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envelope_glycoprotein_M
Euk-VirHuman_alphaherpesvirus_2
envelope_glycoprotein_M__YP_009137161__Human_alphaherpesvirus_2__10310
Identity
- Accession:
- YP_009137161 ↗
- Protein ID:
- envelope_glycoprotein_M
- Kingdom:
- euk
Quality
74.5
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Human_alphaherpesvirus_2
TaxID: 10310
Cluster
View cluster (76 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 86-136
Domain cluster:
representative
CATH (30)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4wv4B00 | 1.10.20.10 | Mainly Alpha › Orthogonal Bundle › Histone, subunit A › Histone, subunit A | 0.78 | 59.0 | 4.76e-01 | 90.2% | 44.1% |
| 1u7lA02 | 1.20.1460.10 | Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › subunit c (vma5p) of the yeast v-atpase, domain 2 | 0.78 | 71.0 | 4.73e-01 | 100.0% | 41.5% |
| 1qsdA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.77 | 67.0 | 5.37e-01 | 100.0% | 52.9% |
| 2gsvA00 | 6.10.140.40 | Special › Helix non-globular › Helix Hairpins › | 0.76 | 53.0 | 4.89e-01 | 74.5% | 56.7% |
| 4gzrC00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.76 | 63.0 | 5.93e-01 | 100.0% | 75.4% |
| 1b06A01 | 1.10.287.990 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain | 0.76 | 60.0 | 5.49e-01 | 96.1% | 65.7% |
| 4q20A01 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.75 | 66.0 | 5.63e-01 | 98.0% | 86.6% |
| 2xokP00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.75 | 64.0 | 5.77e-01 | 100.0% | 81.1% |
| 8a1gC01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.75 | 66.0 | 4.51e-01 | 100.0% | 36.5% |
| 4mtxD00 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.75 | 67.0 | 5.43e-01 | 100.0% | 86.3% |
| 2c0uA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.74 | 64.0 | 4.43e-01 | 98.0% | 39.6% |
| 4ib4A01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.74 | 61.0 | 3.86e-01 | 96.1% | 67.0% |
| 5fgzA02 | 1.10.3810.10 | Mainly Alpha › Orthogonal Bundle › Penicillin binding protein transpeptidase fold › Biosynthetic peptidoglycan transglycosylase-like | 0.73 | 47.0 | 3.25e-01 | 78.4% | 20.2% |
| 2e62A01 | 6.10.140.420 | Special › Helix non-globular › Helix Hairpins › | 0.73 | 52.0 | 5.22e-01 | 84.3% | 75.0% |
| 2gtsA00 | 1.10.287.850 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain | 0.72 | 64.0 | 5.59e-01 | 100.0% | 67.5% |
| 3axjB02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.72 | 52.0 | 4.31e-01 | 80.4% | 44.7% |
| 3l1nA02 | 1.20.1280.140 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.72 | 53.0 | 4.49e-01 | 100.0% | 47.1% |
| 1sg2A00 | 3.30.910.20 | Alpha Beta › 2-Layer Sandwich › Protein Binding, DinI Protein; Chain A › Skp domain | 0.69 | 59.0 | 4.34e-01 | 100.0% | 35.5% |
| 2kz6A01 | 6.10.140.1310 | Special › Helix non-globular › Helix Hairpins › | 0.68 | 55.0 | 4.76e-01 | 92.2% | 60.5% |
| 2q0oC00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.68 | 57.0 | 4.79e-01 | 98.0% | 55.8% |
| 3kr9A02 | 1.10.287.1890 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.65 | 47.0 | 4.47e-01 | 76.5% | 63.9% |
| 4gouA01 | 1.10.167.10 | Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 | 0.64 | 43.0 | 3.12e-01 | 100.0% | 23.6% |
| 3uw3A02 | 3.30.360.10 | Alpha Beta › 2-Layer Sandwich › Dihydrodipicolinate Reductase; domain 2 › Dihydrodipicolinate Reductase; domain 2 | 0.64 | 46.0 | 3.08e-01 | 80.4% | 27.6% |
| 1u8bA02 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.62 | 40.0 | 3.90e-01 | 74.5% | 55.7% |
| 1s35A01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.62 | 49.0 | 4.00e-01 | 90.2% | 61.4% |
| 6mh4A03 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.61 | 43.0 | 3.74e-01 | 74.5% | 48.1% |
| 2yhaA02 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.56 | 48.0 | 3.15e-01 | 96.1% | 26.2% |
| 4ri6A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.56 | 45.0 | 3.45e-01 | 90.2% | 58.8% |
| 5hayA02 | 1.25.40.440 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Nucleoporin, helical domain, central subdomain | 0.53 | 36.0 | 3.15e-01 | 72.5% | 44.3% |
| 6b8hO01 | 1.10.520.20 | Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 1 › N-terminal domain of the delta subunit of the F1F0-ATP synthase | 0.52 | 37.0 | 3.06e-01 | 78.4% | 76.8% |
ECOD (25)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3847053 | 192.15.1.0 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains | 0.86 | 52.0 | 4.46e-01 | 76.5% | 42.7% |
| 4324592 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.82 | 71.0 | 5.75e-01 | 100.0% | 51.0% |
| 3349325 | 5086.1.1.135 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › DUF7615 | 0.81 | 68.0 | 5.82e-01 | 98.0% | 58.7% |
| 4028809 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.79 | 65.0 | 4.66e-01 | 90.2% | 33.8% |
| 4003051 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.78 | 65.0 | 6.13e-01 | 100.0% | 76.9% |
| 3204136 | 3826.1.1.0 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) | 0.77 | 60.0 | 5.20e-01 | 90.2% | 55.0% |
| 3893232 | 4082.1.1.0 ↗ | alpha duplicates or obligate multimers › Hairy Orange domain › Hairy Orange domain › Hairy Orange domain | 0.77 | 67.0 | 5.01e-01 | 100.0% | 40.8% |
| 4139865 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.76 | 65.0 | 4.12e-01 | 100.0% | 19.3% |
| 3889851 | 4082.1.1.1 ↗ | alpha duplicates or obligate multimers › Hairy Orange domain › Hairy Orange domain › Hairy Orange domain › Hairy_orange | 0.75 | 53.0 | 5.66e-01 | 80.4% | 84.4% |
| 3283001 | 605.1.1.4 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA_3 | 0.75 | 64.0 | 5.32e-01 | 100.0% | 62.1% |
| 5020110 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.75 | 64.0 | 5.14e-01 | 100.0% | 49.0% |
| 5063791 | 1075.3.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC importer transmembrane domain fold › Type I ABC importer transmembrane domain fold › BPD_transp_1 | 0.75 | 60.0 | 3.62e-01 | 92.2% | 13.7% |
| 3501323 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.74 | 58.0 | 4.83e-01 | 84.3% | 94.1% |
| 4817720 | 2004.1.1.5 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran | 0.74 | 65.0 | 4.03e-01 | 100.0% | 18.1% |
| 3582573 | 192.24.1.0 ↗ | alpha bundles › Long alpha-hairpin › RPC62 helical hairpin domain › RPC62 helical hairpin domain | 0.73 | 65.0 | 5.07e-01 | 100.0% | 78.2% |
| 3399070 | 4082.1.1.1 ↗ | alpha duplicates or obligate multimers › Hairy Orange domain › Hairy Orange domain › Hairy Orange domain › Hairy_orange | 0.73 | 54.0 | 5.28e-01 | 88.2% | 72.7% |
| 4511884 | 4082.1.1.1 ↗ | alpha duplicates or obligate multimers › Hairy Orange domain › Hairy Orange domain › Hairy Orange domain › Hairy_orange | 0.72 | 51.0 | 5.40e-01 | 80.4% | 84.4% |
| 5045731 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.72 | 59.0 | 5.58e-01 | 98.0% | 78.5% |
| 3261693 | 601.37.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Photosystem II lipoprotein Psb27 › Photosystem II lipoprotein Psb27 | 0.72 | 60.0 | 4.64e-01 | 100.0% | 40.8% |
| 3194783 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.71 | 57.0 | 4.45e-01 | 98.0% | 40.0% |
| 4289707 | 192.15.1.73 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › GrpE | 0.70 | 60.0 | 4.85e-01 | 98.0% | 51.0% |
| 3935027 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.66 | 50.0 | 4.00e-01 | 82.4% | 45.0% |
| 3416398 | 509.1.1.0 ↗ | alpha bundles › PAH2 domain › PAH2 domain › PAH2 domain | 0.64 | 47.0 | 4.20e-01 | 80.4% | 97.3% |
| 3577530 | 2007.2.3.7 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Myotub-related | 0.63 | 53.0 | 3.46e-01 | 98.0% | 54.9% |
| 5037532 | 244.4.1.2 ↗ | a+b two layers › FAD-linked reductases, C-terminal domain-like › Ni-Fe binding domain in nickel-iron hydrogenase large subunit › Ni-Fe binding domain in nickel-iron hydrogenase large subunit › NiFeSe_Hases | 0.58 | 40.0 | 3.09e-01 | 76.5% | 27.4% |
D2
medium
residues 137-248
Domain cluster:
rep: BBRF3__YP_001129479__Human_herpesvirus_4_type_2__12509__D131-232
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01528.23 best | Herpes_glycop | 108.8 | 4.50e-31 | 100.0% | 33.1% |
D3
medium
residues 249-357
Domain cluster:
rep: envelope_glycoprotein_M__YP_009176930__Testudinid_alphaherpesvirus_3__2560801__D231-337
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01528.23 best | Herpes_glycop | 102.8 | 3.00e-29 | 100.0% | 30.4% |