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helicase-primase_helicase_subunit
Euk-VirMacacine_alphaherpesvirus_1
helicase-primase_helicase_subunit__NP_851864__Macacine_alphaherpesvirus_1__10325
Identity
- Accession:
- NP_851864 ↗
- Protein ID:
- helicase-primase_helicase_subunit
- Kingdom:
- euk
Quality
80.8
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Macacine_alphaherpesvirus_1
TaxID: 10325
Cluster
View cluster (90 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 72-127_216-240_256-283
Domain cluster:
rep: helicase-primase_helicase_subunit__YP_004940120__Aotine_betaherpesvirus_1__50290__D122-162_194-222_285-316
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 80.4 | 1.10e-22 | 60.6% | 6.1% |
| PF02689.21 | Herpes_Helicase | 35.2 | 5.40e-09 | 47.7% | 3.6% |
CATH (23)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2ocaA03 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.66 | 56.0 | 4.50e-01 | 91.7% | 76.9% |
| 1wp9A01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.61 | 51.0 | 4.12e-01 | 89.0% | 69.8% |
| 7ml0001 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.61 | 51.0 | 3.95e-01 | 89.9% | 82.0% |
| 1xtiA02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.59 | 49.0 | 4.30e-01 | 89.9% | 78.7% |
| 6b4kB02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.59 | 50.0 | 4.30e-01 | 91.7% | 78.8% |
| 2v1xA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.59 | 48.0 | 3.84e-01 | 89.0% | 66.8% |
| 8kcaB01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.58 | 48.0 | 4.16e-01 | 89.9% | 76.0% |
| 1c4oA03 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.58 | 49.0 | 4.17e-01 | 91.7% | 77.1% |
| 1gkuB03 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.58 | 51.0 | 4.34e-01 | 97.2% | 71.1% |
| 2p6nA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.57 | 49.0 | 4.26e-01 | 91.7% | 79.4% |
| 3vkwA02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.56 | 49.0 | 4.48e-01 | 93.6% | 77.5% |
| 5lklB01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.56 | 46.0 | 4.23e-01 | 90.8% | 91.7% |
| 2p6rA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.55 | 46.0 | 3.80e-01 | 89.9% | 71.6% |
| 2i7xA02 | 3.40.50.10890 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.55 | 42.0 | 3.53e-01 | 80.7% | 99.5% |
| 1a1vA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.54 | 45.0 | 4.22e-01 | 90.8% | 93.3% |
| 7jpoE01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.53 | 45.0 | 3.90e-01 | 89.9% | 75.8% |
| 3bs4A00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.53 | 43.0 | 3.36e-01 | 89.9% | 67.8% |
| 4ydsA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.52 | 44.0 | 3.43e-01 | 89.9% | 60.6% |
| 5l3qB02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.52 | 43.0 | 3.41e-01 | 92.7% | 44.7% |
| 5agaA02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.51 | 41.0 | 3.36e-01 | 88.1% | 75.9% |
| 7jgsD01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.51 | 39.0 | 3.27e-01 | 81.7% | 92.7% |
| 3uhjC01 | 3.40.50.1970 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.50 | 42.0 | 3.81e-01 | 92.7% | 94.7% |
| 1l8qA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.50 | 42.0 | 3.64e-01 | 89.9% | 61.2% |
ECOD (34)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3468181 | 2004.1.1.29 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD | 0.62 | 52.0 | 3.92e-01 | 89.0% | 57.6% |
| 3727265 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.62 | 52.0 | 3.89e-01 | 91.7% | 85.9% |
| 4502519 | 2004.1.1.33 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C,RecQ_Zn_bind | 0.62 | 53.0 | 4.15e-01 | 94.5% | 58.3% |
| 3380943 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.61 | 52.0 | 4.05e-01 | 93.6% | 78.0% |
| 3937677 | 2004.1.1.364 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD+Helicase_C | 0.61 | 55.0 | 3.46e-01 | 100.0% | 33.9% |
| 4014985 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.61 | 54.0 | 3.51e-01 | 100.0% | 46.6% |
| 3599614 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.60 | 53.0 | 3.89e-01 | 96.3% | 47.9% |
| 4032179 | 2004.1.1.33 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C,RecQ_Zn_bind | 0.60 | 52.0 | 4.22e-01 | 94.5% | 65.4% |
| 4952412 | 2004.1.1.233 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Cas3-like_C_2 | 0.59 | 53.0 | 3.55e-01 | 100.0% | 73.4% |
| 3831995 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.59 | 51.0 | 4.04e-01 | 94.5% | 60.4% |
| 4971857 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.59 | 50.0 | 4.02e-01 | 90.8% | 61.5% |
| 3600947 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.59 | 51.0 | 4.40e-01 | 94.5% | 79.4% |
| 5022253 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.59 | 51.0 | 4.09e-01 | 95.4% | 63.7% |
| 3296464 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.59 | 50.0 | 4.83e-01 | 93.6% | 90.4% |
| 4003840 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.59 | 50.0 | 4.06e-01 | 92.7% | 65.9% |
| 3267615 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.58 | 51.0 | 3.75e-01 | 96.3% | 56.6% |
| 5001751 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.58 | 50.0 | 4.05e-01 | 92.7% | 66.0% |
| 3613826 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.58 | 49.0 | 3.98e-01 | 91.7% | 91.2% |
| 5033420 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.57 | 48.0 | 3.98e-01 | 91.7% | 69.2% |
| 3654913 | 2004.1.1.287 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C_4 | 0.57 | 48.0 | 3.95e-01 | 91.7% | 89.2% |
| 5077468 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.56 | 47.0 | 3.77e-01 | 90.8% | 87.9% |
| 3170901 | 2004.1.1.364 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD+Helicase_C | 0.56 | 50.0 | 3.30e-01 | 100.0% | 70.7% |
| 3916692 | 2004.1.1.29 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD | 0.56 | 47.0 | 3.53e-01 | 89.9% | 51.2% |
| 4275904 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.56 | 46.0 | 3.71e-01 | 89.9% | 58.9% |
| None | — | 0.56 | 49.0 | 3.75e-01 | 96.3% | 55.2% | |
| 359186 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.54 | 45.0 | 4.21e-01 | 90.8% | 90.6% |
| 1217671 | 2004.1.1.151 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Flavi_DEAD | 0.54 | 45.0 | 4.13e-01 | 90.8% | 87.5% |
| 3947121 | 2004.1.1.363 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C | 0.54 | 45.0 | 2.88e-01 | 89.0% | 41.6% |
| 1309397 | 2004.1.1.29 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD | 0.53 | 38.0 | 3.49e-01 | 74.3% | 87.1% |
| 5071456 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.53 | 44.0 | 3.60e-01 | 90.8% | 91.7% |
| 5072692 | 2004.1.1.1219 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DUF7504 | 0.52 | 43.0 | 3.69e-01 | 89.9% | 83.3% |
| 5013012 | 2004.1.1.146 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase | 0.52 | 44.0 | 3.39e-01 | 89.9% | 59.6% |
| 4851383 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.51 | 39.0 | 2.95e-01 | 80.7% | 78.2% |
| 3383005 | 247.1.1.0 ↗ | a+b four layers › Metallo-hydrolase/oxidoreductase › Metallo-hydrolase/oxidoreductase › Metallo-hydrolase/oxidoreductase | 0.51 | 38.0 | 2.94e-01 | 90.8% | 34.8% |
D2
medium
residues 355-411_806-863
Domain cluster:
rep: helicase-primase_ATPase_subunit__YP_010087484__Phascolarctid_gammaherpesvirus_1__2249313__D338-366_706-759
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 86.8 | 1.30e-24 | 53.9% | 7.3% |
| PF02689.21 | Herpes_Helicase | 83.1 | 1.80e-23 | 50.4% | 6.9% |
D3
medium
residues 412-487_783-805
Domain cluster:
rep: helicase-primase_helicase_subunit__NP_045354__Bovine_alphaherpesvirus_1__10320__D392-469_736-760
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 78.7 | 3.70e-22 | 80.8% | 9.7% |
D4
medium
residues 488-510_695-782
Domain cluster:
rep: helicase-primase_helicase_subunit__YP_009137079__Human_alphaherpesvirus_1__10298__D496-518_696-779
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 73.4 | 1.60e-20 | 80.2% | 10.5% |
D5
medium
residues 511-577_642-694
Domain cluster:
rep: helicase-primase_helicase_subunit__YP_004940266__Saimiriine_betaherpesvirus_4__1535247__D509-572_638-677
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 29.7 | 2.40e-07 | 60.0% | 7.4% |
| PF02689.21 | Herpes_Helicase | 45.3 | 4.80e-12 | 54.2% | 6.1% |