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helicase-primase_primase_subunit
Euk-VirHuman_alphaherpesvirus_1
helicase-primase_primase_subunit__YP_009137128__Human_alphaherpesvirus_1__10298
Identity
- Accession:
- YP_009137128 ↗
- Protein ID:
- helicase-primase_primase_subunit
- Kingdom:
- euk
Quality
77.4
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Human_alphaherpesvirus_1
TaxID: 10298
Cluster
View cluster (58 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 439-475_502-619_655-681_784-870
Domain cluster:
representative
CATH (1)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2gukA00 | 3.30.2190.10 | Alpha Beta › 2-Layer Sandwich › PG1857-like › PG1857-like | 0.56 | 16.0 | 2.51e-01 | 83.3% | 56.8% |
ECOD (2)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3719042 | 862.1.1.0 ↗ | a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain | 0.56 | 44.0 | 4.78e-01 | 95.5% | 94.8% |
| 3608399 | 862.1.1.7 ↗ | a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain › PPL5 | 0.55 | 44.0 | 4.74e-01 | 97.0% | 94.0% |
D2
high
residues 913-1040
Domain cluster:
rep: helicase-primase_primase_subunit__NP_944382__Psittacid_alphaherpesvirus_1__50294__D1138-1286
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03121.21 best | Herpes_UL52 | 80.2 | 1.10e-22 | 60.2% | 96.0% |
D3
medium
residues 16-148_248-264
D4
medium
residues 149-170_187-227
Domain cluster:
representative
CATH (3)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4tpsD00 | 3.30.300.180 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › DnaA, N-terminal domain | 0.59 | 49.0 | 4.49e-01 | 93.7% | 85.7% |
| 3a98B01 | 6.10.10.90 | Special › Helix non-globular › Helicase, Ruva Protein; domain 3 › | 0.52 | 41.0 | 3.83e-01 | 98.4% | 69.1% |
| 4bkxA01 | 4.10.1240.50 | Few Secondary Structures › Irregular › Hormone receptor fold › | 0.51 | 38.0 | 3.22e-01 | 82.5% | 53.1% |
D5
medium
residues 316-410
D6
medium
residues 620-654_758-783
Domain cluster:
representative
CATH (20)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3u3lC00 | 3.40.33.10 | Alpha Beta › 3-Layer(aba) Sandwich › Pathogenesis-related Protein p14a › CAP | 0.62 | 45.0 | 3.17e-01 | 82.0% | 96.5% |
| 4x30A02 | 2.30.39.10 | Mainly Beta › Roll › Alpha-1-antitrypsin; domain 1 › Alpha-1-antitrypsin, domain 1 | 0.59 | 43.0 | 3.34e-01 | 78.7% | 90.3% |
| 3kg0A00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.58 | 49.0 | 4.21e-01 | 93.4% | 92.8% |
| 2chrA01 | 3.30.390.10 | Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain | 0.57 | 35.0 | 2.77e-01 | 78.7% | 29.9% |
| 3s2cJ01 | 2.60.40.1180 | Mainly Beta › Sandwich › Immunoglobulin-like › Golgi alpha-mannosidase II | 0.57 | 39.0 | 3.04e-01 | 73.8% | 59.3% |
| 1y14D01 | 3.30.1490.120 | Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › RNA polymerase Rpb7-like, N-terminal domain | 0.55 | 42.0 | 4.04e-01 | 86.9% | 97.3% |
| 1zpvA00 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.55 | 46.0 | 4.17e-01 | 95.1% | 70.6% |
| 2cy5A00 | 2.30.29.30 | Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) | 0.55 | 39.0 | 3.08e-01 | 96.7% | 35.7% |
| 5dnlA02 | 3.30.230.40 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › Imidazole glycerol phosphate dehydratase; domain 1 | 0.54 | 38.0 | 3.25e-01 | 75.4% | 99.0% |
| 1u8sA02 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.53 | 44.0 | 3.97e-01 | 91.8% | 96.4% |
| 2rilA00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.53 | 45.0 | 3.97e-01 | 100.0% | 72.6% |
| 1vk8A00 | 3.30.70.930 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.53 | 42.0 | 3.77e-01 | 100.0% | 59.1% |
| 5n0kA05 | 2.60.40.420 | Mainly Beta › Sandwich › Immunoglobulin-like › Cupredoxins - blue copper proteins | 0.53 | 40.0 | 2.94e-01 | 85.2% | 96.2% |
| 3n5fA02 | 3.30.70.360 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.52 | 43.0 | 3.59e-01 | 96.7% | 78.9% |
| 4oq1A01 | 2.60.40.4180 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.51 | 41.0 | 3.39e-01 | 91.8% | 92.6% |
| 2iboA00 | 3.30.70.930 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.51 | 39.0 | 3.46e-01 | 98.4% | 57.3% |
| 5is2A01 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.51 | 41.0 | 3.62e-01 | 90.2% | 87.9% |
| 3znuA00 | 3.30.70.1060 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Dimeric alpha+beta barrel | 0.51 | 38.0 | 3.40e-01 | 83.6% | 88.3% |
| 1u8sA01 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.51 | 42.0 | 3.77e-01 | 93.4% | 93.0% |
| 3p96A02 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.50 | 39.0 | 3.59e-01 | 88.5% | 98.8% |
ECOD (11)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4506614 | 304.12.1.1 ↗ | a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 › Ribosomal_S6 | 0.58 | 48.0 | 4.02e-01 | 93.4% | 83.5% |
| 5015213 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.55 | 47.0 | 3.59e-01 | 100.0% | 89.3% |
| 5014271 | 304.25.1.1 ↗ | a+b two layers › Alpha-beta plaits › Bacterial exopeptidase dimerisation domain › Bacterial exopeptidase dimerisation domain › M20_dimer | 0.54 | 46.0 | 3.77e-01 | 98.4% | 75.0% |
| 4030512 | 2008.1.1.7 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › ERCC4 | 0.54 | 44.0 | 3.10e-01 | 93.4% | 63.3% |
| 3969338 | 11.1.4.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Prealbumin-like | 0.53 | 36.0 | 2.93e-01 | 70.5% | 64.0% |
| 5250 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.53 | 43.0 | 3.90e-01 | 91.8% | 95.3% |
| 4008166 | 3115.1.1.10 ↗ | a+b two layers › GP2-like › RplX-like › RplX-like › PF27430 | 0.51 | 33.0 | 2.92e-01 | 100.0% | 41.1% |
| 2593098 | 304.139.2.1 ↗ | a+b two layers › Alpha-beta plaits › Cas7-related › CRISPR-associated protein Cas7f/Csy3 › Cas_Csy3 | 0.51 | 44.0 | 2.81e-01 | 100.0% | 71.8% |
| 3238788 | 5001.1.1.41 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srw | 0.51 | 43.0 | 2.73e-01 | 98.4% | 76.9% |
| 5249 | 304.8.1.9 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_6 | 0.51 | 42.0 | 3.77e-01 | 93.4% | 93.0% |
| 4323756 | 325.1.7.2 ↗ | a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif › RNA_pol_Rpb2_6 | 0.50 | 36.0 | 2.93e-01 | 80.3% | 100.0% |