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helicase-primase_helicase_subunit

Euk-Vir

Human_alphaherpesvirus_2

helicase-primase_helicase_subunit__YP_009137156__Human_alphaherpesvirus_2__10310

Identity

Accession:: YP_009137156 ↗
Protein ID:: helicase-primase_helicase_subunit
Kingdom:: euk

Quality

76.6 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Simplexvirus› Human_alphaherpesvirus_2

TaxID: 10310

Cluster

View cluster (90 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 58-105_139-237_273-311_326-342

PDB

Domain cluster: rep: helicase_subunit__YP_009179342__Elephant_endotheliotropic_herpesvirus_4__548914__D47-64_102-182_199-230

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02689.21 best	Herpes_Helicase	112.6	2.20e-32	76.8%	23.1%
PF02689.21	Herpes_Helicase	37.4	1.20e-09	25.1%	5.6%

D2 medium residues 106-138_238-272_312-325

PDB

Domain cluster: representative

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02689.21 best	Herpes_Helicase	58.4	5.20e-16	56.1%	4.8%
PF02689.21	Herpes_Helicase	35.1	5.90e-09	42.7%	4.0%

CATH (18)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1wp9A02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.64	57.0	4.68e-01	98.8%	88.6%
6r8gA01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.61	52.0	4.47e-01	100.0%	77.5%
3q41B02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.60	52.0	4.13e-01	100.0%	77.8%
6yhrA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.59	51.0	3.95e-01	100.0%	69.6%
3sm3A00	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.57	49.0	3.74e-01	100.0%	81.6%
2e4uA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.57	49.0	3.96e-01	100.0%	81.5%
3hutA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.57	48.0	4.09e-01	100.0%	73.3%
2f1kA01	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.57	49.0	4.00e-01	100.0%	50.9%
4evqA02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.56	48.0	3.98e-01	100.0%	69.0%
6u8yJ01	3.40.50.12280	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.56	46.0	3.75e-01	93.9%	87.6%
1mgpA01	3.40.50.10170	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.55	42.0	3.46e-01	82.9%	45.2%
2qtcA02	3.40.50.970	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains	0.54	46.0	3.51e-01	100.0%	62.8%
3lfjB00	3.40.35.10	Alpha Beta › 3-Layer(aba) Sandwich › Fructose Permease › Phosphotransferase system, sorbose subfamily IIB component	0.53	43.0	3.51e-01	91.5%	97.0%
6h0cA02	3.40.50.360	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Flavodoxin domain	0.52	40.0	3.32e-01	82.9%	89.5%
3rgoA00	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.52	43.0	3.65e-01	97.6%	73.9%
2qbuA01	3.40.1010.10	Alpha Beta › 3-Layer(aba) Sandwich › Cobalt-precorrin-4 Transmethylase; domain 1 › Tetrapyrrole methylase, N-terminal domain	0.52	41.0	3.64e-01	90.2%	81.8%
4gi5A00	3.40.50.360	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Flavodoxin domain	0.52	39.0	2.83e-01	82.9%	45.9%
1h3fA01	3.40.50.620	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs	0.52	39.0	3.06e-01	84.1%	85.1%

ECOD (10)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3959040	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.57	44.0	3.44e-01	82.9%	67.8%
4261317	2005.1.1.13 ↗	a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › CTP_transf_like	0.54	41.0	3.28e-01	82.9%	76.6%
4963806	2007.1.2.13 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_6	0.54	47.0	4.10e-01	100.0%	87.7%
4961565	2007.1.2.13 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_6	0.54	46.0	3.83e-01	100.0%	86.9%
3241495	2007.1.2.0 ↗	a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I	0.54	47.0	3.57e-01	98.8%	64.9%
4946723	7592.1.1.13 ↗	a/b three-layered sandwiches › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains › Csm6_6H	0.53	47.0	3.89e-01	100.0%	62.7%
4928818	2003.1.6.1 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Tubulin nucleotide-binding domain-like › Tubulin	0.53	46.0	3.58e-01	100.0%	88.4%
3170706	2004.1.1.284 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › tRNA_lig_kinase	0.53	46.0	3.37e-01	100.0%	58.7%
5048282	2007.2.1.1 ↗	a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › Flavoproteins › Flavodoxin_1	0.52	42.0	3.61e-01	89.0%	71.9%
3959775	2002.1.1.0 ↗	a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels	0.51	46.0	3.41e-01	100.0%	84.3%

D3 medium residues 343-419_801-863

PDB

Domain cluster: rep: helicase-primase_ATPase_subunit__YP_010087484__Phascolarctid_gammaherpesvirus_1__2249313__D338-366_706-759

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02689.21 best	Herpes_Helicase	129.1	2.20e-37	55.7%	9.4%
PF02689.21	Herpes_Helicase	94.3	7.30e-27	47.1%	7.8%

D4 medium residues 420-494_778-800

PDB

Domain cluster: rep: helicase-primase_helicase_subunit__NP_045354__Bovine_alphaherpesvirus_1__10320__D392-469_736-760

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02689.21 best	Herpes_Helicase	82.1	3.60e-23	77.5%	9.2%

D5 medium residues 495-513_701-777

PDB

Domain cluster: rep: helicase-primase_helicase_subunit__YP_009137079__Human_alphaherpesvirus_1__10298__D496-518_696-779

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02689.21 best	Herpes_Helicase	60.0	1.70e-16	81.2%	8.9%

D6 medium residues 514-585_650-700

PDB

Domain cluster: rep: helicase-primase_helicase_subunit__YP_004940266__Saimiriine_betaherpesvirus_4__1535247__D509-572_638-677

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02689.21 best	Herpes_Helicase	59.2	2.90e-16	67.5%	8.4%