←Back to structures
envelope_glycoprotein_K
Euk-VirHuman_alphaherpesvirus_2
envelope_glycoprotein_K__YP_009137206__Human_alphaherpesvirus_2__10310
Identity
- Accession:
- YP_009137206 ↗
- Protein ID:
- envelope_glycoprotein_K
- Kingdom:
- euk
Quality
77.0
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Human_alphaherpesvirus_2
TaxID: 10310
Cluster
View cluster (31 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 7-30_115-148_211-272_299-331
Domain cluster:
rep: envelope_glycoprotein_K__NP_944381__Psittacid_alphaherpesvirus_1__50294__D1-33_137-163_231-311
Pfam (3)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01621.23 best | Fusion_gly_K | 60.0 | 2.90e-16 | 41.2% | 18.3% |
| PF01621.23 | Fusion_gly_K | 40.3 | 2.90e-10 | 24.2% | 10.6% |
| PF01621.23 | Fusion_gly_K | 36.7 | 3.60e-09 | 23.5% | 9.7% |
CATH (28)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1x8zB00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.82 | 56.0 | 5.76e-01 | 78.4% | 72.8% |
| 1yo7A00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.80 | 54.0 | 6.05e-01 | 77.8% | 86.7% |
| 1aepA00 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.78 | 53.0 | 5.36e-01 | 78.4% | 69.3% |
| 1sj8A02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.77 | 55.0 | 6.14e-01 | 78.4% | 92.6% |
| 1eq1A00 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.75 | 52.0 | 5.11e-01 | 78.4% | 65.7% |
| 1xg2B00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.74 | 51.0 | 5.20e-01 | 78.4% | 70.9% |
| 3zciA00 | 1.20.58.1660 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.74 | 55.0 | 5.10e-01 | 76.5% | 91.6% |
| 7p3rA01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.74 | 55.0 | 4.29e-01 | 77.8% | 87.4% |
| 2zw3A00 | 1.20.1440.80 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Gap junction channel protein cysteine-rich domain | 0.71 | 54.0 | 4.90e-01 | 78.4% | 90.0% |
| 2z1qB04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.70 | 49.0 | 5.17e-01 | 77.1% | 79.4% |
| 3owaB04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.69 | 51.0 | 5.10e-01 | 77.1% | 80.3% |
| 1dlcA01 | 1.20.190.10 | Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain | 0.68 | 51.0 | 4.49e-01 | 78.4% | 55.5% |
| 6xpdA01 | 1.20.1510.10 | Mainly Alpha › Up-down Bundle › Alpha-lytic protease prodomain-like › Cation efflux protein transmembrane domain | 0.67 | 50.0 | 4.57e-01 | 77.8% | 65.3% |
| 3m9vA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.67 | 50.0 | 5.00e-01 | 77.8% | 83.4% |
| 2c41C01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.67 | 45.0 | 4.59e-01 | 78.4% | 69.8% |
| 1r2jA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.67 | 48.0 | 4.96e-01 | 77.8% | 78.5% |
| 5gj7A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.65 | 49.0 | 4.96e-01 | 77.8% | 84.1% |
| 7rkxR01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.65 | 49.0 | 4.09e-01 | 78.4% | 86.5% |
| 2gs4A00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.65 | 46.0 | 4.62e-01 | 78.4% | 70.9% |
| 2lqgA00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.65 | 48.0 | 5.07e-01 | 77.8% | 87.0% |
| 1r0dA00 | 1.20.1410.10 | Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain | 0.64 | 48.0 | 4.45e-01 | 78.4% | 70.5% |
| 4hr1A00 | 1.20.1270.410 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.63 | 45.0 | 5.01e-01 | 73.9% | 96.6% |
| 7akwA01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.59 | 45.0 | 3.98e-01 | 78.4% | 82.0% |
| 8sbeA02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.59 | 45.0 | 4.18e-01 | 77.8% | 96.8% |
| 2bg9C02 | 1.20.58.390 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain | 0.57 | 40.0 | 3.98e-01 | 71.9% | 88.1% |
| 4djhA01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.56 | 49.0 | 3.97e-01 | 94.1% | 96.5% |
| 1yc9A01 | 1.20.1600.10 | Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) | 0.54 | 45.0 | 3.47e-01 | 88.2% | 51.4% |
| 7c4sB01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.53 | 48.0 | 3.90e-01 | 96.7% | 90.2% |
ECOD (43)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3976441 | 633.10.1.0 ↗ | alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like | 0.82 | 57.0 | 6.23e-01 | 77.8% | 86.4% |
| 3802836 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.80 | 59.0 | 5.60e-01 | 77.8% | 65.7% |
| 3836366 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.79 | 58.0 | 5.68e-01 | 77.8% | 70.3% |
| 3826788 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.78 | 59.0 | 5.69e-01 | 78.4% | 69.4% |
| 3393338 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.76 | 54.0 | 5.40e-01 | 78.4% | 71.9% |
| 3389454 | 633.10.1.0 ↗ | alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like | 0.76 | 53.0 | 5.93e-01 | 78.4% | 91.7% |
| 3459699 | 633.4.1.0 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor | 0.75 | 53.0 | 5.36e-01 | 78.4% | 71.6% |
| 3830809 | 633.4.1.0 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor | 0.75 | 50.0 | 5.55e-01 | 78.4% | 85.0% |
| 5020412 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.75 | 50.0 | 5.97e-01 | 77.8% | 99.0% |
| 3354508 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.74 | 56.0 | 5.27e-01 | 78.4% | 77.8% |
| 3641736 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.73 | 50.0 | 4.90e-01 | 78.4% | 64.2% |
| 3214864 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.73 | 54.0 | 5.48e-01 | 78.4% | 77.3% |
| 4619139 | 633.23.1.21 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin › TM140 | 0.73 | 55.0 | 5.28e-01 | 78.4% | 87.4% |
| 3247549 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.72 | 53.0 | 5.56e-01 | 78.4% | 82.9% |
| 3936715 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.72 | 53.0 | 5.56e-01 | 78.4% | 84.1% |
| 3741788 | 633.21.1.10 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › MARVEL | 0.71 | 53.0 | 5.35e-01 | 77.8% | 87.1% |
| 3926101 | 601.1.2.11 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › CD20 | 0.71 | 54.0 | 5.19e-01 | 78.4% | 94.1% |
| 5042399 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.70 | 53.0 | 4.52e-01 | 78.4% | 83.3% |
| 3733145 | 633.23.1.0 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin | 0.70 | 52.0 | 5.47e-01 | 77.8% | 87.9% |
| 3741398 | 632.1.1.8 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain › SOG2 | 0.69 | 52.0 | 5.63e-01 | 78.4% | 93.1% |
| 3453205 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.69 | 52.0 | 5.47e-01 | 78.4% | 87.1% |
| 3885386 | 150.1.1.180 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › PF27925 | 0.69 | 52.0 | 5.35e-01 | 77.1% | 84.1% |
| 5035274 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.69 | 47.0 | 5.28e-01 | 73.2% | 88.3% |
| 3929825 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.69 | 50.0 | 5.57e-01 | 78.4% | 95.0% |
| 3931307 | 601.1.2.4 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Talin_R4 | 0.68 | 51.0 | 5.27e-01 | 77.8% | 86.2% |
| 3690392 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.67 | 51.0 | 4.73e-01 | 77.8% | 65.4% |
| 3225015 | 5001.1.1.27 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Sre | 0.66 | 50.0 | 4.14e-01 | 78.4% | 83.7% |
| 3500881 | 133.1.1.1 ↗ | alpha bundles › DH domain-like › DBL homology domain (DH-domain) › DBL homology domain (DH-domain) › RhoGEF | 0.66 | 50.0 | 4.53e-01 | 78.4% | 69.8% |
| 4977923 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.66 | 46.0 | 4.55e-01 | 71.2% | 100.0% |
| 3215760 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.65 | 49.0 | 3.99e-01 | 78.4% | 79.6% |
| 3275656 | 174.1.1.1 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin | 0.63 | 48.0 | 4.85e-01 | 78.4% | 85.3% |
| 3480029 | 5069.1.1.7 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Cytochrom_B561 | 0.63 | 47.0 | 4.45e-01 | 77.8% | 82.5% |
| 3543668 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.63 | 48.0 | 4.16e-01 | 79.1% | 97.3% |
| 4961958 | 5001.1.1.292 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › HisKA_7TM | 0.62 | 47.0 | 4.16e-01 | 78.4% | 87.6% |
| 3245983 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.62 | 54.0 | 4.29e-01 | 93.5% | 94.1% |
| 3411187 | 633.6.1.0 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like | 0.61 | 53.0 | 3.72e-01 | 92.8% | 67.6% |
| 3934625 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.60 | 44.0 | 4.84e-01 | 78.4% | 92.8% |
| 4964661 | 5001.1.1.292 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › HisKA_7TM | 0.60 | 46.0 | 3.99e-01 | 78.4% | 88.1% |
| 3720032 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.60 | 41.0 | 4.59e-01 | 71.2% | 89.2% |
| 4983897 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.57 | 41.0 | 4.12e-01 | 74.5% | 91.3% |
| 3926440 | 5001.1.1.127 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Tmemb_185A | 0.57 | 44.0 | 3.55e-01 | 81.7% | 90.0% |
| 4565029 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.54 | 41.0 | 3.75e-01 | 78.4% | 82.8% |
| 4663376 | 3593.1.1.1 ↗ | a+b complex topology › Oncogenic effector CagA meander beta sheet domain › Oncogenic effector CagA meander beta sheet domain › Oncogenic effector CagA meander beta sheet domain › CagA_N | 0.54 | 44.0 | 3.29e-01 | 87.6% | 54.1% |
D2
high
residues 33-114
Domain cluster:
rep: envelope_glycoprotein_K__YP_010084935__Beluga_whale_alphaherpesvirus_1__1434720__D38-110
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01621.23 best | Fusion_gly_K | 73.8 | 1.90e-20 | 100.0% | 24.5% |