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envelope_glycoprotein_H

Euk-Vir

Equid_gammaherpesvirus_2

envelope_glycoprotein_H__NP_042618__Equid_gammaherpesvirus_2__12657

Identity

Accession:
NP_042618 ↗
Protein ID:
envelope_glycoprotein_H
Kingdom:
euk

Quality

82.2 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 68-121
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 43.1 3.20e-11 70.4% 7.6%
D2 medium residues 187-311
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 134.3 7.50e-39 100.0% 25.6%
CATH (28)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
5w0kA01 3.90.380.20 Alpha Beta › Alpha-Beta Complex › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 › Herpesvirus glycoprotein H, domain D-II 0.94 92.0 6.44e-01 100.0% 38.5%
1y8cA02 2.20.25.110 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › S-adenosyl-L-methionine-dependent methyltransferases 0.74 32.0 4.64e-01 73.6% 86.7%
2nvnA00 2.30.31.10 Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Transcriptional Coactivator Pc4; Chain A 0.63 33.0 3.39e-01 79.2% 53.3%
7zgmA01 2.70.98.10 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › 0.63 53.0 4.23e-01 90.4% 82.8%
2it9A00 2.30.31.10 Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Transcriptional Coactivator Pc4; Chain A 0.63 33.0 3.42e-01 79.2% 54.2%
2wvxA01 2.70.98.10 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › 0.62 53.0 3.98e-01 91.2% 66.9%
6f91A01 2.70.98.10 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › 0.62 52.0 4.01e-01 90.4% 78.1%
2xsgB01 2.70.98.10 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › 0.62 53.0 4.01e-01 91.2% 77.5%
6f90A01 2.70.98.10 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › 0.59 48.0 3.79e-01 88.8% 75.6%
3w7tA01 2.70.98.50 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › putative glycoside hydrolase family protein from bacillus halodurans 0.59 45.0 3.68e-01 80.8% 78.9%
7szeB02 3.90.380.10 Alpha Beta › Alpha-Beta Complex › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 0.58 43.0 3.80e-01 100.0% 53.3%
4ggtB00 2.40.128.30 Mainly Beta › Beta Barrel › Lipocalin › Avidin-like 0.56 41.0 4.50e-01 76.0% 89.6%
5gv0A00 2.40.160.110 Mainly Beta › Beta Barrel › Porin › 0.56 44.0 3.99e-01 80.8% 66.0%
1vyfA00 2.40.128.20 Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain 0.56 41.0 4.02e-01 75.2% 90.4%
1xn5A00 3.30.530.20 Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain 0.55 41.0 3.98e-01 82.4% 70.3%
6r3wA00 2.40.128.20 Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain 0.54 39.0 3.63e-01 76.0% 76.4%
4orlA00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.54 37.0 3.99e-01 71.2% 89.1%
2p4bB02 3.30.200.100 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › MucB/RseB, C-terminal domain 0.54 38.0 4.23e-01 72.8% 100.0%
2plgA01 3.30.1460.10 Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › 0.53 39.0 3.87e-01 75.2% 73.5%
3jv1A00 3.10.280.10 Alpha Beta › Roll › Mitochondrial Matrix Protein; Chain A › Mitochondrial glycoprotein 0.53 35.0 3.11e-01 98.4% 46.2%
1tlyA00 2.40.230.20 Mainly Beta › Beta Barrel › Outer membrane phospholipase (ompla); Chain C › Nucleoside-specific channel-forming protein, Tsx-like 0.52 44.0 3.48e-01 89.6% 69.3%
2zylA02 3.90.380.10 Alpha Beta › Alpha-Beta Complex › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 0.52 44.0 3.71e-01 92.0% 72.4%
2m47A00 3.30.530.20 Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain 0.52 41.0 3.79e-01 100.0% 65.0%
4azpA00 2.40.128.20 Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain 0.52 38.0 3.72e-01 75.2% 90.3%
2ntkB00 3.60.20.20 Alpha Beta › 4-Layer Sandwich › Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 › Inosine monophosphate cyclohydrolase-like 0.52 33.0 2.80e-01 100.0% 38.1%
3ijtB00 3.30.530.20 Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain 0.51 44.0 4.25e-01 93.6% 100.0%
1zc3B00 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.51 32.0 3.48e-01 79.2% 73.4%
2e3nA00 3.30.530.20 Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain 0.50 45.0 3.73e-01 100.0% 97.0%
ECOD (25)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2095478 3146.1.1.1 a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H 0.94 91.0 5.74e-01 100.0% 24.6%
3474457 319.1.1.0 beta sandwiches › HSP20-like › HSP20-like chaperones › HSP20-like chaperones 0.73 35.0 4.01e-01 80.8% 60.0%
3733630 12.3.1.0 beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich 0.66 53.0 4.21e-01 86.4% 84.7%
5033173 5084.1.1.0 beta barrels › Outer membrane meander beta-barrels › OMPA-like › OMPA-like 0.63 38.0 4.09e-01 79.2% 68.8%
5791 295.1.1.6 a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain › DUF1818 0.63 33.0 3.43e-01 79.2% 54.6%
3587042 331.3.1.32 a+b two layers › TBP-like › Bet v1-like › Bet v1-like › DUF3284 0.63 39.0 3.86e-01 78.4% 58.5%
3265841 216.1.1.20 a+b two layers › UBC-like › UBC-like › UBC-like › UBC_like 0.62 35.0 3.91e-01 79.2% 69.0%
3785596 216.1.1.2 a+b two layers › UBC-like › UBC-like › UBC-like › Autophagy_act_C 0.62 44.0 4.01e-01 89.6% 55.8%
5081796 633.23.1.0 alpha bundles › Bromodomain-like › Claudin › Claudin 0.62 33.0 2.94e-01 99.2% 37.1%
2582184 5087.3.1.2 beta meanders › Lipovitellin-phosvitin complex › Lipovitellin LV-1C › Lipovitellin LV-1C › MTP_lip_bd 0.59 46.0 3.59e-01 84.0% 91.5%
4018089 4099.1.1.0 a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like 0.58 44.0 4.51e-01 79.2% 83.3%
3894207 3369.1.1.1 beta meanders › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › Lamp2-like_luminal 0.58 45.0 4.15e-01 80.0% 66.9%
4989818 12.3.1.0 beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich 0.58 47.0 3.86e-01 85.6% 93.6%
3274430 12.3.1.40 beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › TREH_N 0.58 49.0 4.21e-01 95.2% 99.5%
3398781 5087.3.1.2 beta meanders › Lipovitellin-phosvitin complex › Lipovitellin LV-1C › Lipovitellin LV-1C › MTP_lip_bd 0.57 45.0 3.42e-01 83.2% 61.1%
3593518 9.1.1.0 beta barrels › Lipocalins/Streptavidin › Lipocalins › Lipocalins 0.57 41.0 3.63e-01 74.4% 77.7%
3861601 3369.1.1.1 beta meanders › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › Lamp2-like_luminal 0.56 43.0 3.94e-01 80.0% 68.1%
4983588 295.1.1.0 a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain 0.56 34.0 4.11e-01 98.4% 98.7%
4964630 331.3.1.11 a+b two layers › TBP-like › Bet v1-like › Bet v1-like › Polyketide_cyc2 0.55 41.0 3.96e-01 76.8% 72.7%
3487462 9.1.1.0 beta barrels › Lipocalins/Streptavidin › Lipocalins › Lipocalins 0.55 40.0 3.98e-01 75.2% 91.5%
3833570 298.1.1.24 a+b two layers › FwdE/GAPDH domain-like › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › GFO_IDH_MocA_C3 0.54 40.0 3.16e-01 76.0% 65.0%
3179717 9.14.1.0 beta barrels › Lipocalins/Streptavidin › Uncharacterized protein YLR301W › Uncharacterized protein YLR301W 0.53 40.0 4.09e-01 82.4% 80.8%
2080133 3521.1.1.0 a+b three layers › Polymerase basic protein 2 cap-binding domain › Polymerase basic protein 2 cap-binding domain › Polymerase basic protein 2 cap-binding domain 0.52 39.0 4.24e-01 82.4% 94.2%
5033737 71.1.1.0 beta meanders › Lipoprotein localization factors LolAB › Lipoprotein localization factors LolAB › Lipoprotein localization factors LolAB 0.52 36.0 3.11e-01 83.2% 47.3%
3644145 5.1.3.0 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed 0.51 38.0 2.79e-01 77.6% 93.7%
D3 medium residues 496-575
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 106.6 1.80e-30 100.0% 16.0%
CATH (18)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3dfgA01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.66 40.0 4.87e-01 76.2% 100.0%
1qgtB00 1.10.4090.10 Mainly Alpha › Orthogonal Bundle › Hepatitis B viral capsid (hbcag) fold › Viral capsid, core domain supefamily, Hepatitis B virus 0.64 38.0 3.12e-01 100.0% 32.2%
2xseA00 1.20.120.1440 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › JBP1, DNA-binding domain 0.63 52.0 4.27e-01 93.8% 69.2%
3e3vA01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.62 38.0 4.45e-01 76.2% 92.5%
4eqqA02 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.62 35.0 4.21e-01 70.0% 89.6%
2ou3A01 1.10.3680.10 Mainly Alpha › Orthogonal Bundle › TerB-like › TerB-like 0.61 48.0 3.97e-01 88.7% 66.9%
1f5oA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.58 47.0 3.92e-01 90.0% 65.8%
2nr4A02 1.20.58.290 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Hypothetical membrane protein ta0354_69_121. 0.57 37.0 4.17e-01 83.7% 91.4%
3oy2A02 3.40.50.2000 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; 0.55 43.0 3.15e-01 98.8% 29.3%
7p5hB03 1.20.1440.230 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain 0.55 37.0 3.61e-01 87.5% 62.9%
3vhlA02 1.20.58.740 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › DOCK DHR2 domain, lobe C 0.54 46.0 4.11e-01 100.0% 95.8%
4dveA00 1.10.1760.20 Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 › 0.53 43.0 3.37e-01 92.5% 49.2%
3pvlA03 1.20.80.10 Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › 0.52 45.0 4.04e-01 100.0% 75.4%
6qlyA02 1.20.80.10 Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › 0.51 42.0 4.04e-01 100.0% 78.4%
3un6A01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.51 43.0 3.24e-01 91.3% 76.6%
3lcnB00 1.10.340.40 Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain 0.51 43.0 4.05e-01 93.8% 75.3%
2vunA02 3.20.20.140 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Metal-dependent hydrolases 0.51 43.0 3.12e-01 97.5% 46.9%
8gccA03 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.50 34.0 3.17e-01 70.0% 67.3%
ECOD (18)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2701125 3146.1.1.1 a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H 0.94 83.0 4.92e-01 100.0% 14.9%
4075843 185.1.1.1 alpha superhelices › Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin-like › Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin/Protein HNS-dependent expression A HdeA › Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin › Tryp_alpha_amyl 0.69 55.0 5.13e-01 88.7% 84.6%
3202292 101.38.1.3 alpha arrays › HTH › DNA-binding domain of the replication initiator protein ColE2-Rep › DNA-binding domain of the replication initiator protein ColE2-Rep › DUF6891 0.65 44.0 4.73e-01 81.2% 80.0%
3390104 109.4.1.3523 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF29546, PF29547 0.64 51.0 3.74e-01 87.5% 32.1%
5077614 182.1.3.3 alpha complex topology › Cryptochrome/photolyase FAD-binding domain-related › Cryptochrome/photolyase FAD-binding domain-related › PriX › DNA_primase_lrg 0.57 44.0 4.54e-01 88.7% 88.0%
3261420 109.2.1.60 alpha superhelices › Repetitive alpha hairpins › alpha/alpha toroid › alpha/alpha toroid › SGL_GH162 0.56 46.0 2.87e-01 95.0% 63.3%
3981539 532.2.1.1 alpha arrays › Type III secretion system domain-like › Type III secretion system domains › Type III secretion system domains › HrpJ 0.56 43.0 4.35e-01 90.0% 87.5%
3787103 1203.1.2.0 alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 0.55 44.0 3.69e-01 87.5% 85.0%
None 0.55 42.0 2.75e-01 98.8% 18.8%
3490129 189.1.1.2 alpha bundles › GTPase activation domain, GAP › GTPase activation domain, GAP › GTPase activation domain, GAP › RhoGAP 0.55 46.0 3.40e-01 95.0% 79.6%
5049375 182.1.2.1 alpha complex topology › Cryptochrome/photolyase FAD-binding domain-related › Cryptochrome/photolyase FAD-binding domain-related › Fe-S cluster domain of DNA primase › DNA_primase_lrg 0.55 43.0 3.64e-01 90.0% 50.4%
3227781 5059.1.1.0 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter 0.55 39.0 3.55e-01 75.0% 82.7%
4990335 182.1.3.3 alpha complex topology › Cryptochrome/photolyase FAD-binding domain-related › Cryptochrome/photolyase FAD-binding domain-related › PriX › DNA_primase_lrg 0.54 45.0 4.01e-01 91.3% 65.2%
5043574 182.1.3.3 alpha complex topology › Cryptochrome/photolyase FAD-binding domain-related › Cryptochrome/photolyase FAD-binding domain-related › PriX › DNA_primase_lrg 0.54 45.0 3.90e-01 93.8% 59.2%
4970738 182.1.3.3 alpha complex topology › Cryptochrome/photolyase FAD-binding domain-related › Cryptochrome/photolyase FAD-binding domain-related › PriX › DNA_primase_lrg 0.54 43.0 3.81e-01 92.5% 59.2%
3457160 7579.1.1.6 a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Abhydrolase_1 0.54 40.0 2.85e-01 81.2% 57.5%
3200582 101.1.2.111 alpha arrays › HTH › HTH › winged helix domain › RQC 0.53 39.0 3.40e-01 78.8% 71.2%
3554580 197.1.1.1 alpha bundles › Acyl-CoA binding protein-like › Acyl-CoA binding protein-like › Acyl-CoA binding protein-like › FERM_M 0.51 42.0 3.92e-01 100.0% 73.3%
D4 medium residues 576-728
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF17488.8 best Herpes_glycoH_C 193.6 1.80e-57 92.8% 98.6%