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fusion
Euk-VirHendra_henipavirus
fusion__NP_047111__Hendra_henipavirus__63330
Identity
- Accession:
- NP_047111 ↗
- Protein ID:
- fusion
- Kingdom:
- euk
Quality
71.6
mean pLDDT
Taxonomy
Orthornavirae›
Negarnaviricota›
Monjiviricetes›
Mononegavirales›
Paramyxoviridae›
Henipavirus›
Henipavirus_hendraense
TaxID: 63330
Cluster
View cluster (59 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 26-51_285-380
Domain cluster:
rep: fusion_protein__YP_009094215__Avian_paraavulavirus_3__2560327__D22-48_279-286_288-356
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00523.24 best | Fusion_gly | 108.4 | 4.10e-31 | 80.3% | 19.5% |
D2
medium
residues 52-68_149-177_226-284
Domain cluster:
rep: fusion_protein__YP_009094032__Sosuga_virus__1452514__D38-58_218-282
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00523.24 best | Fusion_gly | 61.2 | 8.70e-17 | 57.1% | 12.1% |
CATH (21)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2joqA01 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.73 | 35.0 | 4.15e-01 | 100.0% | 65.3% |
| 1kcvL02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.67 | 35.0 | 3.53e-01 | 100.0% | 49.5% |
| 3k59A02 | 3.30.70.2250 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › B family DNA polymerase, N domain, alpha/beta motif | 0.64 | 30.0 | 3.63e-01 | 100.0% | 68.7% |
| 4o5lL02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.63 | 32.0 | 3.30e-01 | 100.0% | 48.1% |
| 4rv9A02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.63 | 38.0 | 3.10e-01 | 100.0% | 31.8% |
| 3qwuA03 | 3.30.70.2160 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.60 | 32.0 | 2.91e-01 | 100.0% | 39.6% |
| 3t05A02 | 2.40.33.10 | Mainly Beta › Beta Barrel › M1 Pyruvate Kinase; Domain 3 › PK beta-barrel domain-like | 0.59 | 35.0 | 3.67e-01 | 100.0% | 63.9% |
| 1ztmA02 | 1.10.287.2480 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.59 | 55.0 | 4.33e-01 | 100.0% | 97.5% |
| 1khmA00 | 3.30.1370.10 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › K Homology domain, type 1 | 0.58 | 31.0 | 3.30e-01 | 100.0% | 57.3% |
| 1g5gA02 | 1.10.287.2480 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.57 | 54.0 | 4.47e-01 | 99.0% | 100.0% |
| 2khdA00 | 3.30.70.860 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.57 | 32.0 | 3.22e-01 | 100.0% | 51.9% |
| 5hl8C00 | 3.30.1360.100 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › General secretion pathway protein M, EpsM | 0.57 | 28.0 | 3.24e-01 | 100.0% | 62.0% |
| 2f4lA03 | 3.10.28.20 | Alpha Beta › Roll › Endonuclease I-creI › Acetamidase/Formamidase-like domains | 0.55 | 36.0 | 4.01e-01 | 100.0% | 86.3% |
| 1v4pC01 | 3.30.980.10 | Alpha Beta › 2-Layer Sandwich › Threonyl-tRNA Synthetase; Chain A, domain 2 › Threonyl-trna Synthetase; Chain A, domain 2 | 0.55 | 36.0 | 3.62e-01 | 100.0% | 64.8% |
| 6hhnA01 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.54 | 31.0 | 3.33e-01 | 100.0% | 65.2% |
| 1x8dA01 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.54 | 31.0 | 3.23e-01 | 100.0% | 61.9% |
| 4lecA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.53 | 42.0 | 3.46e-01 | 87.6% | 98.5% |
| 3dmlA00 | 3.40.30.10 | Alpha Beta › 3-Layer(aba) Sandwich › Glutaredoxin › Glutaredoxin | 0.53 | 34.0 | 3.56e-01 | 98.1% | 71.6% |
| 5iceA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.53 | 43.0 | 3.24e-01 | 87.6% | 96.0% |
| 1j4wA01 | 3.30.1370.10 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › K Homology domain, type 1 | 0.52 | 29.0 | 3.29e-01 | 100.0% | 71.6% |
| 6ahuH01 | 3.30.70.3250 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribonuclease P, Pop5 subunit | 0.51 | 31.0 | 3.21e-01 | 100.0% | 62.1% |
ECOD (34)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4871594 | 11.40.1.1 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-like domain in paramyxoviruses fusion protein › Immunoglobulin-like domain in paramyxoviruses fusion protein › Fusion_gly | 0.81 | 75.0 | 5.13e-01 | 99.0% | 65.8% |
| 4884487 | 11.40.1.1 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-like domain in paramyxoviruses fusion protein › Immunoglobulin-like domain in paramyxoviruses fusion protein › Fusion_gly | 0.79 | 73.0 | 4.95e-01 | 99.0% | 66.7% |
| 1737404 | 5093.1.1.1 ↗ | a+b complex topology › Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein › Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein › Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein › Fusion_gly | 0.77 | 71.0 | 4.87e-01 | 100.0% | 65.4% |
| 1738158 | 5093.1.1.1 ↗ | a+b complex topology › Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein › Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein › Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein › Fusion_gly | 0.76 | 70.0 | 4.81e-01 | 100.0% | 68.0% |
| 5377 | 304.52.1.1 ↗ | a+b two layers › Alpha-beta plaits › YbeD/HP0495-like › YbeD/HP0495-like › DUF493 | 0.71 | 34.0 | 3.79e-01 | 100.0% | 57.0% |
| 4043865 | 304.28.1.0 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain | 0.67 | 35.0 | 3.83e-01 | 100.0% | 61.2% |
| 3374317 | 327.11.2.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) › KH_1 | 0.60 | 32.0 | 3.40e-01 | 100.0% | 57.9% |
| 3725795 | 304.126.1.0 ↗ | a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C | 0.58 | 37.0 | 3.45e-01 | 100.0% | 51.5% |
| 5074728 | 304.162.1.0 ↗ | a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain | 0.58 | 31.0 | 3.49e-01 | 99.0% | 67.5% |
| 3362546 | 327.11.2.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) › KH_1 | 0.57 | 31.0 | 3.31e-01 | 100.0% | 57.9% |
| 184732 | 3313.1.1.1 ↗ | a+b two layers › Uncharacterized protein VC_A0919 › Uncharacterized protein VC_A0919 › Uncharacterized protein VC_A0919 › DUF406 | 0.57 | 32.0 | 3.22e-01 | 100.0% | 51.9% |
| 3763545 | 304.47.1.0 ↗ | a+b two layers › Alpha-beta plaits › SEA domain › SEA domain | 0.57 | 40.0 | 3.94e-01 | 100.0% | 67.0% |
| 3537609 | 304.47.1.1 ↗ | a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA | 0.57 | 40.0 | 3.93e-01 | 100.0% | 67.0% |
| 3605723 | 320.1.1.0 ↗ | a+b two layers › R3H domain-like › R3H domain › R3H domain | 0.57 | 32.0 | 3.66e-01 | 100.0% | 73.8% |
| 3795688 | 246.3.1.1 ↗ | a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › Exo_endo_phos | 0.56 | 49.0 | 3.47e-01 | 100.0% | 94.0% |
| 4871079 | 11.40.1.1 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-like domain in paramyxoviruses fusion protein › Immunoglobulin-like domain in paramyxoviruses fusion protein › Fusion_gly | 0.56 | 52.0 | 3.68e-01 | 100.0% | 62.5% |
| 4996918 | 3685.1.1.1 ↗ | a+b two layers › Putative acetamidase tm0119 C-terminal domain › Putative acetamidase tm0119 C-terminal domain › Putative acetamidase tm0119 C-terminal domain › FmdA_AmdA | 0.55 | 36.0 | 3.95e-01 | 100.0% | 85.0% |
| 3304252 | 320.1.1.3 ↗ | a+b two layers › R3H domain-like › R3H domain › R3H domain › YlmH_1st | 0.55 | 27.0 | 3.22e-01 | 99.0% | 68.6% |
| 3797594 | 246.3.1.0 ↗ | a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like | 0.54 | 47.0 | 3.34e-01 | 100.0% | 94.3% |
| 3867328 | 304.47.1.0 ↗ | a+b two layers › Alpha-beta plaits › SEA domain › SEA domain | 0.54 | 38.0 | 3.72e-01 | 100.0% | 67.0% |
| 3942012 | 304.4.1.8 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › rhaM | 0.54 | 31.0 | 3.20e-01 | 100.0% | 60.0% |
| 3763542 | 304.47.1.1 ↗ | a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA | 0.54 | 38.0 | 3.80e-01 | 100.0% | 70.0% |
| 3912991 | 246.3.1.1 ↗ | a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › Exo_endo_phos | 0.54 | 46.0 | 3.22e-01 | 100.0% | 92.2% |
| 3468215 | 246.3.1.1 ↗ | a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › Exo_endo_phos | 0.54 | 47.0 | 3.27e-01 | 100.0% | 96.3% |
| 3792947 | 2003.1.5.73 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_16 | 0.53 | 43.0 | 3.34e-01 | 87.6% | 86.8% |
| 5044537 | 3012.1.1.0 ↗ | a+b two layers › Cof C2 cap domain › Cof C2 cap domain › Cof C2 cap domain | 0.53 | 29.0 | 3.32e-01 | 98.1% | 71.2% |
| 3625370 | 2003.1.5.73 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_16 | 0.52 | 43.0 | 3.33e-01 | 88.6% | 84.7% |
| 3358067 | 246.3.1.1 ↗ | a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › Exo_endo_phos | 0.52 | 45.0 | 3.34e-01 | 100.0% | 92.6% |
| 4596174 | 2003.1.5.73 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_16 | 0.51 | 42.0 | 3.14e-01 | 89.5% | 91.3% |
| 4337810 | 2003.1.5.73 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_16 | 0.51 | 42.0 | 3.31e-01 | 89.5% | 99.1% |
| 3928059 | 327.11.2.14 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) › KH_9 | 0.51 | 29.0 | 3.06e-01 | 100.0% | 61.1% |
| 4969016 | 2003.1.5.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases | 0.50 | 41.0 | 3.24e-01 | 89.5% | 83.0% |
| 4328804 | 2003.1.5.46 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › MTS | 0.50 | 39.0 | 3.04e-01 | 82.9% | 97.9% |
| 5014776 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.50 | 36.0 | 4.08e-01 | 100.0% | 96.2% |
D3
medium
residues 69-104_123-148_178-225
Domain cluster:
representative
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00523.24 best | Fusion_gly | 55.4 | 4.90e-15 | 44.5% | 9.7% |
| PF00523.24 | Fusion_gly | 33.2 | 2.60e-08 | 28.2% | 5.5% |
CATH (13)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3qa8A04 | 1.20.1270.250 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.57 | 50.0 | 3.97e-01 | 98.2% | 78.1% |
| 2ewfA02 | 1.20.1270.310 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.56 | 35.0 | 4.00e-01 | 93.6% | 86.4% |
| 3gi7A00 | 1.20.1270.180 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.55 | 44.0 | 4.50e-01 | 98.2% | 91.3% |
| 1rtwB00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.54 | 47.0 | 3.86e-01 | 96.4% | 99.5% |
| 2rdcA00 | 1.10.287.800 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › protein ne1242 | 0.53 | 35.0 | 3.28e-01 | 90.9% | 53.4% |
| 3rguB00 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.52 | 37.0 | 4.07e-01 | 90.0% | 92.0% |
| 3m9vA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.52 | 46.0 | 4.08e-01 | 96.4% | 68.2% |
| 3owaA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.52 | 44.0 | 3.82e-01 | 92.7% | 67.3% |
| 3bt5A00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.52 | 43.0 | 3.88e-01 | 99.1% | 65.6% |
| 2wpgA01 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.51 | 32.0 | 3.57e-01 | 91.8% | 80.5% |
| 1uruA01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.51 | 43.0 | 3.46e-01 | 90.9% | 80.9% |
| 1avoB00 | 1.20.120.180 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Proteasome activator pa28, C-terminal domain | 0.51 | 45.0 | 4.17e-01 | 99.1% | 92.1% |
| 3uo2B02 | 1.20.1280.20 | Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain | 0.50 | 35.0 | 3.97e-01 | 95.5% | 94.0% |
ECOD (10)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4871594 | 11.40.1.1 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-like domain in paramyxoviruses fusion protein › Immunoglobulin-like domain in paramyxoviruses fusion protein › Fusion_gly | 0.92 | 88.0 | 5.94e-01 | 100.0% | 43.7% |
| 4884487 | 11.40.1.1 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-like domain in paramyxoviruses fusion protein › Immunoglobulin-like domain in paramyxoviruses fusion protein › Fusion_gly | 0.90 | 85.0 | 5.79e-01 | 100.0% | 45.1% |
| 4025710 | 3871.1.1.0 ↗ | alpha duplicates or obligate multimers › PHIST › PHIST › PHIST | 0.59 | 52.0 | 5.08e-01 | 99.1% | 96.8% |
| 4942761 | 4009.1.1.0 ↗ | alpha bundles › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins | 0.59 | 43.0 | 4.82e-01 | 90.0% | 96.5% |
| 3832190 | 611.11.1.0 ↗ | alpha bundles › N-cbl like › Plasmodium host cell traversal protein SPECT1 › Plasmodium host cell traversal protein SPECT1 | 0.57 | 50.0 | 4.30e-01 | 99.1% | 67.2% |
| 3609697 | 1128.1.1.0 ↗ | alpha bundles › LYR protein › LYR protein › LYR protein | 0.56 | 49.0 | 4.47e-01 | 96.4% | 93.8% |
| 3289741 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.54 | 43.0 | 3.02e-01 | 87.3% | 76.3% |
| 5074065 | 632.11.1.18 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like › DUF5658 | 0.54 | 42.0 | 4.44e-01 | 96.4% | 96.9% |
| 3499218 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.52 | 40.0 | 4.09e-01 | 97.3% | 83.6% |
| 3932046 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.52 | 40.0 | 4.31e-01 | 91.8% | 98.9% |