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helicase-primase_helicase_subunit
Euk-VirCercopithecine_alphaherpesvirus_2
helicase-primase_helicase_subunit__YP_164447__Cercopithecine_alphaherpesvirus_2__10317
Identity
- Accession:
- YP_164447 ↗
- Protein ID:
- helicase-primase_helicase_subunit
- Kingdom:
- euk
Quality
81.4
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Cercopithecine_alphaherpesvirus_2
TaxID: 10317
Cluster
View cluster (90 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 66-113_148-240_253-276
Domain cluster:
rep: helicase_subunit__YP_009179342__Elephant_endotheliotropic_herpesvirus_4__548914__D47-64_102-182_199-230
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 75.7 | 3.10e-21 | 71.5% | 13.7% |
| PF02689.21 | Herpes_Helicase | 50.9 | 9.50e-14 | 29.7% | 5.8% |
D2
medium
residues 365-420_799-854
Domain cluster:
rep: helicase-primase_ATPase_subunit__YP_010087484__Phascolarctid_gammaherpesvirus_1__2249313__D338-366_706-759
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 77.4 | 9.20e-22 | 50.9% | 6.9% |
| PF02689.21 | Herpes_Helicase | 83.6 | 1.20e-23 | 50.9% | 6.9% |
D3
medium
residues 421-493_774-798
Domain cluster:
rep: helicase-primase_helicase_subunit__NP_045354__Bovine_alphaherpesvirus_1__10320__D392-469_736-760
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 76.9 | 1.30e-21 | 76.5% | 9.0% |
D4
medium
residues 494-550_674-773
Domain cluster:
rep: helicase-primase_helicase_subunit__YP_009010991__Chimpanzee_herpesvirus_strain_105640__332937__D496-582_686-776
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02689.21 best | Herpes_Helicase | 84.2 | 8.20e-24 | 64.3% | 11.9% |
| PF02689.21 | Herpes_Helicase | 66.4 | 2.00e-18 | 38.2% | 7.0% |
D5
medium
residues 551-581_651-673
Domain cluster:
rep: helicase-primase_helicase_subunit__NP_040177__Human_alphaherpesvirus_3__10335__D546-582_654-686
CATH (28)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 8igrI01 | 2.40.270.10 | Mainly Beta › Beta Barrel › Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6 › DNA-directed RNA polymerase, subunit 2, domain 6 | 0.78 | 60.0 | 4.07e-01 | 81.5% | 25.6% |
| 2ffjA01 | 1.10.8.380 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Uncharacterised protein PF01937, DUF89, domain 1 | 0.73 | 58.0 | 5.82e-01 | 100.0% | 83.9% |
| 2x2vA00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.73 | 54.0 | 5.01e-01 | 79.6% | 67.6% |
| 4v1gA00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.72 | 55.0 | 4.71e-01 | 81.5% | 67.1% |
| 1ywmA02 | 1.20.1270.150 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Surface Active Protein | 0.70 | 60.0 | 5.38e-01 | 100.0% | 68.4% |
| 1sxjD03 | 1.20.272.10 | Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › | 0.70 | 56.0 | 4.77e-01 | 100.0% | 53.8% |
| 3r0qA02 | 2.70.160.11 | Mainly Beta › Distorted Sandwich › Hnrnp arginine n-methyltransferase1 › Hnrnp arginine n-methyltransferase1 | 0.69 | 52.0 | 3.41e-01 | 79.6% | 20.7% |
| 1r4gA00 | 1.10.8.10 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain | 0.68 | 47.0 | 4.76e-01 | 100.0% | 75.5% |
| 2ewfA03 | 3.40.91.50 | Alpha Beta › 3-Layer(aba) Sandwich › Restriction Endonuclease › | 0.68 | 59.0 | 3.88e-01 | 100.0% | 24.9% |
| 3n71A03 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.67 | 55.0 | 3.72e-01 | 94.4% | 62.0% |
| 4jd9G00 | 1.10.238.20 | Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › Pheromone/general odorant binding protein domain | 0.66 | 57.0 | 4.43e-01 | 100.0% | 61.7% |
| 1oizA01 | 1.10.8.20 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › N-terminal domain of phosphatidylinositol transfer protein sec14p | 0.65 | 40.0 | 3.69e-01 | 79.6% | 47.2% |
| 1c00A00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.63 | 54.0 | 3.17e-01 | 98.1% | 73.7% |
| 1cpyA02 | 1.10.287.410 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.62 | 52.0 | 4.82e-01 | 100.0% | 86.1% |
| 1xl7A01 | 1.10.275.20 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Choline/Carnitine o-acyltransferase | 0.60 | 53.0 | 4.30e-01 | 100.0% | 72.8% |
| 2i53A02 | 1.10.472.10 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like | 0.60 | 51.0 | 4.08e-01 | 100.0% | 47.7% |
| 5nl6A02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.58 | 41.0 | 3.34e-01 | 77.8% | 38.0% |
| 2qycA00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.57 | 49.0 | 4.02e-01 | 100.0% | 74.5% |
| 1vplA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.56 | 45.0 | 3.09e-01 | 100.0% | 25.6% |
| 4azcA02 | 1.20.1270.90 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like | 0.56 | 44.0 | 4.31e-01 | 100.0% | 83.1% |
| 1luwA01 | 1.10.287.990 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain | 0.54 | 41.0 | 3.88e-01 | 81.5% | 75.0% |
| 2fq3A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.54 | 45.0 | 3.89e-01 | 94.4% | 60.0% |
| 3gonA02 | 3.30.70.890 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › GHMP kinase, C-terminal domain | 0.54 | 43.0 | 3.33e-01 | 92.6% | 37.3% |
| 1yjgA00 | 1.20.120.240 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Lipoprotein, type 6 | 0.53 | 43.0 | 3.27e-01 | 100.0% | 51.0% |
| 3t46A00 | 1.20.1270.10 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.53 | 47.0 | 4.24e-01 | 100.0% | 72.0% |
| 1wkbA03 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.52 | 46.0 | 3.58e-01 | 100.0% | 47.9% |
| 1e3oC02 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.52 | 35.0 | 3.62e-01 | 96.3% | 77.1% |
| 2zueA03 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.52 | 45.0 | 3.46e-01 | 94.4% | 98.3% |
ECOD (40)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3965106 | 605.1.1.4 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA_3 | 0.76 | 53.0 | 4.77e-01 | 74.1% | 92.0% |
| None | — | 0.73 | 59.0 | 3.38e-01 | 100.0% | 8.9% | |
| 4034571 | 632.19.1.3 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Choline binding protein A › Choline binding protein A › DUF1542 | 0.69 | 57.0 | 5.28e-01 | 100.0% | 80.0% |
| 4940746 | 3457.1.1.1 ↗ | alpha bundles › GxGD membrane protease › GxGD membrane protease › GxGD membrane protease › Peptidase_A24 | 0.66 | 55.0 | 3.93e-01 | 100.0% | 35.0% |
| 4938670 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.65 | 53.0 | 4.85e-01 | 100.0% | 68.0% |
| 4382088 | 1175.1.1.1 ↗ | alpha complex topology › Apolipoprotein N-acyltransferase transmembrane domain › Apolipoprotein N-acyltransferase transmembrane domain › Apolipoprotein N-acyltransferase transmembrane domain › LNT_N | 0.65 | 48.0 | 3.07e-01 | 77.8% | 16.8% |
| 3036200 | 108.2.1.0 ↗ | alpha arrays › EF-hand › Insect pheromone/odorant-binding proteins › Insect pheromone/odorant-binding proteins | 0.65 | 55.0 | 4.30e-01 | 100.0% | 58.3% |
| 4114810 | 4049.1.1.1 ↗ | alpha superhelices › alpha-helical domain in siroheme synthase middle domains-like › alpha-helical domain in siroheme synthase middle domains-like › alpha-helical domain in siroheme synthase middle domains-like › CysG_dimeriser | 0.64 | 52.0 | 5.08e-01 | 100.0% | 83.3% |
| 4928347 | 304.48.1.4 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Guanylate_cyc | 0.64 | 56.0 | 3.93e-01 | 100.0% | 47.8% |
| 3775067 | 198.1.1.21 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapA, SapB_2 | 0.62 | 47.0 | 3.69e-01 | 83.3% | 57.5% |
| 5041397 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.62 | 52.0 | 4.61e-01 | 100.0% | 74.1% |
| 3396074 | 198.1.1.2 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_2,SapB_1 | 0.62 | 39.0 | 3.39e-01 | 83.3% | 40.0% |
| 4542315 | 304.1.1.1 ↗ | a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C | 0.61 | 51.0 | 3.82e-01 | 98.1% | 42.3% |
| 2741727 | 101.1.10.14 ↗ | alpha arrays › HTH › HTH › Cyclin-like › Cyclin_C_2 | 0.61 | 53.0 | 4.80e-01 | 100.0% | 76.3% |
| 3343753 | 101.1.10.7 ↗ | alpha arrays › HTH › HTH › Cyclin-like › Cyclin_C | 0.61 | 51.0 | 4.35e-01 | 100.0% | 55.8% |
| 4927152 | 4049.1.1.0 ↗ | alpha superhelices › alpha-helical domain in siroheme synthase middle domains-like › alpha-helical domain in siroheme synthase middle domains-like › alpha-helical domain in siroheme synthase middle domains-like | 0.61 | 49.0 | 4.77e-01 | 100.0% | 83.3% |
| 5048856 | 4033.1.1.1 ↗ | alpha arrays › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA_dh_N | 0.60 | 46.0 | 3.52e-01 | 83.3% | 36.8% |
| 5061333 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.60 | 49.0 | 4.92e-01 | 100.0% | 87.3% |
| 3473374 | 138.1.1.1 ↗ | alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › RFC1 | 0.60 | 52.0 | 3.96e-01 | 100.0% | 48.5% |
| 3495276 | 3826.1.1.0 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) | 0.60 | 44.0 | 3.25e-01 | 81.5% | 30.0% |
| 2845 | 101.1.10.17 ↗ | alpha arrays › HTH › HTH › Cyclin-like › CycT2-like_C | 0.60 | 51.0 | 4.10e-01 | 100.0% | 48.2% |
| 3923696 | 198.1.1.0 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like | 0.58 | 41.0 | 3.53e-01 | 74.1% | 78.9% |
| 4998428 | 304.1.1.1 ↗ | a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C | 0.58 | 49.0 | 3.67e-01 | 92.6% | 40.7% |
| 4943584 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.58 | 48.0 | 4.36e-01 | 100.0% | 72.5% |
| 3568856 | 198.1.1.1 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_2 | 0.58 | 44.0 | 3.86e-01 | 88.9% | 87.8% |
| 4955756 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.57 | 50.0 | 4.52e-01 | 100.0% | 78.7% |
| 4465007 | 3004.1.1.5 ↗ | alpha bundles › Hypothetical protein YfhH, N-terminal domain › Hypothetical protein YfhH, N-terminal domain › Hypothetical protein YfhH, N-terminal domain › FCD | 0.57 | 49.0 | 4.47e-01 | 100.0% | 74.7% |
| 3337428 | 7579.1.1.5 ↗ | a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Peptidase_S10 | 0.56 | 47.0 | 3.10e-01 | 100.0% | 20.4% |
| 2581423 | 632.18.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › hypothetical protein PA2901 › hypothetical protein PA2901 | 0.56 | 46.0 | 4.20e-01 | 100.0% | 67.9% |
| 1682983 | 3998.1.1.1 ↗ | alpha arrays › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Inhibitor_I29 | 0.56 | 49.0 | 4.21e-01 | 100.0% | 66.7% |
| 3577735 | 3998.1.1.1 ↗ | alpha arrays › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Inhibitor_I29 | 0.55 | 50.0 | 4.37e-01 | 100.0% | 68.8% |
| 3885048 | 3998.1.1.1 ↗ | alpha arrays › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Inhibitor_I29 | 0.55 | 49.0 | 4.39e-01 | 100.0% | 73.3% |
| 3498923 | 3998.1.1.1 ↗ | alpha arrays › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Inhibitor_I29 | 0.55 | 49.0 | 4.50e-01 | 100.0% | 78.6% |
| 3881339 | 3998.1.1.1 ↗ | alpha arrays › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Inhibitor_I29 | 0.55 | 48.0 | 4.45e-01 | 100.0% | 84.3% |
| 3626406 | 2004.1.1.29 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD | 0.55 | 48.0 | 3.13e-01 | 100.0% | 28.8% |
| 4984543 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.55 | 45.0 | 4.10e-01 | 100.0% | 83.7% |
| 3481568 | 3998.1.1.1 ↗ | alpha arrays › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Peptidase inhibitors family I29 › Inhibitor_I29 | 0.55 | 48.0 | 4.43e-01 | 100.0% | 78.6% |
| None | — | 0.54 | 48.0 | 3.00e-01 | 100.0% | 19.0% | |
| 3505989 | 198.1.1.0 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like | 0.52 | 37.0 | 3.16e-01 | 81.5% | 72.4% |
| 3520309 | 198.1.1.1 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_2 | 0.51 | 35.0 | 3.26e-01 | 75.9% | 58.7% |