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envelope_glycoprotein_H
Euk-VirHuman_alphaherpesvirus_3
envelope_glycoprotein_H__NP_040160__Human_alphaherpesvirus_3__10335
Identity
- Accession:
- NP_040160 ↗
- Protein ID:
- envelope_glycoprotein_H
- Kingdom:
- euk
Quality
71.3
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Varicellovirus›
Human_alphaherpesvirus_3
TaxID: 10335
Cluster
View cluster (30 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 33-100
D2
medium
residues 198-215_324-422
Domain cluster:
rep: envelope_glycoprotein_H__YP_068353__Suid_alphaherpesvirus_1__10345__D240-339
D3
medium
residues 216-323
Domain cluster:
rep: envelope_glycoprotein_H__YP_010087581__Cervid_alphaherpesvirus_3__2115790__D207-328
D4
medium
residues 423-545
Domain cluster:
rep: envelope_glycoprotein_H__NP_045257__Equid_alphaherpesvirus_4__10331__D432-555
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02489.22 best | Herpes_glycop_H | 29.8 | 3.60e-07 | 74.0% | 15.0% |
CATH (37)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1rz4A01 | 1.25.40.250 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › ARM repeat; domain 1 | 0.71 | 53.0 | 5.43e-01 | 91.9% | 80.0% |
| 1elwA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.69 | 48.0 | 4.90e-01 | 84.6% | 73.5% |
| 6i57A00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.68 | 48.0 | 4.81e-01 | 87.8% | 71.2% |
| 4dloB02 | 1.25.40.610 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.67 | 53.0 | 5.48e-01 | 85.4% | 97.4% |
| 2lo6A00 | 1.25.40.90 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.67 | 53.0 | 4.93e-01 | 84.6% | 83.1% |
| 4c0eA01 | 1.25.40.790 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.66 | 55.0 | 4.20e-01 | 89.4% | 48.1% |
| 3zc0D00 | 1.20.58.2140 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.65 | 51.0 | 4.47e-01 | 83.7% | 66.8% |
| 3rk6A00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.65 | 58.0 | 4.83e-01 | 99.2% | 86.2% |
| 6tblB01 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.63 | 47.0 | 4.97e-01 | 86.2% | 87.4% |
| 2of3A00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.60 | 54.0 | 4.23e-01 | 100.0% | 65.0% |
| 3kavA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.60 | 39.0 | 4.28e-01 | 80.5% | 80.4% |
| 5an3A01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.60 | 45.0 | 4.50e-01 | 82.9% | 76.7% |
| 2a2fX02 | 1.20.58.670 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Dsl1p vesicle tethering complex, Tip20p subunit, domain D | 0.60 | 46.0 | 4.55e-01 | 82.1% | 93.8% |
| 1sgmA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.60 | 46.0 | 4.05e-01 | 82.1% | 96.2% |
| 5vjcA00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.59 | 51.0 | 4.06e-01 | 95.9% | 53.1% |
| 3beeA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.59 | 42.0 | 4.66e-01 | 88.6% | 100.0% |
| 1umpA01 | 1.50.10.20 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.59 | 53.0 | 3.84e-01 | 100.0% | 57.6% |
| 1u5pA01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 45.0 | 4.77e-01 | 87.8% | 94.4% |
| 2ze7A02 | 1.10.287.890 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Crystal structure of tRNA isopentenylpyrophosphate transferase (bh2366) domain | 0.57 | 33.0 | 3.56e-01 | 88.6% | 65.7% |
| 1lshA02 | 1.25.10.20 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Vitellinogen, superhelical | 0.56 | 50.0 | 3.72e-01 | 100.0% | 63.9% |
| 2q9rA01 | 1.20.1590.10 | Mainly Alpha › Up-down Bundle › YP_001051499.1 fold like › YP_001051499.1 domain like | 0.56 | 37.0 | 3.16e-01 | 78.0% | 41.5% |
| 1sumB01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.55 | 42.0 | 4.55e-01 | 84.6% | 92.5% |
| 4i4cB00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.54 | 47.0 | 3.32e-01 | 95.1% | 31.4% |
| 6wb9201 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.54 | 43.0 | 3.28e-01 | 98.4% | 36.0% |
| 1e6bA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.54 | 42.0 | 4.42e-01 | 84.6% | 92.8% |
| 2lqgA00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.54 | 41.0 | 3.98e-01 | 80.5% | 84.1% |
| 3kp9A01 | 1.20.1440.130 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › VKOR domain | 0.54 | 42.0 | 3.90e-01 | 83.7% | 87.7% |
| 1ldjA04 | 1.20.1310.10 | Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats | 0.53 | 41.0 | 4.23e-01 | 83.7% | 88.7% |
| 2fbqA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.53 | 40.0 | 3.39e-01 | 80.5% | 74.2% |
| 4ap2B01 | 1.20.1310.10 | Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats | 0.53 | 43.0 | 4.23e-01 | 88.6% | 97.0% |
| 2ggfA00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.52 | 42.0 | 4.15e-01 | 90.2% | 85.4% |
| 4bujE03 | 1.10.3380.30 | Mainly Alpha › Orthogonal Bundle › Sec63 N-terminal domain-like fold › | 0.51 | 46.0 | 3.83e-01 | 100.0% | 100.0% |
| 2hjmA01 | 1.20.120.460 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › protein pf1176 like | 0.51 | 33.0 | 3.84e-01 | 78.9% | 93.0% |
| 3juiA00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.51 | 43.0 | 3.92e-01 | 95.9% | 98.9% |
| 1h0oA00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.50 | 43.0 | 3.30e-01 | 93.5% | 97.6% |
| 4bmoA00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.50 | 44.0 | 3.43e-01 | 99.2% | 95.9% |
| 1x42A02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.50 | 28.0 | 3.33e-01 | 78.0% | 80.7% |
ECOD (42)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1554358 | 3146.1.1.1 ↗ | a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H | 0.94 | 81.0 | 4.98e-01 | 100.0% | 18.4% |
| 3793706 | 109.4.1.941 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › LTN1_E3_ligase_5th | 0.75 | 68.0 | 5.89e-01 | 98.4% | 83.2% |
| 3814948 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.75 | 69.0 | 5.41e-01 | 100.0% | 67.6% |
| 3323936 | 109.24.1.2 ↗ | alpha superhelices › Repetitive alpha hairpins › Helical domain in dedicator of cytokinesis protein 9 › Helical domain in dedicator of cytokinesis protein 9 › DHR-2_Lobe_C | 0.74 | 54.0 | 5.29e-01 | 75.6% | 88.9% |
| 3905315 | 109.24.1.2 ↗ | alpha superhelices › Repetitive alpha hairpins › Helical domain in dedicator of cytokinesis protein 9 › Helical domain in dedicator of cytokinesis protein 9 › DHR-2_Lobe_C | 0.74 | 54.0 | 5.28e-01 | 75.6% | 83.7% |
| 3846009 | 109.4.1.300 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ZER1-like_2nd | 0.70 | 59.0 | 4.43e-01 | 92.7% | 37.8% |
| 3739499 | 109.4.1.101 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › CENP-I | 0.70 | 64.0 | 4.00e-01 | 100.0% | 31.2% |
| 3697513 | 109.4.1.356 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans | 0.70 | 62.0 | 4.85e-01 | 98.4% | 55.5% |
| None | — | 0.69 | 62.0 | 3.60e-01 | 100.0% | 14.7% | |
| 3818455 | 109.4.1.163 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SYMPK_PTA1_N | 0.68 | 59.0 | 3.65e-01 | 94.3% | 19.2% |
| 3671842 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.68 | 59.0 | 5.08e-01 | 97.6% | 61.1% |
| 3814731 | 109.4.1.575 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DUF577 | 0.68 | 62.0 | 4.57e-01 | 100.0% | 50.6% |
| 3720031 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.67 | 57.0 | 5.24e-01 | 91.9% | 76.2% |
| 3598209 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.67 | 59.0 | 4.41e-01 | 98.4% | 64.9% |
| 3788179 | 109.4.1.501 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › UME | 0.67 | 56.0 | 4.31e-01 | 94.3% | 40.7% |
| 3256210 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.66 | 59.0 | 3.73e-01 | 99.2% | 27.9% |
| 1108450 | 109.4.1.58 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Not1 | 0.66 | 55.0 | 3.63e-01 | 89.4% | 26.9% |
| 4100830 | 109.4.1.1360 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › CBF, NOC3p | 0.66 | 59.0 | 4.07e-01 | 100.0% | 36.7% |
| 3791727 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.66 | 53.0 | 4.23e-01 | 87.0% | 59.2% |
| 4616633 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.66 | 58.0 | 4.45e-01 | 98.4% | 42.8% |
| 3929752 | 109.4.1.209 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Katanin_con80 | 0.66 | 50.0 | 4.91e-01 | 86.2% | 75.4% |
| 3235931 | 206.1.1.0 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase | 0.65 | 58.0 | 3.24e-01 | 99.2% | 11.9% |
| 3696544 | 109.4.1.1508 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Not1, ARM_Cnot1 | 0.65 | 55.0 | 3.65e-01 | 91.1% | 27.6% |
| 3511096 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.64 | 52.0 | 3.63e-01 | 98.4% | 26.8% |
| 3355292 | 601.1.1.66 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › At5g52880_ARM | 0.64 | 50.0 | 5.22e-01 | 82.9% | 100.0% |
| 3417343 | 109.4.1.1718 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF26716 | 0.64 | 58.0 | 5.77e-01 | 99.2% | 100.0% |
| 3741922 | 109.4.1.335 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SEN1_N | 0.64 | 57.0 | 4.53e-01 | 100.0% | 67.7% |
| 3480009 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.64 | 56.0 | 4.54e-01 | 98.4% | 57.6% |
| 4016927 | 109.4.1.58 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Not1 | 0.63 | 54.0 | 4.13e-01 | 94.3% | 44.1% |
| 3732211 | 3924.1.1.0 ↗ | alpha complex topology › Sterol uptake control protein 2 › Sterol uptake control protein 2 › Sterol uptake control protein 2 | 0.62 | 51.0 | 4.35e-01 | 100.0% | 54.0% |
| 3271437 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.61 | 50.0 | 4.46e-01 | 90.2% | 67.8% |
| 3581894 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.61 | 43.0 | 4.12e-01 | 77.2% | 62.9% |
| 3635885 | 109.4.1.18 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPTA | 0.60 | 52.0 | 4.67e-01 | 95.9% | 69.4% |
| 3487084 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.60 | 46.0 | 4.52e-01 | 82.9% | 92.6% |
| 4027101 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.59 | 52.0 | 3.69e-01 | 97.6% | 47.2% |
| 3701884 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.57 | 48.0 | 4.52e-01 | 91.9% | 83.3% |
| 3182667 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.57 | 45.0 | 3.68e-01 | 84.6% | 63.9% |
| 3256816 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.56 | 43.0 | 4.09e-01 | 91.9% | 68.0% |
| 3695075 | 109.4.1.583 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DNA_pol_phi | 0.55 | 48.0 | 3.90e-01 | 100.0% | 53.7% |
| 3679873 | 109.4.1.90 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TOM20_plant | 0.55 | 44.0 | 4.06e-01 | 95.9% | 66.3% |
| 3939816 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.51 | 40.0 | 4.11e-01 | 84.6% | 88.3% |
| 3657376 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.51 | 43.0 | 3.94e-01 | 95.1% | 92.9% |
D5
medium
residues 546-650
Domain cluster:
rep: envelope_glycoprotein_H__NP_045337__Bovine_alphaherpesvirus_1__10320__D538-631
CATH (4)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5c98A01 | 3.30.497.10 | Alpha Beta › 2-Layer Sandwich › Antithrombin; Chain I, domain 2 › Antithrombin, subunit I, domain 2 | 0.57 | 41.0 | 3.23e-01 | 74.3% | 84.1% |
| 2iw3A02 | 1.20.1390.20 | Mainly Alpha › Up-down Bundle › PWI domain › | 0.52 | 38.0 | 4.02e-01 | 82.9% | 90.0% |
| 2dn0A00 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.51 | 32.0 | 3.65e-01 | 93.3% | 86.8% |
| 2vj4A01 | 1.10.10.2060 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › | 0.50 | 30.0 | 3.17e-01 | 71.4% | 66.7% |
ECOD (3)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1554358 | 3146.1.1.1 ↗ | a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H | 0.92 | 89.0 | 5.31e-01 | 100.0% | 17.7% |
| 3307612 | 171.1.1.0 ↗ | alpha arrays › RNase III catalytic domain-like › RNase III catalytic domain-like › RNase III catalytic domain-like | 0.56 | 41.0 | 3.30e-01 | 77.1% | 60.0% |
| 3971367 | 179.1.1.1 ↗ | alpha bundles › CO dehydrogenase ISP C-domain like › CO dehydrogenase ISP C-domain like › CO dehydrogenase ISP C-domain like › Fer2_2 | 0.52 | 36.0 | 3.95e-01 | 88.6% | 91.6% |
D6
medium
residues 651-797
Domain cluster:
rep: UL22__YP_003084400__Anatid_alphaherpesvirus_1__104388__D647-783
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF17488.8 best | Herpes_glycoH_C | 59.3 | 4.90e-16 | 95.2% | 92.2% |
D7
medium
residues 802-834
Domain cluster:
representative