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envelope_glycoprotein_M
Euk-VirSuid_alphaherpesvirus_1
envelope_glycoprotein_M__YP_068365__Suid_alphaherpesvirus_1__10345
Identity
- Accession:
- YP_068365 ↗
- Protein ID:
- envelope_glycoprotein_M
- Kingdom:
- euk
Quality
83.6
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Varicellovirus›
Suid_alphaherpesvirus_1
TaxID: 10345
Cluster
View cluster (76 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 6-52_70-258
Domain cluster:
rep: envelope_glycoprotein_M__YP_009176930__Testudinid_alphaherpesvirus_3__2560801__D21-51_67-230
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01528.23 best | Herpes_glycop | 191.6 | 3.00e-56 | 99.2% | 74.9% |
CATH (25)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1qoyA00 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.74 | 53.0 | 4.83e-01 | 72.0% | 82.2% |
| 2ff4A02 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.71 | 31.0 | 3.51e-01 | 96.2% | 51.6% |
| 1rx0A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.69 | 44.0 | 5.28e-01 | 70.3% | 96.1% |
| 2yevA03 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.66 | 41.0 | 4.64e-01 | 72.9% | 79.3% |
| 2wb7A03 | 1.20.120.870 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › pT26-6p, five-helical bundle domain | 0.65 | 38.0 | 4.79e-01 | 75.0% | 97.1% |
| 1zb1A00 | 1.25.40.280 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › alix/aip1 like domains | 0.64 | 47.0 | 4.03e-01 | 98.7% | 47.7% |
| 3i9wA00 | 1.20.58.920 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.64 | 47.0 | 4.47e-01 | 74.6% | 83.7% |
| 4rg6A03 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.63 | 29.0 | 3.85e-01 | 94.1% | 76.7% |
| 1foeA01 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.63 | 49.0 | 5.28e-01 | 80.5% | 97.0% |
| 3ro3A00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.63 | 31.0 | 3.74e-01 | 100.0% | 69.8% |
| 3l39A01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.62 | 46.0 | 4.98e-01 | 89.4% | 90.0% |
| 2ntxA01 | 1.20.58.2010 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › PRONE domain, subdomain 1 | 0.60 | 41.0 | 4.37e-01 | 81.8% | 77.6% |
| 3i9yA00 | 1.20.58.920 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 47.0 | 4.83e-01 | 81.4% | 84.7% |
| 4abnA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.58 | 32.0 | 3.03e-01 | 100.0% | 44.8% |
| 1auwA02 | 1.20.200.10 | Mainly Alpha › Up-down Bundle › Fumarase C; Chain A, domain 2 › Fumarase/aspartase (Central domain) | 0.57 | 42.0 | 4.34e-01 | 74.6% | 78.5% |
| 3r9mA00 | 1.25.40.280 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › alix/aip1 like domains | 0.56 | 48.0 | 4.08e-01 | 98.7% | 57.2% |
| 4uiqB00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.55 | 28.0 | 3.42e-01 | 74.2% | 72.5% |
| 2o6yA02 | 1.20.200.10 | Mainly Alpha › Up-down Bundle › Fumarase C; Chain A, domain 2 › Fumarase/aspartase (Central domain) | 0.55 | 43.0 | 3.86e-01 | 84.3% | 59.9% |
| 2cmrA00 | 1.20.58.1860 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.54 | 42.0 | 4.61e-01 | 86.9% | 99.0% |
| 4bmoA00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.53 | 49.0 | 4.62e-01 | 99.6% | 82.8% |
| 8a1gC01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.53 | 38.0 | 4.29e-01 | 92.4% | 94.5% |
| 4mt4A00 | 1.20.1600.10 | Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) | 0.52 | 38.0 | 3.06e-01 | 75.4% | 85.6% |
| 2kbbA00 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.52 | 37.0 | 4.31e-01 | 87.3% | 98.9% |
| 7zo9A01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.52 | 40.0 | 3.66e-01 | 80.1% | 98.7% |
| 4f4cA01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.51 | 41.0 | 2.89e-01 | 82.6% | 65.6% |
ECOD (37)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5002523 | 3861.1.1.3 ↗ | alpha bundles › Mitochondrial translocator protein (TSPO) › Mitochondrial translocator protein (TSPO) › Mitochondrial translocator protein (TSPO) › PF30661 | 0.84 | 60.0 | 7.03e-01 | 85.2% | 100.0% |
| 3920855 | 3861.1.1.3 ↗ | alpha bundles › Mitochondrial translocator protein (TSPO) › Mitochondrial translocator protein (TSPO) › Mitochondrial translocator protein (TSPO) › PF30661 | 0.84 | 76.0 | 7.17e-01 | 98.3% | 80.7% |
| 3236500 | 174.1.1.1 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin | 0.80 | 47.0 | 6.09e-01 | 70.3% | 100.0% |
| 3923182 | 174.1.1.43 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › CD20 | 0.80 | 49.0 | 6.17e-01 | 70.8% | 96.7% |
| 3405706 | 174.1.1.1 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin | 0.79 | 45.0 | 5.94e-01 | 71.6% | 100.0% |
| 3888824 | 601.1.2.11 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › CD20 | 0.79 | 48.0 | 5.93e-01 | 74.2% | 94.0% |
| 3411108 | 174.1.1.1 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin | 0.78 | 46.0 | 5.95e-01 | 71.2% | 100.0% |
| 3400366 | 174.1.1.1 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin | 0.78 | 47.0 | 6.01e-01 | 70.8% | 100.0% |
| 3416038 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.78 | 44.0 | 5.83e-01 | 70.8% | 100.0% |
| 3868831 | 174.1.1.43 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › CD20 | 0.78 | 50.0 | 5.91e-01 | 71.6% | 91.5% |
| 3824159 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.77 | 46.0 | 5.48e-01 | 85.2% | 84.8% |
| 3394756 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.77 | 54.0 | 4.93e-01 | 70.8% | 69.0% |
| 3357886 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.76 | 48.0 | 5.49e-01 | 89.0% | 82.8% |
| 3390014 | 174.1.1.1 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin | 0.75 | 47.0 | 5.84e-01 | 70.8% | 99.3% |
| 3856927 | 633.23.1.34 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin › CD20 | 0.75 | 52.0 | 5.95e-01 | 72.9% | 94.3% |
| 3212117 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.74 | 50.0 | 6.02e-01 | 74.6% | 100.0% |
| 4020850 | 3758.1.1.0 ↗ | alpha bundles › Bacterial hemolysins-like › Bacterial hemolysins › Bacterial hemolysins | 0.73 | 52.0 | 4.83e-01 | 72.0% | 78.9% |
| 3417703 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.73 | 44.0 | 5.18e-01 | 80.9% | 84.2% |
| 3756853 | 174.1.1.43 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › CD20 | 0.72 | 51.0 | 5.68e-01 | 71.6% | 88.9% |
| 4398872 | 174.1.1.43 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › CD20 | 0.72 | 48.0 | 5.81e-01 | 72.5% | 99.4% |
| 3733826 | 5001.1.1.131 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › DUF7702 | 0.66 | 47.0 | 4.74e-01 | 81.8% | 71.2% |
| 3177695 | 133.1.1.1 ↗ | alpha bundles › DH domain-like › DBL homology domain (DH-domain) › DBL homology domain (DH-domain) › RhoGEF | 0.64 | 50.0 | 5.15e-01 | 81.8% | 95.2% |
| 4952953 | 604.5.1.2 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU | 0.61 | 49.0 | 4.99e-01 | 96.2% | 85.8% |
| 4948739 | 604.5.1.2 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU | 0.61 | 47.0 | 4.93e-01 | 94.1% | 89.0% |
| 3390900 | 174.1.1.29 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › DUF4728 | 0.59 | 40.0 | 4.71e-01 | 70.3% | 99.4% |
| 4022048 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.56 | 41.0 | 4.71e-01 | 87.7% | 99.4% |
| 3282600 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.56 | 50.0 | 4.56e-01 | 96.2% | 88.4% |
| 3414588 | 603.2.1.12 ↗ | alpha bundles › STAT-like › STAT › STAT › 7tm_7 | 0.56 | 50.0 | 4.30e-01 | 97.5% | 96.3% |
| 3747748 | 604.5.1.31 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › TRAM_LAG1_CLN8 | 0.56 | 50.0 | 4.69e-01 | 93.6% | 89.3% |
| 3879700 | 5054.1.1.17 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › TRAM_LAG1_CLN8 | 0.55 | 49.0 | 4.86e-01 | 93.6% | 97.1% |
| 3990526 | 4177.1.1.4 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › IMD | 0.55 | 41.0 | 4.20e-01 | 90.7% | 79.1% |
| 4258212 | 603.2.1.12 ↗ | alpha bundles › STAT-like › STAT › STAT › 7tm_7 | 0.53 | 48.0 | 4.54e-01 | 97.9% | 91.0% |
| 3388835 | 603.2.1.12 ↗ | alpha bundles › STAT-like › STAT › STAT › 7tm_7 | 0.53 | 49.0 | 4.10e-01 | 100.0% | 81.3% |
| 5060597 | 633.6.1.56 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA_dh_C | 0.53 | 49.0 | 4.50e-01 | 99.6% | 93.8% |
| 3221645 | 5001.1.1.27 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Sre | 0.52 | 45.0 | 4.15e-01 | 89.8% | 80.0% |
| 3404805 | 603.2.1.9 ↗ | alpha bundles › STAT-like › STAT › STAT › 7tm_6 | 0.52 | 46.0 | 4.40e-01 | 97.0% | 96.1% |
| 3613359 | 1075.5.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE | 0.51 | 36.0 | 3.69e-01 | 72.0% | 89.8% |
D2
medium
residues 259-357
Domain cluster:
rep: envelope_glycoprotein_M__YP_009176930__Testudinid_alphaherpesvirus_3__2560801__D231-337
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01528.23 best | Herpes_glycop | 71.5 | 9.70e-20 | 87.9% | 24.8% |