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helicase-primase_complex
Euk-VirAlcelaphine_gammaherpesvirus_1
helicase-primase_complex__NP_065538__Alcelaphine_gammaherpesvirus_1__35252
Identity
- Accession:
- NP_065538 ↗
- Protein ID:
- helicase-primase_complex
- Kingdom:
- euk
Quality
78.9
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Macavirus›
Alcelaphine_gammaherpesvirus_1
TaxID: 35252
Cluster
View cluster (61 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 347-455
Domain cluster:
rep: ORF31__NP_733884__Callitrichine_gammaherpesvirus_3__106331__D382-518
CATH (16)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1azsA00 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.78 | 46.0 | 3.75e-01 | 78.9% | 34.2% |
| 6yiiA02 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.77 | 47.0 | 3.72e-01 | 71.6% | 32.1% |
| 2py5A02 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.68 | 46.0 | 3.84e-01 | 89.9% | 41.3% |
| 4wp3C00 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.66 | 47.0 | 3.89e-01 | 88.1% | 43.3% |
| 4dmvA01 | 1.20.58.1190 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 37.0 | 4.14e-01 | 80.7% | 78.8% |
| 4aimA03 | 3.30.1370.10 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › K Homology domain, type 1 | 0.60 | 29.0 | 3.49e-01 | 70.6% | 69.0% |
| 2kzcA00 | 1.10.790.20 | Mainly Alpha › Orthogonal Bundle › Major Prion Protein › Domain of unknown function DUF1476 | 0.56 | 27.0 | 3.08e-01 | 89.9% | 58.8% |
| 1d5aA03 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.55 | 47.0 | 4.03e-01 | 89.9% | 67.1% |
| 1s5jA03 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.54 | 46.0 | 4.04e-01 | 91.7% | 68.2% |
| 2w01B00 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.53 | 41.0 | 3.41e-01 | 82.6% | 49.2% |
| 1hxdA02 | 3.30.930.10 | Alpha Beta › 2-Layer Sandwich › BirA Bifunctional Protein; domain 2 › Bira Bifunctional Protein; Domain 2 | 0.53 | 42.0 | 3.50e-01 | 85.3% | 88.8% |
| 6i9gA01 | 3.30.2400.30 | Alpha Beta › 2-Layer Sandwich › Major capsid protein gp5 fold › | 0.53 | 44.0 | 3.84e-01 | 90.8% | 87.0% |
| 3r5gA00 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.53 | 40.0 | 3.37e-01 | 81.7% | 51.8% |
| 1hyrC01 | 3.30.500.10 | Alpha Beta › 2-Layer Sandwich › Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 › MHC class I-like antigen recognition-like | 0.52 | 40.0 | 3.39e-01 | 80.7% | 96.7% |
| 7uinD01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.52 | 45.0 | 3.93e-01 | 95.4% | 67.7% |
| 1q8iA04 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.51 | 40.0 | 3.24e-01 | 83.5% | 46.4% |
ECOD (36)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3738415 | 304.7.1.0 ↗ | a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors | 0.69 | 31.0 | 3.52e-01 | 70.6% | 54.1% |
| 5044377 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.67 | 57.0 | 4.35e-01 | 91.7% | 67.8% |
| 5041308 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.67 | 57.0 | 4.21e-01 | 91.7% | 61.1% |
| 5073476 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.67 | 55.0 | 4.31e-01 | 89.9% | 64.7% |
| 4944833 | 304.48.1.31 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Cas10-Cmr2_palm2 | 0.66 | 41.0 | 3.43e-01 | 81.7% | 37.8% |
| 4956224 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.66 | 55.0 | 4.29e-01 | 90.8% | 71.1% |
| 5025209 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.66 | 56.0 | 4.29e-01 | 90.8% | 68.5% |
| 4461958 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.65 | 55.0 | 4.27e-01 | 91.7% | 61.3% |
| 4958554 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.65 | 55.0 | 4.26e-01 | 90.8% | 71.9% |
| 4932480 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.65 | 55.0 | 4.35e-01 | 90.8% | 71.8% |
| 3968795 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.65 | 54.0 | 4.04e-01 | 89.9% | 57.0% |
| 3993981 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.65 | 55.0 | 4.29e-01 | 90.8% | 71.1% |
| 4978605 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.65 | 54.0 | 4.00e-01 | 90.8% | 58.2% |
| 4674811 | 304.48.1.17 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_2 | 0.65 | 55.0 | 3.90e-01 | 91.7% | 59.1% |
| 4942685 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.65 | 55.0 | 3.53e-01 | 90.8% | 34.0% |
| 4977369 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.65 | 54.0 | 4.13e-01 | 90.8% | 67.2% |
| 4959101 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.64 | 55.0 | 4.18e-01 | 91.7% | 68.6% |
| 5017083 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.64 | 54.0 | 4.02e-01 | 90.8% | 63.0% |
| 4983223 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.64 | 54.0 | 4.13e-01 | 91.7% | 67.2% |
| 4981193 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.63 | 53.0 | 4.02e-01 | 90.8% | 63.1% |
| 5012084 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.63 | 53.0 | 4.17e-01 | 91.7% | 72.0% |
| 3831499 | 304.48.1.63 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B, DUF1744 | 0.62 | 52.0 | 3.18e-01 | 92.7% | 42.8% |
| 3924217 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.61 | 50.0 | 3.82e-01 | 89.9% | 64.6% |
| 4928319 | 304.48.1.4 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Guanylate_cyc | 0.60 | 48.0 | 3.68e-01 | 100.0% | 38.0% |
| 4144335 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.60 | 50.0 | 3.77e-01 | 90.8% | 64.2% |
| 3266689 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.59 | 49.0 | 3.73e-01 | 89.9% | 64.6% |
| 3474156 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.59 | 49.0 | 3.70e-01 | 91.7% | 60.7% |
| 4022145 | 2484.1.1.153 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DUF1744 | 0.59 | 49.0 | 3.07e-01 | 91.7% | 24.8% |
| 4264107 | 304.48.1.17 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_2 | 0.58 | 50.0 | 3.57e-01 | 91.7% | 56.7% |
| 3877126 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.58 | 48.0 | 2.98e-01 | 91.7% | 24.9% |
| 4629010 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.58 | 48.0 | 3.83e-01 | 90.8% | 60.9% |
| 4939489 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.56 | 48.0 | 3.88e-01 | 90.8% | 53.8% |
| 3381141 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.53 | 45.0 | 3.84e-01 | 90.8% | 62.4% |
| 2833283 | 301.2.1.1 ↗ | a+b three layers › Bacillus chorismate mutase-like › PurM N-terminal domain-like › PurM N-terminal domain-like › AIRS | 0.53 | 44.0 | 3.94e-01 | 90.8% | 85.7% |
| 3210590 | 304.160.1.3 ↗ | a+b two layers › Alpha-beta plaits › Gas vesicle protein GvpF › Gas vesicle protein GvpF › PF28298 | 0.52 | 36.0 | 3.38e-01 | 71.6% | 66.7% |
| 3984781 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.51 | 44.0 | 3.85e-01 | 93.6% | 73.1% |
D2
medium
residues 12-45_62-148
D3
medium
residues 149-192_207-335
Domain cluster:
rep: ORF31__NP_733884__Callitrichine_gammaherpesvirus_3__106331__D132-145_190-351
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03324.21 best | Herpes_HEPA | 76.4 | 2.50e-21 | 50.9% | 100.0% |
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4fvmA03 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.56 | 46.0 | 4.15e-01 | 86.7% | 99.6% |
| 4qclA03 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.53 | 48.0 | 4.14e-01 | 98.8% | 99.3% |
| 2py5A01 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.52 | 43.0 | 4.28e-01 | 87.9% | 100.0% |
| 1d5aA02 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.52 | 47.0 | 4.39e-01 | 99.4% | 98.6% |
| 2a6aB01 | 3.30.420.40 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain | 0.52 | 35.0 | 4.08e-01 | 90.2% | 99.2% |
ECOD (19)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3683968 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.60 | 37.0 | 3.86e-01 | 85.0% | 64.8% |
| 3683241 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.59 | 53.0 | 4.32e-01 | 96.5% | 92.5% |
| 3466667 | 2484.1.1.161 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.58 | 53.0 | 3.56e-01 | 98.3% | 63.2% |
| 3167764 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.56 | 50.0 | 4.14e-01 | 97.1% | 94.1% |
| 3619214 | 295.1.1.0 ↗ | a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain | 0.55 | 20.0 | 3.35e-01 | 76.3% | 100.0% |
| 4953602 | 205.1.1.16 ↗ | a+b two layers › 4Fe-4S ferredoxin › 4Fe-4S ferredoxin › 4Fe-4S ferredoxin › Fer4_7 | 0.54 | 21.0 | 3.29e-01 | 72.3% | 85.7% |
| 3492151 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.54 | 48.0 | 3.89e-01 | 97.7% | 92.1% |
| 3193111 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.53 | 49.0 | 3.78e-01 | 100.0% | 69.7% |
| 3597964 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.53 | 47.0 | 3.93e-01 | 96.5% | 94.8% |
| 1790898 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.53 | 48.0 | 4.16e-01 | 98.8% | 98.2% |
| 3692564 | 2.1.1.25 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1 | 0.53 | 49.0 | 3.70e-01 | 100.0% | 65.1% |
| 4874454 | 2.1.1.25 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1 | 0.53 | 48.0 | 4.15e-01 | 97.7% | 99.6% |
| 3702504 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.53 | 47.0 | 3.96e-01 | 96.5% | 98.0% |
| 4378664 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.52 | 43.0 | 3.74e-01 | 87.3% | 88.8% |
| 3506686 | 2484.1.1.36 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_2 | 0.52 | 46.0 | 4.26e-01 | 97.1% | 100.0% |
| 4973288 | 1.1.3.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › AbrB | 0.51 | 19.0 | 3.08e-01 | 76.3% | 100.0% |
| 4973203 | 1.1.3.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › AbrB | 0.50 | 18.0 | 2.87e-01 | 71.7% | 96.0% |
| 5025208 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.50 | 46.0 | 4.18e-01 | 100.0% | 92.2% |
| 5018575 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.50 | 29.0 | 3.44e-01 | 87.3% | 83.5% |