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helicase-primase_helicase_subunit

Euk-Vir

Spheniscid_alphaherpesvirus_1

helicase-primase_helicase_subunit__YP_009342401__Spheniscid_alphaherpesvirus_1__2560777

Identity

Accession:
YP_009342401 ↗
Protein ID:
helicase-primase_helicase_subunit
Kingdom:
euk

Quality

76.3 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Mardivirus› Spheniscid_alphaherpesvirus_1

TaxID: 2560777

Cluster

View cluster (90 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 34-85_103-133_251-325
PDB
Domain cluster: rep: ORF35__NP_733888__Callitrichine_gammaherpesvirus_3__106331__D45-78_114-298
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 55.5 4.10e-15 53.2% 11.3%
PF02689.21 Herpes_Helicase 121.9 3.40e-35 48.7% 9.2%
CATH (3)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1puiA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.56 30.0 2.95e-01 78.5% 46.7%
5gvrA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.51 37.0 3.26e-01 75.3% 78.6%
8jx6B01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.50 47.0 4.31e-01 99.4% 91.5%
ECOD (1)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3256710 2004.1.1.29 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD 0.57 42.0 3.52e-01 76.6% 84.5%
D2 medium residues 134-183_216-250
PDB
Domain cluster: rep: helicase-primase_helicase_subunit__YP_010087597__Cervid_alphaherpesvirus_3__2115790__D111-202
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 79.8 1.80e-22 100.0% 12.5%
D3 medium residues 398-480_755-778
PDB
Domain cluster: rep: helicase-primase_helicase_subunit__NP_045354__Bovine_alphaherpesvirus_1__10320__D392-469_736-760
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 77.3 1.00e-21 79.4% 10.3%
D4 medium residues 481-492_673-754
PDB
Domain cluster: rep: helicase-primase_helicase_subunit__YP_009137079__Human_alphaherpesvirus_1__10298__D496-518_696-779
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 56.3 2.30e-15 100.0% 10.0%
D5 medium residues 493-564_633-672
PDB
Domain cluster: rep: helicase-primase_helicase_subunit__YP_004940266__Saimiriine_betaherpesvirus_4__1535247__D509-572_638-677
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 59.5 2.40e-16 69.6% 8.2%
D6 medium residues 779-840
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 97.5 8.00e-28 100.0% 7.7%
CATH (27)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3e1sA03 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.80 70.0 5.29e-01 95.2% 61.0%
1w36D03 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.79 70.0 5.00e-01 96.8% 38.2%
2hyiC02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.67 54.0 3.98e-01 90.3% 44.3%
7pliF02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.65 54.0 4.12e-01 95.2% 50.3%
1e8cB03 3.90.190.20 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Mur ligase, C-terminal domain 0.63 48.0 3.77e-01 85.5% 60.6%
3kd6A00 3.40.1190.20 Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Ribokinase 0.62 48.0 3.14e-01 87.1% 60.0%
3dtnA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.62 48.0 3.56e-01 90.3% 50.3%
2yjtD00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.62 50.0 3.76e-01 95.2% 47.1%
3e9eB00 3.40.50.1240 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphoglycerate mutase-like 0.62 44.0 2.99e-01 77.4% 33.5%
3mczA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.61 46.0 3.17e-01 85.5% 55.3%
7e6iA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.60 47.0 3.50e-01 88.7% 88.0%
2vxoA02 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.59 42.0 2.97e-01 79.0% 90.5%
2gfiA02 3.40.50.1240 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphoglycerate mutase-like 0.59 47.0 3.26e-01 93.5% 95.2%
4ej6A02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.58 47.0 3.70e-01 91.9% 75.5%
7n29C01 3.40.50.10330 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Probable inorganic polyphosphate/atp-NAD kinase; domain 1 0.56 43.0 3.37e-01 87.1% 73.2%
3qocA00 3.40.350.10 Alpha Beta › 3-Layer(aba) Sandwich › Creatine Amidinohydrolase; Chain A, domain 1 › Creatinase/prolidase N-terminal domain 0.56 40.0 3.28e-01 79.0% 60.5%
4igiA00 3.40.50.410 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › von Willebrand factor, type A domain 0.55 41.0 3.00e-01 83.9% 55.8%
1nfgA02 3.20.20.140 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Metal-dependent hydrolases 0.55 44.0 2.86e-01 96.8% 38.3%
3ctzA01 3.40.350.10 Alpha Beta › 3-Layer(aba) Sandwich › Creatine Amidinohydrolase; Chain A, domain 1 › Creatinase/prolidase N-terminal domain 0.55 39.0 3.04e-01 79.0% 54.2%
2xdqA03 3.40.50.1980 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase molybdenum iron protein domain 0.54 38.0 3.16e-01 79.0% 65.3%
4go1A02 3.40.50.1360 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.53 42.0 2.98e-01 96.8% 76.1%
3ey9A03 3.40.50.970 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains 0.53 39.0 2.81e-01 87.1% 48.2%
5ahkA03 3.40.50.970 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains 0.53 39.0 2.93e-01 85.5% 80.9%
3jy6D02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.52 38.0 3.18e-01 85.5% 77.0%
4rweA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.51 38.0 3.01e-01 87.1% 52.8%
3n6xA02 3.40.50.11290 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.51 35.0 3.15e-01 75.8% 68.7%
2ohoB02 3.40.50.1860 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.50 35.0 3.07e-01 77.4% 59.5%
ECOD (60)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3663731 2004.1.1.496 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Viral_helicase1, UvrD_C_2 0.84 61.0 4.61e-01 75.8% 51.9%
3677902 219.1.1.16 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C48 0.82 62.0 3.50e-01 79.0% 11.0%
3682367 2004.1.1.496 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Viral_helicase1, UvrD_C_2 0.82 63.0 4.74e-01 87.1% 37.0%
3789466 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.81 70.0 5.17e-01 98.4% 38.1%
3372829 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.81 67.0 4.98e-01 88.7% 57.2%
3662519 2004.1.1.62 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Viral_helicase1 0.80 68.0 5.67e-01 96.8% 56.0%
3890170 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.80 69.0 5.22e-01 98.4% 41.4%
3363137 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.80 70.0 5.35e-01 98.4% 43.7%
3385675 2004.1.1.298 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_Helicase 0.80 72.0 5.36e-01 98.4% 45.5%
3605939 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.79 70.0 5.35e-01 98.4% 44.4%
3600234 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.78 70.0 4.99e-01 96.8% 42.9%
3882209 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.78 68.0 5.23e-01 95.2% 54.8%
3601738 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.78 68.0 5.34e-01 95.2% 59.2%
3716782 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.78 68.0 5.27e-01 95.2% 54.6%
3610095 2004.1.1.298 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_Helicase 0.78 68.0 4.87e-01 95.2% 42.4%
3362146 2004.1.1.135 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 0.77 70.0 4.85e-01 100.0% 35.0%
3653111 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.77 67.0 6.00e-01 93.5% 81.0%
3719002 2004.1.1.203 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C_2 0.77 69.0 5.31e-01 98.4% 49.6%
3671414 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.77 68.0 4.77e-01 95.2% 44.4%
3777175 2004.1.1.203 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C_2 0.77 70.0 5.03e-01 100.0% 37.6%
3242523 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.77 68.0 5.27e-01 96.8% 62.3%
3658525 2004.1.1.62 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Viral_helicase1 0.77 63.0 4.72e-01 87.1% 52.1%
3596401 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.77 68.0 5.25e-01 98.4% 45.2%
None — 0.77 70.0 4.47e-01 98.4% 30.0%
3656784 2004.1.1.62 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Viral_helicase1 0.77 68.0 4.81e-01 96.8% 55.6%
3682236 2004.1.1.496 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Viral_helicase1, UvrD_C_2 0.76 68.0 4.92e-01 98.4% 46.5%
3683589 2004.1.1.135 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 0.76 69.0 4.15e-01 98.4% 25.3%
3648251 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.76 70.0 4.69e-01 100.0% 37.3%
3676955 2004.1.1.203 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C_2 0.76 68.0 4.89e-01 98.4% 45.7%
3807611 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.76 70.0 5.12e-01 100.0% 41.9%
3777141 2004.1.1.298 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_Helicase 0.76 68.0 5.13e-01 98.4% 42.1%
3305691 2004.1.1.298 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_Helicase 0.76 69.0 5.04e-01 98.4% 42.6%
3680771 2004.1.1.135 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 0.76 69.0 4.45e-01 98.4% 40.0%
3372759 2004.1.1.135 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 0.76 68.0 4.38e-01 98.4% 32.2%
3370015 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.75 68.0 4.80e-01 98.4% 48.9%
3682824 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.75 63.0 4.74e-01 88.7% 50.4%
3307009 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.74 64.0 5.04e-01 98.4% 65.7%
3679203 2004.1.1.135 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 0.72 54.0 3.85e-01 79.0% 37.1%
4664948 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.69 49.0 3.68e-01 77.4% 84.2%
3942031 2004.1.1.102 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › TerL_ATPase 0.67 52.0 3.38e-01 88.7% 24.4%
4809618 2004.1.1.30 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.67 58.0 4.53e-01 100.0% 67.1%
4031261 2004.1.1.102 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › TerL_ATPase 0.66 52.0 3.36e-01 90.3% 24.0%
3587034 2004.1.1.102 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › TerL_ATPase 0.66 52.0 3.36e-01 90.3% 23.7%
5016241 2003.1.5.55 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PrmA 0.65 46.0 3.00e-01 77.4% 25.5%
3937477 2004.1.1.30 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.65 51.0 3.73e-01 90.3% 61.6%
3713218 2004.1.1.30 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.64 52.0 4.27e-01 95.2% 70.4%
3219500 207.1.1.0 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats 0.63 49.0 3.19e-01 88.7% 22.8%
3434867 207.1.1.0 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats 0.63 48.0 3.09e-01 87.1% 32.2%
4640251 7570.1.1.1 ↗ a/b three-layered sandwiches › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › Mur_ligase_C 0.63 48.0 3.65e-01 87.1% 57.0%
4890330 2004.1.1.30 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.62 53.0 4.46e-01 98.4% 89.1%
3251180 7579.1.1.47 ↗ a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › BD-FAE 0.62 45.0 2.87e-01 80.6% 66.2%
4030806 7579.1.1.36 ↗ a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Abhydrolase_3 0.61 49.0 3.23e-01 90.3% 55.8%
3791564 2003.1.5.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.61 48.0 3.83e-01 90.3% 47.1%
3421589 207.1.1.79 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › F-box 0.61 50.0 3.11e-01 95.2% 35.3%
4928094 2002.1.1.8 ↗ a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Cellulase 0.60 47.0 3.02e-01 88.7% 34.9%
4069990 2007.1.19.4 ↗ a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › FabD/lysophospholipase-like › SAT 0.59 46.0 3.00e-01 85.5% 60.0%
1178351 2484.3.1.1 ↗ mixed a+b and a/b › Ribonuclease H-like › Creatinase/prolidase N-terminal domain › Creatinase/prolidase N-terminal domain › Creatinase_N 0.56 40.0 3.28e-01 79.0% 60.5%
5038089 4143.1.1.0 ↗ a+b two layers › THUMP domain-like › THUMP domain-like › THUMP domain-like 0.55 39.0 3.72e-01 75.8% 82.7%
3214497 2484.3.1.1 ↗ mixed a+b and a/b › Ribonuclease H-like › Creatinase/prolidase N-terminal domain › Creatinase/prolidase N-terminal domain › Creatinase_N 0.52 39.0 3.03e-01 83.9% 50.3%
4015411 4143.1.1.1 ↗ a+b two layers › THUMP domain-like › THUMP domain-like › THUMP domain-like › THUMP 0.50 35.0 2.90e-01 74.2% 49.6%