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glycoprotein_B

Euk-Vir

Human_betaherpesvirus_6A

glycoprotein_B__NP_042932__Human_betaherpesvirus_6A__32603

Identity

Accession:
NP_042932 ↗
Protein ID:
glycoprotein_B
Kingdom:
euk

Quality

72.4 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 27-41_488-578
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00606.24 best Glycoprotein_B 101.2 8.70e-29 87.7% 38.3%
D2 high residues 67-78_288-390
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF17417.9 best Glycoprot_B_PH2 129.1 8.90e-38 84.4% 99.0%
CATH (19)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2gumB03 2.30.29.100 Mainly Beta › Roll › PH-domain like › 0.94 88.0 8.65e-01 96.5% 94.2%
3fvcA03 2.30.29.100 Mainly Beta › Roll › PH-domain like › 0.94 86.0 8.78e-01 95.7% 98.2%
4osnA00 2.30.29.100 Mainly Beta › Roll › PH-domain like › 0.93 83.0 8.57e-01 93.9% 97.3%
7dl8C01 3.30.110.20 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Alba-like domain 0.66 35.0 3.89e-01 100.0% 65.2%
3uebF00 3.30.300.100 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › MTH677-like 0.62 39.0 4.13e-01 98.3% 72.0%
5j3tA00 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.61 43.0 4.16e-01 92.2% 65.1%
1i7qA00 3.60.120.10 Alpha Beta › 4-Layer Sandwich › Anthranilate synthase › Anthranilate synthase 0.59 42.0 2.73e-01 73.0% 71.8%
2wdtC02 3.30.1490.420 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › Ubiquitin carboxyl-terminal hydrolase, domain 2 0.58 33.0 3.52e-01 80.0% 62.4%
4djbA00 3.30.70.2870 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Mastadenovirus E4 ORF3 0.58 35.0 3.50e-01 93.9% 57.6%
2e7vA01 3.30.70.960 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › SEA domain 0.56 37.0 3.83e-01 93.9% 71.4%
4lfhD02 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.56 33.0 3.70e-01 87.0% 76.5%
3onrJ00 3.30.1660.10 Alpha Beta › 2-Layer Sandwich › Dodecin subunit-like › Flavin-binding protein dodecin 0.55 31.0 3.77e-01 98.3% 91.2%
2oikA00 3.30.428.10 Alpha Beta › 2-Layer Sandwich › HIT family, subunit A › HIT-like 0.54 39.0 3.73e-01 90.4% 62.6%
4ndhB00 3.30.428.10 Alpha Beta › 2-Layer Sandwich › HIT family, subunit A › HIT-like 0.53 42.0 3.63e-01 87.0% 53.9%
2lydA00 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.53 38.0 3.64e-01 92.2% 64.2%
3gk6A00 3.20.80.10 Alpha Beta › Alpha-Beta Barrel › Multidrug-efflux Transporter 1 Regulator Bmrr; Chain A › Regulatory factor, effector binding domain 0.53 41.0 3.71e-01 81.7% 100.0%
3fm2A00 3.40.1570.10 Alpha Beta › 3-Layer(aba) Sandwich › Heme iron utilization protein-like fold › HemS/ChuS/ChuX like domains 0.52 38.0 3.72e-01 78.3% 88.7%
3a54A01 2.40.50.340 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › 0.51 32.0 3.56e-01 76.5% 80.0%
3npfB01 2.30.30.40 Mainly Beta › Roll › SH3 type barrels. › SH3 Domains 0.50 29.0 3.61e-01 93.0% 98.5%
ECOD (12)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3924669 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.73 39.0 4.31e-01 95.7% 63.2%
3932886 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.72 40.0 4.35e-01 94.8% 65.3%
3199835 220.1.1.0 beta barrels › PH domain-like › PH domain-like › PH domain-like 0.69 43.0 5.07e-01 93.0% 94.7%
5032759 9.23.1.0 beta barrels › Lipocalins/Streptavidin › Hypothetical protein BT_0869 › Hypothetical protein BT_0869 0.66 35.0 4.03e-01 89.6% 70.2%
4028741 304.20.1.1 a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP_RNA-bind 0.62 39.0 3.70e-01 96.5% 52.6%
4558605 220.5.1.1 beta barrels › PH domain-like › NucS N-terminal domain › NucS N-terminal domain › NucS_N 0.53 45.0 4.44e-01 93.0% 89.2%
4020386 881.1.1.0 a+b three layers › Mog1p/PsbP-like › Mog1p/PsbP-like › Mog1p/PsbP-like 0.52 36.0 3.08e-01 80.0% 43.2%
5030082 206.1.1.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase 0.51 43.0 3.74e-01 94.8% 59.4%
3725022 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.51 45.0 3.34e-01 100.0% 37.3%
3743802 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.51 42.0 2.98e-01 100.0% 27.3%
3476903 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.51 45.0 3.33e-01 100.0% 38.7%
3271955 206.1.1.28 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Haspin_kinase 0.50 44.0 2.92e-01 98.3% 35.3%
D3 medium residues 42-59_439-487
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00606.24 best Glycoprotein_B 66.9 2.70e-18 86.6% 22.1%
CATH (27)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3fvcA02 1.20.5.1890 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.90 78.0 6.64e-01 91.0% 100.0%
2gumA02 1.20.5.1890 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.85 72.0 6.24e-01 92.5% 100.0%
6vudA02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.59 39.0 3.80e-01 91.0% 61.3%
4hziB00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.59 42.0 2.91e-01 77.6% 87.8%
2ihyA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.57 44.0 2.99e-01 82.1% 23.0%
1in0A01 3.30.70.860 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.57 36.0 3.58e-01 88.1% 61.4%
1wr8A02 3.90.1070.10 Alpha Beta › Alpha-Beta Complex › Hypothetical Protein Ta0175; Chain: A, domain 2 › 0.56 34.0 3.40e-01 85.1% 58.0%
2hf2B02 3.30.1240.10 Alpha Beta › 2-Layer Sandwich › Hypothetical Protein, Haloacid Dehalogenase-like Hydrolase; Chain: A; domain 2 › 0.55 34.0 3.02e-01 86.6% 39.3%
2b30A02 3.30.1240.10 Alpha Beta › 2-Layer Sandwich › Hypothetical Protein, Haloacid Dehalogenase-like Hydrolase; Chain: A; domain 2 › 0.54 34.0 2.97e-01 88.1% 39.4%
6lcqA00 3.30.30.10 Alpha Beta › 2-Layer Sandwich › Defensin A-like › Knottin, scorpion toxin-like 0.53 39.0 4.25e-01 88.1% 98.1%
2j0wA04 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.53 37.0 3.64e-01 94.0% 68.0%
5mmjh01 3.30.1370.30 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.53 35.0 3.41e-01 89.6% 60.0%
3znuA00 3.30.70.1060 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Dimeric alpha+beta barrel 0.53 40.0 3.68e-01 91.0% 60.6%
1lfwA03 3.30.70.360 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.53 34.0 3.16e-01 88.1% 48.9%
3onqA02 3.30.70.2730 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.53 35.0 3.34e-01 88.1% 56.8%
3aqoA01 3.30.70.3400 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.52 38.0 3.68e-01 89.6% 66.3%
3vcaA02 2.102.10.10 Mainly Beta › 3-layer Sandwich › Rieske Iron-sulfur Protein › Rieske [2Fe-2S] iron-sulphur domain 0.52 43.0 3.61e-01 92.5% 95.8%
3cjsA00 3.30.70.1170 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Sun protein; domain 3 0.52 31.0 3.32e-01 86.6% 69.0%
2kl8A00 3.30.70.600 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S10 0.52 35.0 3.32e-01 92.5% 56.5%
2e4qA00 2.102.10.10 Mainly Beta › 3-layer Sandwich › Rieske Iron-sulfur Protein › Rieske [2Fe-2S] iron-sulphur domain 0.51 42.0 3.62e-01 92.5% 97.2%
5mrvA00 3.40.630.10 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Zn peptidases 0.51 41.0 2.72e-01 92.5% 82.7%
2l01A00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.51 35.0 3.36e-01 71.6% 80.5%
2ebbA00 3.30.1360.20 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › Transcriptional coactivator/pterin dehydratase 0.51 37.0 3.37e-01 97.0% 56.2%
1fokA02 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.51 36.0 3.34e-01 85.1% 58.6%
1usmA00 3.30.1360.20 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › Transcriptional coactivator/pterin dehydratase 0.50 36.0 3.52e-01 95.5% 67.5%
1nf2A02 3.30.1240.10 Alpha Beta › 2-Layer Sandwich › Hypothetical Protein, Haloacid Dehalogenase-like Hydrolase; Chain: A; domain 2 › 0.50 32.0 2.81e-01 85.1% 39.6%
8k1fC01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.50 37.0 2.81e-01 89.6% 29.1%
ECOD (31)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2488247 4300.1.1.1 beta complex topology › Viral glycoprotein ectodomain-like › Viral glycoprotein ectodomain-like › Viral glycoprotein ectodomain-like › Glycoprotein_B 0.86 80.0 5.63e-01 100.0% 41.2%
3287096 2004.1.1.5 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran 0.62 48.0 3.22e-01 85.1% 84.4%
3624413 320.1.1.0 a+b two layers › R3H domain-like › R3H domain › R3H domain 0.58 37.0 3.83e-01 88.1% 69.2%
3742471 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.57 39.0 3.88e-01 88.1% 68.6%
4946820 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.55 38.0 3.00e-01 86.6% 33.1%
3728757 3016.1.1.0 a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases 0.55 41.0 3.92e-01 89.6% 67.5%
4603561 304.14.1.1 a+b two layers › Alpha-beta plaits › Sporulation related repeat (SPOR) › Sporulation related repeat (SPOR) › SPOR 0.55 37.0 3.53e-01 89.6% 58.7%
3785836 3016.1.1.0 a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases 0.55 39.0 3.76e-01 92.5% 65.0%
3603400 304.120.1.6 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI › ThiI_fer 0.54 41.0 3.95e-01 86.6% 72.0%
5042968 304.120.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI 0.54 34.0 3.50e-01 83.6% 66.2%
5035384 306.4.1.0 a+b two layers › Glucose permease domain IIB-like › YggU-like › YggU-like 0.54 43.0 4.30e-01 92.5% 98.6%
3877590 327.11.2.0 a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) 0.54 39.0 3.76e-01 94.0% 68.0%
4965344 328.9.1.4 a+b two layers › IF3-like › SepF C-terminal domain › SepF C-terminal domain › DUF5779 0.53 33.0 3.24e-01 86.6% 54.7%
5038034 304.120.1.6 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI › ThiI_fer 0.53 41.0 3.86e-01 100.0% 67.8%
5001157 304.120.1.6 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI › ThiI_fer 0.52 39.0 3.63e-01 85.1% 63.5%
5013039 242.1.1.0 a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases 0.52 34.0 3.16e-01 91.0% 51.8%
3953208 305.2.1.1 a+b two layers › DCoH-like › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin_4a 0.52 38.0 3.42e-01 95.5% 55.3%
4934435 309.1.1.15 a+b two layers › LuxS, MPP, ThrRS/AlaRS common domain › LuxS, MPP, ThrRS/AlaRS common domain › LuxS/MPP-like metallohydrolase › DEAD_assoc 0.52 35.0 2.87e-01 86.6% 36.2%
5035783 304.120.1.6 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI › ThiI_fer 0.52 39.0 3.70e-01 89.6% 68.8%
5051188 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.52 34.0 3.51e-01 83.6% 75.0%
4518792 304.28.1.4 a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › SecD_1st 0.52 43.0 3.73e-01 95.5% 72.7%
4609740 305.2.1.1 a+b two layers › DCoH-like › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin_4a 0.51 37.0 3.34e-01 95.5% 54.7%
4621064 305.2.1.1 a+b two layers › DCoH-like › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin_4a 0.51 37.0 3.39e-01 95.5% 57.8%
3513071 323.1.1.6 a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › Carn_acyltransf 0.51 39.0 2.64e-01 92.5% 32.9%
4555558 304.120.1.6 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI › ThiI_fer 0.51 40.0 3.91e-01 91.0% 77.3%
4948690 2004.1.1.30 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.51 37.0 2.40e-01 79.1% 21.4%
3588013 101.1.2.89 alpha arrays › HTH › HTH › winged helix domain › HTH_DeoR 0.51 36.0 3.49e-01 88.1% 65.0%
5040317 309.1.1.15 a+b two layers › LuxS, MPP, ThrRS/AlaRS common domain › LuxS, MPP, ThrRS/AlaRS common domain › LuxS/MPP-like metallohydrolase › DEAD_assoc 0.51 35.0 2.59e-01 88.1% 25.9%
4980798 304.120.1.6 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI › ThiI_fer 0.51 38.0 3.72e-01 88.1% 73.3%
3189664 3016.1.1.3 a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › Aminotran_5 0.50 41.0 2.53e-01 94.0% 85.7%
5058130 304.120.1.6 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in ThiI › Ferredoxin-like domain in ThiI › ThiI_fer 0.50 37.0 3.56e-01 83.6% 69.3%
D4 medium residues 82-203
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF17416.9 best Glycoprot_B_PH1 139.4 1.80e-40 100.0% 56.7%
D5 medium residues 204-284_609-635
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF17416.9 best Glycoprot_B_PH1 79.3 4.60e-22 79.6% 38.1%
D6 medium residues 644-710
PDB