←Back to structures
helicase-primase_helicase_subunit
Euk-VirHuman_alphaherpesvirus_3
helicase-primase_helicase_subunit__NP_040177__Human_alphaherpesvirus_3__10335
Identity
- Accession:
- NP_040177 ↗
- Protein ID:
- helicase-primase_helicase_subunit
- Kingdom:
- euk
Quality
80.5
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Varicellovirus›
Human_alphaherpesvirus_3
TaxID: 10335
Cluster
View cluster (90 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 35-334
Domain cluster:
rep: ORF35__NP_733888__Callitrichine_gammaherpesvirus_3__106331__D45-78_114-298
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 413.6 | 2.20e-123 | 100.0% | 34.4% |
CATH (36)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 6jimB01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.83 | 36.0 | 5.38e-01 | 83.3% | 88.8% |
| 5fhgA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.79 | 46.0 | 5.75e-01 | 99.7% | 89.1% |
| 5o6bB01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.79 | 46.0 | 6.11e-01 | 99.7% | 100.0% |
| 3vkwA02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.78 | 38.0 | 5.62e-01 | 85.3% | 100.0% |
| 8bnsD01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.77 | 45.0 | 5.79e-01 | 99.7% | 94.6% |
| 6s3eB01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.77 | 46.0 | 5.73e-01 | 99.3% | 91.7% |
| 8jx6B01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.72 | 47.0 | 5.72e-01 | 100.0% | 97.0% |
| 7r7jA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.68 | 41.0 | 5.14e-01 | 100.0% | 95.2% |
| 1pjrA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.67 | 44.0 | 5.31e-01 | 100.0% | 97.0% |
| 7clgB02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.67 | 35.0 | 4.84e-01 | 99.0% | 98.1% |
| 1a1vA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.66 | 31.0 | 4.66e-01 | 83.0% | 100.0% |
| 1l8qA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.65 | 34.0 | 4.57e-01 | 100.0% | 92.1% |
| 1gkuB03 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.64 | 35.0 | 4.43e-01 | 89.0% | 86.1% |
| 8kcaB01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.64 | 35.0 | 4.55e-01 | 83.0% | 91.8% |
| 7swlB01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.62 | 35.0 | 4.66e-01 | 99.7% | 98.2% |
| 5e7pA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.62 | 34.0 | 4.41e-01 | 99.7% | 91.3% |
| 3dmnA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.62 | 34.0 | 4.65e-01 | 91.3% | 100.0% |
| 7wd3A01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.62 | 35.0 | 4.67e-01 | 99.7% | 100.0% |
| 2l82A00 | 3.40.50.11230 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.60 | 30.0 | 3.99e-01 | 94.3% | 85.8% |
| 5agaA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.60 | 38.0 | 4.57e-01 | 99.7% | 93.6% |
| 7nadx02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.59 | 33.0 | 3.76e-01 | 84.0% | 68.8% |
| 3a8tA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.58 | 28.0 | 3.53e-01 | 94.0% | 73.0% |
| 6mfvC01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.58 | 30.0 | 4.15e-01 | 98.7% | 97.3% |
| 1g41A01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.58 | 36.0 | 4.37e-01 | 100.0% | 93.8% |
| 3hl0A01 | 3.40.50.1970 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.57 | 29.0 | 3.89e-01 | 83.3% | 89.9% |
| 5dcaA09 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.57 | 39.0 | 4.62e-01 | 100.0% | 98.1% |
| 4c6sA00 | 3.40.50.10140 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Toll/interleukin-1 receptor homology (TIR) domain | 0.56 | 26.0 | 3.57e-01 | 76.0% | 85.2% |
| 1pjrA03 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.55 | 36.0 | 4.41e-01 | 94.3% | 97.5% |
| 5ybwA02 | 3.40.50.1100 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.54 | 21.0 | 3.42e-01 | 99.7% | 100.0% |
| 4xqkB01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.54 | 39.0 | 4.52e-01 | 100.0% | 98.2% |
| 2x7jA01 | 3.40.50.970 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains | 0.53 | 23.0 | 2.76e-01 | 94.7% | 55.9% |
| 4b3fX01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.53 | 41.0 | 4.05e-01 | 100.0% | 74.2% |
| 6eudA02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.52 | 30.0 | 3.98e-01 | 71.3% | 100.0% |
| 6bogA05 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.52 | 36.0 | 4.27e-01 | 90.0% | 100.0% |
| 7pt4A01 | 3.40.50.970 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains | 0.52 | 29.0 | 3.57e-01 | 99.0% | 83.0% |
| 5ailA00 | 3.40.220.10 | Alpha Beta › 3-Layer(aba) Sandwich › Leucine Aminopeptidase, subunit E; domain 1 › Leucine Aminopeptidase, subunit E, domain 1 | 0.52 | 31.0 | 3.85e-01 | 92.7% | 95.6% |
ECOD (59)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4202661 | 2004.1.1.135 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 | 0.79 | 46.0 | 5.95e-01 | 100.0% | 95.6% |
| 4164708 | 2004.1.1.135 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 | 0.79 | 46.0 | 5.53e-01 | 99.7% | 82.4% |
| 3272957 | 2004.1.1.135 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 | 0.79 | 45.0 | 5.27e-01 | 100.0% | 76.0% |
| 3387945 | 2004.1.1.135 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 | 0.79 | 46.0 | 6.05e-01 | 99.3% | 98.9% |
| 3498029 | 2004.1.1.135 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 | 0.79 | 50.0 | 6.06e-01 | 99.7% | 94.0% |
| 3718866 | 2004.1.1.135 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 | 0.79 | 47.0 | 5.51e-01 | 100.0% | 80.9% |
| None | — | 0.78 | 47.0 | 6.03e-01 | 100.0% | 96.8% | |
| 3594078 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.78 | 47.0 | 5.79e-01 | 100.0% | 90.0% |
| 3332236 | 2004.1.1.135 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 | 0.77 | 48.0 | 4.74e-01 | 100.0% | 58.7% |
| 3930015 | 2004.1.1.135 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 | 0.77 | 47.0 | 5.30e-01 | 100.0% | 77.0% |
| 3592526 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.77 | 47.0 | 5.37e-01 | 100.0% | 80.0% |
| 3939461 | 2004.1.1.135 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 | 0.76 | 50.0 | 5.72e-01 | 100.0% | 86.7% |
| None | — | 0.76 | 46.0 | 5.45e-01 | 100.0% | 84.2% | |
| 3703483 | 2004.1.1.135 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 | 0.75 | 46.0 | 5.24e-01 | 99.7% | 78.7% |
| 3601026 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.74 | 45.0 | 5.74e-01 | 100.0% | 98.4% |
| 3605124 | 2004.1.1.135 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 | 0.73 | 44.0 | 5.42e-01 | 100.0% | 90.0% |
| 3366827 | 2004.1.1.135 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 | 0.73 | 41.0 | 4.84e-01 | 100.0% | 75.9% |
| None | — | 0.72 | 47.0 | 5.65e-01 | 100.0% | 94.1% | |
| 5061061 | 2004.1.1.66 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase_2 | 0.65 | 34.0 | 4.10e-01 | 100.0% | 71.9% |
| 3839112 | 2004.1.1.364 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD+Helicase_C | 0.65 | 40.0 | 3.34e-01 | 100.0% | 38.1% |
| 4255084 | 2004.1.1.35 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Bac_DnaA | 0.64 | 35.0 | 4.66e-01 | 100.0% | 96.4% |
| 4968232 | 2004.1.1.66 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase_2 | 0.63 | 36.0 | 3.96e-01 | 100.0% | 66.0% |
| 4177136 | 2004.1.1.35 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Bac_DnaA | 0.63 | 34.0 | 4.25e-01 | 100.0% | 81.0% |
| 5014105 | 2004.1.1.66 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase_2 | 0.63 | 35.0 | 3.45e-01 | 100.0% | 49.7% |
| 5078701 | 2004.1.1.66 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase_2 | 0.62 | 35.0 | 3.96e-01 | 100.0% | 70.4% |
| 3402837 | 2004.1.1.1 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA | 0.60 | 35.0 | 4.29e-01 | 100.0% | 87.4% |
| 3211520 | 2004.1.1.98 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Rad17 | 0.60 | 35.0 | 4.35e-01 | 100.0% | 90.3% |
| 4100589 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.60 | 36.0 | 4.10e-01 | 85.3% | 77.0% |
| 3781041 | 2004.1.1.29 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD | 0.60 | 43.0 | 4.62e-01 | 100.0% | 83.8% |
| 4329588 | 2004.1.1.1 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA | 0.59 | 33.0 | 4.02e-01 | 100.0% | 80.5% |
| 4030700 | 2004.1.1.292 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AFG1_ATPase | 0.59 | 36.0 | 4.46e-01 | 100.0% | 94.2% |
| 3175116 | 2004.1.1.240 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Utp25_C | 0.59 | 37.0 | 4.54e-01 | 85.0% | 94.5% |
| 3628354 | 2004.1.1.29 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD | 0.58 | 40.0 | 4.70e-01 | 100.0% | 95.0% |
| 3574781 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.58 | 35.0 | 4.33e-01 | 98.3% | 94.2% |
| 5054853 | 2004.1.1.194 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C_2 | 0.57 | 36.0 | 4.33e-01 | 93.0% | 91.2% |
| 3388747 | 2004.1.1.294 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ELP6 | 0.57 | 37.0 | 4.12e-01 | 99.0% | 79.6% |
| None | — | 0.57 | 41.0 | 4.74e-01 | 100.0% | 97.3% | |
| 3937474 | 2004.1.1.29 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD | 0.57 | 40.0 | 4.55e-01 | 100.0% | 92.6% |
| 4969947 | 2004.1.1.66 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase_2 | 0.56 | 37.0 | 4.02e-01 | 100.0% | 76.8% |
| 1840675 | 2004.1.1.120 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ResIII | 0.56 | 40.0 | 4.65e-01 | 100.0% | 98.2% |
| 3955103 | 2004.1.1.415 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA, RuvB_N | 0.56 | 33.0 | 4.06e-01 | 100.0% | 89.2% |
| 3705868 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.55 | 38.0 | 4.18e-01 | 87.0% | 83.7% |
| 3200172 | 2004.1.1.366 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › NPHP3_N | 0.55 | 36.0 | 4.15e-01 | 100.0% | 88.6% |
| 3611430 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.55 | 38.0 | 4.10e-01 | 86.3% | 81.6% |
| 4387003 | 2004.1.1.1 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA | 0.55 | 33.0 | 3.55e-01 | 100.0% | 68.2% |
| 3956498 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.54 | 33.0 | 3.24e-01 | 100.0% | 54.9% |
| 4962923 | 7590.1.1.1 ↗ | a/b three-layered sandwiches › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Peptidase_M29 | 0.54 | 30.0 | 3.94e-01 | 81.7% | 97.5% |
| 5047713 | 7590.1.1.1 ↗ | a/b three-layered sandwiches › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Peptidase_M29 | 0.54 | 30.0 | 3.95e-01 | 81.3% | 98.1% |
| 4960789 | 7590.1.1.0 ↗ | a/b three-layered sandwiches › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs | 0.54 | 31.0 | 3.96e-01 | 81.7% | 98.2% |
| 4936905 | 7590.1.1.1 ↗ | a/b three-layered sandwiches › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Peptidase_M29 | 0.53 | 31.0 | 4.00e-01 | 81.7% | 98.2% |
| 3727158 | 2004.1.1.366 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › NPHP3_N | 0.53 | 35.0 | 3.81e-01 | 100.0% | 78.8% |
| 5071478 | 7590.1.1.0 ↗ | a/b three-layered sandwiches › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs › Middle domain in Argonaute homologs | 0.52 | 28.0 | 3.70e-01 | 81.3% | 97.3% |
| 4006300 | 2004.1.1.455 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, UvrD_C, UvrD_C_2 | 0.52 | 46.0 | 3.46e-01 | 100.0% | 41.5% |
| 1501440 | 7529.1.1.1 ↗ | a/b three-layered sandwiches › Macro domain-like › Macro domain-like › Macro domain-like › Macro | 0.52 | 31.0 | 3.90e-01 | 93.7% | 96.2% |
| 4266784 | 2004.1.1.455 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, UvrD_C, UvrD_C_2 | 0.51 | 44.0 | 3.38e-01 | 99.3% | 41.2% |
| 4161177 | 304.9.1.1 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 | 0.51 | 37.0 | 3.10e-01 | 100.0% | 42.5% |
| 3284594 | 2004.1.1.455 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, UvrD_C, UvrD_C_2 | 0.51 | 47.0 | 3.51e-01 | 100.0% | 41.1% |
| 5041195 | 2004.1.1.120 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ResIII | 0.51 | 39.0 | 3.82e-01 | 100.0% | 72.5% |
| 3642135 | 2004.1.1.23 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SNF2-rel_dom | 0.51 | 39.0 | 4.16e-01 | 100.0% | 87.8% |
D2
high
residues 343-410_812-872
Domain cluster:
rep: helicase-primase_ATPase_subunit__YP_010087484__Phascolarctid_gammaherpesvirus_1__2249313__D338-366_706-759
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 105.1 | 3.90e-30 | 52.7% | 8.2% |
| PF02689.21 | Herpes_Helicase | 90.9 | 7.80e-26 | 51.2% | 8.0% |
D3
high
residues 416-496_750-803
Domain cluster:
rep: helicase-primase_helicase_subunit__NP_045354__Bovine_alphaherpesvirus_1__10320__D392-469_736-760
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 90.9 | 7.60e-26 | 63.0% | 10.3% |
| PF02689.21 | Herpes_Helicase | 58.9 | 3.70e-16 | 41.5% | 6.6% |
D4
medium
residues 546-582_654-686
Domain cluster:
representative
CATH (42)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1dd5A01 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.80 | 61.0 | 5.18e-01 | 80.0% | 74.3% |
| 8igrI01 | 2.40.270.10 | Mainly Beta › Beta Barrel › Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6 › DNA-directed RNA polymerase, subunit 2, domain 6 | 0.80 | 49.0 | 3.60e-01 | 81.4% | 25.0% |
| 1m6nA04 | 1.10.3060.10 | Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA | 0.71 | 64.0 | 5.14e-01 | 100.0% | 61.5% |
| 4tpoA00 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.71 | 55.0 | 3.38e-01 | 82.9% | 33.2% |
| 2bduA02 | 1.10.150.340 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain | 0.69 | 55.0 | 5.48e-01 | 97.1% | 83.8% |
| 1m62A00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.68 | 47.0 | 4.45e-01 | 72.9% | 63.2% |
| 8dq6A01 | 3.30.429.10 | Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor | 0.68 | 63.0 | 5.49e-01 | 98.6% | 89.0% |
| 2g8lB01 | 1.10.8.380 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Uncharacterised protein PF01937, DUF89, domain 1 | 0.68 | 53.0 | 5.40e-01 | 98.6% | 88.1% |
| 2mpkA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.68 | 47.0 | 4.65e-01 | 72.9% | 74.3% |
| 3d36B02 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.67 | 47.0 | 5.03e-01 | 72.9% | 91.8% |
| 4h63H01 | 1.20.58.1710 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 50.0 | 5.00e-01 | 80.0% | 94.4% |
| 2x2vA00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.65 | 47.0 | 4.75e-01 | 75.7% | 95.6% |
| 2xokP00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.65 | 49.0 | 4.86e-01 | 81.4% | 90.5% |
| 2uxwA04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.64 | 55.0 | 4.58e-01 | 98.6% | 67.7% |
| 2pmrA00 | 1.20.1270.90 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like | 0.64 | 55.0 | 5.36e-01 | 100.0% | 86.8% |
| 6r1nA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.64 | 47.0 | 4.15e-01 | 78.6% | 98.1% |
| 4v1gA00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.64 | 49.0 | 4.58e-01 | 81.4% | 80.0% |
| 3fxdC00 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.64 | 41.0 | 4.78e-01 | 71.4% | 94.0% |
| 2qywA00 | 1.20.58.400 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins | 0.64 | 47.0 | 4.27e-01 | 78.6% | 75.8% |
| 3lphC00 | 6.10.140.630 | Special › Helix non-globular › Helix Hairpins › | 0.63 | 46.0 | 4.97e-01 | 78.6% | 98.3% |
| 2kg7B00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.63 | 48.0 | 4.28e-01 | 81.4% | 68.0% |
| 2nr4A02 | 1.20.58.290 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Hypothetical membrane protein ta0354_69_121. | 0.62 | 36.0 | 3.90e-01 | 75.7% | 69.0% |
| 4e4eA01 | 1.10.287.990 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain | 0.62 | 43.0 | 4.36e-01 | 72.9% | 91.5% |
| 3h6pC00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.62 | 43.0 | 4.66e-01 | 72.9% | 98.2% |
| 3r84B00 | 6.10.280.160 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Mediator of RNA polymerase II transcription subunit 22 | 0.62 | 45.0 | 4.37e-01 | 77.1% | 78.8% |
| 3owaB04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.61 | 53.0 | 4.15e-01 | 100.0% | 58.0% |
| 2wgmA01 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.61 | 45.0 | 4.36e-01 | 81.4% | 87.8% |
| 1cpyA02 | 1.10.287.410 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.61 | 52.0 | 5.19e-01 | 97.1% | 95.8% |
| 3eabE00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.61 | 42.0 | 3.99e-01 | 72.9% | 61.6% |
| 1y6xA00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.60 | 42.0 | 3.87e-01 | 71.4% | 59.8% |
| 1rv2D04 | 1.10.287.690 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › B family DNA polymerase, finger domain | 0.60 | 42.0 | 4.29e-01 | 74.3% | 85.7% |
| 1or7B01 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.59 | 44.0 | 4.05e-01 | 97.1% | 60.6% |
| 1s35A01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.58 | 43.0 | 3.84e-01 | 78.6% | 56.4% |
| 1grjA01 | 1.10.287.180 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Transcription elongation factor, GreA/GreB, N-terminal domain | 0.58 | 40.0 | 3.97e-01 | 71.4% | 74.3% |
| 3rq9A00 | 1.10.287.2500 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.58 | 42.0 | 4.05e-01 | 75.7% | 73.1% |
| 4fxdA04 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.58 | 50.0 | 3.95e-01 | 98.6% | 68.6% |
| 1luwA01 | 1.10.287.990 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain | 0.57 | 40.0 | 4.15e-01 | 74.3% | 92.2% |
| 2i53A02 | 1.10.472.10 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like | 0.57 | 49.0 | 4.27e-01 | 100.0% | 62.2% |
| 1ku9A02 | 1.10.287.450 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.54 | 39.0 | 4.11e-01 | 78.6% | 100.0% |
| 1zymA02 | 1.10.274.10 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › PtsI, HPr-binding domain | 0.54 | 45.0 | 3.80e-01 | 95.7% | 100.0% |
| 2e9xA01 | 1.20.58.1030 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.54 | 40.0 | 3.34e-01 | 80.0% | 45.3% |
| 2kiwA01 | 1.10.150.130 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Tyrosine recombinase, N-terminal domain | 0.50 | 44.0 | 4.14e-01 | 97.1% | 80.2% |
ECOD (34)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3715110 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.74 | 66.0 | 5.90e-01 | 100.0% | 85.0% |
| 3635975 | 3681.1.1.0 ↗ | a+b complex topology › Helical hairpin insertion in E. coli DNA-directed RNA polymerase beta subunit › Helical hairpin insertion in E. coli DNA-directed RNA polymerase beta subunit › Helical hairpin insertion in E. coli DNA-directed RNA polymerase beta subunit | 0.74 | 58.0 | 5.41e-01 | 84.3% | 92.9% |
| 4927047 | 632.19.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Choline binding protein A › Choline binding protein A | 0.72 | 60.0 | 5.86e-01 | 91.4% | 85.3% |
| 3175548 | 524.1.1.1 ↗ | alpha arrays › Ypt/Rab-GAP domain of gyp1p-like › Ypt/Rab-GAP domain of gyp1p › Ypt/Rab-GAP domain of gyp1p › RabGAP-TBC | 0.71 | 63.0 | 4.61e-01 | 97.1% | 61.7% |
| 3267156 | 633.24.1.0 ↗ | alpha bundles › Bromodomain-like › RABEX-5 helical domain › RABEX-5 helical domain | 0.69 | 58.0 | 5.24e-01 | 97.1% | 71.0% |
| 3375617 | 192.5.1.30 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › DUF641 | 0.69 | 49.0 | 4.67e-01 | 74.3% | 75.0% |
| 3940151 | 604.33.1.0 ↗ | alpha bundles › Spectrin repeat-like › Repulsive guidance molecule (RGM) N-terminal domain › Repulsive guidance molecule (RGM) N-terminal domain | 0.68 | 59.0 | 5.15e-01 | 100.0% | 76.4% |
| 3486453 | 310.2.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF | 0.67 | 50.0 | 4.40e-01 | 80.0% | 71.4% |
| 5002748 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.67 | 50.0 | 4.92e-01 | 78.6% | 85.3% |
| 3703063 | 604.3.1.0 ↗ | alpha bundles › Spectrin repeat-like › BAG domain › BAG domain | 0.67 | 50.0 | 4.48e-01 | 78.6% | 66.3% |
| 4521514 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.66 | 50.0 | 4.95e-01 | 80.0% | 85.3% |
| 3377889 | 632.1.1.31 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain › TB2_DP1_HVA22 | 0.66 | 55.0 | 4.86e-01 | 92.9% | 68.6% |
| 3493322 | 2006.1.1.8 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › 5_nucleotid | 0.66 | 50.0 | 3.43e-01 | 82.9% | 26.0% |
| 3944950 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.66 | 48.0 | 5.02e-01 | 77.1% | 96.9% |
| 3959988 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.65 | 46.0 | 3.96e-01 | 75.7% | 62.8% |
| 4974229 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.64 | 46.0 | 3.47e-01 | 75.7% | 34.3% |
| 3702772 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.64 | 56.0 | 4.67e-01 | 97.1% | 65.8% |
| 3958889 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.64 | 45.0 | 3.40e-01 | 74.3% | 37.1% |
| 3810801 | 632.22.1.139 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › KIF21A_4th | 0.64 | 46.0 | 3.55e-01 | 75.7% | 94.7% |
| 3588754 | 101.1.4.0 ↗ | alpha arrays › HTH › HTH › tetra-helical, lambda repressor-like | 0.63 | 55.0 | 4.06e-01 | 100.0% | 43.6% |
| 3626530 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.62 | 45.0 | 4.06e-01 | 75.7% | 56.8% |
| 3411768 | 627.1.1.2 ↗ | alpha complex topology › VPS9 domain › VPS9 domain › VPS9 domain › DUF5601 | 0.62 | 49.0 | 4.52e-01 | 88.6% | 69.5% |
| 4031740 | 622.1.1.0 ↗ | alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain | 0.62 | 44.0 | 4.17e-01 | 74.3% | 65.5% |
| 4940598 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.62 | 53.0 | 5.21e-01 | 97.1% | 94.7% |
| 3906775 | 3921.1.1.0 ↗ | alpha complex topology › Na(+)-translocating NADH-quinone reductase subunit D › Na(+)-translocating NADH-quinone reductase subunit D › Na(+)-translocating NADH-quinone reductase subunit D | 0.61 | 50.0 | 4.10e-01 | 97.1% | 53.1% |
| 3614296 | 5076.1.1.1 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Mitochondrial ADP/ATP carrier › Mitochondrial ADP/ATP carrier › Mito_carr | 0.59 | 50.0 | 3.28e-01 | 94.3% | 82.9% |
| 5074955 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.58 | 49.0 | 4.59e-01 | 98.6% | 74.4% |
| 4081214 | 605.1.1.290 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › Phage_Nu1 | 0.58 | 43.0 | 4.34e-01 | 80.0% | 92.9% |
| 4236831 | 604.6.1.50 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › DUF2524 | 0.57 | 42.0 | 4.04e-01 | 78.6% | 68.8% |
| 3406875 | 518.1.1.0 ↗ | alpha arrays › Chemotaxis receptor methyltransferase CheR, N-terminal domain › Chemotaxis receptor methyltransferase CheR, N-terminal domain › Chemotaxis receptor methyltransferase CheR, N-terminal domain | 0.56 | 46.0 | 4.76e-01 | 92.9% | 98.5% |
| 3163896 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.56 | 49.0 | 3.50e-01 | 98.6% | 51.0% |
| 3904823 | 150.3.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine | 0.55 | 47.0 | 3.59e-01 | 97.1% | 54.7% |
| 3940067 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.54 | 48.0 | 3.09e-01 | 100.0% | 21.9% |
| 1145707 | 650.1.1.3 ↗ | alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › HsbA | 0.54 | 40.0 | 3.91e-01 | 80.0% | 73.3% |