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envelope_glycoprotein_H

Euk-Vir

Human_gammaherpesvirus_4

envelope_glycoprotein_H__YP_401700__Human_gammaherpesvirus_4__10376

Identity

Accession:
YP_401700 ↗
Protein ID:
envelope_glycoprotein_H
Kingdom:
euk

Quality

83.9 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 6-74
PDB
D2 high residues 543-671
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF17488.8 best Herpes_glycoH_C 169.2 6.00e-50 100.0% 90.1%
D3 medium residues 101-121_315-359
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 33.8 2.10e-08 97.0% 9.8%
D4 medium residues 122-241
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 140.9 7.20e-41 99.2% 22.6%
D5 medium residues 242-314
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 76.3 2.80e-21 100.0% 15.0%
D6 medium residues 360-452
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 68.6 6.30e-19 100.0% 18.4%
CATH (48)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2d9dA00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.75 54.0 5.59e-01 75.3% 84.3%
2jqqA00 1.20.58.1240 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.73 66.0 5.57e-01 100.0% 94.2%
1m62A00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.72 52.0 5.40e-01 75.3% 87.4%
1quuA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.72 53.0 4.78e-01 77.4% 77.0%
3kp9A01 1.20.1440.130 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › VKOR domain 0.70 55.0 4.65e-01 86.0% 61.7%
1u6gC00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.69 62.0 3.47e-01 100.0% 12.5%
3tjzB00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.67 53.0 3.85e-01 100.0% 30.3%
3mpxA01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.66 57.0 4.40e-01 94.6% 91.7%
4gouA03 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.66 49.0 3.87e-01 78.5% 91.4%
4dkcB00 1.20.1250.80 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interleukin-34 0.66 47.0 3.94e-01 74.2% 72.5%
4u7iA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.66 49.0 5.00e-01 79.6% 90.3%
1yxrA01 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.66 47.0 5.13e-01 77.4% 93.2%
4id0A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.66 55.0 5.23e-01 92.5% 89.3%
4i4cB00 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.65 58.0 3.81e-01 100.0% 44.7%
4epzA00 1.25.40.810 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › UpxZ 0.64 58.0 4.91e-01 100.0% 90.3%
7e84A02 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.64 46.0 4.08e-01 75.3% 65.5%
1aepA00 1.20.120.20 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein 0.63 45.0 3.85e-01 75.3% 51.6%
1yo7A00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.63 46.0 4.26e-01 77.4% 70.0%
4n4gA01 1.20.920.10 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like 0.63 43.0 4.04e-01 77.4% 58.6%
4etrB00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.62 46.0 4.25e-01 78.5% 92.6%
2wl8C00 1.20.120.900 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pex19, mPTS binding domain 0.62 42.0 4.04e-01 71.0% 59.6%
6fndA01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.62 54.0 4.39e-01 100.0% 52.2%
3pe0A02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.61 44.0 4.21e-01 74.2% 87.7%
8fbnB01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.61 54.0 4.15e-01 100.0% 56.8%
2qfcA00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.60 52.0 3.77e-01 100.0% 32.4%
1tfkB00 1.20.120.650 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Colicin D 0.60 41.0 4.30e-01 71.0% 79.1%
3k2jA00 1.20.920.10 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like 0.60 41.0 3.81e-01 78.5% 54.5%
7cc7A01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.60 52.0 3.96e-01 100.0% 40.7%
2i2xB01 1.10.1240.10 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain 0.60 49.0 4.80e-01 91.4% 83.0%
2vixA03 1.20.1280.240 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.59 46.0 4.30e-01 82.8% 70.8%
1ki1B01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.59 48.0 3.92e-01 94.6% 70.9%
1eqfA02 1.20.920.10 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like 0.59 41.0 3.76e-01 78.5% 54.4%
1fafA00 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.58 37.0 3.93e-01 74.2% 74.7%
1k90B03 1.20.140.60 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › 0.57 46.0 4.25e-01 91.4% 68.7%
6nmnA02 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.57 41.0 3.74e-01 76.3% 68.0%
5c9eB01 1.20.1280.80 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.56 41.0 4.22e-01 76.3% 97.7%
3kyiA00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.56 39.0 3.61e-01 74.2% 55.5%
2w31A00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.55 42.0 3.66e-01 82.8% 76.3%
4py6C00 1.20.920.10 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like 0.55 40.0 3.66e-01 76.3% 70.9%
3u5nA02 1.20.920.10 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like 0.54 41.0 3.82e-01 82.8% 67.5%
6bmeA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.53 40.0 3.70e-01 82.8% 65.4%
1iuqA01 1.10.1200.50 Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › Glycerol-3-phosphate acyltransferase, alpha helical bundle, N-terminal 0.53 32.0 3.54e-01 87.1% 75.0%
3n00A00 1.10.565.10 Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor 0.53 47.0 3.77e-01 100.0% 85.3%
2ijqA00 1.10.3450.10 Mainly Alpha › Orthogonal Bundle › Hyaluronidase domain-like › TTHA0068-like 0.52 45.0 4.00e-01 100.0% 64.8%
3k3uA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.52 40.0 3.59e-01 83.9% 88.3%
1s0pA01 1.25.40.330 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Adenylate cyclase-associated CAP, N-terminal domain 0.52 45.0 3.78e-01 100.0% 71.3%
1jwnA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.52 37.0 3.22e-01 74.2% 77.9%
4nufA02 1.10.565.10 Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor 0.52 44.0 3.58e-01 94.6% 73.7%
ECOD (49)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2095478 3146.1.1.1 a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H 0.88 83.0 5.04e-01 100.0% 18.3%
2701125 3146.1.1.1 a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H 0.82 76.0 4.67e-01 100.0% 18.7%
3169336 109.4.1.427 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › SDA1_HEAT 0.72 65.0 4.03e-01 100.0% 27.3%
3498448 604.3.1.0 alpha bundles › Spectrin repeat-like › BAG domain › BAG domain 0.72 51.0 5.40e-01 73.1% 90.0%
3306315 109.4.1.189 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_2 0.70 60.0 6.03e-01 98.9% 92.6%
3442529 109.4.1.2339 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF26724 0.69 63.0 4.86e-01 100.0% 50.0%
3352169 109.4.1.1296 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_1, PPR_2, PPR_long, TPR_24 0.68 55.0 4.16e-01 92.5% 35.7%
3736151 109.4.1.356 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans 0.68 61.0 3.81e-01 100.0% 23.4%
3710484 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.68 60.0 4.54e-01 100.0% 44.3%
3190611 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.68 61.0 4.32e-01 100.0% 41.4%
3706364 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.68 61.0 5.09e-01 100.0% 76.9%
3875003 133.1.1.1 alpha bundles › DH domain-like › DBL homology domain (DH-domain) › DBL homology domain (DH-domain) › RhoGEF 0.68 53.0 3.99e-01 82.8% 77.7%
3681983 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.68 57.0 5.63e-01 91.4% 90.0%
3432381 109.4.1.1242 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT_RRP12_N 0.67 60.0 4.26e-01 100.0% 36.1%
143387 601.3.1.1 alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain › Hpt 0.67 47.0 4.36e-01 72.0% 78.8%
3188288 109.4.1.268 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › LARP1_HEAT 0.67 51.0 4.76e-01 93.5% 65.0%
3176029 192.13.1.0 alpha bundles › Long alpha-hairpin › ISY1 N-terminal domain-like › ISY1 N-terminal domain-like 0.66 52.0 5.52e-01 96.8% 96.2%
3613828 109.54.1.1 alpha superhelices › Repetitive alpha hairpins › C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 › C-terminal tetramerization domain of Utp1/Utp21/Utp12/Utp13 › Utp12 0.66 56.0 4.69e-01 100.0% 53.7%
2775146 184.1.1.0 alpha arrays › Nucleoside phosphorylase/phosphoribosyltransferase-N › Nucleoside phosphorylase/phosphoribosyltransferase-N › Nucleoside phosphorylase/phosphoribosyltransferase-N 0.66 55.0 5.67e-01 91.4% 96.6%
3993870 109.40.1.0 alpha superhelices › Repetitive alpha hairpins › DNA polymerase alpha-binding protein Ctf4 C-terminal domain › DNA polymerase alpha-binding protein Ctf4 C-terminal domain 0.66 54.0 5.02e-01 92.5% 82.5%
3990193 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.65 58.0 4.61e-01 100.0% 81.0%
3273098 109.4.1.1289 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF30856 0.65 58.0 3.47e-01 100.0% 34.5%
5001327 601.28.1.0 alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like 0.65 42.0 4.34e-01 76.3% 67.8%
3690755 109.5.1.1 alpha superhelices › Repetitive alpha hairpins › adenylylcyclase associated protein, CAP-N › adenylylcyclase associated protein, CAP-N › CAP_N 0.65 45.0 3.63e-01 73.1% 40.5%
3605147 1189.1.1.1 alpha bundles › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › Trypan_glycop 0.65 45.0 3.13e-01 72.0% 48.1%
3893710 109.4.1.198 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_12 0.63 49.0 3.97e-01 86.0% 46.7%
3783971 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.63 55.0 4.11e-01 100.0% 50.8%
5039441 633.21.1.47 alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › SPW 0.62 44.0 4.27e-01 75.3% 70.9%
4023225 3924.1.1.0 alpha complex topology › Sterol uptake control protein 2 › Sterol uptake control protein 2 › Sterol uptake control protein 2 0.62 54.0 3.89e-01 100.0% 68.3%
957021 4995.1.1.1 alpha arrays › Methionine synthase domain-like › Methionine synthase domain-like › Methionine synthase domain-like › B12-binding_2 0.61 48.0 4.46e-01 84.9% 68.9%
3735101 109.3.1.8 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › Ank_2 0.61 54.0 4.65e-01 100.0% 76.7%
3503440 633.1.1.1 alpha bundles › Bromodomain-like › Bromodomain › Bromodomain › Bromodomain 0.61 41.0 3.84e-01 77.4% 56.5%
3255975 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.60 54.0 4.28e-01 100.0% 50.3%
4602548 109.4.1.206 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › YfiO 0.60 46.0 4.18e-01 92.5% 58.5%
3681643 109.4.1.146 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cohesin_load 0.60 52.0 3.53e-01 100.0% 26.4%
3931889 633.1.1.1 alpha bundles › Bromodomain-like › Bromodomain › Bromodomain › Bromodomain 0.60 40.0 3.80e-01 77.4% 56.5%
3456067 633.1.1.1 alpha bundles › Bromodomain-like › Bromodomain › Bromodomain › Bromodomain 0.58 40.0 3.75e-01 78.5% 56.7%
3455413 633.1.1.1 alpha bundles › Bromodomain-like › Bromodomain › Bromodomain › Bromodomain 0.58 41.0 3.71e-01 73.1% 64.8%
3744846 633.1.1.1 alpha bundles › Bromodomain-like › Bromodomain › Bromodomain › Bromodomain 0.58 39.0 3.70e-01 77.4% 56.5%
3483981 633.1.1.0 alpha bundles › Bromodomain-like › Bromodomain › Bromodomain 0.57 41.0 3.86e-01 80.6% 60.9%
3250076 633.1.1.1 alpha bundles › Bromodomain-like › Bromodomain › Bromodomain › Bromodomain 0.56 40.0 3.53e-01 75.3% 67.1%
4411218 172.2.1.1 alpha complex topology › Citrate synthase-like › Urease accessory protein ureF › Urease accessory protein ureF › UreF 0.55 40.0 3.04e-01 77.4% 72.0%
1412473 188.1.1.1 alpha arrays › Nuclear receptor ligand-binding domain › Nuclear receptor ligand-binding domain › Nuclear receptor ligand-binding domain › Hormone_recep 0.53 45.0 3.49e-01 93.5% 71.6%
4032961 601.18.1.0 alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 0.52 36.0 3.77e-01 72.0% 78.8%
3840771 3615.1.1.28 alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › DUF7605 0.52 37.0 2.78e-01 73.1% 66.1%
4881969 109.4.1.1300 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8, TPR_16, TPR_19 0.52 46.0 3.19e-01 98.9% 30.0%
3785302 109.5.1.1 alpha superhelices › Repetitive alpha hairpins › adenylylcyclase associated protein, CAP-N › adenylylcyclase associated protein, CAP-N › CAP_N 0.52 46.0 3.68e-01 98.9% 49.7%
4511973 3965.1.1.1 alpha arrays › Origin recognition complex subunit 3 helical insert domain › Origin recognition complex subunit 3 helical insert domain › Origin recognition complex subunit 3 helical insert domain › ORC3_ins 0.51 40.0 2.83e-01 83.9% 98.0%
4927302 1075.1.2.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain 0.51 42.0 3.69e-01 91.4% 72.9%
D7 medium residues 453-542
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 76.1 3.20e-21 78.9% 14.6%