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envelope_glycoprotein_H

Euk-Vir

Human_betaherpesvirus_5

envelope_glycoprotein_H__YP_081523__Human_betaherpesvirus_5__10359

Identity

Accession:
YP_081523 ↗
Protein ID:
envelope_glycoprotein_H
Kingdom:
euk

Quality

78.3 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Cytomegalovirus› Human_betaherpesvirus_5

TaxID: 10359

Cluster

View cluster (43 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 40-102
PDB
D2 medium residues 128-140_188-284
PDB
Domain cluster: rep: orf22__YP_009044405__Alcelaphine_gammaherpesvirus_2__138184__D149-254
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 81.6 7.20e-23 97.3% 21.6%
D3 medium residues 285-357
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 59.9 2.70e-16 100.0% 15.4%
CATH (31)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2wmmA01 1.20.5.420 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C 0.79 47.0 5.65e-01 72.6% 89.8%
6r1nA01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.78 54.0 4.73e-01 71.2% 50.5%
4e6nA02 6.10.140.1010 Special › Helix non-globular › Helix Hairpins › 0.78 53.0 5.56e-01 72.6% 77.3%
1yo7A00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.77 62.0 5.16e-01 84.9% 87.5%
4iggA01 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.77 53.0 5.57e-01 71.2% 94.0%
1ydxA02 1.10.287.1120 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Bipartite methylase S protein 0.75 52.0 4.82e-01 71.2% 60.0%
5jrcA00 1.20.58.2140 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.75 56.0 4.11e-01 79.5% 37.1%
4e4eA01 1.10.287.990 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain 0.75 50.0 5.05e-01 71.2% 70.4%
2dq0A01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.74 51.0 4.45e-01 71.2% 50.5%
2b1eA01 1.20.58.1150 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.71 57.0 5.39e-01 86.3% 82.6%
2ib0A01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.71 54.0 4.37e-01 80.8% 88.9%
2ch7A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.71 49.0 3.19e-01 72.6% 93.5%
1tjoB00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.69 54.0 4.05e-01 83.6% 77.7%
2e9xA01 1.20.58.1030 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.68 52.0 4.41e-01 84.9% 68.0%
1r2jA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.66 52.0 4.13e-01 83.6% 80.6%
2lm9A00 1.20.58.970 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.65 53.0 4.91e-01 91.8% 100.0%
2mpkA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.65 49.0 4.90e-01 80.8% 93.2%
1vf7A03 1.10.287.470 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.64 44.0 4.72e-01 72.6% 90.0%
1nt2B02 1.10.287.660 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.63 43.0 4.51e-01 72.6% 95.5%
3u3iA02 1.20.58.1110 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 49.0 4.34e-01 86.3% 75.9%
1j1jA02 1.20.58.200 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 0.62 48.0 4.66e-01 87.7% 87.1%
4q5qA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.61 42.0 3.76e-01 71.2% 53.3%
2vf8B02 1.20.1580.10 Mainly Alpha › Up-down Bundle › ABC transporter ATPase like fold › ABC transporter ATPase like domain 0.60 49.0 3.87e-01 91.8% 78.6%
1i36A02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.60 43.0 3.87e-01 75.3% 87.9%
3h36A00 1.10.10.400 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain 0.58 45.0 4.49e-01 86.3% 92.3%
3tp3A02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.57 47.0 3.78e-01 91.8% 56.1%
3vm9A02 6.10.140.2110 Special › Helix non-globular › Helix Hairpins › 0.57 40.0 4.43e-01 72.6% 93.0%
3on2A00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.56 46.0 3.53e-01 94.5% 45.3%
1gcvB00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.54 42.0 3.51e-01 87.7% 74.3%
2pbxA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.52 44.0 3.34e-01 100.0% 69.5%
3hyuA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.50 39.0 3.27e-01 87.7% 70.2%
ECOD (28)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2095503 3146.1.1.1 ↗ a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H 0.97 93.0 5.38e-01 100.0% 14.2%
3653618 5069.1.3.69 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › ETR1_N 0.81 54.0 4.87e-01 72.6% 52.6%
5039404 604.2.1.0 ↗ alpha bundles › Spectrin repeat-like › Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain › Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 0.76 61.0 6.12e-01 84.9% 93.3%
4600409 507.1.1.0 ↗ alpha arrays › DnaB helicase N-terminal domain-related › DnaB helicase N-terminal domain-related › DnaB helicase N-terminal domain-related 0.76 53.0 4.27e-01 72.6% 43.0%
3960783 605.1.1.1 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA 0.76 52.0 5.07e-01 71.2% 76.2%
4505128 192.7.1.2 ↗ alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N 0.75 52.0 4.81e-01 71.2% 68.9%
3327622 605.1.1.272 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › Aa_trans 0.75 54.0 3.97e-01 75.3% 92.2%
3640629 3843.1.1.0 ↗ alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K 0.70 49.0 3.70e-01 72.6% 31.8%
3218643 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.70 54.0 4.85e-01 84.9% 89.5%
3799978 7015.1.1.0 ↗ alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain 0.69 55.0 4.46e-01 86.3% 82.9%
5049144 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.69 49.0 3.34e-01 74.0% 25.8%
4962556 633.10.1.0 ↗ alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like 0.68 55.0 4.73e-01 89.0% 84.3%
3262581 4156.1.1.0 ↗ alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like 0.66 55.0 4.25e-01 91.8% 93.9%
1556809 604.12.1.1 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT 0.65 49.0 5.01e-01 80.8% 100.0%
3576223 604.33.1.1 ↗ alpha bundles › Spectrin repeat-like › Repulsive guidance molecule (RGM) N-terminal domain › Repulsive guidance molecule (RGM) N-terminal domain › RGM_N 0.65 48.0 4.85e-01 79.5% 86.5%
3499593 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.64 47.0 4.60e-01 79.5% 76.2%
3245731 604.6.1.0 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.64 52.0 5.10e-01 91.8% 93.8%
3371141 6155.1.1.2 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop 0.63 54.0 4.78e-01 97.3% 86.4%
3372083 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.60 41.0 3.63e-01 72.6% 47.3%
401159 191.1.1.8 ↗ alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_33 0.57 40.0 3.51e-01 75.3% 55.5%
3936950 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.57 45.0 4.09e-01 86.3% 70.0%
3959098 191.1.1.17 ↗ alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_13 0.56 46.0 3.67e-01 93.2% 57.4%
3592846 633.1.1.0 ↗ alpha bundles › Bromodomain-like › Bromodomain › Bromodomain 0.54 45.0 4.24e-01 97.3% 82.1%
3286 106.1.1.1 ↗ alpha arrays › Globin-like › Globin-like › Globin-like › Globin 0.54 42.0 3.51e-01 87.7% 74.3%
3782144 109.46.1.1 ↗ alpha superhelices › Repetitive alpha hairpins › Helical domain in TOPLESS related protein 2 (TPR2) › Helical domain in TOPLESS related protein 2 (TPR2) › CTLH 0.53 41.0 3.38e-01 89.0% 50.7%
2438938 129.1.1.8 ↗ alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › HMD 0.52 41.0 3.26e-01 89.0% 58.4%
4196397 106.1.1.1 ↗ alpha arrays › Globin-like › Globin-like › Globin-like › Globin 0.52 41.0 3.40e-01 87.7% 75.0%
4675165 2004.1.1.71 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › IPPT 0.51 43.0 3.02e-01 93.2% 63.3%
D4 medium residues 358-462
PDB
Domain cluster: rep: glycoprotein_UL75__YP_004933840__Cynomolgus_macaque_cytomegalovirus_strain_Ottawa__944969__D362-449
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 72.1 5.20e-20 100.0% 21.0%
D5 medium residues 463-562
PDB
Domain cluster: rep: envelope_glycoprotein_H__YP_009388523__Common_bottlenose_dolphin_gammaherpesvirus_1_strain_Sarasota__2022783__D447-588
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 98.7 4.60e-28 99.0% 21.8%
D6 medium residues 563-633
PDB
Domain cluster: rep: envelope_glycoprotein_H__YP_009179315__Elephant_endotheliotropic_herpesvirus_4__548914__D571-650
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF17488.8 best Herpes_glycoH_C 53.4 3.30e-14 93.0% 44.0%