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envelope_glycoprotein_H

Euk-Vir

Murine_roseolovirus

envelope_glycoprotein_H__YP_009344893__Murine_roseolovirus__1940555

Identity

Accession:: YP_009344893 ↗
Protein ID:: envelope_glycoprotein_H
Kingdom:: euk

Quality

72.4 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Roseolovirus› Murine_roseolovirus

TaxID: 1940555

Cluster

View cluster (43 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 32-113

PDB

D2 medium residues 125-144_247-373

PDB

Domain cluster: rep: envelope_glycoprotein_H__YP_009253953__Macaca_nemestrina_herpesvirus_7__1846169__D249-354

CATH (26)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5fzsA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.72	41.0	4.72e-01	70.7%	75.7%
5o5jT00	1.20.58.110	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Ribosomal protein S20	0.72	37.0	4.74e-01	73.5%	84.7%
2d2sA01	1.20.58.1210	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, N-terminal helical domain	0.65	43.0	4.82e-01	75.5%	84.5%
3nbxX03	1.20.58.1510	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.63	41.0	4.83e-01	72.1%	95.0%
4dloB02	1.25.40.610	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.62	45.0	5.00e-01	76.2%	100.0%
1ugoA00	1.20.58.120	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain	0.61	38.0	4.51e-01	73.5%	91.9%
2b1eA04	1.20.1280.170	Mainly Alpha › Up-down Bundle › Monooxygenase › Exocyst complex component Exo70	0.59	46.0	4.91e-01	83.7%	94.5%
4crwA00	1.25.40.180	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.59	46.0	4.02e-01	83.0%	70.8%
1f7uA02	1.10.730.10	Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1	0.59	41.0	4.41e-01	81.6%	84.0%
2a9uA01	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.57	39.0	4.19e-01	83.7%	80.2%
2l1lB00	1.20.1440.250	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) ›	0.57	41.0	4.40e-01	74.1%	89.0%
5j1hA01	1.20.58.1060	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.57	43.0	4.02e-01	78.9%	86.8%
4q5nA02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.56	41.0	4.61e-01	83.7%	99.1%
6t0bc02	1.20.120.80	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle	0.56	41.0	3.72e-01	74.8%	64.4%
1yy7A02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.56	39.0	4.50e-01	83.7%	100.0%
2yevA03	1.20.120.80	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle	0.56	41.0	3.82e-01	75.5%	62.0%
1g8xA06	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.56	40.0	3.09e-01	74.1%	49.2%
1o5hA00	1.20.120.680	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle	0.56	46.0	4.20e-01	89.8%	80.0%
6adqG01	1.20.120.80	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle	0.56	41.0	3.82e-01	74.8%	62.9%
2oerA00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.56	43.0	4.05e-01	81.0%	95.0%
4mc3A00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.54	40.0	3.25e-01	76.2%	99.3%
1gqeA01	1.20.58.410	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Release factor	0.53	32.0	3.54e-01	98.0%	74.3%
7wf6A01	1.10.167.10	Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2	0.52	36.0	3.68e-01	72.8%	72.7%
2nrjA01	1.20.1170.10	Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; ›	0.52	37.0	2.88e-01	72.8%	74.8%
3nrgA00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.52	42.0	3.74e-01	85.7%	98.6%
2nwbA02	1.20.58.480	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.52	46.0	3.89e-01	94.6%	83.5%

ECOD (23)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4874432	109.3.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat	0.73	50.0	5.36e-01	80.3%	79.8%
3794221	109.4.1.587 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Mon2_C	0.70	51.0	4.29e-01	74.1%	70.4%
3761553	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.70	54.0	4.31e-01	80.3%	57.5%
3423437	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.67	50.0	4.83e-01	76.9%	90.3%
3628706	109.4.1.587 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Mon2_C	0.66	53.0	3.71e-01	85.0%	44.7%
3847975	604.12.1.9 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › ATG1-like_MIT2	0.65	35.0	4.30e-01	76.2%	82.1%
3600477	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.65	48.0	3.19e-01	76.9%	28.5%
3662136	109.4.1.903 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_28	0.64	49.0	3.86e-01	82.3%	72.0%
3390666	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.63	50.0	5.35e-01	83.0%	96.9%
3196706	603.1.1.97 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin, SNARE	0.62	50.0	4.19e-01	84.4%	80.4%
3587904	7011.1.1.0 ↗	alpha bundles › RodA transmembrane domain › RodA transmembrane domain › RodA transmembrane domain	0.62	46.0	3.42e-01	76.9%	52.7%
4520832	109.4.1.1542 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_DOP1, PF26706	0.62	48.0	3.00e-01	83.0%	30.5%
4581682	109.4.1.560 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Mus7	0.61	47.0	2.93e-01	82.3%	21.5%
5051368	3883.1.1.1 ↗	alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf	0.61	43.0	3.92e-01	72.8%	65.5%
4997237	109.4.1.95 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_2	0.60	42.0	4.81e-01	90.5%	95.5%
4995342	3883.1.1.1 ↗	alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf	0.60	42.0	3.81e-01	71.4%	56.6%
3284180	109.3.1.160 ↗	alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › EccD	0.60	46.0	4.59e-01	80.3%	88.0%
4027896	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.59	47.0	4.25e-01	85.0%	92.2%
3644372	109.4.1.224 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › CNOT1_CAF1_bind	0.57	42.0	4.09e-01	77.6%	85.9%
3781313	3883.1.1.1 ↗	alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf	0.57	48.0	4.17e-01	90.5%	64.0%
4946004	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.55	43.0	3.98e-01	82.3%	82.6%
3996900	601.25.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › TrmE connector domain › TrmE connector domain	0.53	33.0	3.58e-01	76.9%	72.3%
4954785	3883.1.1.1 ↗	alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf	0.53	41.0	3.66e-01	81.6%	68.3%

D3 medium residues 145-246

PDB

Domain cluster: rep: orf22__YP_009044405__Alcelaphine_gammaherpesvirus_2__138184__D149-254

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02489.22 best	Herpes_glycop_H	32.7	4.70e-08	94.1%	12.6%

CATH (44)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5w0kA01	3.90.380.20	Alpha Beta › Alpha-Beta Complex › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 › Herpesvirus glycoprotein H, domain D-II	0.89	84.0	5.68e-01	100.0%	33.2%
1o8vA00	2.40.128.20	Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain	0.83	48.0	4.35e-01	95.1%	44.4%
4azpA00	2.40.128.20	Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain	0.81	47.0	4.24e-01	95.1%	44.0%
1p6pA00	2.40.128.20	Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain	0.80	43.0	4.04e-01	94.1%	44.0%
1mdcA00	2.40.128.20	Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain	0.79	48.0	4.34e-01	95.1%	46.6%
2it9A00	2.30.31.10	Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Transcriptional Coactivator Pc4; Chain A	0.70	38.0	3.59e-01	93.1%	45.0%
4ok4A02	2.70.98.70	Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 ›	0.70	62.0	4.20e-01	96.1%	80.9%
2xqyA01	3.30.500.50	Alpha Beta › 2-Layer Sandwich › Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 ›	0.69	46.0	3.77e-01	89.2%	38.8%
1omoA01	3.30.1780.10	Alpha Beta › 2-Layer Sandwich › ornithine cyclodeaminase, domain 1 › ornithine cyclodeaminase, domain 1	0.68	48.0	4.26e-01	73.5%	91.9%
1p32B00	3.10.280.10	Alpha Beta › Roll › Mitochondrial Matrix Protein; Chain A › Mitochondrial glycoprotein	0.68	43.0	3.55e-01	93.1%	38.0%
3rbyA02	2.40.128.310	Mainly Beta › Beta Barrel › Lipocalin › Protein HRI1, C-terminal domain	0.67	41.0	4.22e-01	98.0%	64.2%
4nkbA01	3.30.1120.120	Alpha Beta › 2-Layer Sandwich › Arylsulfatase, C-terminal domain ›	0.66	37.0	3.62e-01	99.0%	48.2%
3d2lA02	2.20.25.110	Mainly Beta › Single Sheet › N-terminal domain of TfIIb › S-adenosyl-L-methionine-dependent methyltransferases	0.66	38.0	4.80e-01	90.2%	93.7%
2fpnA01	3.30.2030.10	Alpha Beta › 2-Layer Sandwich › TBP-like › YwmB-like	0.66	50.0	4.43e-01	78.4%	67.1%
3dcdA00	2.70.98.10	Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 ›	0.66	56.0	3.99e-01	92.2%	91.3%
8bddA02	2.70.98.70	Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 ›	0.65	57.0	3.89e-01	95.1%	79.2%
3actA01	2.70.98.40	Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › Glycoside hydrolase, family 65, N-terminal domain	0.65	57.0	4.09e-01	95.1%	89.4%
6fopA01	2.70.98.30	Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › Golgi alpha-mannosidase II; domain 4	0.64	56.0	4.28e-01	94.1%	75.2%
3w7tA01	2.70.98.50	Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › putative glycoside hydrolase family protein from bacillus halodurans	0.63	55.0	4.19e-01	94.1%	78.9%
2eabB01	2.70.98.50	Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › putative glycoside hydrolase family protein from bacillus halodurans	0.63	55.0	4.16e-01	96.1%	85.1%
3mswA00	2.40.128.720	Mainly Beta › Beta Barrel › Lipocalin ›	0.62	44.0	3.97e-01	96.1%	54.0%
3bgaA05	2.70.98.10	Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 ›	0.62	52.0	3.88e-01	93.1%	94.8%
3ecqA02	2.70.98.10	Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 ›	0.61	52.0	3.83e-01	93.1%	86.1%
2qziA00	3.40.1720.10	Alpha Beta › 3-Layer(aba) Sandwich › Streptococcus thermophilus LMG 18311 protein like › Streptococcus thermophilus LMG 18311 protein like	0.59	45.0	4.58e-01	79.4%	98.0%
4xmeA00	2.40.128.20	Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain	0.58	42.0	3.55e-01	76.5%	90.2%
1lfoA00	2.40.128.20	Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain	0.58	43.0	4.01e-01	91.2%	62.2%
1x53A01	3.30.530.20	Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain	0.58	41.0	3.81e-01	74.5%	57.3%
4ggtB00	2.40.128.30	Mainly Beta › Beta Barrel › Lipocalin › Avidin-like	0.58	47.0	4.69e-01	86.3%	87.7%
5gv0A00	2.40.160.110	Mainly Beta › Beta Barrel › Porin ›	0.57	49.0	4.20e-01	93.1%	64.8%
1nqnA00	2.40.128.30	Mainly Beta › Beta Barrel › Lipocalin › Avidin-like	0.56	45.0	4.29e-01	87.3%	91.5%
2kd2A01	2.40.128.180	Mainly Beta › Beta Barrel › Lipocalin ›	0.55	42.0	4.62e-01	87.3%	97.6%
4akmB00	2.40.160.110	Mainly Beta › Beta Barrel › Porin ›	0.55	47.0	4.08e-01	93.1%	66.2%
1epaA00	2.40.128.20	Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain	0.55	43.0	3.71e-01	94.1%	53.1%
3p24A01	2.40.128.470	Mainly Beta › Beta Barrel › Lipocalin ›	0.55	47.0	4.16e-01	96.1%	64.7%
3ke7B00	3.10.450.50	Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, ›	0.54	42.0	3.89e-01	83.3%	85.7%
3p0lD00	3.30.530.20	Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain	0.54	46.0	3.75e-01	92.2%	83.2%
1xn5A00	3.30.530.20	Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain	0.54	41.0	3.80e-01	94.1%	61.6%
2owpA00	3.10.450.50	Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, ›	0.53	40.0	3.76e-01	80.4%	86.0%
6rtqA00	2.40.128.30	Mainly Beta › Beta Barrel › Lipocalin › Avidin-like	0.53	43.0	3.95e-01	87.3%	84.2%
6mv2A01	2.60.40.790	Mainly Beta › Sandwich › Immunoglobulin-like ›	0.53	40.0	4.08e-01	80.4%	100.0%
4hbrA00	3.10.450.360	Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, ›	0.53	40.0	3.64e-01	91.2%	59.3%
3kg8A01	3.10.129.10	Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Hotdog Thioesterase	0.51	35.0	3.25e-01	70.6%	85.4%
3ijtB00	3.30.530.20	Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain	0.51	43.0	3.85e-01	92.2%	77.6%
4ktpB02	2.60.420.10	Mainly Beta › Sandwich › Maltose phosphorylase, domain 3 › Maltose phosphorylase, domain 3	0.51	35.0	3.86e-01	92.2%	90.2%

ECOD (45)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2095503	3146.1.1.1 ↗	a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H	0.87	80.0	4.90e-01	100.0%	18.8%
3953943	9.27.1.1 ↗	beta barrels › Lipocalins/Streptavidin › LpqH › LpqH › Myco_19_kDa	0.72	48.0	4.71e-01	94.1%	62.7%
3474457	319.1.1.0 ↗	beta sandwiches › HSP20-like › HSP20-like chaperones › HSP20-like chaperones	0.72	40.0	4.20e-01	96.1%	60.0%
3593518	9.1.1.0 ↗	beta barrels › Lipocalins/Streptavidin › Lipocalins › Lipocalins	0.71	49.0	3.99e-01	95.1%	40.6%
3223040	12.3.1.13 ↗	beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Glyco_hydro_38C	0.70	61.0	4.52e-01	94.1%	92.5%
5791	295.1.1.6 ↗	a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain › DUF1818	0.70	38.0	3.60e-01	93.1%	45.4%
5014277	274.1.1.0 ↗	a+b two layers › Pili subunits › Pili subunits › Pili subunits	0.70	39.0	4.29e-01	83.3%	67.1%
4569249	9.14.1.1 ↗	beta barrels › Lipocalins/Streptavidin › Uncharacterized protein YLR301W › Uncharacterized protein YLR301W › HRI1	0.69	40.0	4.29e-01	97.1%	65.6%
3584281	12.3.1.13 ↗	beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Glyco_hydro_38C	0.68	61.0	4.37e-01	98.0%	95.2%
5014493	331.3.1.12 ↗	a+b two layers › TBP-like › Bet v1-like › Bet v1-like › STK_08120-like	0.68	48.0	3.62e-01	93.1%	32.2%
3483747	12.3.1.13 ↗	beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Glyco_hydro_38C	0.67	59.0	4.27e-01	97.1%	93.9%
3190914	12.3.1.12 ↗	beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Glyco_transf_36	0.67	58.0	4.12e-01	95.1%	89.7%
5084039	12.3.1.3 ↗	beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Aldose_epim	0.65	55.0	3.91e-01	92.2%	90.5%
3953302	331.2.1.1 ↗	a+b two layers › TBP-like › Phosphoglucomutase, C-terminal domain › Phosphoglucomutase, C-terminal domain › PGM_PMM_IV	0.65	42.0	4.21e-01	71.6%	64.4%
3191832	12.3.1.36 ↗	beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › DUF5127	0.64	55.0	4.03e-01	94.1%	81.5%
4927380	12.3.1.0 ↗	beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich	0.64	56.0	4.15e-01	95.1%	91.2%
2717534	12.3.1.31 ↗	beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › YgjK_N	0.64	56.0	4.02e-01	94.1%	71.8%
4008120	5.1.5.139 ↗	beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 8-bladed › DUF1481	0.64	44.0	4.21e-01	96.1%	60.8%
3274430	12.3.1.40 ↗	beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › TREH_N	0.62	53.0	4.18e-01	93.1%	81.9%
4961936	12.3.1.77 ↗	beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › PF25978	0.62	52.0	3.88e-01	92.2%	77.4%
2801583	9.2.1.1 ↗	beta barrels › Lipocalins/Streptavidin › Avidin/Streptavidin › Avidin/Streptavidin › Avidin	0.61	45.0	4.26e-01	92.2%	64.5%
4989818	12.3.1.0 ↗	beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich	0.61	52.0	4.04e-01	92.2%	88.2%
184900	6044.1.1.1 ↗	a+b three layers › DUF1827-like › DUF1827-like › DUF1827-like › DUF1827	0.59	45.0	4.58e-01	79.4%	98.0%
3479716	3459.1.1.0 ↗	beta sandwiches › Fas apoptotic inhibitory molecule › Fas apoptotic inhibitory molecule › Fas apoptotic inhibitory molecule	0.59	44.0	4.84e-01	86.3%	95.3%
5014159	331.3.1.0 ↗	a+b two layers › TBP-like › Bet v1-like › Bet v1-like	0.57	49.0	4.59e-01	92.2%	76.0%
3920853	3369.1.1.1 ↗	beta meanders › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › Lamp2-like_luminal	0.57	49.0	4.24e-01	93.1%	67.5%
3861601	3369.1.1.1 ↗	beta meanders › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › Lamp2-like_luminal	0.57	49.0	4.15e-01	93.1%	67.5%
5021455	4252.1.1.0 ↗	beta barrels › AttH-like › AttH-like › AttH-like	0.57	49.0	4.46e-01	94.1%	72.6%
3519601	216.1.1.0 ↗	a+b two layers › UBC-like › UBC-like › UBC-like	0.57	38.0	3.68e-01	94.1%	59.2%
3520453	386.1.1.0 ↗	few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers	0.57	41.0	3.83e-01	93.1%	60.0%
3785596	216.1.1.2 ↗	a+b two layers › UBC-like › UBC-like › UBC-like › Autophagy_act_C	0.56	49.0	4.14e-01	94.1%	60.6%
5046173	4252.1.1.7 ↗	beta barrels › AttH-like › AttH-like › AttH-like › Tocopherol_cycl	0.56	48.0	4.29e-01	94.1%	67.6%
5043414	4252.1.1.0 ↗	beta barrels › AttH-like › AttH-like › AttH-like	0.56	48.0	4.40e-01	94.1%	76.3%
3575893	3459.1.1.1 ↗	beta sandwiches › Fas apoptotic inhibitory molecule › Fas apoptotic inhibitory molecule › Fas apoptotic inhibitory molecule › FAIM1	0.55	42.0	4.32e-01	87.3%	86.3%
3962450	9.27.1.0 ↗	beta barrels › Lipocalins/Streptavidin › LpqH › LpqH	0.55	45.0	4.46e-01	87.3%	95.2%
1952891	9.1.1.9 ↗	beta barrels › Lipocalins/Streptavidin › Lipocalins › Lipocalins › CpeT	0.54	45.0	4.07e-01	89.2%	75.0%
4108467	3459.1.1.1 ↗	beta sandwiches › Fas apoptotic inhibitory molecule › Fas apoptotic inhibitory molecule › Fas apoptotic inhibitory molecule › FAIM1	0.54	40.0	4.37e-01	86.3%	95.3%
3707402	12.6.1.1 ↗	beta sandwiches › Glycosyl hydrolase domain-like › Glycoside hydrolase family 127 middle domain-related › Glycoside hydrolase family 127 middle domain-related › Glyco_hydro_65C	0.54	37.0	4.27e-01	90.2%	98.7%
4259150	295.1.1.46 ↗	a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain › WapI	0.53	45.0	4.16e-01	94.1%	73.3%
3825682	243.3.1.1 ↗	a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin › Cystatin	0.53	41.0	4.16e-01	85.3%	83.8%
3377988	243.3.1.0 ↗	a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin	0.52	40.0	4.07e-01	85.3%	84.0%
4023095	3385.1.1.0 ↗	beta barrels › Allergen Alt a 1 › Allergen Alt a 1 › Allergen Alt a 1	0.51	43.0	3.88e-01	89.2%	70.4%
3512529	216.1.1.2 ↗	a+b two layers › UBC-like › UBC-like › UBC-like › Autophagy_act_C	0.51	44.0	3.81e-01	95.1%	65.6%
5036807	3111.1.1.0 ↗	beta barrels › STT3/PglB/AglB beta-barrel domain › STT3/PglB/AglB beta-barrel domain › STT3/PglB/AglB beta-barrel domain	0.51	37.0	3.78e-01	76.5%	85.3%
3192871	220.1.1.194 ↗	beta barrels › PH domain-like › PH domain-like › PH domain-like › PH_2nd_LRR	0.51	39.0	3.30e-01	83.3%	65.1%

D4 medium residues 374-571

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02489.22 best	Herpes_glycop_H	35.5	6.50e-09	73.2%	25.4%

CATH (11)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
8a0rA02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.62	35.0	4.23e-01	74.2%	83.8%
1sz9C00	1.25.40.90	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.61	38.0	4.39e-01	89.9%	86.4%
4jxtA00	1.25.40.90	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.57	36.0	4.33e-01	99.0%	95.4%
2e2eA01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.57	32.0	3.59e-01	93.4%	68.9%
1vdyA00	1.25.40.90	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.57	38.0	4.35e-01	93.9%	93.6%
1lshA02	1.25.10.20	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Vitellinogen, superhelical	0.56	43.0	3.59e-01	82.3%	46.0%
4epzA00	1.25.40.810	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › UpxZ	0.56	41.0	4.60e-01	80.3%	98.1%
3feyA02	1.25.40.180	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.53	41.0	4.18e-01	89.9%	82.8%
7tj9A01	1.20.120.350	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C	0.53	25.0	3.29e-01	78.8%	79.2%
8g0lB01	1.25.40.1040	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.52	41.0	3.33e-01	100.0%	42.4%
3caxA01	1.20.120.520	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › nmb1532 protein domain like	0.51	25.0	2.43e-01	75.3%	38.2%

ECOD (14)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3712357	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.59	51.0	3.65e-01	92.9%	70.4%
3996669	109.4.1.1492 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT_SCC3-SA, PF31007	0.59	54.0	3.89e-01	99.5%	48.5%
3442573	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.58	37.0	4.23e-01	100.0%	86.9%
4443552	109.4.1.912 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ARM_KDM8_N	0.57	33.0	3.82e-01	78.8%	75.9%
1146575	109.39.1.1 ↗	alpha superhelices › Repetitive alpha hairpins › transcription anti-terminator antagonist UpxZ › transcription anti-terminator antagonist UpxZ › UpxZ	0.56	41.0	4.60e-01	80.3%	98.1%
3929528	109.4.1.405 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › FANCI_HD2	0.56	44.0	4.05e-01	82.3%	78.4%
5061713	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.55	39.0	3.40e-01	90.4%	46.6%
3519854	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.53	50.0	3.82e-01	99.5%	59.8%
None	—		0.53	46.0	3.00e-01	93.4%	42.7%
3583634	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.53	43.0	4.29e-01	96.5%	82.4%
3686950	109.4.1.121 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Mo25	0.52	47.0	3.77e-01	98.5%	70.2%
3497154	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.52	46.0	4.09e-01	96.5%	78.3%
3182325	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.51	44.0	4.34e-01	99.5%	86.0%
3995455	109.4.1.177 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cnd3	0.50	46.0	3.58e-01	100.0%	55.9%

D5 medium residues 572-670

PDB

Domain cluster: rep: envelope_glycoprotein_H__YP_004936041__Cercopithecine_betaherpesvirus_5__50292__D611-687

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF17488.8 best	Herpes_glycoH_C	59.9	3.20e-16	97.0%	65.2%