two layers › dsRBD-like › Ribosome binding protein Y (YfiA homologue) › Ribosome binding protein Y (YfiA homologue) › PF29181 | 0.74 | 54.0 | 5.52e-01 | 80.4% | 78.0% |
| 3596522 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.73 | 57.0 | 5.59e-01 | 81.4% | 76.4% |
| 5071146 | 330.2.1.5 ↗ | a+b two layers › dsRBD-like › Ribosome binding protein Y (YfiA homologue) › Ribosome binding protein Y (YfiA homologue) › PF29181 | 0.73 | 54.0 | 5.45e-01 | 80.4% | 78.0% |
| 5040123 | 330.2.1.5 ↗ | a+b two layers › dsRBD-like › Ribosome binding protein Y (YfiA homologue) › Ribosome binding protein Y (YfiA homologue) › PF29181 | 0.73 | 53.0 | 5.38e-01 | 80.4% | 77.0% |
| 223631 | 2484.1.1.4 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_H | 0.72 | 52.0 | 4.04e-01 | 92.2% | 36.0% |
| 3611338 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.72 | 56.0 | 5.21e-01 | 81.4% | 79.2% |
| 3607862 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.72 | 55.0 | 5.71e-01 | 80.4% | 94.7% |
| 5075859 | 330.2.1.5 ↗ | a+b two layers › dsRBD-like › Ribosome binding protein Y (YfiA homologue) › Ribosome binding protein Y (YfiA homologue) › PF29181 | 0.71 | 54.0 | 5.26e-01 | 80.4% | 72.7% |
| 3658408 | 4325.1.1.13 ↗ | mixed a+b and a/b › YegP-like › YegP-like › YegP-like › DUF4371 | 0.71 | 50.0 | 5.66e-01 | 99.0% | 98.7% |
| 3824181 | 375.1.1.21 ↗ | few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › zf-ZPR1 | 0.71 | 36.0 | 4.55e-01 | 77.5% | 83.3% |
| 5013672 | 295.1.1.0 ↗ | a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain | 0.69 | 41.0 | 4.90e-01 | 97.1% | 90.8% |
| 3808123 | 2484.1.1.67 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 | 0.67 | 45.0 | 3.91e-01 | 71.6% | 45.8% |
| 4330094 | 330.4.1.1 ↗ | a+b two layers › dsRBD-like › Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain › Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain › Porphobil_deamC | 0.66 | 47.0 | 4.97e-01 | 79.4% | 83.3% |
| 3396462 | 295.1.1.0 ↗ | a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain | 0.66 | 41.0 | 4.96e-01 | 98.0% | 98.5% |
| 3961802 | 243.5.1.9 ↗ | a+b two layers › Cystatin-like › Amine oxidase N-terminal region › Amine oxidase N-terminal region › UPF0182 | 0.66 | 45.0 | 3.60e-01 | 73.5% | 35.5% |
| 3413325 | 5.1.4.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed | 0.65 | 48.0 | 3.26e-01 | 76.5% | 29.2% |
| 4010500 | 7503.1.1.24 ↗ | a/b three-layered sandwiches › TolB, N-terminal domain › TolB, N-terminal domain › TolB, N-terminal domain › PF25851 | 0.65 | 56.0 | 4.93e-01 | 95.1% | 100.0% |
| 5056195 | 5.1.4.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed | 0.63 | 43.0 | 3.00e-01 | 70.6% | 26.3% |
| 3222710 | 295.1.1.0 ↗ | a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain | 0.62 | 41.0 | 4.56e-01 | 98.0% | 87.2% |
| 2581837 | 7503.1.1.0 ↗ | a/b three-layered sandwiches › TolB, N-terminal domain › TolB, N-terminal domain › TolB, N-terminal domain | 0.62 | 55.0 | 4.79e-01 | 100.0% | 91.8% |
| 5029482 | 295.1.1.0 ↗ | a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain | 0.61 | 38.0 | 4.18e-01 | 78.4% | 78.8% |
| 3481504 | 330.4.1.1 ↗ | a+b two layers › dsRBD-like › Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain › Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain › Porphobil_deamC | 0.61 | 46.0 | 4.39e-01 | 80.4% | 85.8% |
| 4844428 | 295.1.1.4 ↗ | a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain › COMM_domain | 0.60 | 39.0 | 4.41e-01 | 98.0% | 89.3% |
| 2494924 | 295.1.1.4 ↗ | a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain › COMM_domain | 0.60 | 39.0 | 4.31e-01 | 98.0% | 84.6% |
| 3251381 | 295.1.1.4 ↗ | a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain › COMM_domain | 0.60 | 38.0 | 4.50e-01 | 98.0% | 100.0% |
| 3838085 | 7503.1.1.11 ↗ | a/b three-layered sandwiches › TolB, N-terminal domain › TolB, N-terminal domain › TolB, N-terminal domain › HP1454-like_C | 0.59 | 50.0 | 5.04e-01 | 92.2% | 99.0% |
| 5075588 | 512.1.1.0 ↗ | a+b two layers › a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) › a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) › a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) | 0.59 | 43.0 | 4.52e-01 | 77.5% | 86.7% |
| 4652688 | 504.1.1.1 ↗ | a+b two layers › Bacterial protein-export protein SecB › Bacterial protein-export protein SecB › Bacterial protein-export protein SecB › SecB | 0.58 | 53.0 | 4.79e-01 | 100.0% | 72.9% |
| 4583731 | 2484.1.1.231 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_Tnp_IS66, DDE_Tnp_IS66_C | 0.58 | 44.0 | 3.41e-01 | 83.3% | 79.2% |
| 3700323 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.58 | 32.0 | 3.98e-01 | 76.5% | 96.4% |
| 3584211 | 243.1.1.0 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like | 0.57 | 44.0 | 3.86e-01 | 80.4% | 66.2% |
| 4199388 | 504.1.1.1 ↗ | a+b two layers › Bacterial protein-export protein SecB › Bacterial protein-export protein SecB › Bacterial protein-export protein SecB › SecB | 0.57 | 51.0 | 4.57e-01 | 100.0% | 72.4% |
| 3594550 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.56 | 42.0 | 3.58e-01 | 78.4% | 93.3% |
| 4136826 | 7520.1.1.0 ↗ | a/b three-layered sandwiches › CinA-like › CinA-like › CinA-like | 0.56 | 47.0 | 4.27e-01 | 93.1% | 92.0% |
| 5018204 | 7520.1.1.0 ↗ | a/b three-layered sandwiches › CinA-like › CinA-like › CinA-like | 0.55 | 44.0 | 3.81e-01 | 87.3% | 95.2% |
| 3170704 | 5.1.4.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed | 0.55 | 40.0 | 2.68e-01 | 75.5% | 21.7% |
| 4984424 | 2484.1.1.59 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › NurA | 0.54 | 43.0 | 2.93e-01 | 88.2% | 22.5% |
| 4180585 | 7520.1.1.1 ↗ | a/b three-layered sandwiches › CinA-like › CinA-like › CinA-like › CinA | 0.54 | 45.0 | 4.01e-01 | 93.1% | 88.0% |
| 4494466 | 2484.1.1.231 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_Tnp_IS66, DDE_Tnp_IS66_C | 0.52 | 44.0 | 3.36e-01 | 100.0% | 39.2% |
| 3283095 | 4321.1.1.0 ↗ | a+b two layers › Peptidoglycan deacetylase N-terminal noncatalytic region › Peptidoglycan deacetylase N-terminal noncatalytic region › Peptidoglycan deacetylase N-terminal noncatalytic region | 0.51 | 37.0 | 2.98e-01 | 75.5% | 60.3% |
| 3742201 | 216.1.1.4 ↗ | a+b two layers › UBC-like › UBC-like › UBC-like › RWD | 0.51 | 40.0 | 3.67e-01 | 83.3% | 78.5% |
| 4932446 | 504.1.1.0 ↗ | a+b two layers › Bacterial protein-export protein SecB › Bacterial protein-export protein SecB › Bacterial protein-export protein SecB | 0.51 | 45.0 | 4.30e-01 | 100.0% | 86.7% |
| 3425790 | 243.3.1.19 ↗ | a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin › DUF3615 | 0.50 | 34.0 | 3.51e-01 | 92.2% | 73.7% |
| 3418267 | 3887.2.1.1 ↗ | a+b two layers › Yeast killer toxin-like › Antifungal protein ginkbilobin-2 › Antifungal protein ginkbilobin-2 › Stress-antifung | 0.50 | 39.0 | 3.80e-01 | 100.0% | 74.2% |