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helicase-primase_helicase_subunit

Euk-Vir

Cervid_alphaherpesvirus_3

helicase-primase_helicase_subunit__YP_010087597__Cervid_alphaherpesvirus_3__2115790

Identity

Accession:
YP_010087597 ↗
Protein ID:
helicase-primase_helicase_subunit
Kingdom:
euk

Quality

81.6 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› Cervid_alphaherpesvirus_3

TaxID: 2115790

Cluster

View cluster (90 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 111-202
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 52.9 2.40e-14 95.7% 8.8%
CATH (1)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2xqhA02 6.10.250.1970 Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.56 28.0 3.35e-01 70.7% 73.2%
ECOD (1)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4941848 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.54 43.0 2.95e-01 90.2% 95.7%
D2 medium residues 223-257_288-319
PDB
Domain cluster: representative
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 42.7 2.90e-11 55.2% 4.5%
PF02689.21 Herpes_Helicase 38.5 5.40e-10 52.2% 4.1%
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1hbxA01 3.40.1810.10 Alpha Beta › 3-Layer(aba) Sandwich › SRF-like › Transcription factor, MADS-box 0.51 40.0 4.01e-01 88.1% 98.6%
1pixA03 3.90.226.10 Alpha Beta › Alpha-Beta Complex › 2-enoyl-CoA Hydratase; Chain A, domain 1 › 2-enoyl-CoA Hydratase; Chain A, domain 1 0.51 39.0 2.56e-01 83.6% 46.5%
ECOD (2)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3175298 130.1.1.51 ↗ alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › LEM/SAP HeH motif › Tho1_MOS11_C 0.56 38.0 4.04e-01 85.1% 80.0%
3700981 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.52 36.0 3.81e-01 74.6% 98.3%
D3 medium residues 320-392_787-829
PDB
Domain cluster: rep: helicase-primase_ATPase_subunit__YP_010087484__Phascolarctid_gammaherpesvirus_1__2249313__D338-366_706-759
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 102.8 2.00e-29 63.8% 8.5%
PF02689.21 Herpes_Helicase 46.3 2.30e-12 42.2% 5.5%
D4 medium residues 393-470_746-786
PDB
Domain cluster: rep: helicase-primase_helicase_subunit__NP_045354__Bovine_alphaherpesvirus_1__10320__D392-469_736-760
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 78.0 6.40e-22 66.4% 9.5%
PF02689.21 Herpes_Helicase 56.4 2.20e-15 37.0% 5.2%
D5 medium residues 471-512_648-745
PDB
Domain cluster: rep: helicase-primase_helicase_subunit__YP_009137079__Human_alphaherpesvirus_1__10298__D496-518_696-779
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 64.5 7.50e-18 72.1% 11.5%
PF02689.21 Herpes_Helicase 38.8 4.50e-10 32.1% 5.2%
D6 medium residues 513-564_613-647
PDB
Domain cluster: rep: helicase-primase_helicase_subunit__NP_040177__Human_alphaherpesvirus_3__10335__D546-582_654-686
CATH (48)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2qgsB01 1.10.472.50 Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › HD-domain/PDEase-like 0.66 45.0 4.50e-01 92.0% 68.2%
3ay5A02 1.20.1410.10 Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain 0.66 57.0 4.63e-01 100.0% 50.3%
2ot4A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.65 55.0 5.21e-01 100.0% 77.6%
4hr1A00 1.20.1270.410 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.65 58.0 5.25e-01 100.0% 79.7%
6p73A02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.64 54.0 4.63e-01 100.0% 58.0%
3ed5A02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.63 39.0 4.00e-01 83.9% 64.3%
8hk0B03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.62 55.0 4.74e-01 100.0% 63.8%
2rldA00 1.20.1440.60 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence 0.62 50.0 4.58e-01 100.0% 67.5%
2gscC00 1.20.1440.60 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence 0.61 46.0 4.28e-01 96.6% 63.6%
2rfqC03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.61 54.0 4.32e-01 100.0% 54.3%
2jnsA01 1.20.1270.220 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.61 43.0 4.41e-01 94.3% 79.0%
3itfA00 1.20.120.1490 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.61 50.0 4.58e-01 88.5% 70.3%
6v9zA02 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.61 44.0 2.95e-01 75.9% 55.4%
1nu7D01 1.20.120.750 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Staphylcoagulase, helix bundle domain 1 0.60 54.0 4.67e-01 100.0% 78.5%
3owaB04 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.59 53.0 4.37e-01 100.0% 59.9%
2c5iT00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.59 39.0 3.87e-01 77.0% 62.8%
1h6gA02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.58 51.0 4.60e-01 100.0% 85.5%
4p9tA01 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.58 52.0 4.73e-01 100.0% 79.2%
8h72B01 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.58 40.0 2.83e-01 73.6% 82.6%
4l8iB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.58 39.0 3.60e-01 70.1% 61.6%
2oduA02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 38.0 3.58e-01 79.3% 55.2%
2q00B00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.57 50.0 4.49e-01 100.0% 80.3%
1t72A02 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.57 38.0 3.69e-01 75.9% 61.2%
2qkwA00 1.20.1270.140 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AvrPto 0.56 49.0 4.74e-01 100.0% 86.1%
3lnnB03 1.10.287.470 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.56 36.0 3.92e-01 73.6% 83.6%
1qv9A02 6.10.140.120 Special › Helix non-globular › Helix Hairpins › 0.56 49.0 4.68e-01 100.0% 85.4%
2yf4F00 1.10.3420.10 Mainly Alpha › Orthogonal Bundle › putative ntp pyrophosphohydrolase like fold › putative ntp pyrophosphohydrolase like domain 0.55 35.0 3.04e-01 71.3% 39.9%
3g67A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.54 36.0 2.79e-01 74.7% 28.2%
1vljA02 1.20.1090.10 Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain 0.54 40.0 3.17e-01 100.0% 34.1%
4iloA00 1.10.287.1490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.54 35.0 2.62e-01 74.7% 24.6%
3edvB01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.54 38.0 3.33e-01 74.7% 52.2%
1j1jA01 1.20.58.190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1 0.54 37.0 3.22e-01 70.1% 47.0%
1nktA04 1.10.3060.10 Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA 0.54 44.0 3.56e-01 92.0% 84.2%
3d36B02 1.10.287.130 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain 0.54 34.0 3.87e-01 71.3% 91.8%
3icxA01 1.10.287.660 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.54 38.0 4.08e-01 75.9% 97.3%
1wcrA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.53 37.0 3.58e-01 73.6% 62.1%
2w53B00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.52 40.0 3.26e-01 82.8% 71.1%
2q5zB00 1.10.287.1080 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like 0.52 34.0 3.31e-01 79.3% 59.6%
2oezA02 1.10.3900.10 Mainly Alpha › Orthogonal Bundle › YacF-like › YacF-like 0.52 45.0 3.77e-01 100.0% 78.5%
1q16C01 1.20.950.20 Mainly Alpha › Up-down Bundle › Fumarate Reductase Cytochrome B subunit › Transmembrane di-heme cytochromes, Chain C 0.52 45.0 3.48e-01 100.0% 94.4%
1s35A02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.52 36.0 3.43e-01 74.7% 58.2%
4dwlA00 1.20.1440.60 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence 0.52 42.0 4.02e-01 96.6% 74.1%
2wsiA00 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.52 45.0 3.20e-01 100.0% 67.0%
3iqtA01 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.52 36.0 3.37e-01 83.9% 56.1%
4gf0A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.51 39.0 3.63e-01 82.8% 66.4%
5ts9B00 1.20.59.10 Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase 0.51 42.0 3.44e-01 89.7% 93.8%
2wdqC00 1.20.1300.10 Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit 0.50 43.0 3.96e-01 100.0% 87.6%
4fbcA01 3.40.420.10 Alpha Beta › 3-Layer(aba) Sandwich › Ricin (A subunit); domain 1 › Ricin (A subunit), domain 1 0.50 39.0 3.13e-01 83.9% 95.4%
ECOD (39)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3507177 2484.1.1.204 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › PF27046, PF27073 0.70 48.0 3.05e-01 70.1% 52.9%
5023098 632.22.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.66 59.0 5.23e-01 100.0% 77.6%
3422266 3562.1.1.0 ↗ alpha bundles › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 0.64 57.0 5.10e-01 100.0% 76.8%
3581259 604.6.1.0 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.64 40.0 4.00e-01 74.7% 61.1%
4508874 632.11.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.63 56.0 5.51e-01 100.0% 91.6%
3461370 604.3.1.0 ↗ alpha bundles › Spectrin repeat-like › BAG domain › BAG domain 0.63 42.0 4.29e-01 70.1% 69.4%
5043412 1025.1.1.0 ↗ alpha bundles › Stonustoxin helical domain › Stonustoxin helical domain › Stonustoxin helical domain 0.63 56.0 5.12e-01 100.0% 86.1%
3249529 601.1.2.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.62 55.0 4.78e-01 100.0% 80.7%
3617266 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.61 55.0 4.98e-01 100.0% 80.8%
3437011 601.1.2.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.60 53.0 4.85e-01 100.0% 78.3%
3278154 191.1.1.8 ↗ alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_33 0.60 36.0 2.92e-01 89.7% 29.8%
3423731 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.60 52.0 4.56e-01 98.9% 73.3%
3306934 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.60 52.0 4.88e-01 100.0% 92.7%
5032080 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.59 41.0 3.75e-01 75.9% 53.9%
3834159 603.1.1.17 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE 0.58 42.0 3.37e-01 77.0% 56.1%
3854561 601.1.1.1 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Vinculin 0.58 51.0 4.41e-01 100.0% 65.7%
3269062 5001.1.1.0 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.58 51.0 3.48e-01 100.0% 35.1%
3226089 3998.1.1.1 ↗ alpha arrays › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Inhibitor_I29 0.58 37.0 3.99e-01 85.1% 74.7%
3276285 601.1.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.58 50.0 4.52e-01 100.0% 72.8%
3178900 192.2.1.30 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Uds1 0.57 38.0 3.26e-01 78.2% 40.7%
3471897 601.1.1.7 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Talin_IBS2B 0.57 49.0 4.32e-01 100.0% 63.6%
5047417 601.1.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.57 50.0 4.42e-01 100.0% 68.5%
3999930 603.1.1.105 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PF31021 0.57 37.0 3.49e-01 75.9% 52.7%
4025954 3758.1.1.0 ↗ alpha bundles › Bacterial hemolysins-like › Bacterial hemolysins › Bacterial hemolysins 0.56 49.0 3.50e-01 95.4% 45.2%
3837777 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.56 37.0 3.53e-01 75.9% 56.2%
3237761 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.56 40.0 3.82e-01 74.7% 65.0%
3187973 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.54 48.0 3.13e-01 98.9% 35.4%
3621306 150.1.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.54 47.0 4.06e-01 100.0% 82.1%
5065165 1075.5.1.4 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt 0.53 45.0 3.46e-01 100.0% 39.1%
2877633 141.1.1.3 ↗ alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › UbiA 0.53 44.0 3.15e-01 95.4% 49.8%
3594516 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.52 36.0 2.88e-01 72.4% 35.7%
3996707 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.52 35.0 3.29e-01 74.7% 54.5%
3704359 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.52 37.0 2.99e-01 75.9% 38.3%
3941457 1203.1.2.3 ↗ alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 › YiaAB 0.52 44.0 3.92e-01 92.0% 91.7%
3502636 5041.1.1.0 ↗ extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C 0.51 48.0 3.67e-01 100.0% 70.3%
3786522 604.6.1.22 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › EMC4 0.51 43.0 4.03e-01 95.4% 74.5%
5028356 601.7.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain 0.51 43.0 3.93e-01 100.0% 76.0%
3543620 604.1.1.95 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › KIAA1755_C 0.50 39.0 3.77e-01 80.5% 80.0%
4683248 5086.1.1.66 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › GNVR 0.50 35.0 3.07e-01 74.7% 47.1%