←Back to structures
glycoprotein_H
Euk-VirHuman_betaherpesvirus_6B
glycoprotein_H__NP_050229__Human_betaherpesvirus_6B__32604
Identity
- Accession:
- NP_050229 ↗
- Protein ID:
- glycoprotein_H
- Kingdom:
- euk
Quality
81.9
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Roseolovirus›
Human_betaherpesvirus_6B
TaxID: 32604
Cluster
View cluster (43 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 42-91
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02489.22 best | Herpes_glycop_H | 33.8 | 2.20e-08 | 100.0% | 7.8% |
CATH (10)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5w0kA01 | 3.90.380.20 | Alpha Beta › Alpha-Beta Complex › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 › Herpesvirus glycoprotein H, domain D-II | 0.68 | 58.0 | 3.59e-01 | 100.0% | 16.3% |
| 1zcdA00 | 1.20.1530.10 | Mainly Alpha › Up-down Bundle › Na+/H+ antiporter like fold › Na+/H+ antiporter like domain | 0.55 | 40.0 | 2.49e-01 | 86.0% | 35.1% |
| 4dnhA01 | 3.20.20.70 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I | 0.54 | 40.0 | 2.50e-01 | 92.0% | 51.3% |
| 3c6cA00 | 3.20.20.70 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I | 0.52 | 40.0 | 2.61e-01 | 96.0% | 49.0% |
| 1b35B00 | 2.60.120.20 | Mainly Beta › Sandwich › Jelly Rolls › | 0.52 | 37.0 | 2.41e-01 | 78.0% | 72.5% |
| 1mhyD00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.52 | 40.0 | 2.43e-01 | 100.0% | 80.0% |
| 6yiiA01 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.52 | 41.0 | 2.74e-01 | 94.0% | 78.2% |
| 4ijaA03 | 3.30.420.40 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain | 0.51 | 41.0 | 3.00e-01 | 92.0% | 49.3% |
| 3u1nB01 | 1.10.3210.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 | 0.51 | 38.0 | 2.46e-01 | 92.0% | 79.0% |
| 2incA00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.50 | 37.0 | 2.23e-01 | 88.0% | 40.7% |
ECOD (9)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3600193 | 327.19.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › DNA mismatch repair protein MutL regulatory subdomain › DNA mismatch repair protein MutL regulatory subdomain | 0.61 | 38.0 | 3.37e-01 | 74.0% | 41.0% |
| 4024768 | 330.3.1.7 ↗ | a+b two layers › dsRBD-like › Peptidyl-tRNA hydrolase domain-like › Peptidyl-tRNA hydrolase domain-like › AP2 | 0.56 | 36.0 | 3.55e-01 | 72.0% | 60.0% |
| 2991657 | 7602.1.1.1 ↗ | a/b three-layered sandwiches › Lactate racemase C-terminal domain › Lactate racemase C-terminal domain › Lactate racemase C-terminal domain › LarA_C | 0.55 | 33.0 | 3.78e-01 | 78.0% | 100.0% |
| 3839900 | 2004.1.1.220 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SWI2_SNF2 | 0.54 | 44.0 | 2.90e-01 | 100.0% | 54.7% |
| 4026577 | 252.2.1.1 ↗ | a+b two layers › DNA-binding domain › GCC-box binding domain-like › GCC-box binding domain-like › AP2 | 0.53 | 34.0 | 3.34e-01 | 72.0% | 60.0% |
| 3455885 | 101.1.9.118 ↗ | alpha arrays › HTH › HTH › Putative DNA-binding domain › Auxin_inducible | 0.53 | 37.0 | 3.40e-01 | 74.0% | 60.0% |
| 3789547 | 859.1.1.3 ↗ | a+b two layers › The spindle assembly checkpoint protein mad2 › The spindle assembly checkpoint protein mad2 › The spindle assembly checkpoint protein mad2 › ATG101 | 0.52 | 37.0 | 2.65e-01 | 96.0% | 22.9% |
| 4927100 | 4312.1.1.0 ↗ | a+b two layers › RelE-like › RelE-like › RelE-like | 0.50 | 38.0 | 3.27e-01 | 98.0% | 46.7% |
| 4977735 | 2004.1.1.19 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Ras | 0.50 | 34.0 | 2.49e-01 | 76.0% | 61.1% |
D2
medium
residues 138-243
Domain cluster:
rep: orf22__YP_009044405__Alcelaphine_gammaherpesvirus_2__138184__D149-254
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02489.22 best | Herpes_glycop_H | 74.9 | 7.30e-21 | 100.0% | 25.6% |
D3
medium
residues 382-526
Domain cluster:
rep: BXLF2__YP_001129496__Human_herpesvirus_4_type_2__12509__D346-529
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02489.22 best | Herpes_glycop_H | 153.3 | 1.30e-44 | 91.7% | 28.3% |
CATH (32)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2xqyA02 | 1.20.58.1340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.71 | 61.0 | 6.17e-01 | 95.2% | 91.6% |
| 4ga4A01 | 1.20.970.10 | Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C | 0.69 | 32.0 | 4.51e-01 | 80.0% | 94.0% |
| 1gw5A00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.63 | 52.0 | 3.43e-01 | 89.0% | 21.9% |
| 3h5qA01 | 1.20.970.10 | Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C | 0.62 | 32.0 | 4.30e-01 | 85.5% | 100.0% |
| 2d2sA01 | 1.20.58.1210 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, N-terminal helical domain | 0.62 | 44.0 | 4.85e-01 | 77.2% | 91.4% |
| 3rk6A00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.61 | 56.0 | 4.90e-01 | 100.0% | 90.8% |
| 2fbnA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.60 | 46.0 | 4.53e-01 | 82.1% | 75.2% |
| 3o4zA02 | 1.25.40.720 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tel2 C-terminal domain | 0.60 | 49.0 | 4.45e-01 | 91.0% | 64.9% |
| 3vwaA03 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.58 | 46.0 | 3.65e-01 | 93.8% | 40.6% |
| 4ga6A02 | 1.20.970.50 | Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 › | 0.58 | 43.0 | 4.30e-01 | 77.9% | 88.8% |
| 5cwhA01 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.57 | 47.0 | 4.63e-01 | 95.2% | 81.4% |
| 3t6aA00 | 1.10.840.10 | Mainly Alpha › Orthogonal Bundle › Son of Sevenless (SoS) protein; Chain S, domain 2 › Ras guanine-nucleotide exchange factors catalytic domain | 0.57 | 50.0 | 3.92e-01 | 95.2% | 71.8% |
| 4eadA01 | 1.20.970.10 | Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C | 0.57 | 40.0 | 4.54e-01 | 80.0% | 96.3% |
| 3vhlA02 | 1.20.58.740 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › DOCK DHR2 domain, lobe C | 0.57 | 44.0 | 4.81e-01 | 94.5% | 99.2% |
| 1xqrA00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.57 | 48.0 | 3.97e-01 | 100.0% | 50.2% |
| 2h7oA01 | 1.20.120.1330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Rac1-binding domain, N-terminal GTPase binding subdomain | 0.57 | 42.0 | 4.56e-01 | 85.5% | 91.1% |
| 1h2uA01 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.56 | 50.0 | 4.13e-01 | 97.9% | 84.4% |
| 3qmlD00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.56 | 48.0 | 3.96e-01 | 97.9% | 50.2% |
| 4dvgB00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.56 | 50.0 | 4.01e-01 | 100.0% | 59.3% |
| 3nqwA00 | 1.10.3210.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 | 0.56 | 35.0 | 3.28e-01 | 92.4% | 48.9% |
| 7ep3A01 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.55 | 47.0 | 4.02e-01 | 93.1% | 57.3% |
| 5mj6A04 | 1.25.50.20 | Mainly Alpha › Alpha Horseshoe › Zincin-like fold › | 0.55 | 49.0 | 3.75e-01 | 97.2% | 89.4% |
| 2e9xB02 | 1.20.58.1020 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.54 | 37.0 | 4.17e-01 | 76.6% | 92.7% |
| 2pmvA01 | 1.50.10.20 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.54 | 47.0 | 3.89e-01 | 95.9% | 85.2% |
| 4mo7A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.53 | 38.0 | 3.90e-01 | 86.9% | 76.1% |
| 1orsC00 | 1.20.120.350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C | 0.53 | 35.0 | 3.67e-01 | 77.9% | 72.7% |
| 4g12A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.53 | 40.0 | 4.05e-01 | 80.0% | 99.3% |
| 3ltjA00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.52 | 42.0 | 3.92e-01 | 91.0% | 67.5% |
| 3gi8C00 | 1.20.1740.10 | Mainly Alpha › Up-down Bundle › Amino acid/polyamine transporter I › Amino acid/polyamine transporter I | 0.51 | 42.0 | 3.04e-01 | 88.3% | 94.0% |
| 3aqtA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.51 | 37.0 | 3.39e-01 | 75.9% | 82.6% |
| 3cllA00 | 1.20.1080.10 | Mainly Alpha › Up-down Bundle › Glycerol uptake facilitator protein › Glycerol uptake facilitator protein. | 0.50 | 40.0 | 3.41e-01 | 84.8% | 88.0% |
| 4xvxA01 | 1.10.540.10 | Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain | 0.50 | 32.0 | 3.55e-01 | 91.0% | 82.0% |
ECOD (17)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2095503 | 3146.1.1.1 ↗ | a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H | 0.93 | 83.0 | 5.39e-01 | 95.2% | 25.5% |
| 1554358 | 3146.1.1.1 ↗ | a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H | 0.81 | 76.0 | 4.93e-01 | 100.0% | 37.1% |
| 3416373 | 109.3.1.1 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › Ank | 0.64 | 51.0 | 4.47e-01 | 84.1% | 70.3% |
| 3712076 | 109.4.1.506 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Nop14 | 0.63 | 58.0 | 4.31e-01 | 100.0% | 55.6% |
| 3674906 | 3291.1.1.3 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Ist1 | 0.61 | 33.0 | 3.64e-01 | 88.3% | 61.7% |
| 3465716 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.57 | 50.0 | 4.41e-01 | 97.9% | 67.6% |
| 3592402 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.57 | 50.0 | 4.22e-01 | 97.2% | 90.0% |
| 4026720 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.57 | 47.0 | 3.31e-01 | 100.0% | 27.1% |
| 4104262 | 109.3.1.254 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › TMEM232 | 0.56 | 51.0 | 4.69e-01 | 100.0% | 91.9% |
| 5069603 | 601.18.1.30 ↗ | alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 › Cytochrom_C_asm | 0.55 | 36.0 | 3.84e-01 | 80.0% | 75.2% |
| 3651297 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.55 | 48.0 | 3.84e-01 | 95.9% | 68.3% |
| 3706812 | 603.1.1.17 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE | 0.54 | 47.0 | 3.79e-01 | 95.2% | 78.6% |
| 3972478 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.53 | 37.0 | 4.01e-01 | 84.8% | 87.4% |
| 4972834 | 3883.1.1.1 ↗ | alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf | 0.51 | 41.0 | 3.68e-01 | 86.9% | 78.0% |
| 4263900 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 37.0 | 3.27e-01 | 82.8% | 51.9% |
| 4017588 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.51 | 39.0 | 3.95e-01 | 97.2% | 83.6% |
| 3675831 | 601.7.1.35 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › UFL1_C | 0.50 | 33.0 | 3.40e-01 | 77.9% | 69.6% |
D4
medium
residues 527-663
Domain cluster:
rep: envelope_glycoprotein_H__NP_077452__Cercopithecine_alphaherpesvirus_9__35246__D674-695_717-808
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF17488.8 best | Herpes_glycoH_C | 143.2 | 6.20e-42 | 97.8% | 92.9% |