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helicase-primase_helicase_subunit
Euk-VirTestudinid_alphaherpesvirus_3
helicase-primase_helicase_subunit__YP_009176935__Testudinid_alphaherpesvirus_3__2560801
Identity
- Accession:
- YP_009176935 ↗
- Protein ID:
- helicase-primase_helicase_subunit
- Kingdom:
- euk
Quality
74.8
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Scutavirus›
Testudinid_alphaherpesvirus_3
TaxID: 2560801
Cluster
View cluster (90 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 325-393_774-830
Domain cluster:
rep: helicase-primase_ATPase_subunit__YP_010087484__Phascolarctid_gammaherpesvirus_1__2249313__D338-366_706-759
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 97.6 | 7.20e-28 | 54.8% | 8.2% |
| PF02689.21 | Herpes_Helicase | 85.1 | 4.60e-24 | 48.4% | 7.2% |
D2
high
residues 493-581_601-660
Domain cluster:
rep: helicase-primase_subunit__YP_009042021__Bovine_gammaherpesvirus_6__1504288__D477-585
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 74.0 | 9.80e-21 | 100.0% | 18.8% |
CATH (23)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2g3kA00 | 1.20.120.1130 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Vps28 C-terminal domain | 0.62 | 36.0 | 4.38e-01 | 95.3% | 90.4% |
| 1aepA00 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.61 | 48.0 | 4.84e-01 | 82.6% | 100.0% |
| 1g4uS01 | 1.20.120.260 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Virulence factor YopE uncharacterised domain | 0.60 | 44.0 | 4.74e-01 | 98.0% | 89.0% |
| 2hsbA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.60 | 45.0 | 4.81e-01 | 98.7% | 91.3% |
| 1rj1A00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.59 | 45.0 | 4.55e-01 | 95.3% | 79.7% |
| 2qupA00 | 1.20.120.490 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hypothetical protein TM1646-like domain | 0.59 | 39.0 | 4.29e-01 | 92.6% | 84.0% |
| 3vadA01 | 1.20.140.20 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain | 0.58 | 46.0 | 4.61e-01 | 98.7% | 80.8% |
| 4oh3A00 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.56 | 44.0 | 3.03e-01 | 81.9% | 88.3% |
| 1jqkA03 | 1.20.1270.30 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.55 | 44.0 | 4.18e-01 | 84.6% | 92.0% |
| 1j1jA02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.55 | 31.0 | 4.02e-01 | 83.9% | 97.6% |
| 3i01A01 | 1.20.1270.30 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.54 | 44.0 | 4.19e-01 | 86.6% | 93.2% |
| 3f4mA00 | 1.20.1440.160 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Tumor necrosis factor alpha-induced protein 8-like | 0.54 | 33.0 | 3.31e-01 | 85.9% | 58.4% |
| 3tdoA00 | 1.20.1080.10 | Mainly Alpha › Up-down Bundle › Glycerol uptake facilitator protein › Glycerol uptake facilitator protein. | 0.53 | 43.0 | 3.60e-01 | 85.9% | 78.6% |
| 3k1hA00 | 3.30.1120.180 | Alpha Beta › 2-Layer Sandwich › Arylsulfatase, C-terminal domain › Flagellar FLiS export co-chaperone, HP1076 | 0.52 | 33.0 | 3.65e-01 | 98.0% | 80.9% |
| 4nswB01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.52 | 43.0 | 3.58e-01 | 88.6% | 77.3% |
| 1wdzA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.52 | 42.0 | 3.60e-01 | 85.2% | 88.7% |
| 3a7mA01 | 1.20.58.380 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Flagellar protein flit. | 0.51 | 30.0 | 3.44e-01 | 84.6% | 77.3% |
| 3l8rA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.51 | 33.0 | 4.00e-01 | 84.6% | 96.1% |
| 6todA01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.51 | 42.0 | 3.36e-01 | 87.2% | 99.0% |
| 1rp3G02 | 1.20.140.160 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › PhyR, sigma-like (SL) domain | 0.51 | 44.0 | 4.49e-01 | 92.6% | 97.9% |
| 4nqiD00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.51 | 41.0 | 3.52e-01 | 84.6% | 81.9% |
| 7dl9A01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.51 | 36.0 | 3.38e-01 | 98.0% | 57.2% |
| 4ib4A01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.50 | 45.0 | 3.61e-01 | 96.6% | 78.9% |
ECOD (30)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3492896 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.71 | 35.0 | 3.41e-01 | 87.9% | 43.1% |
| 3227678 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.66 | 41.0 | 4.80e-01 | 84.6% | 91.0% |
| 3928979 | 4336.2.1.0 ↗ | alpha duplicates or obligate multimers › YheA/YmcA-like › Protein SUS1 › Protein SUS1 | 0.63 | 41.0 | 4.33e-01 | 97.3% | 71.9% |
| 2329732 | 3718.1.1.1 ↗ | alpha bundles › Flagellar protein fliT › Flagellar protein fliT › Flagellar protein fliT › FliT | 0.63 | 37.0 | 3.77e-01 | 82.6% | 58.3% |
| 3273600 | 601.20.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Apolipophorin-III › Apolipophorin-III | 0.63 | 51.0 | 4.41e-01 | 85.2% | 85.3% |
| 5049791 | 601.7.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HepT-like | 0.61 | 48.0 | 4.98e-01 | 98.0% | 87.9% |
| 3286925 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.59 | 46.0 | 5.03e-01 | 94.0% | 99.2% |
| 3423128 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.57 | 44.0 | 4.44e-01 | 96.0% | 80.7% |
| 3442603 | 611.9.1.0 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain | 0.56 | 37.0 | 3.96e-01 | 83.9% | 75.4% |
| 3815191 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.56 | 44.0 | 4.32e-01 | 94.6% | 77.8% |
| 4948130 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.56 | 44.0 | 4.62e-01 | 96.0% | 91.1% |
| 5081092 | 601.7.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN | 0.56 | 42.0 | 4.63e-01 | 93.3% | 95.9% |
| 3621079 | 4177.2.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › Inhibitor of kappaB kinase beta dimerization domain › Inhibitor of kappaB kinase beta dimerization domain | 0.56 | 51.0 | 4.19e-01 | 97.3% | 83.5% |
| 3259409 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.55 | 31.0 | 3.22e-01 | 87.9% | 57.1% |
| 5029372 | 601.7.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN | 0.55 | 42.0 | 4.56e-01 | 95.3% | 95.3% |
| 5032282 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.55 | 43.0 | 4.56e-01 | 94.0% | 95.4% |
| 5035117 | 601.7.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN | 0.54 | 43.0 | 4.40e-01 | 97.3% | 86.1% |
| 4183373 | 601.7.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN | 0.54 | 42.0 | 4.55e-01 | 95.3% | 97.6% |
| 3914530 | 601.39.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Enhancer of filamentation 1 › Enhancer of filamentation 1 › Serine_rich | 0.54 | 48.0 | 4.69e-01 | 98.0% | 87.9% |
| 5017862 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.54 | 41.0 | 4.47e-01 | 91.9% | 95.2% |
| 3319537 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.53 | 41.0 | 4.12e-01 | 94.0% | 79.2% |
| 3223368 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.53 | 38.0 | 3.84e-01 | 91.9% | 72.3% |
| 4619002 | 4177.1.1.66 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › ATG17_like | 0.53 | 42.0 | 3.30e-01 | 83.2% | 62.3% |
| 4992531 | 601.7.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN | 0.53 | 39.0 | 4.28e-01 | 91.3% | 94.2% |
| 4348000 | 563.2.1.1 ↗ | alpha bundles › ATPD N-terminal domain-like › Cas Cmr5-like › Cas Cmr5-like › Cas_Cmr5 | 0.53 | 32.0 | 3.57e-01 | 98.0% | 75.7% |
| 3512735 | 633.23.1.0 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin | 0.52 | 43.0 | 3.76e-01 | 87.9% | 76.9% |
| 3175356 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.52 | 47.0 | 4.46e-01 | 97.3% | 95.4% |
| 5001606 | 5059.1.1.1 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA | 0.52 | 36.0 | 3.73e-01 | 96.6% | 73.1% |
| 3699448 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.52 | 30.0 | 2.90e-01 | 79.2% | 49.1% |
| 3817156 | 601.14.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Hemerythrin › Hemerythrin | 0.50 | 38.0 | 3.55e-01 | 78.5% | 91.9% |
D3
medium
residues 68-144_214-227_246-322_831-851
Domain cluster:
rep: helicase-primase_helicase_subunit__NP_077469__Cercopithecine_alphaherpesvirus_9__35246__D94-136_227-238_265-286_299-331_845-869
Pfam (4)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01443.25 best | Viral_helicase1 | 31.5 | 2.20e-07 | 87.3% | 56.6% |
| PF13245.13 | AAA_19 | 28.2 | 2.60e-06 | 63.0% | 69.4% |
| PF02689.21 | Herpes_Helicase | 127.9 | 5.30e-37 | 59.3% | 11.1% |
| PF02689.21 | Herpes_Helicase | 111.6 | 4.20e-32 | 44.4% | 9.5% |
D4
medium
residues 400-465
Domain cluster:
rep: helicase-primase_helicase_subunit__YP_009252281__Canid_alphaherpesvirus_1__170325__D443-504
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 55.2 | 4.80e-15 | 98.5% | 6.9% |
D5
medium
residues 466-492_661-772
Domain cluster:
rep: helicase-primase_helicase_subunit__YP_009137079__Human_alphaherpesvirus_1__10298__D496-518_696-779
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 92.9 | 1.90e-26 | 81.3% | 13.4% |