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glycoprotein_UL75

Euk-Vir

Cynomolgus_macaque_cytomegalovirus_strain_Ottawa

glycoprotein_UL75__YP_004933840__Cynomolgus_macaque_cytomegalovirus_strain_Ottawa__944969

Identity

Accession:: YP_004933840 ↗
Protein ID:: glycoprotein_UL75
Kingdom:: euk

Quality

80.7 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Cytomegalovirus› Cynomolgus_macaque_cytomegalovirus_strain_Ottawa

TaxID: 944969

Cluster

View cluster (43 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 37-115

PDB

D2 medium residues 118-135_152-269

PDB

Domain cluster: rep: orf22__YP_009044405__Alcelaphine_gammaherpesvirus_2__138184__D149-254

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02489.22 best	Herpes_glycop_H	47.1	2.00e-12	98.5%	18.8%

D3 medium residues 270-361

PDB

Domain cluster: rep: envelope_glycoprotein_H__YP_081523__Human_betaherpesvirus_5__10359__D285-357

D4 medium residues 362-449

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02489.22 best	Herpes_glycop_H	22.2	7.40e-05	87.5%	14.2%

CATH (15)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4cruB00	1.25.10.10	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant	0.71	56.0	3.94e-01	85.2%	29.6%
3zilA00	1.25.10.60	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Rad61, Wapl domain	0.68	56.0	3.70e-01	89.8%	24.3%
7zcvA02	1.25.40.400	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.64	49.0	3.69e-01	90.9%	34.3%
1i5pA02	1.20.190.10	Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain	0.63	52.0	3.89e-01	92.0%	82.1%
2w00A05	1.20.58.2040	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.59	47.0	4.53e-01	87.5%	99.0%
2pqrA01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.57	44.0	4.35e-01	98.9%	79.6%
2lhrA00	1.20.58.1270	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.56	39.0	4.05e-01	73.9%	82.1%
3mzkB03	1.20.58.940	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.52	34.0	3.72e-01	94.3%	84.3%
4a64A01	1.20.1310.10	Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats	0.52	38.0	3.36e-01	77.3%	89.4%
2qtqB00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.52	41.0	3.29e-01	90.9%	75.6%
2ggfA00	1.25.40.180	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.51	41.0	3.61e-01	88.6%	65.7%
1paqA00	1.25.40.180	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.51	39.0	3.22e-01	83.0%	58.4%
8hixR01	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.50	41.0	3.01e-01	94.3%	78.3%
4ksaA02	1.20.140.90	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Malonyl-CoA decarboxylase, oligemerization domain	0.50	40.0	3.52e-01	88.6%	81.0%
7r0kB01	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.50	43.0	3.21e-01	100.0%	85.3%

ECOD (16)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2095503	3146.1.1.1 ↗	a+b complex topology › gH main domain › gH main domain › gH main domain › Herpes_glycop_H	0.96	92.0	5.45e-01	100.0%	16.9%
4548949	109.4.1.228 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Exo84_C	0.65	50.0	3.58e-01	81.8%	36.9%
3240123	109.4.1.17 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Cullin	0.62	49.0	3.25e-01	85.2%	40.5%
3742992	109.4.1.228 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Exo84_C	0.62	46.0	3.53e-01	80.7%	40.2%
4547644	109.4.1.228 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Exo84_C	0.62	48.0	3.67e-01	85.2%	41.9%
3520887	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.61	44.0	3.53e-01	75.0%	71.7%
3311468	109.4.1.883 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR+PPR_2	0.60	46.0	3.69e-01	90.9%	41.8%
3258417	109.4.1.192 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8	0.59	46.0	3.93e-01	89.8%	50.7%
4590812	109.4.1.434 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › FAST_1	0.59	51.0	3.31e-01	98.9%	21.4%
3510170	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.58	47.0	3.25e-01	88.6%	25.7%
3262901	109.4.1.228 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Exo84_C	0.58	42.0	2.65e-01	77.3%	17.9%
3935704	5001.1.1.1 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1	0.56	47.0	3.10e-01	93.2%	88.4%
4858192	4967.1.1.32 ↗	alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › Bunya_RdRp	0.55	42.0	3.68e-01	80.7%	67.2%
3436107	109.4.1.228 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Exo84_C	0.55	38.0	2.89e-01	72.7%	41.3%
4993188	1075.1.2.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain › FtsX	0.53	36.0	2.89e-01	71.6%	88.7%
3786307	109.4.1.228 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Exo84_C	0.51	43.0	2.99e-01	93.2%	34.0%

D5 medium residues 450-540

PDB

Domain cluster: rep: UL75__YP_009137470__Papio_ursinus_cytomegalovirus__1667587__D473-538

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02489.22 best	Herpes_glycop_H	67.4	1.50e-18	97.8%	18.4%

D6 medium residues 541-617_635-685

PDB

Domain cluster: rep: UL22__YP_003084400__Anatid_alphaherpesvirus_1__104388__D647-783

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF17488.8 best	Herpes_glycoH_C	42.8	6.10e-11	56.2%	48.2%
PF17488.8	Herpes_glycoH_C	38.9	9.50e-10	44.5%	38.3%

CATH (5)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
7b7nH01	2.60.40.3190	Mainly Beta › Sandwich › Immunoglobulin-like › Herpesvirus glycoprotein H, C-terminal domain	0.82	70.0	7.09e-01	88.3%	100.0%
3m1cA04	2.60.40.3190	Mainly Beta › Sandwich › Immunoglobulin-like › Herpesvirus glycoprotein H, C-terminal domain	0.80	69.0	6.81e-01	89.1%	95.5%
2xqyA03	2.60.40.3190	Mainly Beta › Sandwich › Immunoglobulin-like › Herpesvirus glycoprotein H, C-terminal domain	0.76	70.0	6.96e-01	97.7%	100.0%
6brbD00	2.60.40.10	Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins	0.54	26.0	3.13e-01	84.4%	67.8%
3pg4A00	3.60.15.10	Alpha Beta › 4-Layer Sandwich › Metallo-beta-lactamase; Chain A › Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	0.51	36.0	3.01e-01	72.7%	90.9%

ECOD (14)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2095502	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.95	90.0	8.52e-01	96.9%	96.6%
1936537	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.83	79.0	7.44e-01	100.0%	98.0%
119479	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.77	71.0	6.70e-01	96.1%	95.9%
1309233	3145.1.1.1 ↗	beta sandwiches › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › C-terminal domain of envelope glycoprotein H › Herpes_glycoH_C	0.76	72.0	6.81e-01	100.0%	91.9%
4951904	211.1.1.1 ↗	a+b two layers › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase	0.58	22.0	3.03e-01	92.2%	66.2%
3897583	11.1.1.2 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3	0.56	26.0	3.10e-01	84.4%	62.2%
3891518	11.1.1.0 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like	0.55	26.0	3.04e-01	84.4%	61.1%
3878602	11.1.1.2 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3	0.55	27.0	3.01e-01	84.4%	58.6%
3910739	11.1.1.2 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3	0.54	26.0	3.04e-01	84.4%	63.3%
3777592	11.1.1.2 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3	0.54	26.0	3.07e-01	84.4%	64.4%
3528265	11.1.1.2 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3	0.53	26.0	3.07e-01	83.6%	67.1%
3893505	11.1.1.2 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3	0.52	25.0	2.92e-01	84.4%	62.2%
3571185	11.1.1.2 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3	0.51	25.0	2.85e-01	84.4%	60.0%
3891718	11.1.1.2 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3	0.50	25.0	3.00e-01	83.6%	69.4%

D7 medium residues 618-634_686-720

PDB

Domain cluster: representative

ECOD (8)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3490165	109.4.1.3619 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ARM_TT21_C	0.80	52.0	3.23e-01	100.0%	13.8%
4287641	5000.4.1.1 ↗	alpha arrays › Toxins' membrane translocation domains › delta-Endotoxin (insectocide), N-terminal domain › delta-Endotoxin (insectocide), N-terminal domain › Endotoxin_N	0.69	56.0	3.40e-01	100.0%	15.8%
3252927	3866.1.1.0 ↗	extended segments › Mitochondrial 54S ribosomal protein L25 › Mitochondrial 54S ribosomal protein L25 › Mitochondrial 54S ribosomal protein L25	0.63	41.0	3.41e-01	94.2%	36.0%
4645961	102.2.1.3 ↗	alpha arrays › HhH/H2TH › H2TH › H2TH › NFACT_N	0.61	54.0	3.67e-01	100.0%	45.3%
3489266	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.60	53.0	3.45e-01	100.0%	82.6%
869286	5069.1.3.4 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › CybS	0.59	46.0	3.45e-01	86.5%	86.8%
4352176	5050.1.1.1 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr	0.57	53.0	3.25e-01	100.0%	66.3%
3351959	207.1.1.102 ↗	beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › LRR_1+LRR_8+LRR_14	0.56	49.0	2.69e-01	100.0%	6.6%