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helicase-primase_primase_subunit

Euk-Vir

Equid_alphaherpesvirus_1

helicase-primase_primase_subunit__YP_053052__Equid_alphaherpesvirus_1__10326

Identity

Accession:
YP_053052 ↗
Protein ID:
helicase-primase_primase_subunit
Kingdom:
euk

Quality

77.7 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› Equid_alphaherpesvirus_1

TaxID: 10326

Cluster

View cluster (58 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 943-1076
PDB
Domain cluster: rep: helicase-primase_primase_subunit__NP_944382__Psittacid_alphaherpesvirus_1__50294__D1138-1286
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03121.21 best Herpes_UL52 81.0 6.50e-23 58.2% 96.0%
D2 medium residues 225-310
PDB
Domain cluster: rep: UL52__YP_003084367__Anatid_alphaherpesvirus_1__104388__D241-302
D3 medium residues 311-387
PDB
Domain cluster: representative
CATH (25)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2y39A00 1.20.120.1490 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.71 46.0 4.10e-01 79.2% 46.4%
4cb8A00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.70 53.0 3.18e-01 79.2% 13.1%
2yf4F00 1.10.3420.10 Mainly Alpha › Orthogonal Bundle › putative ntp pyrophosphohydrolase like fold › putative ntp pyrophosphohydrolase like domain 0.70 48.0 3.87e-01 80.5% 38.5%
2uv8A07 6.10.140.1410 Special › Helix non-globular › Helix Hairpins › 0.68 55.0 5.38e-01 89.6% 82.4%
2vkzA02 3.40.47.10 Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase 0.68 55.0 3.82e-01 89.6% 26.7%
2yfaA02 1.20.1440.210 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.67 52.0 4.58e-01 84.4% 100.0%
2oauA01 1.10.287.1260 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.66 51.0 4.73e-01 89.6% 63.7%
4dciA00 6.10.140.1110 Special › Helix non-globular › Helix Hairpins › 0.65 53.0 4.34e-01 89.6% 57.8%
2bdeA03 1.20.58.1160 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.65 45.0 4.59e-01 74.0% 71.4%
3r0qA02 2.70.160.11 Mainly Beta › Distorted Sandwich › Hnrnp arginine n-methyltransferase1 › Hnrnp arginine n-methyltransferase1 0.65 51.0 3.71e-01 84.4% 64.9%
4gzrC00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.65 47.0 5.18e-01 81.8% 98.4%
6mh4A03 1.10.1740.10 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif 0.64 42.0 4.24e-01 85.7% 65.8%
3lbxB01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 49.0 4.39e-01 81.8% 65.4%
2xokP00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.63 49.0 4.97e-01 84.4% 87.8%
3cwzB01 1.20.58.900 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › RUN domain 0.62 45.0 3.61e-01 75.3% 41.1%
6aveA01 1.10.287.770 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like 0.62 41.0 4.24e-01 79.2% 71.6%
2qywA00 1.20.58.400 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins 0.61 44.0 4.17e-01 85.7% 62.1%
3v9pB00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.61 46.0 3.42e-01 80.5% 32.7%
4ioeA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.59 47.0 4.51e-01 85.7% 77.0%
4b6xA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 39.0 4.08e-01 74.0% 100.0%
4ijjB00 1.20.120.910 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › DksA, coiled-coil domain 0.55 48.0 4.07e-01 100.0% 76.2%
3favD00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.54 44.0 4.42e-01 90.9% 94.9%
3h6pC00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.53 36.0 4.00e-01 75.3% 100.0%
1gnlA01 1.20.1270.20 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.51 45.0 3.72e-01 97.4% 77.0%
5jnmA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.50 41.0 3.19e-01 90.9% 57.5%
ECOD (34)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4940986 5058.1.1.0 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.78 62.0 5.80e-01 89.6% 70.5%
3278450 547.1.1.1 ↗ alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer 0.77 67.0 6.61e-01 94.8% 93.8%
4623986 2003.1.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.76 69.0 4.76e-01 100.0% 32.4%
None — 0.76 68.0 4.62e-01 100.0% 30.4%
4541657 547.1.1.1 ↗ alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer 0.75 65.0 6.46e-01 94.8% 96.2%
3457079 605.1.1.150 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › IQ 0.74 51.0 4.65e-01 85.7% 55.0%
4996194 5058.1.1.0 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.73 56.0 5.33e-01 81.8% 71.1%
4964984 5058.1.1.0 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.72 58.0 5.33e-01 88.3% 70.0%
3971072 5058.1.1.0 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.71 53.0 4.98e-01 80.5% 75.8%
1877692 6026.1.1.1 ↗ alpha duplicates or obligate multimers › cwf21 domain › cwf21 domain › cwf21 domain › cwf21 0.70 43.0 5.09e-01 77.9% 100.0%
3218921 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.70 57.0 5.15e-01 92.2% 67.9%
3174635 4207.1.1.102 ↗ alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › RNA polymerase II holoenzyme component SRB7 (MED21) › PF29925 0.70 56.0 5.36e-01 88.3% 83.3%
3518978 4009.1.1.0 ↗ alpha bundles › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins 0.69 59.0 5.59e-01 98.7% 80.0%
4951918 5058.1.1.0 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.69 53.0 5.01e-01 89.6% 68.4%
3993361 622.4.1.41 ↗ alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related › DUF7753 0.69 53.0 5.71e-01 87.0% 100.0%
4964387 5058.1.1.0 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.68 54.0 5.04e-01 88.3% 71.0%
5040843 5058.1.1.0 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.68 55.0 5.17e-01 89.6% 73.7%
4950718 246.3.1.1 ↗ a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › Exo_endo_phos 0.67 56.0 3.73e-01 93.5% 88.5%
3582573 192.24.1.0 ↗ alpha bundles › Long alpha-hairpin › RPC62 helical hairpin domain › RPC62 helical hairpin domain 0.67 47.0 4.17e-01 72.7% 51.8%
3630104 192.24.1.6 ↗ alpha bundles › Long alpha-hairpin › RPC62 helical hairpin domain › RPC62 helical hairpin domain › RNA_pol_Rpc82, HTH_9, POLR3C_WHD 0.67 47.0 2.98e-01 72.7% 15.0%
3945095 601.33.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain 0.65 52.0 4.72e-01 88.3% 69.5%
3739839 5063.1.1.0 ↗ alpha bundles › Photosystem I reaction center subunit X, PsaK › Photosystem I reaction center subunit X, PsaK › Photosystem I reaction center subunit X, PsaK 0.65 54.0 4.83e-01 93.5% 70.9%
3644932 5069.1.3.62 ↗ alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › Mito_carr 0.65 47.0 4.10e-01 83.1% 48.8%
4462775 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.65 53.0 4.85e-01 92.2% 86.7%
3623842 601.24.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) › FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) 0.64 47.0 4.03e-01 81.8% 48.0%
3242284 1075.1.2.13 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain › CNNM 0.64 55.0 4.54e-01 100.0% 54.7%
4981299 5058.1.1.0 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.63 50.0 4.69e-01 89.6% 72.0%
4983511 7064.1.1.1 ↗ alpha bundles › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › VIT1 0.63 54.0 4.40e-01 97.4% 52.0%
4217669 2003.1.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.63 53.0 3.88e-01 100.0% 32.9%
5054557 604.3.1.0 ↗ alpha bundles › Spectrin repeat-like › BAG domain › BAG domain 0.59 49.0 4.70e-01 98.7% 78.9%
3899945 3937.1.1.0 ↗ alpha bundles › Connexin 26 › Connexin 26 › Connexin 26 0.59 51.0 3.31e-01 98.7% 66.0%
3198546 4120.1.1.63 ↗ few secondary structure elements › Tim10/DDP › Tim10/DDP › Tim10/DDP › PF30356 0.59 44.0 3.78e-01 83.1% 57.0%
3666876 5058.1.1.0 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.57 45.0 3.94e-01 92.2% 57.7%
3571351 5086.1.1.116 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › Tcp11 0.53 38.0 3.22e-01 100.0% 43.7%
D4 medium residues 388-445
PDB
Domain cluster: representative
D5 medium residues 446-473_524-571
PDB
Domain cluster: rep: helicase-primase_primase_subunit__YP_001033982__Gallid_alphaherpesvirus_2__10390__D447-473_538-595
D6 medium residues 605-705_791-942
PDB
Domain cluster: rep: NTPase,_DNA_primase__YP_009408038__Eptesipox_virus__1329402__D10-229