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envelope_glycoprotein_H

Euk-Vir

Equid_alphaherpesvirus_4

envelope_glycoprotein_H__NP_045257__Equid_alphaherpesvirus_4__10331

Identity

Accession:
NP_045257 ↗
Protein ID:
envelope_glycoprotein_H
Kingdom:
euk

Quality

73.7 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 58-102
PDB
D2 medium residues 197-322
PDB
D3 medium residues 323-431
PDB
D4 medium residues 432-555
PDB
Domain cluster: representative
CATH (35)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2jqqA00 1.20.58.1240 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.70 54.0 5.05e-01 81.5% 66.9%
1j1jA02 1.20.58.200 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 0.70 42.0 4.98e-01 93.5% 88.2%
1vctA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.68 49.0 5.17e-01 97.6% 83.5%
3ha4B00 1.20.58.690 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.67 60.0 6.09e-01 98.4% 100.0%
3h3mA00 1.20.58.380 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Flagellar protein flit. 0.66 42.0 4.76e-01 91.1% 86.5%
3l8rA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.65 46.0 4.99e-01 91.1% 88.2%
4epzA00 1.25.40.810 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › UpxZ 0.64 44.0 4.11e-01 75.8% 55.8%
3swhA01 1.10.357.50 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.64 54.0 4.89e-01 90.3% 90.3%
1lvfB00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 49.0 5.35e-01 93.5% 96.2%
1br0A00 1.20.58.70 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 52.0 5.30e-01 93.5% 88.3%
1t72A01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.62 45.0 4.70e-01 93.5% 81.2%
1sumB01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.60 42.0 4.53e-01 91.1% 85.0%
2fji101 1.10.357.50 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.59 50.0 4.28e-01 92.7% 83.7%
2b1eA02 1.20.1310.30 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › 0.59 49.0 4.65e-01 91.9% 99.3%
3qwwA03 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.58 47.0 4.13e-01 100.0% 57.6%
3vvaA00 1.20.1260.140 Mainly Alpha › Up-down Bundle › Ferritin › Alternative oxidase 0.56 42.0 3.35e-01 78.2% 68.8%
3mvuA00 1.20.910.10 Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like 0.56 41.0 3.36e-01 75.0% 71.4%
3e7qA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.56 44.0 3.77e-01 85.5% 63.0%
2hz8A00 1.20.120.660 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain 0.55 37.0 3.81e-01 91.1% 72.2%
3kavA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.55 36.0 3.94e-01 84.7% 79.4%
2pziA04 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.55 44.0 4.00e-01 94.4% 61.6%
2qgmA03 1.20.1440.30 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Biosynthetic Protein domain 0.55 35.0 3.68e-01 87.9% 69.0%
3u5nA02 1.20.920.10 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like 0.54 35.0 3.62e-01 96.8% 67.5%
3v5uA01 6.10.280.80 Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › NCX, peripheral helical region 0.54 29.0 3.58e-01 71.8% 84.2%
1yo7A00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.53 40.0 4.08e-01 84.7% 82.5%
4a64C03 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.53 40.0 4.34e-01 87.9% 100.0%
2cdqA02 1.20.120.1320 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartokinase, catalytic domain 0.52 29.0 3.26e-01 86.3% 69.1%
6fndA01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.52 46.0 4.06e-01 100.0% 69.9%
2z0qA01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.52 45.0 3.96e-01 97.6% 87.6%
3kp9A01 1.20.1440.130 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › VKOR domain 0.52 42.0 3.89e-01 88.7% 87.7%
7cfmR01 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.52 44.0 3.52e-01 95.2% 75.7%
4f4cA01 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.52 42.0 2.69e-01 91.1% 94.3%
2fd5A02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.51 37.0 3.65e-01 91.1% 69.7%
4v3iA00 1.25.40.590 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Type IV / VI secretion system, DotU 0.51 41.0 3.92e-01 90.3% 83.0%
1cqxA01 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.50 36.0 3.46e-01 100.0% 62.0%
ECOD (42)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3407107 109.4.1.496 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Sec5 0.70 51.0 5.50e-01 78.2% 89.5%
3867624 109.4.1.3415 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF28426 0.69 61.0 4.72e-01 95.2% 51.7%
3274860 109.25.1.0 alpha superhelices › Repetitive alpha hairpins › GPCR-autoproteolysis inducing domain subdomain A › GPCR-autoproteolysis inducing domain subdomain A 0.69 63.0 5.50e-01 100.0% 71.4%
5053943 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.68 48.0 4.54e-01 73.4% 74.0%
4567001 604.34.1.1 alpha bundles › Spectrin repeat-like › Helical bundle domain in arginine decarboxylase › Helical bundle domain in arginine decarboxylase › Arg_decarb_HB 0.67 43.0 4.87e-01 75.0% 84.2%
3518832 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.67 54.0 4.64e-01 100.0% 54.4%
3528632 109.4.1.447 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PI4K_N 0.66 59.0 5.37e-01 100.0% 95.3%
4147954 604.34.1.1 alpha bundles › Spectrin repeat-like › Helical bundle domain in arginine decarboxylase › Helical bundle domain in arginine decarboxylase › Arg_decarb_HB 0.65 42.0 4.83e-01 75.0% 90.0%
3994343 109.25.1.0 alpha superhelices › Repetitive alpha hairpins › GPCR-autoproteolysis inducing domain subdomain A › GPCR-autoproteolysis inducing domain subdomain A 0.65 53.0 5.26e-01 88.7% 96.2%
3907391 109.25.1.0 alpha superhelices › Repetitive alpha hairpins › GPCR-autoproteolysis inducing domain subdomain A › GPCR-autoproteolysis inducing domain subdomain A 0.64 52.0 5.54e-01 88.7% 100.0%
4378444 109.25.1.1 alpha superhelices › Repetitive alpha hairpins › GPCR-autoproteolysis inducing domain subdomain A › GPCR-autoproteolysis inducing domain subdomain A › GAIN 0.63 55.0 5.57e-01 94.4% 100.0%
3659038 603.1.1.102 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › DUF3537 0.63 58.0 4.09e-01 100.0% 96.8%
4095580 604.34.1.1 alpha bundles › Spectrin repeat-like › Helical bundle domain in arginine decarboxylase › Helical bundle domain in arginine decarboxylase › Arg_decarb_HB 0.63 42.0 4.65e-01 75.0% 86.3%
4008156 109.37.1.1 alpha superhelices › Repetitive alpha hairpins › Anion channel SLAC1-related › Anion channel SLAC1-related › SLAC1 0.63 53.0 4.00e-01 93.5% 45.3%
3351812 601.1.3.11 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › A middle domain of Talin 1 › PF28566 0.63 47.0 4.13e-01 79.0% 54.6%
3188377 109.4.1.356 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans 0.62 57.0 3.89e-01 100.0% 34.2%
3695573 109.4.1.356 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans 0.62 56.0 3.75e-01 100.0% 92.0%
3528568 109.25.1.0 alpha superhelices › Repetitive alpha hairpins › GPCR-autoproteolysis inducing domain subdomain A › GPCR-autoproteolysis inducing domain subdomain A 0.62 51.0 4.95e-01 87.9% 97.0%
3941457 1203.1.2.3 alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 › YiaAB 0.61 40.0 4.07e-01 87.9% 67.5%
3189654 109.4.1.356 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans 0.61 55.0 3.75e-01 100.0% 33.5%
3511390 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.60 50.0 4.43e-01 96.8% 61.7%
3732149 109.4.1.681 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans_2 0.60 51.0 3.64e-01 92.7% 42.6%
3186833 5059.1.1.8 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › Mg_trans_NIPA 0.60 43.0 4.04e-01 74.2% 93.5%
3885417 109.4.1.586 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fanconi_A 0.60 52.0 3.73e-01 95.2% 35.3%
4944333 633.10.1.0 alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like 0.59 40.0 4.08e-01 98.4% 68.8%
3821602 109.4.1.1412 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_2, TPR_7, TPR_12 0.59 47.0 4.22e-01 99.2% 59.4%
3245201 6155.1.1.1 alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MtN3_slv 0.59 44.0 4.29e-01 79.0% 72.9%
3724523 4121.1.1.7 a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › PF26616 0.59 53.0 3.84e-01 100.0% 93.6%
3371755 109.4.1.1286 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8, TPR_12 0.58 46.0 4.38e-01 96.0% 70.7%
3456183 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.57 43.0 4.72e-01 79.8% 98.0%
3614196 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.57 51.0 3.96e-01 100.0% 72.9%
3711208 601.1.1.0 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.57 51.0 4.52e-01 100.0% 70.8%
3837397 310.2.1.57 a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF › DUF7798 0.57 43.0 4.02e-01 80.6% 88.1%
3286634 109.3.1.160 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › EccD 0.55 49.0 3.66e-01 100.0% 60.6%
3396404 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.55 47.0 4.74e-01 93.5% 92.0%
3486470 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.54 47.0 3.44e-01 99.2% 37.8%
3185102 6155.1.1.0 alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter 0.53 44.0 4.33e-01 91.1% 90.4%
3997689 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.52 45.0 3.34e-01 96.8% 61.7%
4467862 603.5.1.0 alpha bundles › STAT-like › FlgN-like › FlgN-like 0.52 44.0 4.22e-01 93.5% 80.0%
4997920 7516.1.1.2 a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2 0.51 44.0 3.11e-01 92.7% 91.5%
3608391 101.1.10.1 alpha arrays › HTH › HTH › Cyclin-like › Cyclin_N 0.51 39.0 3.77e-01 80.6% 90.3%
3227635 150.1.1.0 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.51 40.0 3.68e-01 84.7% 87.5%
D5 medium residues 556-655
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 20.3 2.60e-04 76.0% 6.6%
CATH (13)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2i39B00 1.10.437.20 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › dsDNA poxvirus 0.61 33.0 3.16e-01 81.0% 43.7%
1w2qA01 1.10.110.10 Mainly Alpha › Orthogonal Bundle › Hydrophobic Seed Protein › Plant lipid-transfer and hydrophobic proteins 0.59 47.0 4.56e-01 88.0% 78.8%
2w53B00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.54 46.0 3.94e-01 97.0% 65.9%
2yfaA02 1.20.1440.210 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.54 36.0 3.46e-01 90.0% 58.6%
1vi0A02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.54 45.0 4.09e-01 96.0% 80.7%
2fi1A02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.53 33.0 3.87e-01 89.0% 96.9%
6dewA01 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.52 43.0 3.58e-01 93.0% 77.4%
1jt6A02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.52 43.0 3.94e-01 92.0% 82.5%
1bc0A03 1.10.220.10 Mainly Alpha › Orthogonal Bundle › Annexin V; domain 1 › Annexin 0.52 38.0 4.08e-01 79.0% 90.7%
5c4yA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.51 42.0 3.88e-01 94.0% 83.8%
2icwG02 1.10.10.530 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › mam-mhc complex, Chain D, Domain 2 0.51 33.0 3.46e-01 78.0% 73.0%
2b1eA01 1.20.58.1150 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.51 33.0 3.56e-01 89.0% 77.9%
3gi7A00 1.20.1270.180 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.50 30.0 3.05e-01 100.0% 56.3%
ECOD (9)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2095476 3146.1.1.1 a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H 0.86 73.0 4.43e-01 100.0% 15.7%
1554358 3146.1.1.1 a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H 0.83 78.0 4.67e-01 100.0% 16.9%
3876785 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.62 32.0 3.23e-01 98.0% 49.0%
3508996 5059.1.1.34 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA, Nuc_sug_transp 0.58 47.0 3.37e-01 90.0% 62.0%
4002037 109.4.1.338 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › RIC1 0.56 38.0 2.79e-01 94.0% 24.5%
3518177 106.1.1.1 alpha arrays › Globin-like › Globin-like › Globin-like › Globin 0.53 44.0 3.74e-01 92.0% 76.6%
3216584 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.52 34.0 3.52e-01 97.0% 70.5%
3307612 171.1.1.0 alpha arrays › RNase III catalytic domain-like › RNase III catalytic domain-like › RNase III catalytic domain-like 0.51 44.0 3.46e-01 98.0% 66.8%
4945403 3745.1.1.1 alpha bundles › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Na_Ca_ex 0.50 39.0 2.75e-01 85.0% 71.2%
D6 medium residues 656-732
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF17488.8 best Herpes_glycoH_C 30.4 4.00e-07 90.9% 42.5%