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helicase-primase_primase_subunit

Euk-Vir

Suid_alphaherpesvirus_1

helicase-primase_primase_subunit__YP_068322__Suid_alphaherpesvirus_1__10345

Identity

Accession:
YP_068322 ↗
Protein ID:
helicase-primase_primase_subunit
Kingdom:
euk

Quality

79.4 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 5-215_234-260
PDB
D2 high residues 823-944
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03121.21 best Herpes_UL52 77.3 9.30e-22 57.4% 96.0%
CATH (28)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1h91A00 2.40.128.20 Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain 0.66 45.0 3.95e-01 97.5% 47.2%
2imjD01 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.59 44.0 4.24e-01 78.7% 82.4%
2x8fA02 2.40.128.10 Mainly Beta › Beta Barrel › Lipocalin › 0.57 42.0 4.71e-01 84.4% 100.0%
7dd9A02 2.70.98.30 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › Golgi alpha-mannosidase II; domain 4 0.57 45.0 3.59e-01 86.1% 93.4%
3ia8A00 2.40.128.20 Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain 0.57 48.0 4.40e-01 92.6% 96.3%
4bboA00 2.40.128.30 Mainly Beta › Beta Barrel › Lipocalin › Avidin-like 0.56 45.0 4.72e-01 96.7% 93.8%
2fwvA00 2.40.128.20 Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain 0.56 49.0 4.24e-01 95.1% 94.7%
3eyrA00 3.15.10.40 Alpha Beta › Super Roll › Bactericidal permeability-increasing protein; domain 1 › Uncharacterised protein PF07273 family, DUF1439 0.56 48.0 4.32e-01 95.1% 74.0%
4r1kB00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.55 46.0 4.48e-01 91.0% 97.8%
3hx8A00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.55 43.0 4.27e-01 83.6% 100.0%
3soyA00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.55 43.0 4.17e-01 85.2% 100.0%
4bj8K00 2.40.128.30 Mainly Beta › Beta Barrel › Lipocalin › Avidin-like 0.55 47.0 4.78e-01 99.2% 96.7%
3d9rB00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.54 41.0 4.04e-01 80.3% 96.2%
4fuvA00 2.40.160.170 Mainly Beta › Beta Barrel › Porin › 0.54 43.0 3.67e-01 87.7% 97.2%
3ff2A00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.54 40.0 4.12e-01 78.7% 100.0%
3er7B00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.54 38.0 3.86e-01 73.8% 98.4%
1wnhA01 3.10.450.10 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.53 39.0 4.26e-01 78.7% 95.0%
6dnzA02 2.70.160.11 Mainly Beta › Distorted Sandwich › Hnrnp arginine n-methyltransferase1 › Hnrnp arginine n-methyltransferase1 0.53 42.0 3.73e-01 84.4% 100.0%
3doaA01 2.30.310.10 Mainly Beta › Roll › ibrinogen binding protein from staphylococcus aureus fold › ibrinogen binding protein from staphylococcus aureus domain 0.53 47.0 4.40e-01 98.4% 88.2%
3kg6C00 3.10.129.110 Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Polyketide synthase dehydratase 0.53 41.0 3.15e-01 81.1% 85.2%
5is8A02 2.70.160.11 Mainly Beta › Distorted Sandwich › Hnrnp arginine n-methyltransferase1 › Hnrnp arginine n-methyltransferase1 0.53 42.0 3.66e-01 87.7% 91.5%
3h51A00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.53 42.0 4.01e-01 85.2% 88.7%
4fczA00 3.10.450.710 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › Tgt2/MlaC 0.52 44.0 3.85e-01 92.6% 82.0%
5dstA02 2.70.160.11 Mainly Beta › Distorted Sandwich › Hnrnp arginine n-methyltransferase1 › Hnrnp arginine n-methyltransferase1 0.52 41.0 3.70e-01 86.9% 100.0%
3f1tB00 3.10.129.10 Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Hotdog Thioesterase 0.51 41.0 4.05e-01 88.5% 98.5%
2r5rA00 3.10.270.10 Alpha Beta › Roll › Urate Oxidase › Urate Oxidase; 0.51 42.0 3.38e-01 91.0% 63.4%
5dl7A00 2.40.160.10 Mainly Beta › Beta Barrel › Porin › Porin 0.51 42.0 3.00e-01 92.6% 60.9%
3bgaA05 2.70.98.10 Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › 0.50 44.0 3.47e-01 98.4% 97.0%
ECOD (28)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3408795 12.1.1.60 beta sandwiches › Glycosyl hydrolase domain-like › Glycosyl hydrolase domain › Glycosyl hydrolase domain › Chitin_bind_4 0.63 29.0 3.90e-01 91.8% 83.6%
3486056 223.2.1.0 a+b three layers › Profilin-like › profilin-like › profilin-like 0.63 42.0 3.94e-01 93.4% 55.0%
3414586 11.1.1.824 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Chitin_bind_4 0.63 30.0 3.35e-01 93.4% 57.0%
4348187 243.3.1.0 a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin 0.63 41.0 4.69e-01 87.7% 94.1%
3466699 243.3.1.0 a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin 0.61 42.0 4.63e-01 77.0% 88.8%
3270456 331.3.1.17 a+b two layers › TBP-like › Bet v1-like › Bet v1-like › VASt 0.60 46.0 3.97e-01 95.1% 50.8%
3228525 241.15.1.0 a+b two layers › Type III secretory system chaperone-like › FP (Fbxo7/PI31) dimerization domain › FP (Fbxo7/PI31) dimerization domain 0.60 42.0 4.47e-01 96.7% 80.9%
None 0.60 42.0 3.48e-01 94.3% 39.5%
3934854 243.3.1.0 a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin 0.58 47.0 4.44e-01 87.7% 78.7%
3733248 243.1.1.0 a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.57 43.0 3.99e-01 80.3% 82.5%
3179489 216.1.1.4 a+b two layers › UBC-like › UBC-like › UBC-like › RWD 0.57 41.0 3.99e-01 100.0% 66.4%
3247589 243.1.1.0 a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.57 43.0 4.22e-01 80.3% 95.5%
3697793 206.1.1.10 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Choline_kinase 0.56 47.0 3.15e-01 91.8% 61.4%
3544803 331.3.1.17 a+b two layers › TBP-like › Bet v1-like › Bet v1-like › VASt 0.56 43.0 3.74e-01 94.3% 51.8%
3412007 292.2.1.13 a+b two layers › RIP/Polo-box domain › Polo-box domain › Polo-box domain › Chitin_bind_4 0.55 31.0 3.95e-01 97.5% 97.1%
4957055 708.1.1.0 beta complex topology › ETN0001 domain-like › ETN0001 domain-like › NAC/WRKY/GCM/WOPR domain 0.54 33.0 4.00e-01 77.9% 97.3%
3799143 292.2.1.0 a+b two layers › RIP/Polo-box domain › Polo-box domain › Polo-box domain 0.54 42.0 4.07e-01 97.5% 73.3%
3400513 77.1.1.4 beta meanders › open-sided beta-meander › Outer surface protein › Outer surface protein › Chitin_bind_4 0.53 34.0 4.05e-01 90.2% 100.0%
4888729 243.19.1.0 a+b two layers › Cystatin-like › Phi ETA orf 56-like protein C-terminal domains › Phi ETA orf 56-like protein C-terminal domains 0.53 36.0 3.81e-01 82.0% 78.3%
5002369 243.1.1.0 a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.53 42.0 4.33e-01 84.4% 99.1%
3429047 5084.5.1.0 beta barrels › Outer membrane meander beta-barrels › Porins › Porin 0.52 43.0 3.28e-01 90.2% 42.7%
3783541 708.1.1.6 beta complex topology › ETN0001 domain-like › ETN0001 domain-like › NAC/WRKY/GCM/WOPR domain › Gti1_Pac2 0.52 36.0 3.32e-01 72.1% 70.3%
3217508 243.1.1.97 a+b two layers › Cystatin-like › NTF2-like › NTF2-like › DUF5382_N 0.52 40.0 4.05e-01 83.6% 100.0%
4451874 222.1.1.12 a+b two layers › Thioesterase/thiol ester dehydrase-isomerase-like › Thioesterase/thiol ester dehydrase-isomerase › Thioesterase/thiol ester dehydrase-isomerase › PS-DH 0.51 43.0 3.73e-01 90.2% 78.9%
4464528 243.1.1.0 a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.51 39.0 4.13e-01 82.0% 100.0%
4976692 844.1.1.0 beta barrels › Transcriptional factor tubby, C-terminal domain › Transcriptional factor tubby, C-terminal domain › Transcriptional factor tubby, C-terminal domain 0.51 41.0 3.28e-01 86.9% 42.9%
3169052 3561.1.1.1 a+b complex topology › Mediator of RNA polymerase II transcription subunit 17 › Mediator of RNA polymerase II transcription subunit 17 › Mediator of RNA polymerase II transcription subunit 17 › Med17 0.51 44.0 3.03e-01 99.2% 44.0%
4015605 3385.1.1.0 beta barrels › Allergen Alt a 1 › Allergen Alt a 1 › Allergen Alt a 1 0.51 44.0 3.90e-01 94.3% 68.0%
D3 medium residues 216-233_265-335
PDB
D4 medium residues 371-392_494-588_680-818
PDB
CATH (20)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4djbA00 3.30.70.2870 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Mastadenovirus E4 ORF3 0.66 32.0 4.58e-01 83.6% 99.2%
4fprB00 3.30.70.2910 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.65 33.0 4.53e-01 88.3% 95.3%
1ekrA00 3.30.70.640 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Molybdopterin cofactor biosynthesis C (MoaC) domain 0.64 35.0 4.51e-01 87.1% 92.3%
4j37A01 3.30.70.580 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Pseudouridine synthase I, catalytic domain, N-terminal subdomain 0.62 28.0 4.14e-01 87.5% 96.3%
2nyiA02 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.62 25.0 3.95e-01 86.7% 98.9%
3d2uA02 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.62 23.0 3.74e-01 86.3% 90.2%
1ivzA00 3.30.70.960 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › SEA domain 0.62 32.0 4.33e-01 80.5% 94.7%
5xoyB02 3.30.70.360 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.62 28.0 4.20e-01 82.4% 100.0%
1f3vA00 3.30.70.680 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › TRADD, N-terminal domain 0.61 34.0 4.24e-01 85.2% 87.3%
1lq9A00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.60 28.0 4.06e-01 78.5% 98.2%
5wy8B03 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.59 25.0 3.65e-01 71.1% 86.6%
4q7aC02 3.30.70.360 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 27.0 3.99e-01 86.3% 100.0%
3io1A02 3.30.70.360 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.58 28.0 4.05e-01 85.2% 100.0%
2cc6A00 3.30.1660.10 Alpha Beta › 2-Layer Sandwich › Dodecin subunit-like › Flavin-binding protein dodecin 0.55 17.0 3.17e-01 85.9% 100.0%
1m55A00 3.40.1310.20 Alpha Beta › 3-Layer(aba) Sandwich › Replication Protein E1; Chain: A, › 0.54 37.0 4.25e-01 77.0% 91.2%
1pbuA00 3.30.70.1010 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Translation elongation factor EF1B, gamma chain, conserved domain 0.54 34.0 4.12e-01 84.8% 96.9%
5a2fA02 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.53 25.0 3.50e-01 71.5% 94.6%
4kw3A00 3.40.1310.20 Alpha Beta › 3-Layer(aba) Sandwich › Replication Protein E1; Chain: A, › 0.52 40.0 4.03e-01 79.7% 98.5%
3f8uB02 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.52 26.0 3.56e-01 72.3% 94.4%
6wl5A01 3.20.80.10 Alpha Beta › Alpha-Beta Barrel › Multidrug-efflux Transporter 1 Regulator Bmrr; Chain A › Regulatory factor, effector binding domain 0.51 29.0 3.74e-01 74.2% 96.0%
ECOD (38)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3512046 862.1.1.0 a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain 0.71 60.0 6.06e-01 87.1% 91.8%
3608399 862.1.1.7 a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain › PPL5 0.71 58.0 6.09e-01 87.5% 91.5%
3717917 862.1.1.0 a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain 0.71 60.0 5.25e-01 87.9% 93.1%
4673704 862.1.1.0 a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain 0.70 60.0 5.79e-01 87.5% 80.7%
3596656 862.1.1.0 a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain 0.70 59.0 5.75e-01 86.7% 91.6%
3715696 862.1.1.0 a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain 0.70 59.0 5.64e-01 87.1% 89.2%
4001493 862.1.1.0 a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain 0.69 57.0 5.92e-01 85.9% 92.1%
4933653 304.31.1.1 a+b two layers › Alpha-beta plaits › HMG-CoA reductase › NAD-binding domain of HMG-CoA reductase › HMG-CoA_red 0.69 33.0 4.77e-01 80.9% 100.0%
4943953 304.31.1.1 a+b two layers › Alpha-beta plaits › HMG-CoA reductase › NAD-binding domain of HMG-CoA reductase › HMG-CoA_red 0.69 33.0 4.76e-01 80.5% 100.0%
3626314 862.1.1.11 a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain › AEP_C962R 0.68 57.0 5.84e-01 86.7% 89.2%
3621161 304.47.1.0 a+b two layers › Alpha-beta plaits › SEA domain › SEA domain 0.68 34.0 4.82e-01 84.8% 100.0%
3993060 304.47.1.1 a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA 0.68 34.0 4.77e-01 85.2% 100.0%
3582249 304.47.1.1 a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA 0.66 31.0 4.57e-01 89.5% 99.1%
3619535 304.47.1.1 a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA 0.65 30.0 4.43e-01 82.0% 97.3%
3717098 862.1.1.7 a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain › PPL5 0.65 56.0 5.32e-01 88.3% 93.8%
1124197 304.141.1.1 a+b two layers › Alpha-beta plaits › Avirulence Effector AvrLm4-7 › Avirulence Effector AvrLm4-7 › AvrLm4-7 0.65 33.0 4.54e-01 89.1% 95.4%
4236888 304.10.1.0 a+b two layers › Alpha-beta plaits › RuBisCO, large subunit, small (N-terminal) domain › RuBisCO, large subunit, small (N-terminal) domain 0.65 29.0 4.35e-01 83.6% 97.3%
3883294 304.47.1.1 a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA 0.65 34.0 4.66e-01 71.1% 98.5%
3753506 304.47.1.1 a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA 0.64 33.0 4.50e-01 84.4% 96.9%
3611742 304.42.1.1 a+b two layers › Alpha-beta plaits › Molybdenum cofactor biosynthesis protein C, MoaC › Molybdenum cofactor biosynthesis protein C, MoaC › MoaC 0.61 35.0 4.39e-01 89.5% 92.8%
3934872 3122.1.1.2 a+b complex topology › MESD › MESD › MESD › SCVP 0.60 27.0 4.06e-01 75.4% 100.0%
1219773 11.1.1.96 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › C1-set 0.59 22.0 3.44e-01 85.9% 85.6%
4053989 304.9.1.71 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › SNU71_RBD 0.58 31.0 4.03e-01 85.5% 90.7%
3770950 304.47.1.1 a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA 0.58 32.0 4.28e-01 82.8% 100.0%
3609026 304.20.1.0 a+b two layers › Alpha-beta plaits › PAP/Archaeal CCA-adding enzyme, C-terminal domain › PAP/Archaeal CCA-adding enzyme, C-terminal domain 0.58 34.0 4.32e-01 77.7% 99.3%
3635748 304.25.1.0 a+b two layers › Alpha-beta plaits › Bacterial exopeptidase dimerisation domain › Bacterial exopeptidase dimerisation domain 0.57 29.0 4.05e-01 84.4% 100.0%
3559614 304.47.1.1 a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA 0.56 33.0 4.21e-01 84.8% 100.0%
4030594 304.46.1.1 a+b two layers › Alpha-beta plaits › eEF1-gamma domain › eEF1-gamma domain › EF1G 0.56 34.0 4.19e-01 78.9% 95.0%
3588046 304.55.1.14 a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Origin of replication-binding domains › Y2_Tnp 0.53 40.0 4.04e-01 77.3% 100.0%
4007464 304.55.1.19 a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Origin of replication-binding domains › Inovirus_Gp2 0.53 38.0 4.33e-01 72.7% 100.0%
4170426 304.8.1.70 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › Phage_GPA 0.52 41.0 4.00e-01 81.2% 92.3%
3986356 304.55.1.14 a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Origin of replication-binding domains › Y2_Tnp 0.52 40.0 3.90e-01 78.1% 91.8%
4511949 304.48.1.74 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Phage_GPA 0.52 41.0 4.24e-01 81.2% 90.8%
4315665 304.8.1.91 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › DUF1424 0.52 39.0 4.29e-01 79.7% 94.8%
3679255 304.55.1.15 a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Origin of replication-binding domains › Helitron_like_N 0.52 27.0 3.71e-01 75.4% 98.5%
4962041 304.55.1.0 a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Origin of replication-binding domains 0.51 36.0 3.98e-01 71.1% 97.5%
3968511 304.45.1.1 a+b two layers › Alpha-beta plaits › 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK › 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK › HPPK 0.50 34.0 3.97e-01 83.6% 97.7%
None 0.50 37.0 3.79e-01 74.2% 95.9%