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glycoprotein_H

Euk-Vir

Bovine_gammaherpesvirus_6

glycoprotein_H__YP_009042001__Bovine_gammaherpesvirus_6__1504288

Identity

Accession:
YP_009042001 ↗
Protein ID:
glycoprotein_H
Kingdom:
euk

Quality

82.8 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Macavirus› Bovine_gammaherpesvirus_6

TaxID: 1504288

Cluster

View cluster (43 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 551-701
PDB
Domain cluster: rep: UL22__YP_003084400__Anatid_alphaherpesvirus_1__104388__D647-783
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF17488.8 best Herpes_glycoH_C 174.3 1.60e-51 94.7% 98.6%
D2 medium residues 100-112_159-267
PDB
Domain cluster: rep: orf22__YP_009044405__Alcelaphine_gammaherpesvirus_2__138184__D149-254
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 81.5 7.80e-23 95.9% 21.4%
CATH (25)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
5w0kA01 3.90.380.20 Alpha Beta › Alpha-Beta Complex › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 › Herpesvirus glycoprotein H, domain D-II 0.94 91.0 6.35e-01 100.0% 50.8%
3n8bA00 3.10.450.700 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.73 36.0 4.67e-01 75.4% 80.0%
1n9eA01 2.70.98.20 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › Copper amine oxidase, catalytic domain 0.66 54.0 3.53e-01 86.1% 82.1%
3pgbA01 2.70.98.20 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › Copper amine oxidase, catalytic domain 0.65 53.0 3.50e-01 86.9% 80.7%
1ksiA03 2.70.98.20 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › Copper amine oxidase, catalytic domain 0.64 50.0 3.47e-01 82.8% 89.4%
1av4A03 2.70.98.20 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › Copper amine oxidase, catalytic domain 0.63 50.0 3.48e-01 84.4% 95.0%
1pu4A03 2.70.98.20 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › Copper amine oxidase, catalytic domain 0.63 49.0 3.44e-01 82.8% 89.2%
3rbyA02 2.40.128.310 Mainly Beta › Beta Barrel › Lipocalin › Protein HRI1, C-terminal domain 0.63 35.0 3.87e-01 73.8% 67.4%
1a2vA03 2.70.98.20 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › Copper amine oxidase, catalytic domain 0.62 51.0 3.45e-01 86.9% 94.1%
6f91A01 2.70.98.10 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › 0.62 52.0 3.96e-01 89.3% 78.1%
3w7tA01 2.70.98.50 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › putative glycoside hydrolase family protein from bacillus halodurans 0.60 47.0 3.79e-01 82.8% 78.9%
4bj8K00 2.40.128.30 Mainly Beta › Beta Barrel › Lipocalin › Avidin-like 0.59 44.0 4.46e-01 77.0% 92.5%
1omoA01 3.30.1780.10 Alpha Beta › 2-Layer Sandwich › ornithine cyclodeaminase, domain 1 › ornithine cyclodeaminase, domain 1 0.58 44.0 4.12e-01 79.5% 99.3%
5gv0A00 2.40.160.110 Mainly Beta › Beta Barrel › Porin › 0.57 46.0 4.14e-01 83.6% 78.4%
2kd2A01 2.40.128.180 Mainly Beta › Beta Barrel › Lipocalin › 0.57 37.0 4.39e-01 74.6% 96.4%
4akmB00 2.40.160.110 Mainly Beta › Beta Barrel › Porin › 0.57 45.0 4.10e-01 82.8% 66.9%
5evhA00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.55 39.0 3.99e-01 73.0% 86.0%
2h36X00 3.30.160.300 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.55 31.0 3.36e-01 93.4% 63.9%
2vf9A00 3.30.380.10 Alpha Beta › 2-Layer Sandwich › MS2 Viral Coat Protein › MS2 Viral Coat Protein 0.54 37.0 3.69e-01 82.0% 66.4%
2it9A00 2.30.31.10 Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Transcriptional Coactivator Pc4; Chain A 0.54 36.0 3.65e-01 93.4% 68.3%
2nvnA00 2.30.31.10 Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Transcriptional Coactivator Pc4; Chain A 0.53 34.0 3.52e-01 93.4% 67.5%
3h2gA01 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.52 38.0 2.96e-01 77.0% 96.4%
4qqsB00 2.115.10.20 Mainly Beta › 5 Propeller › Tachylectin-2; Chain A › Glycosyl hydrolase domain; family 43 0.50 36.0 2.72e-01 74.6% 45.7%
5c0pA00 2.115.10.20 Mainly Beta › 5 Propeller › Tachylectin-2; Chain A › Glycosyl hydrolase domain; family 43 0.50 35.0 2.76e-01 72.1% 70.8%
3fh1A00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.50 36.0 3.61e-01 73.8% 82.0%
ECOD (29)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
2095478 3146.1.1.1 ↗ a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H 0.94 91.0 5.71e-01 100.0% 32.4%
2095503 3146.1.1.1 ↗ a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H 0.83 79.0 4.98e-01 100.0% 39.8%
2701125 3146.1.1.1 ↗ a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H 0.82 78.0 5.00e-01 100.0% 40.0%
5081796 633.23.1.0 ↗ alpha bundles › Bromodomain-like › Claudin › Claudin 0.75 33.0 2.87e-01 74.6% 30.6%
4964031 7089.1.1.7 ↗ a+b two layers › Methane monooxygenase hydroxylase, MmoD › Methane monooxygenase hydroxylase, MmoD › Methane monooxygenase hydroxylase, MmoD › DUF7543 0.67 34.0 4.50e-01 72.1% 87.1%
3265841 216.1.1.20 ↗ a+b two layers › UBC-like › UBC-like › UBC-like › UBC_like 0.65 37.0 4.07e-01 80.3% 68.0%
5015778 12.3.1.0 ↗ beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich 0.65 54.0 4.19e-01 88.5% 85.7%
3632840 12.3.1.2 ↗ beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Cu_amine_oxid 0.65 51.0 3.61e-01 82.8% 89.3%
3786031 12.3.1.2 ↗ beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Cu_amine_oxid 0.64 50.0 3.38e-01 82.8% 81.3%
3875849 12.3.1.2 ↗ beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Cu_amine_oxid 0.63 49.0 3.50e-01 82.8% 87.2%
4018118 12.3.1.40 ↗ beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › TREH_N 0.63 52.0 4.04e-01 89.3% 96.7%
4084359 12.3.1.2 ↗ beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Cu_amine_oxid 0.62 50.0 3.41e-01 86.1% 86.9%
2717534 12.3.1.31 ↗ beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › YgjK_N 0.62 52.0 3.96e-01 89.3% 75.7%
4113988 12.3.1.2 ↗ beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Cu_amine_oxid 0.62 50.0 3.44e-01 86.9% 94.4%
3538089 12.3.1.0 ↗ beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich 0.60 48.0 3.85e-01 83.6% 72.3%
3250134 9.1.1.0 ↗ beta barrels › Lipocalins/Streptavidin › Lipocalins › Lipocalins 0.59 44.0 4.47e-01 93.4% 77.5%
3894207 3369.1.1.1 ↗ beta meanders › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › Lamp2-like_luminal 0.58 46.0 4.25e-01 82.8% 79.9%
5039993 12.3.1.40 ↗ beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › TREH_N 0.58 47.0 4.03e-01 88.5% 86.3%
3274430 12.3.1.40 ↗ beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › TREH_N 0.58 47.0 3.98e-01 88.5% 93.8%
3326913 12.3.1.2 ↗ beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Cu_amine_oxid 0.57 45.0 3.53e-01 82.8% 90.0%
185647 3369.1.1.1 ↗ beta meanders › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › Lamp2-like_luminal 0.57 45.0 4.13e-01 82.8% 67.7%
4961667 5084.1.1.45 ↗ beta barrels › Outer membrane meander beta-barrels › OMPA-like › OMPA-like › PF26421 0.55 39.0 4.00e-01 82.8% 76.5%
3368132 4099.1.1.4 ↗ a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like › CENP-O 0.54 38.0 3.87e-01 76.2% 72.5%
3225806 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.54 39.0 3.98e-01 82.0% 75.8%
3328470 4099.1.1.0 ↗ a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like 0.53 38.0 3.74e-01 76.2% 69.2%
4248683 9.1.1.14 ↗ beta barrels › Lipocalins/Streptavidin › Lipocalins › Lipocalins › CpeS 0.51 45.0 3.88e-01 93.4% 80.5%
4310253 9.1.1.14 ↗ beta barrels › Lipocalins/Streptavidin › Lipocalins › Lipocalins › CpeS 0.51 45.0 4.02e-01 93.4% 87.3%
4136961 9.1.1.14 ↗ beta barrels › Lipocalins/Streptavidin › Lipocalins › Lipocalins › CpeS 0.50 44.0 3.87e-01 93.4% 85.1%
4353273 331.9.1.10 ↗ a+b two layers › TBP-like › Subdomain of clathrin and coatomer appendage domain › Subdomain of clathrin and coatomer appendage domain › PF28631 0.50 40.0 3.72e-01 83.6% 88.0%
D3 medium residues 113-158_322-440
PDB
Domain cluster: rep: gH__YP_010087392__Vombatid_gammaherpesvirus_1__2052651__D82-121_163-275
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 65.2 6.60e-18 72.7% 23.8%
D4 medium residues 268-321
PDB
Domain cluster: representative
CATH (17)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4a17U01 1.10.287.310 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.68 60.0 5.29e-01 96.3% 75.3%
2fu2A00 1.20.1440.50 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Ta0600-like 0.68 57.0 5.05e-01 94.4% 94.9%
3fxdC00 1.20.5.420 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C 0.66 48.0 4.95e-01 77.8% 94.0%
2i0mA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.65 53.0 4.25e-01 90.7% 69.8%
1tfeA02 1.10.286.20 Mainly Alpha › Orthogonal Bundle › GTP Cyclohydrolase I; Chain A, domain 1 › 0.63 43.0 4.69e-01 72.2% 86.7%
3v48A00 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.61 41.0 2.61e-01 70.4% 56.7%
2l09A01 1.10.8.550 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Proto-chlorophyllide reductase 57 kD subunit B 0.61 42.0 4.27e-01 88.9% 75.0%
4i9oA00 1.10.246.20 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › Coactivator CBP, KIX domain 0.60 44.0 3.97e-01 81.5% 64.1%
2ffjA01 1.10.8.380 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Uncharacterised protein PF01937, DUF89, domain 1 0.58 40.0 4.01e-01 74.1% 71.4%
3uebF00 3.30.300.100 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › MTH677-like 0.58 47.0 3.85e-01 100.0% 49.0%
2wyhB04 1.20.1270.50 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Glycoside hydrolase family 38, central domain 0.55 40.0 3.36e-01 79.6% 42.6%
1gpeA03 3.30.560.10 Alpha Beta › 2-Layer Sandwich › Glucose Oxidase; domain 3 › Glucose Oxidase, domain 3 0.55 44.0 2.82e-01 92.6% 38.7%
4kxfB02 1.10.1900.50 Mainly Alpha › Orthogonal Bundle › c-terminal domain of poly(a) binding protein › 0.54 37.0 3.68e-01 81.5% 66.7%
2jnsA01 1.20.1270.220 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.54 42.0 3.73e-01 88.9% 65.4%
3cx5A02 3.30.830.10 Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like 0.53 46.0 3.08e-01 100.0% 64.1%
3p7nA02 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.51 43.0 3.95e-01 94.4% 100.0%
4eziA02 1.10.260.160 Mainly Alpha › Orthogonal Bundle › 434 Repressor (Amino-terminal Domain) › 0.50 40.0 3.41e-01 90.7% 73.1%
ECOD (21)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3171363 605.8.1.2 ↗ alpha duplicates or obligate multimers › ROP-like › BAS1536-like › BAS1536-like › PF27894 0.71 51.0 5.08e-01 75.9% 87.3%
3929572 6155.1.1.2 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop 0.71 62.0 5.34e-01 100.0% 81.2%
4567993 632.21.1.2 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Helical bundle domain in endo-beta-N-acetylglucosaminidase F2 › Helical bundle domain in endo-beta-N-acetylglucosaminidase F2 › FIVAR 0.68 47.0 4.44e-01 75.9% 60.0%
4027645 192.4.1.0 ↗ alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) 0.68 60.0 5.39e-01 98.1% 78.7%
5018187 192.4.1.0 ↗ alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) 0.68 56.0 5.34e-01 98.1% 87.7%
3876213 1045.1.1.0 ↗ alpha bundles › Rad50-binding domain of Mre11 › Rad50-binding domain of Mre11 › Rad50-binding domain of Mre11 0.66 45.0 3.54e-01 70.4% 35.5%
3618523 604.6.1.0 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.66 55.0 4.70e-01 94.4% 73.3%
5081076 5059.1.1.1 ↗ alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA 0.63 46.0 2.89e-01 77.8% 83.0%
3897328 2003.1.5.111 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Rsm22 0.63 43.0 2.63e-01 74.1% 11.1%
3476112 109.23.1.5 ↗ alpha superhelices › Repetitive alpha hairpins › C-terminal domain in vacuolar protein sorting-associated protein 54 › C-terminal domain in vacuolar protein sorting-associated protein 54 › EMC6 0.62 46.0 3.88e-01 79.6% 75.6%
3676691 650.1.1.1 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.62 51.0 4.36e-01 94.4% 68.9%
4796680 148.1.3.206 ↗ alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › PF31015 0.62 45.0 4.51e-01 81.5% 76.8%
3271063 650.1.1.1 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.61 52.0 4.50e-01 100.0% 67.8%
4259997 192.15.1.133 ↗ alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › NST1 0.60 43.0 3.40e-01 75.9% 38.2%
4420136 650.1.1.1 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.59 50.0 4.63e-01 98.1% 92.9%
3995749 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.59 50.0 3.06e-01 100.0% 26.0%
3236773 174.1.1.0 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.59 48.0 3.77e-01 100.0% 82.2%
4652715 3831.1.1.0 ↗ alpha bundles › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 0.58 47.0 3.81e-01 88.9% 87.6%
3915663 632.22.1.9 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › Ciart 0.57 43.0 3.86e-01 81.5% 69.2%
224014 6080.1.1.0 ↗ 0.55 41.0 3.46e-01 83.3% 96.0%
2766590 101.11.1.1 ↗ alpha arrays › HTH › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 › PNPase 0.53 47.0 3.85e-01 100.0% 63.3%
D5 medium residues 441-548
PDB
Domain cluster: rep: envelope_glycoprotein_H__YP_009388523__Common_bottlenose_dolphin_gammaherpesvirus_1_strain_Sarasota__2022783__D447-588
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02489.22 best Herpes_glycop_H 100.7 1.20e-28 100.0% 20.6%