←Back to structures
helicase-primase_helicase_subunit
Euk-VirGallid_alphaherpesvirus_2
helicase-primase_helicase_subunit__YP_001033933__Gallid_alphaherpesvirus_2__10390
Identity
- Accession:
- YP_001033933 ↗
- Protein ID:
- helicase-primase_helicase_subunit
- Kingdom:
- euk
Quality
72.8
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Mardivirus›
Gallid_alphaherpesvirus_2
TaxID: 10390
Cluster
View cluster (90 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 328-381_783-834
Domain cluster:
rep: helicase-primase_ATPase_subunit__YP_010087484__Phascolarctid_gammaherpesvirus_1__2249313__D338-366_706-759
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 76.3 | 2.00e-21 | 50.9% | 6.6% |
| PF02689.21 | Herpes_Helicase | 76.5 | 1.80e-21 | 50.9% | 6.6% |
D2
medium
residues 55-98_228-261
Domain cluster:
rep: helicase-primase_helicase_subunit__YP_004940120__Aotine_betaherpesvirus_1__50290__D122-162_194-222_285-316
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 51.9 | 4.70e-14 | 57.7% | 4.3% |
| PF02689.21 | Herpes_Helicase | 40.2 | 1.70e-10 | 44.9% | 4.1% |
D3
medium
residues 382-481_751-782
Domain cluster:
rep: helicase-primase_helicase_subunit__NP_045354__Bovine_alphaherpesvirus_1__10320__D392-469_736-760
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 93.1 | 1.70e-26 | 78.0% | 12.5% |
| PF02689.21 | Herpes_Helicase | 28.3 | 6.80e-07 | 25.8% | 4.1% |
D4
medium
residues 482-528_672-750
Domain cluster:
rep: helicase-primase_helicase_subunit__YP_009137079__Human_alphaherpesvirus_1__10298__D496-518_696-779
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 56.2 | 2.50e-15 | 63.5% | 9.3% |
| PF02689.21 | Herpes_Helicase | 53.5 | 1.60e-14 | 38.9% | 5.8% |
D5
medium
residues 529-563_630-671
Domain cluster:
rep: helicase-primase_helicase_subunit__NP_040177__Human_alphaherpesvirus_3__10335__D546-582_654-686
CATH (23)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1ywmA02 | 1.20.1270.150 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Surface Active Protein | 0.70 | 53.0 | 5.35e-01 | 85.7% | 81.6% |
| 2e62A01 | 6.10.140.420 | Special › Helix non-globular › Helix Hairpins › | 0.69 | 45.0 | 5.36e-01 | 70.1% | 100.0% |
| 4h63H01 | 1.20.58.1710 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.68 | 47.0 | 4.85e-01 | 70.1% | 94.4% |
| 1nu7D01 | 1.20.120.750 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Staphylcoagulase, helix bundle domain 1 | 0.68 | 55.0 | 4.58e-01 | 88.3% | 81.5% |
| 2wyhB04 | 1.20.1270.50 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Glycoside hydrolase family 38, central domain | 0.67 | 55.0 | 5.00e-01 | 88.3% | 79.2% |
| 1k04A02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.67 | 53.0 | 4.87e-01 | 88.3% | 81.7% |
| 2pmrA00 | 1.20.1270.90 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like | 0.66 | 53.0 | 5.37e-01 | 92.2% | 88.2% |
| 4jd9G00 | 1.10.238.20 | Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › Pheromone/general odorant binding protein domain | 0.65 | 58.0 | 5.00e-01 | 100.0% | 80.0% |
| 2g8lB01 | 1.10.8.380 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Uncharacterised protein PF01937, DUF89, domain 1 | 0.65 | 49.0 | 5.15e-01 | 87.0% | 92.5% |
| 4p9tA01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.64 | 50.0 | 4.42e-01 | 88.3% | 67.5% |
| 6yz2A01 | 1.20.120.350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C | 0.63 | 47.0 | 4.06e-01 | 79.2% | 82.5% |
| 1cpyA02 | 1.10.287.410 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.63 | 50.0 | 5.11e-01 | 85.7% | 97.2% |
| 1jkvA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.62 | 50.0 | 3.76e-01 | 89.6% | 87.3% |
| 4fxdA04 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.58 | 47.0 | 3.83e-01 | 90.9% | 70.6% |
| 2i53A02 | 1.10.472.10 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like | 0.57 | 49.0 | 4.43e-01 | 98.7% | 74.8% |
| 2crbA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.55 | 41.0 | 3.81e-01 | 79.2% | 68.0% |
| 6qs7C01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.54 | 41.0 | 3.47e-01 | 81.8% | 82.6% |
| 2fq3A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.53 | 39.0 | 3.85e-01 | 88.3% | 71.8% |
| 2zueA03 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.53 | 48.0 | 4.14e-01 | 98.7% | 100.0% |
| 4fppB01 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.53 | 37.0 | 3.91e-01 | 85.7% | 78.9% |
| 5nl6A02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.53 | 39.0 | 3.58e-01 | 80.5% | 84.3% |
| 2ktmA00 | 1.10.790.10 | Mainly Alpha › Orthogonal Bundle › Major Prion Protein › Prion/Doppel protein, beta-ribbon domain | 0.52 | 36.0 | 3.79e-01 | 72.7% | 100.0% |
| 1wkbA03 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.51 | 45.0 | 3.91e-01 | 100.0% | 83.5% |
ECOD (25)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3833888 | 3846.1.1.0 ↗ | alpha bundles › IcmR › IcmR › IcmR | 0.70 | 53.0 | 4.66e-01 | 79.2% | 69.1% |
| 4241645 | 632.22.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA | 0.68 | 54.0 | 5.14e-01 | 85.7% | 84.4% |
| 4275057 | 1075.5.1.12 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MurJ, Polysacc_synt_3 | 0.65 | 55.0 | 3.79e-01 | 93.5% | 88.3% |
| 5012657 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.63 | 51.0 | 4.78e-01 | 88.3% | 71.6% |
| 3988781 | 604.6.1.63 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › DUF3169 | 0.63 | 46.0 | 3.82e-01 | 77.9% | 76.3% |
| 2581423 | 632.18.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › hypothetical protein PA2901 › hypothetical protein PA2901 | 0.62 | 47.0 | 4.68e-01 | 83.1% | 77.8% |
| 4105677 | 150.1.1.59 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Coat_F | 0.62 | 44.0 | 4.15e-01 | 72.7% | 71.1% |
| 3308688 | 142.1.1.0 ↗ | alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors | 0.61 | 48.0 | 4.84e-01 | 85.7% | 89.3% |
| 3729252 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.60 | 44.0 | 3.91e-01 | 79.2% | 96.5% |
| 3775067 | 198.1.1.21 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapA, SapB_2 | 0.60 | 43.0 | 3.76e-01 | 76.6% | 70.8% |
| 5002882 | 4207.1.1.133 ↗ | alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › RNA polymerase II holoenzyme component SRB7 (MED21) › BREX_BrxC_4th | 0.59 | 47.0 | 4.00e-01 | 85.7% | 95.2% |
| 4956241 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.58 | 47.0 | 4.79e-01 | 88.3% | 92.0% |
| 3331938 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.58 | 46.0 | 4.64e-01 | 87.0% | 90.0% |
| 3396074 | 198.1.1.2 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_2,SapB_1 | 0.58 | 41.0 | 3.97e-01 | 74.0% | 100.0% |
| 4015325 | 2008.1.1.0 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like | 0.56 | 48.0 | 3.49e-01 | 94.8% | 73.7% |
| 4977024 | 138.1.1.0 ↗ | alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain | 0.56 | 48.0 | 4.35e-01 | 100.0% | 69.1% |
| 3923698 | 627.1.1.0 ↗ | alpha complex topology › VPS9 domain › VPS9 domain › VPS9 domain | 0.55 | 48.0 | 4.44e-01 | 100.0% | 90.0% |
| 4119718 | 192.7.1.2 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N | 0.54 | 42.0 | 4.07e-01 | 85.7% | 93.3% |
| 3558196 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.54 | 47.0 | 3.22e-01 | 100.0% | 75.8% |
| 5053661 | 2011.1.1.8 ↗ | a/b three-layered sandwiches › Phosphorylase/hydrolase-like › Zn-dependent exopeptidases › Zn-dependent exopeptidases › Peptidase_M28 | 0.53 | 40.0 | 2.67e-01 | 84.4% | 84.0% |
| 4115372 | 192.7.1.2 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N | 0.53 | 42.0 | 3.78e-01 | 87.0% | 94.5% |
| 3495276 | 3826.1.1.0 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) | 0.53 | 43.0 | 3.43e-01 | 88.3% | 58.0% |
| 3181988 | 4336.1.1.5 ↗ | alpha duplicates or obligate multimers › YheA/YmcA-like › YheA/YmcA-like › YheA/YmcA-like › HAM1_N | 0.52 | 40.0 | 3.96e-01 | 85.7% | 87.1% |
| 4935676 | 604.5.1.2 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU | 0.51 | 41.0 | 3.65e-01 | 85.7% | 75.5% |
| 3568856 | 198.1.1.1 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_2 | 0.51 | 37.0 | 3.57e-01 | 77.9% | 93.3% |