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helicase-primase_primase_subunit
Euk-VirFalconid_herpesvirus_1
helicase-primase_primase_subunit__YP_009046553__Falconid_herpesvirus_1__1510155
Identity
- Accession:
- YP_009046553 ↗
- Protein ID:
- helicase-primase_primase_subunit
- Kingdom:
- euk
Quality
73.4
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Mardivirus›
Falconid_herpesvirus_1
TaxID: 1510155
Cluster
View cluster (58 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 359-435
Domain cluster:
representative
CATH (32)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5jazA03 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.71 | 58.0 | 5.49e-01 | 100.0% | 75.8% |
| 2y1eA03 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.71 | 48.0 | 4.62e-01 | 96.1% | 62.1% |
| 3iieB03 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.70 | 54.0 | 5.29e-01 | 100.0% | 75.3% |
| 6whcA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.67 | 40.0 | 2.84e-01 | 93.5% | 20.5% |
| 3a06B03 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.66 | 52.0 | 5.02e-01 | 100.0% | 77.3% |
| 2hqcA01 | 1.20.1640.10 | Mainly Alpha › Up-down Bundle › Multidrug efflux transporter AcrB transmembrane fold › Multidrug efflux transporter AcrB transmembrane domain | 0.65 | 56.0 | 4.13e-01 | 100.0% | 36.6% |
| 1u84A00 | 1.10.340.20 | Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Apc36109-like domain | 0.64 | 41.0 | 4.05e-01 | 94.8% | 60.5% |
| 1iuqA01 | 1.10.1200.50 | Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › Glycerol-3-phosphate acyltransferase, alpha helical bundle, N-terminal | 0.64 | 48.0 | 4.87e-01 | 100.0% | 84.2% |
| 3mzvA00 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.64 | 52.0 | 3.49e-01 | 100.0% | 22.7% |
| 4ymuD00 | 1.10.3720.10 | Mainly Alpha › Orthogonal Bundle › MetI-like fold › MetI-like | 0.64 | 49.0 | 3.64e-01 | 85.7% | 58.6% |
| 2mqaA00 | 1.10.274.60 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, repetitive domain | 0.63 | 55.0 | 4.74e-01 | 100.0% | 95.2% |
| 3of4A00 | 3.40.109.10 | Alpha Beta › 3-Layer(aba) Sandwich › NADH Oxidase › NADH Oxidase | 0.61 | 44.0 | 3.25e-01 | 76.6% | 46.9% |
| 5nl6A02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 45.0 | 4.06e-01 | 81.8% | 67.6% |
| 3tuiD01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.57 | 46.0 | 3.34e-01 | 100.0% | 29.3% |
| 6lo8F01 | 1.10.287.810 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Mitochondrial import inner membrane translocase subunit tim13 like domains | 0.57 | 41.0 | 4.28e-01 | 75.3% | 84.1% |
| 3gaeA00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.57 | 36.0 | 2.53e-01 | 97.4% | 19.4% |
| 2yksA02 | 1.20.58.390 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain | 0.57 | 41.0 | 3.65e-01 | 77.9% | 95.7% |
| 3e1tA01 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.56 | 49.0 | 3.46e-01 | 98.7% | 39.0% |
| 1kblA05 | 1.20.80.30 | Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › | 0.55 | 43.0 | 4.12e-01 | 100.0% | 73.0% |
| 7zxkC01 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.54 | 37.0 | 3.05e-01 | 71.4% | 98.7% |
| 6idxA01 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.54 | 35.0 | 2.59e-01 | 81.8% | 23.3% |
| 2yqyA00 | 1.20.120.450 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain | 0.53 | 46.0 | 3.99e-01 | 100.0% | 96.8% |
| 4azcA02 | 1.20.1270.90 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like | 0.53 | 37.0 | 4.10e-01 | 100.0% | 98.3% |
| 5dicA00 | 1.10.238.20 | Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › Pheromone/general odorant binding protein domain | 0.53 | 43.0 | 3.75e-01 | 87.0% | 59.1% |
| 3vouB00 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.52 | 39.0 | 3.36e-01 | 83.1% | 64.0% |
| 1yozA00 | 1.10.3200.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af0941 › AF0941-like | 0.52 | 36.0 | 3.24e-01 | 72.7% | 51.3% |
| 1f7uA02 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.52 | 40.0 | 3.47e-01 | 85.7% | 52.0% |
| 5a62A00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.52 | 44.0 | 3.12e-01 | 98.7% | 86.4% |
| 6xgzE01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.52 | 45.0 | 3.19e-01 | 100.0% | 39.1% |
| 7watB02 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.52 | 40.0 | 2.71e-01 | 98.7% | 20.4% |
| 1kxpD04 | 1.10.246.10 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › | 0.51 | 45.0 | 4.55e-01 | 100.0% | 100.0% |
| 2qnlA00 | 1.20.120.450 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain | 0.51 | 43.0 | 3.52e-01 | 98.7% | 91.4% |
ECOD (40)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3656623 | 101.1.10.7 ↗ | alpha arrays › HTH › HTH › Cyclin-like › Cyclin_C | 0.66 | 47.0 | 4.26e-01 | 100.0% | 55.2% |
| 3469670 | 1015.1.1.9 ↗ | alpha complex topology › Insulin-induced gene (Insig) homologs › Insulin-induced gene (Insig) homologs › Insulin-induced gene (Insig) homologs › CPP1-like | 0.65 | 58.0 | 5.24e-01 | 100.0% | 72.2% |
| 3759757 | 181.1.1.0 ↗ | alpha bundles › Domain of the SRP/SRP receptor G proteins-like › Domain of the SRP/SRP receptor G-proteins › Domain of the SRP/SRP receptor G-proteins | 0.64 | 57.0 | 5.14e-01 | 100.0% | 78.1% |
| 3699385 | 141.1.1.1 ↗ | alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › polyprenyl_synt | 0.64 | 54.0 | 3.52e-01 | 97.4% | 32.4% |
| 3805926 | 142.1.1.0 ↗ | alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors | 0.64 | 54.0 | 5.31e-01 | 100.0% | 87.1% |
| 3425074 | 103.9.1.2 ↗ | alpha arrays › RuvA-C › RanGAP2 N-terminal domain › RanGAP2 N-terminal domain › CPP1-like | 0.64 | 56.0 | 5.05e-01 | 100.0% | 70.9% |
| 4890335 | 5067.1.1.4 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › MMPL | 0.63 | 53.0 | 4.16e-01 | 100.0% | 42.7% |
| 4225289 | 166.1.1.1 ↗ | alpha superhelices › 1-deoxy-D-xylulose-5-phosphate reductoisomerase-C › 1-deoxy-D-xylulose-5-phosphate reductoisomerase-C › 1-deoxy-D-xylulose-5-phosphate reductoisomerase-C › DXPR_C | 0.63 | 55.0 | 4.88e-01 | 100.0% | 69.6% |
| 3438510 | 101.1.10.0 ↗ | alpha arrays › HTH › HTH › Cyclin-like | 0.62 | 44.0 | 4.11e-01 | 100.0% | 58.0% |
| 5022995 | 5067.1.1.4 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › MMPL | 0.62 | 53.0 | 4.09e-01 | 100.0% | 40.5% |
| 4024445 | 3871.1.1.1 ↗ | alpha duplicates or obligate multimers › PHIST › PHIST › PHIST › PRESAN | 0.62 | 54.0 | 4.52e-01 | 100.0% | 72.9% |
| 3787527 | 142.3.1.1 ↗ | alpha complex topology › Sigma2 domain-like › Mitochondrial morphogenesis protein Sld7 C-terminal domain › Mitochondrial morphogenesis protein Sld7 C-terminal domain › Sld7_C | 0.62 | 52.0 | 5.14e-01 | 98.7% | 95.3% |
| 3387847 | 1075.3.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC importer transmembrane domain fold › Type I ABC importer transmembrane domain fold › BPD_transp_1 | 0.61 | 50.0 | 3.56e-01 | 92.2% | 79.2% |
| 4433737 | 5067.1.1.1 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › ACR_tran | 0.61 | 51.0 | 3.80e-01 | 100.0% | 37.8% |
| 3692540 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.61 | 44.0 | 3.17e-01 | 76.6% | 38.7% |
| 3096486 | 5082.1.1.0 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like | 0.60 | 42.0 | 3.74e-01 | 74.0% | 67.0% |
| 4030179 | 181.1.1.0 ↗ | alpha bundles › Domain of the SRP/SRP receptor G proteins-like › Domain of the SRP/SRP receptor G-proteins › Domain of the SRP/SRP receptor G-proteins | 0.58 | 50.0 | 4.52e-01 | 100.0% | 71.4% |
| 3839145 | 2006.1.1.1 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › Hydrolase | 0.57 | 41.0 | 2.98e-01 | 75.3% | 81.8% |
| 3399352 | 5067.1.1.5 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Sterol-sensing | 0.57 | 48.0 | 3.47e-01 | 97.4% | 44.7% |
| 5028154 | 3831.1.1.0 ↗ | alpha bundles › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 › Secreted protein of unknown function DUF1311 | 0.56 | 49.0 | 4.19e-01 | 98.7% | 62.4% |
| 3270116 | 604.6.1.0 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain | 0.56 | 42.0 | 3.98e-01 | 81.8% | 78.9% |
| 5062016 | 604.5.1.0 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) | 0.56 | 41.0 | 3.86e-01 | 81.8% | 76.0% |
| 3412019 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.55 | 47.0 | 4.57e-01 | 100.0% | 93.3% |
| 3580283 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.55 | 42.0 | 4.15e-01 | 85.7% | 78.8% |
| 4555192 | 1079.1.1.5 ↗ | alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › DsbD_2 | 0.54 | 47.0 | 3.52e-01 | 98.7% | 48.5% |
| 3923873 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.53 | 40.0 | 3.41e-01 | 81.8% | 50.8% |
| 4447919 | 171.1.1.4 ↗ | alpha arrays › RNase III catalytic domain-like › RNase III catalytic domain-like › RNase III catalytic domain-like › Ribonucleas_3_3 | 0.53 | 43.0 | 3.48e-01 | 93.5% | 59.4% |
| 3402108 | 108.2.1.2 ↗ | alpha arrays › EF-hand › Insect pheromone/odorant-binding proteins › Insect pheromone/odorant-binding proteins › OBP47_like | 0.53 | 46.0 | 3.77e-01 | 100.0% | 59.3% |
| 5052864 | 171.1.1.1 ↗ | alpha arrays › RNase III catalytic domain-like › RNase III catalytic domain-like › RNase III catalytic domain-like › Ribonuclease_3 | 0.53 | 46.0 | 3.79e-01 | 100.0% | 69.0% |
| 4961745 | 7516.1.1.79 ↗ | a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glyco_trans_2_3 | 0.53 | 38.0 | 2.50e-01 | 80.5% | 15.8% |
| 3681226 | 3336.1.1.1 ↗ | alpha complex topology › plant-specific ROP nucleotide exchanger (PRONE) domain › plant-specific ROP nucleotide exchanger (PRONE) domain › plant-specific ROP nucleotide exchanger (PRONE) domain › PRONE | 0.53 | 40.0 | 2.74e-01 | 84.4% | 82.2% |
| 3221760 | 604.1.1.140 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › PF27005 | 0.52 | 41.0 | 3.98e-01 | 87.0% | 81.2% |
| 3688828 | 604.10.1.0 ↗ | alpha bundles › Spectrin repeat-like › Enzyme IIa from lactose specific PTS, IIa-lac › Enzyme IIa from lactose specific PTS, IIa-lac | 0.52 | 39.0 | 4.05e-01 | 81.8% | 91.4% |
| 4883357 | 171.1.1.4 ↗ | alpha arrays › RNase III catalytic domain-like › RNase III catalytic domain-like › RNase III catalytic domain-like › Ribonucleas_3_3 | 0.52 | 37.0 | 3.48e-01 | 77.9% | 63.6% |
| 4940379 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.51 | 36.0 | 3.21e-01 | 74.0% | 65.2% |
| 3174764 | 148.1.3.113 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › AAA_lid_TRIP13_C | 0.51 | 42.0 | 4.04e-01 | 97.4% | 81.1% |
| 3721449 | 7076.1.1.0 ↗ | 0.51 | 43.0 | 4.22e-01 | 97.4% | 91.8% | |
| 3952601 | 103.12.1.1 ↗ | alpha arrays › RuvA-C › ANTAR domain › ANTAR domain › ANTAR | 0.51 | 40.0 | 4.22e-01 | 90.9% | 97.1% |
| 4030161 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.50 | 43.0 | 3.66e-01 | 96.1% | 63.8% |
| 4982790 | 4163.1.1.1 ↗ | alpha bundles › GINS helical bundle-like › GINS helical bundle-like › PSF1 N-terminal domain-like › Sld5 | 0.50 | 36.0 | 3.38e-01 | 81.8% | 60.0% |
D2
high
residues 983-1116
Domain cluster:
rep: helicase-primase_primase_subunit__NP_944382__Psittacid_alphaherpesvirus_1__50294__D1138-1286
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03121.21 best | Herpes_UL52 | 83.3 | 1.20e-23 | 59.0% | 96.0% |
D3
medium
residues 20-69_112-203_216-255
D4
medium
residues 256-358
Domain cluster:
rep: helicase_primase_complex__NP_050224__Human_betaherpesvirus_6B__32604__D142-241
D5
medium
residues 447-472_830-982
D6
medium
residues 473-500_556-615_653-681
D7
medium
residues 616-652_682-742
Domain cluster:
representative
CATH (3)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3pivA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.56 | 40.0 | 3.43e-01 | 74.5% | 98.7% |
| 4dq5B00 | 1.10.530.50 | Mainly Alpha › Orthogonal Bundle › Lysozyme › Peptidase U40 | 0.54 | 43.0 | 3.63e-01 | 83.7% | 70.6% |
| 4q65A00 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.53 | 43.0 | 2.91e-01 | 92.9% | 87.0% |