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envelope_glycoprotein_H

Euk-Vir

Equid_alphaherpesvirus_9

envelope_glycoprotein_H__YP_002333521__Equid_alphaherpesvirus_9__55744

Identity

Accession:: YP_002333521 ↗
Protein ID:: envelope_glycoprotein_H
Kingdom:: euk

Quality

70.2 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› Equid_alphaherpesvirus_9

TaxID: 55744

Cluster

View cluster (30 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 152-169_211-311

PDB

Domain cluster: rep: envelope_glycoprotein_H__YP_010087581__Cervid_alphaherpesvirus_3__2115790__D207-328

D2 medium residues 199-210_312-431

PDB

Domain cluster: rep: envelope_glycoprotein_H__YP_068353__Suid_alphaherpesvirus_1__10345__D240-339

CATH (30)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2xqyA01	3.30.500.50	Alpha Beta › 2-Layer Sandwich › Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 ›	0.84	65.0	5.85e-01	90.9%	60.1%
5an3A01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.74	47.0	4.81e-01	78.8%	65.1%
4o6mA02	1.20.120.1760	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CDP-alcohol phosphotransferase transmembrane (TM) domain	0.69	54.0	4.70e-01	82.6%	67.7%
2pihA00	1.20.1500.10	Mainly Alpha › Up-down Bundle › YheA-like fold › YheA/YmcA-like	0.68	39.0	4.12e-01	100.0%	61.8%
2yxhA00	1.10.287.1080	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like	0.66	40.0	4.28e-01	81.1%	69.0%
2xzeB00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.66	50.0	4.94e-01	78.0%	75.4%
3t5vA00	1.25.40.990	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.66	51.0	3.90e-01	84.8%	36.1%
4mndA02	1.20.120.1760	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CDP-alcohol phosphotransferase transmembrane (TM) domain	0.66	53.0	4.64e-01	84.1%	65.4%
6xy4A01	1.10.437.10	Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like	0.65	42.0	4.34e-01	74.2%	69.1%
2kw6A00	6.10.140.1300	Special › Helix non-globular › Helix Hairpins ›	0.65	30.0	4.04e-01	71.2%	86.2%
3fnbA01	1.20.1440.110	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › acylaminoacyl peptidase	0.64	46.0	4.96e-01	78.0%	86.0%
3r9mA00	1.25.40.280	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › alix/aip1 like domains	0.64	52.0	3.65e-01	84.8%	53.5%
6tkyA03	1.20.58.740	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › DOCK DHR2 domain, lobe C	0.64	48.0	4.95e-01	78.8%	97.5%
1zu2A00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.64	46.0	4.31e-01	81.8%	61.4%
1qdbA02	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.61	36.0	3.55e-01	75.0%	53.8%
2yevA03	1.20.120.80	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle	0.60	50.0	4.43e-01	88.6%	73.9%
3anwB00	1.20.58.2050	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.59	41.0	3.91e-01	72.0%	69.8%
3agtA00	1.20.120.50	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like	0.59	41.0	4.17e-01	71.2%	78.9%
4g10A02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.58	48.0	4.79e-01	97.7%	85.3%
1tjoB00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.58	47.0	4.23e-01	84.1%	86.3%
3r2qA02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.58	46.0	4.92e-01	96.2%	99.1%
3mkrA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.56	38.0	3.03e-01	90.9%	31.6%
1rqgA04	1.10.730.10	Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1	0.55	48.0	4.65e-01	98.5%	83.4%
1z6oA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.55	43.0	3.69e-01	83.3%	72.6%
2n04A00	1.10.287.110	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain	0.55	35.0	3.88e-01	81.8%	80.0%
3kraC00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.55	46.0	3.65e-01	90.9%	55.7%
2rdcA00	1.10.287.800	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › protein ne1242	0.53	40.0	3.99e-01	77.3%	87.2%
3o10C00	1.20.120.330	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2	0.52	38.0	3.83e-01	75.0%	97.8%
4pdyA02	3.90.1200.10	Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe	0.52	42.0	3.55e-01	87.9%	73.8%
2b5dX01	3.20.110.10	Alpha Beta › Alpha-Beta Barrel › 7-stranded beta/alpha barrel › Glycoside hydrolase 38, N terminal domain	0.51	41.0	2.96e-01	87.9%	75.0%

ECOD (43)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1554358	3146.1.1.1 ↗	a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H	0.86	82.0	5.17e-01	100.0%	40.3%
3610231	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.78	47.0	4.96e-01	75.8%	65.8%
3617262	604.13.1.1 ↗	alpha bundles › Spectrin repeat-like › USP8 N-terminal domain-like › USP8 N-terminal domain-like › USP8_dimer	0.75	53.0	5.36e-01	75.8%	73.1%
3848307	603.1.1.110 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PF26585	0.74	54.0	4.65e-01	75.0%	85.5%
4988598	3883.1.1.1 ↗	alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf	0.74	53.0	4.64e-01	73.5%	88.9%
3623280	603.1.1.110 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PF26585	0.74	54.0	4.72e-01	75.8%	84.1%
4134971	603.1.1.225 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE, PF26585	0.74	54.0	4.77e-01	75.0%	75.7%
3500905	604.13.1.1 ↗	alpha bundles › Spectrin repeat-like › USP8 N-terminal domain-like › USP8 N-terminal domain-like › USP8_dimer	0.74	51.0	5.30e-01	75.8%	75.2%
3969932	604.5.1.0 ↗	alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895)	0.73	50.0	5.58e-01	82.6%	87.6%
5079010	109.3.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat	0.72	55.0	5.32e-01	78.8%	79.3%
3712905	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.69	47.0	3.80e-01	77.3%	39.1%
4658840	3883.1.1.1 ↗	alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf	0.69	53.0	4.68e-01	79.5%	62.2%
5065558	3883.1.1.1 ↗	alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf	0.68	54.0	4.68e-01	83.3%	65.0%
3597548	6155.1.1.0 ↗	alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter	0.68	49.0	4.80e-01	73.5%	82.1%
4975945	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.68	49.0	4.22e-01	84.8%	48.5%
3256198	6155.1.1.1 ↗	alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MtN3_slv	0.68	47.0	4.75e-01	70.5%	79.2%
3495368	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.67	53.0	3.82e-01	84.8%	43.3%
4021824	7579.1.1.0 ↗	a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases	0.67	52.0	3.67e-01	81.8%	44.6%
3627770	6155.1.1.1 ↗	alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MtN3_slv	0.67	46.0	4.76e-01	70.5%	79.2%
3245201	6155.1.1.1 ↗	alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MtN3_slv	0.67	46.0	4.57e-01	71.2%	71.4%
4025397	109.4.1.1307 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Vps52_CC, Vps52_C	0.66	55.0	3.55e-01	88.6%	29.7%
4608674	4121.1.1.0 ↗	a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like	0.66	51.0	4.25e-01	80.3%	75.0%
4972042	3883.1.1.1 ↗	alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf	0.66	52.0	4.37e-01	83.3%	60.5%
3462342	6155.1.1.0 ↗	alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter	0.65	51.0	5.06e-01	82.6%	85.6%
4936976	633.10.1.2 ↗	alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like › Bbp7-like	0.65	44.0	4.86e-01	84.1%	86.7%
4440642	3883.1.1.1 ↗	alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf	0.64	49.0	4.37e-01	80.3%	65.4%
4277373	4994.1.1.1 ↗	alpha duplicates or obligate multimers › EF2458-like › EF2458-like › EF2458-like › DUF1507	0.64	40.0	4.62e-01	81.1%	88.2%
3480514	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.63	53.0	5.14e-01	89.4%	100.0%
1296365	3883.1.1.1 ↗	alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf	0.63	54.0	4.65e-01	92.4%	70.9%
3884763	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.63	44.0	4.28e-01	71.2%	99.3%
4979051	5069.1.1.0 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes	0.63	48.0	4.42e-01	79.5%	84.1%
4014086	109.4.1.777 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.62	52.0	3.93e-01	90.2%	77.8%
2492495	601.33.1.1 ↗	alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain › CHAD	0.58	43.0	4.07e-01	75.8%	79.4%
3214777	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.58	49.0	4.16e-01	90.9%	69.8%
4011751	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.57	47.0	4.08e-01	90.9%	89.0%
3571297	5059.1.1.8 ↗	alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › Mg_trans_NIPA	0.54	39.0	3.92e-01	75.0%	88.1%
3633405	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.53	45.0	3.94e-01	90.2%	80.0%
3544836	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.53	45.0	3.63e-01	89.4%	76.7%
4002586	622.4.1.31 ↗	alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related › TPR_SYVN1_N	0.53	46.0	4.08e-01	96.2%	65.6%
5056276	3567.1.1.0 ↗	a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer	0.52	41.0	3.83e-01	82.6%	90.6%
3385722	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.52	43.0	3.80e-01	87.9%	83.7%
4944148	1075.1.2.0 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain	0.52	46.0	4.14e-01	98.5%	93.0%
4324052	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.51	42.0	3.66e-01	90.2%	72.4%

D3 medium residues 432-520_534-554

PDB

Domain cluster: rep: envelope_glycoprotein_H__NP_045257__Equid_alphaherpesvirus_4__10331__D432-555

D4 medium residues 555-672

PDB

Domain cluster: rep: envelope_glycoprotein_H__NP_045337__Bovine_alphaherpesvirus_1__10320__D538-631

D5 medium residues 673-755

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF17488.8 best	Herpes_glycoH_C	40.4	3.30e-10	100.0%	61.0%

CATH (4)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3m1cA04	2.60.40.3190	Mainly Beta › Sandwich › Immunoglobulin-like › Herpesvirus glycoprotein H, C-terminal domain	0.96	86.0	7.11e-01	100.0%	58.3%
2xqyA03	2.60.40.3190	Mainly Beta › Sandwich › Immunoglobulin-like › Herpesvirus glycoprotein H, C-terminal domain	0.90	84.0	6.95e-01	100.0%	60.9%
7b7nH01	2.60.40.3190	Mainly Beta › Sandwich › Immunoglobulin-like › Herpesvirus glycoprotein H, C-terminal domain	0.82	76.0	6.49e-01	100.0%	64.6%
2ozvA01	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.50	45.0	3.38e-01	98.8%	96.0%

ECOD (4)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
119479	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.96	86.0	6.84e-01	100.0%	52.4%
1309233	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.90	84.0	6.69e-01	100.0%	54.7%
1936537	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.82	75.0	6.10e-01	100.0%	58.4%
2095502	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.78	72.0	5.87e-01	100.0%	57.9%