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helicase-primase_helicase_subunit
Euk-VirEquid_alphaherpesvirus_3
helicase-primase_helicase_subunit__YP_009054960__Equid_alphaherpesvirus_3__80341
Identity
- Accession:
- YP_009054960 ↗
- Protein ID:
- helicase-primase_helicase_subunit
- Kingdom:
- euk
Quality
80.7
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Varicellovirus›
Equid_alphaherpesvirus_3
TaxID: 80341
Cluster
View cluster (90 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 66-77_95-160_253-263_284-315_333-363_867-881
Domain cluster:
rep: ORF35__NP_733888__Callitrichine_gammaherpesvirus_3__106331__D45-78_114-298
Pfam (3)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01443.25 best | Viral_helicase1 | 32.0 | 1.50e-07 | 76.0% | 44.3% |
| PF02689.21 | Herpes_Helicase | 80.6 | 1.00e-22 | 52.7% | 10.4% |
| PF02689.21 | Herpes_Helicase | 95.5 | 3.20e-27 | 46.7% | 8.2% |
D2
medium
residues 78-94_161-212_246-252_264-283_316-332
Domain cluster:
rep: helicase-primase_helicase_subunit__YP_010087597__Cervid_alphaherpesvirus_3__2115790__D111-202
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 40.1 | 1.80e-10 | 54.0% | 6.2% |
D3
medium
residues 364-428_804-866
Domain cluster:
rep: helicase-primase_ATPase_subunit__YP_010087484__Phascolarctid_gammaherpesvirus_1__2249313__D338-366_706-759
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 91.3 | 5.90e-26 | 53.1% | 7.9% |
| PF02689.21 | Herpes_Helicase | 93.2 | 1.60e-26 | 52.3% | 8.2% |
D4
medium
residues 429-504_736-803
Domain cluster:
rep: helicase-primase_helicase_subunit__NP_045354__Bovine_alphaherpesvirus_1__10320__D392-469_736-760
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 71.1 | 7.70e-20 | 60.4% | 9.3% |
| PF02689.21 | Herpes_Helicase | 57.0 | 1.40e-15 | 47.9% | 6.6% |
D5
medium
residues 505-527_699-735
Domain cluster:
representative
CATH (1)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2cuiA00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.50 | 29.0 | 2.45e-01 | 75.0% | 29.5% |
D6
medium
residues 528-589_657-698
Domain cluster:
rep: helicase-primase_helicase_subunit__YP_004940266__Saimiriine_betaherpesvirus_4__1535247__D509-572_638-677
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 49.7 | 2.20e-13 | 62.5% | 7.0% |
CATH (26)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 6p73A02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.70 | 55.0 | 4.95e-01 | 84.6% | 76.9% |
| 2rfqC03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.68 | 53.0 | 4.41e-01 | 81.7% | 65.7% |
| 3d2eA06 | 1.20.1270.10 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.68 | 49.0 | 4.82e-01 | 76.0% | 76.1% |
| 1qdbA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.66 | 52.0 | 4.71e-01 | 85.6% | 76.9% |
| 2uv8A07 | 6.10.140.1410 | Special › Helix non-globular › Helix Hairpins › | 0.65 | 33.0 | 3.65e-01 | 86.5% | 60.0% |
| 2b0hA01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.65 | 52.0 | 4.85e-01 | 86.5% | 83.6% |
| 1i6zA00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.62 | 42.0 | 3.87e-01 | 70.2% | 63.7% |
| 1gvnA00 | 1.10.8.130 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.62 | 43.0 | 4.70e-01 | 73.1% | 97.7% |
| 4iu9B01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.61 | 46.0 | 3.63e-01 | 80.8% | 83.9% |
| 6opmD01 | 1.20.120.920 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CRISPR-associated endonuclease Cas1, C-terminal domain | 0.61 | 50.0 | 3.82e-01 | 88.5% | 99.2% |
| 1tjoB00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.60 | 45.0 | 3.78e-01 | 77.9% | 58.3% |
| 2vxxA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.60 | 44.0 | 3.81e-01 | 78.8% | 61.0% |
| 1sxjD03 | 1.20.272.10 | Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › | 0.59 | 45.0 | 4.76e-01 | 84.6% | 91.2% |
| 4k7bA00 | 1.20.120.1740 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Sodium ion translocating NADH-quinone reductase subunit C-like | 0.58 | 40.0 | 3.98e-01 | 91.3% | 66.7% |
| 7kypB01 | 1.10.3470.10 | Mainly Alpha › Orthogonal Bundle › ABC transporter involved in vitamin B12 uptake, BtuC › ABC transporter involved in vitamin B12 uptake, BtuC | 0.58 | 43.0 | 3.16e-01 | 77.9% | 59.9% |
| 2nsfA01 | 1.20.120.450 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain | 0.58 | 51.0 | 4.43e-01 | 96.2% | 79.2% |
| 5dkoA02 | 1.10.3900.10 | Mainly Alpha › Orthogonal Bundle › YacF-like › YacF-like | 0.55 | 45.0 | 3.94e-01 | 91.3% | 98.8% |
| 4a2qA01 | 1.10.533.10 | Mainly Alpha › Orthogonal Bundle › Death Domain, Fas › Death Domain, Fas | 0.54 | 38.0 | 3.95e-01 | 98.1% | 80.6% |
| 2oezA02 | 1.10.3900.10 | Mainly Alpha › Orthogonal Bundle › YacF-like › YacF-like | 0.53 | 44.0 | 3.88e-01 | 93.3% | 98.8% |
| 2lyiA01 | 1.10.274.60 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, repetitive domain | 0.53 | 47.0 | 4.21e-01 | 100.0% | 76.4% |
| 6hwjA01 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.53 | 42.0 | 3.26e-01 | 86.5% | 77.9% |
| 4yjwA00 | 1.20.120.930 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein PF12889, N-terminal DUF3829 | 0.53 | 42.0 | 3.76e-01 | 86.5% | 76.5% |
| 3rvyA01 | 1.20.120.350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C | 0.53 | 42.0 | 4.14e-01 | 87.5% | 82.5% |
| 1f6fA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.52 | 39.0 | 3.34e-01 | 81.7% | 56.8% |
| 5nl6A02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.52 | 36.0 | 3.56e-01 | 71.2% | 91.7% |
| 3rh3A01 | 1.20.120.930 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein PF12889, N-terminal DUF3829 | 0.51 | 41.0 | 3.80e-01 | 86.5% | 71.4% |
ECOD (23)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5061332 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.68 | 49.0 | 5.58e-01 | 75.0% | 98.8% |
| 4146104 | 632.7.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.66 | 45.0 | 4.94e-01 | 70.2% | 85.9% |
| 4928071 | 3239.1.1.1 ↗ | alpha complex topology › Cas1 › Cas1 › Cas1 › Cas_Cas1 | 0.66 | 52.0 | 3.75e-01 | 86.5% | 70.3% |
| 5058368 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.65 | 46.0 | 4.95e-01 | 74.0% | 96.6% |
| 5042741 | 601.7.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN | 0.64 | 54.0 | 4.89e-01 | 90.4% | 94.2% |
| 4943584 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.64 | 44.0 | 4.86e-01 | 70.2% | 100.0% |
| 4492498 | 632.7.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › HSP70 | 0.63 | 45.0 | 5.08e-01 | 75.0% | 96.2% |
| 4034431 | 632.15.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) › CompInhib_SCIN | 0.63 | 44.0 | 4.81e-01 | 73.1% | 92.9% |
| 3215358 | 603.1.1.98 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE, Syntaxin_2 | 0.60 | 51.0 | 4.06e-01 | 90.4% | 86.0% |
| 4012358 | 310.2.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF | 0.58 | 44.0 | 3.90e-01 | 79.8% | 81.4% |
| 3494116 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.57 | 42.0 | 3.45e-01 | 78.8% | 73.2% |
| 5045166 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.57 | 47.0 | 4.57e-01 | 90.4% | 93.0% |
| 5014127 | 5065.1.1.1 ↗ | alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › ABC-3 | 0.57 | 45.0 | 3.31e-01 | 84.6% | 62.2% |
| 3726873 | 601.1.2.108 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › PigN | 0.56 | 43.0 | 3.65e-01 | 83.7% | 80.6% |
| 4021030 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.55 | 44.0 | 3.64e-01 | 84.6% | 80.5% |
| 3940940 | 3755.3.1.288 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › LMBR1 | 0.55 | 35.0 | 3.36e-01 | 79.8% | 53.6% |
| 3631283 | 5069.1.1.82 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › PigN | 0.55 | 43.0 | 3.59e-01 | 86.5% | 91.3% |
| 3753760 | 5082.1.1.0 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like | 0.54 | 40.0 | 3.20e-01 | 80.8% | 50.5% |
| 4328717 | 604.5.1.41 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PigN | 0.53 | 43.0 | 3.65e-01 | 87.5% | 82.9% |
| 3201364 | 190.1.1.1 ↗ | alpha arrays › HMG-box-like › HMG-box › HMG-box › HMG_box | 0.52 | 31.0 | 3.66e-01 | 86.5% | 84.0% |
| 3239011 | 198.1.1.1 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_2 | 0.52 | 27.0 | 3.09e-01 | 75.0% | 65.3% |
| 3766956 | 622.4.1.22 ↗ | alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related › FAM186A-B_N | 0.51 | 31.0 | 3.05e-01 | 70.2% | 52.5% |
| 2325490 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.50 | 34.0 | 3.38e-01 | 70.2% | 71.4% |