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envelope_glycoprotein_H
Euk-VirMacacine_alphaherpesvirus_1
envelope_glycoprotein_H__NP_851881__Macacine_alphaherpesvirus_1__10325
Identity
- Accession:
- NP_851881 ↗
- Protein ID:
- envelope_glycoprotein_H
- Kingdom:
- euk
Quality
74.3
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Macacine_alphaherpesvirus_1
TaxID: 10325
Cluster
View cluster (30 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 60-160
D2
medium
residues 167-192_222-272_292-345
Domain cluster:
rep: envelope_glycoprotein_H__YP_010087581__Cervid_alphaherpesvirus_3__2115790__D207-328
D3
medium
residues 273-291_346-467
Domain cluster:
rep: envelope_glycoprotein_H__YP_068353__Suid_alphaherpesvirus_1__10345__D240-339
CATH (22)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2xqyA01 | 3.30.500.50 | Alpha Beta › 2-Layer Sandwich › Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 › | 0.74 | 70.0 | 6.41e-01 | 100.0% | 93.8% |
| 1v9vA01 | 1.20.1480.20 | Mainly Alpha › Up-down Bundle › hypothetical protein mp506/mpn330, domain 1 › MAST3 pre-PK domain-like | 0.61 | 38.0 | 4.57e-01 | 89.4% | 92.6% |
| 3q5wA00 | 1.20.58.1590 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Tethering factor for nuclear proteasome Cut8/Sts1 | 0.61 | 45.0 | 4.05e-01 | 80.9% | 55.1% |
| 7odyC01 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.61 | 33.0 | 4.08e-01 | 90.8% | 81.5% |
| 1oxjA02 | 1.25.40.170 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Smaug, PHAT domain | 0.60 | 44.0 | 4.84e-01 | 78.0% | 97.2% |
| 5an3A01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.59 | 42.0 | 4.36e-01 | 78.7% | 79.1% |
| 1r9dA01 | 3.20.70.20 | Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › | 0.57 | 49.0 | 3.11e-01 | 96.5% | 98.7% |
| 4o6mA02 | 1.20.120.1760 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CDP-alcohol phosphotransferase transmembrane (TM) domain | 0.56 | 51.0 | 4.60e-01 | 99.3% | 73.3% |
| 7eu3E01 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.56 | 32.0 | 3.94e-01 | 75.2% | 89.7% |
| 5olkB01 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.56 | 40.0 | 3.23e-01 | 72.3% | 84.9% |
| 2kuaA01 | 1.10.437.10 | Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like | 0.55 | 45.0 | 4.41e-01 | 87.9% | 94.0% |
| 3ztaA00 | 1.10.490.130 | Mainly Alpha › Orthogonal Bundle › Globin-like › | 0.54 | 39.0 | 4.01e-01 | 75.9% | 82.0% |
| 1d8wC00 | 3.20.20.150 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Divalent-metal-dependent TIM barrel enzymes | 0.53 | 39.0 | 2.86e-01 | 77.3% | 53.9% |
| 1zoyD00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.53 | 31.0 | 3.63e-01 | 75.9% | 80.4% |
| 4pdyA02 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.53 | 43.0 | 3.63e-01 | 86.5% | 67.4% |
| 7e4nA01 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.52 | 46.0 | 3.70e-01 | 98.6% | 81.5% |
| 2pg0A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.51 | 39.0 | 3.86e-01 | 92.2% | 75.2% |
| 1k3kA00 | 1.10.437.10 | Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like | 0.51 | 41.0 | 4.13e-01 | 87.9% | 87.0% |
| 3oqvA00 | 3.40.50.11710 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Cyclodipeptide synthase | 0.51 | 34.0 | 2.98e-01 | 77.3% | 44.1% |
| 1a52A00 | 1.10.565.10 | Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor | 0.51 | 36.0 | 3.05e-01 | 73.8% | 79.1% |
| 6lumD01 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.51 | 37.0 | 3.98e-01 | 77.3% | 87.2% |
| 3smvA02 | 1.10.150.750 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › | 0.50 | 27.0 | 3.54e-01 | 95.0% | 96.1% |
ECOD (26)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2095476 | 3146.1.1.1 ↗ | a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H | 0.95 | 93.0 | 5.87e-01 | 100.0% | 33.6% |
| 1554358 | 3146.1.1.1 ↗ | a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H | 0.89 | 85.0 | 5.41e-01 | 100.0% | 32.5% |
| 3454218 | 109.4.1.890 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HAT_Syf1_CNRKL1_C | 0.63 | 48.0 | 4.12e-01 | 78.0% | 65.1% |
| 3307710 | 109.4.1.853 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › AP5B1_middle | 0.63 | 49.0 | 3.81e-01 | 81.6% | 51.3% |
| 3265125 | 604.22.1.1 ↗ | alpha bundles › Spectrin repeat-like › tubulin binding cofactor C N-terminal domain › tubulin binding cofactor C N-terminal domain › TBCC_N | 0.61 | 39.0 | 4.12e-01 | 79.4% | 72.0% |
| 4003115 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.60 | 47.0 | 3.47e-01 | 82.3% | 59.7% |
| 3272586 | 109.4.1.162 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Nup192 | 0.58 | 48.0 | 3.26e-01 | 89.4% | 65.0% |
| 3900237 | 109.4.1.886 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_DOCK | 0.58 | 46.0 | 3.66e-01 | 84.4% | 42.1% |
| 3797233 | 603.5.1.0 ↗ | alpha bundles › STAT-like › FlgN-like › FlgN-like | 0.57 | 44.0 | 4.05e-01 | 80.1% | 92.2% |
| 3368963 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.57 | 38.0 | 3.28e-01 | 94.3% | 43.2% |
| 3612346 | 109.4.1.161 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › mTOR_dom | 0.57 | 42.0 | 3.29e-01 | 83.0% | 34.6% |
| 3490505 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.56 | 43.0 | 2.96e-01 | 82.3% | 27.7% |
| 3652794 | 109.4.1.167 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Rif1_N | 0.55 | 43.0 | 3.04e-01 | 83.0% | 25.3% |
| 5050184 | 3883.1.1.1 ↗ | alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf | 0.55 | 51.0 | 4.50e-01 | 100.0% | 71.5% |
| None | — | 0.55 | 43.0 | 3.86e-01 | 83.0% | 76.5% | |
| 4548132 | 3930.1.1.10 ↗ | alpha bundles › Helical bundle insertion in helicase domains › Helical bundle in Hef helicase › Helical bundle in Hef helicase › DUF5587 | 0.54 | 43.0 | 4.11e-01 | 97.9% | 72.1% |
| 3499049 | 109.46.1.1 ↗ | alpha superhelices › Repetitive alpha hairpins › Helical domain in TOPLESS related protein 2 (TPR2) › Helical domain in TOPLESS related protein 2 (TPR2) › CTLH | 0.53 | 40.0 | 3.99e-01 | 80.1% | 76.0% |
| 3964811 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.53 | 40.0 | 3.59e-01 | 78.7% | 71.5% |
| 5069651 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.53 | 41.0 | 3.78e-01 | 81.6% | 76.1% |
| 4458285 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.52 | 41.0 | 3.53e-01 | 83.7% | 66.5% |
| 3347270 | 3843.1.1.0 ↗ | alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K | 0.52 | 34.0 | 3.80e-01 | 91.5% | 85.7% |
| 3550549 | 109.4.1.673 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fanconi_A_N | 0.52 | 41.0 | 2.93e-01 | 85.1% | 39.6% |
| 3335188 | 5050.1.1.33 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_5 | 0.51 | 42.0 | 3.59e-01 | 88.7% | 62.1% |
| 4261753 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 39.0 | 3.57e-01 | 80.1% | 61.6% |
| 3965327 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.50 | 39.0 | 3.25e-01 | 81.6% | 60.0% |
| 4955374 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.50 | 39.0 | 3.36e-01 | 81.6% | 61.8% |
D4
medium
residues 468-621
Domain cluster:
rep: envelope_glycoprotein_H__YP_053085__Equid_alphaherpesvirus_1__10326__D464-476_499-660
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02489.22 best | Herpes_glycop_H | 30.9 | 1.70e-07 | 95.5% | 23.5% |
D5
medium
residues 622-673
Domain cluster:
representative
CATH (8)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1m3sB00 | 3.40.50.10490 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1 | 0.65 | 45.0 | 3.17e-01 | 75.0% | 33.3% |
| 7egfc01 | 1.10.20.10 | Mainly Alpha › Orthogonal Bundle › Histone, subunit A › Histone, subunit A | 0.62 | 46.0 | 4.07e-01 | 86.5% | 64.0% |
| 1d8cA02 | 2.170.170.11 | Mainly Beta › Beta Complex › Malate synthase G - maily-beta sub-domain › Malate synthase G - maily-beta sub-domain | 0.61 | 42.0 | 3.29e-01 | 75.0% | 60.9% |
| 4rcnA04 | 3.90.226.10 | Alpha Beta › Alpha-Beta Complex › 2-enoyl-CoA Hydratase; Chain A, domain 1 › 2-enoyl-CoA Hydratase; Chain A, domain 1 | 0.59 | 52.0 | 3.39e-01 | 100.0% | 23.4% |
| 4hfvA02 | 6.10.280.170 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Substrate of the Dot/Icm secretion system | 0.58 | 44.0 | 4.02e-01 | 82.7% | 84.5% |
| 4csrB00 | 1.10.20.10 | Mainly Alpha › Orthogonal Bundle › Histone, subunit A › Histone, subunit A | 0.57 | 43.0 | 3.93e-01 | 92.3% | 64.6% |
| 5y27A00 | 1.10.20.10 | Mainly Alpha › Orthogonal Bundle › Histone, subunit A › Histone, subunit A | 0.57 | 42.0 | 3.59e-01 | 86.5% | 57.1% |
| 3axjB02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.52 | 40.0 | 3.44e-01 | 84.6% | 94.1% |
ECOD (6)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5068933 | 101.1.7.0 ↗ | alpha arrays › HTH › HTH › Methylated DNA-protein cysteine methyltransferase-C | 0.68 | 50.0 | 4.33e-01 | 82.7% | 51.2% |
| 3589208 | 3227.1.1.1 ↗ | alpha complex topology › phosphorylation-coupled saccharide transporter ChbC › phosphorylation-coupled saccharide transporter ChbC › phosphorylation-coupled saccharide transporter ChbC › PTS_EIIC | 0.63 | 51.0 | 3.09e-01 | 100.0% | 14.3% |
| 3741853 | 148.1.1.12 ↗ | alpha arrays › Histone-like › Histone-related › Histone › Bromo_TP | 0.60 | 44.0 | 3.88e-01 | 84.6% | 54.4% |
| 3866897 | 148.1.1.12 ↗ | alpha arrays › Histone-like › Histone-related › Histone › Bromo_TP | 0.60 | 45.0 | 3.86e-01 | 86.5% | 47.4% |
| 4374797 | 507.1.1.2 ↗ | alpha arrays › DnaB helicase N-terminal domain-related › DnaB helicase N-terminal domain-related › DnaB helicase N-terminal domain-related › DnaG_DnaB_bind | 0.58 | 46.0 | 3.60e-01 | 98.1% | 85.9% |
| 3742145 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.53 | 43.0 | 3.11e-01 | 94.2% | 79.4% |
D6
medium
residues 674-817
Domain cluster:
rep: UL22__YP_003084400__Anatid_alphaherpesvirus_1__104388__D647-783
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF17488.8 best | Herpes_glycoH_C | 43.1 | 4.80e-11 | 95.8% | 92.9% |