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helicase-primase_subunit

Euk-Vir

Cercopithecine_alphaherpesvirus_9

helicase-primase_subunit__NP_077466__Cercopithecine_alphaherpesvirus_9__35246

Identity

Accession:
NP_077466 ↗
Protein ID:
helicase-primase_subunit
Kingdom:
euk

Quality

87.3 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› Cercopithecine_alphaherpesvirus_9

TaxID: 35246

Cluster

View cluster (61 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 7-159_237-259_278-314
PDB
Domain cluster: rep: helicase-primase_subunit__YP_009010994__Chimpanzee_herpesvirus_strain_105640__332937__D1-146_230-250_272-307
CATH (5)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2jq5A00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.65 21.0 2.75e-01 75.6% 46.9%
2k5qA00 2.40.50.480 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Protein of unknown function DUF1093 0.61 30.0 4.06e-01 70.9% 91.4%
3er7B00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.58 21.0 2.76e-01 72.3% 52.8%
1of5B00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.53 24.0 3.05e-01 76.1% 68.8%
3n8bA00 3.10.450.700 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.52 18.0 2.92e-01 95.3% 82.7%
ECOD (5)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3941717 243.3.1.0 ↗ a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin 0.66 22.0 3.34e-01 74.2% 69.3%
3678591 243.3.1.12 ↗ a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin › SQAPI 0.63 22.0 3.28e-01 75.1% 70.0%
3468093 243.3.1.19 ↗ a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin › DUF3615 0.60 24.0 3.35e-01 78.4% 73.5%
5003654 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.51 21.0 3.27e-01 74.2% 100.0%
3828737 243.1.1.2 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like › NTF2 0.51 23.0 3.08e-01 75.6% 76.7%
D2 medium residues 394-418_483-590
PDB
Domain cluster: rep: NC_004735.1__NP_835679.1__Rm378p092__00092__D1-33_185-289
D3 medium residues 419-482
PDB
Domain cluster: representative
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4gpkF02 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.58 44.0 3.04e-01 85.9% 74.2%
4p3yB00 3.40.30.10 Alpha Beta › 3-Layer(aba) Sandwich › Glutaredoxin › Glutaredoxin 0.56 46.0 3.47e-01 100.0% 37.0%
1oq4A00 1.10.620.20 Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A 0.54 41.0 2.70e-01 87.5% 41.3%
2go7A02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.53 46.0 4.54e-01 100.0% 95.5%
ECOD (1)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3240158 3525.1.1.0 ↗ alpha arrays › Bromodomain-containing protein 4 ET domain › Bromodomain-containing protein 4 ET domain › Bromodomain-containing protein 4 ET domain 0.64 43.0 3.91e-01 70.3% 78.9%
D4 medium residues 591-765
PDB
Domain cluster: rep: helicase-primase_subunit__YP_009342398__Spheniscid_alphaherpesvirus_1__2560777__D627-772
CATH (31)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3udcA01 1.10.287.1260 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.75 34.0 4.16e-01 72.6% 66.1%
6xxvC00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.70 42.0 5.13e-01 89.1% 92.8%
4l8iB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.70 43.0 5.33e-01 90.3% 97.3%
4oydB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.68 43.0 5.15e-01 89.1% 94.9%
2cazD00 6.10.140.820 Special › Helix non-globular › Helix Hairpins › 0.65 22.0 3.73e-01 81.1% 88.3%
3cqcB01 1.20.58.1380 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 25.0 3.36e-01 85.1% 67.8%
1aj3A00 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 35.0 4.47e-01 92.0% 96.9%
3s63A00 1.10.225.10 Mainly Alpha › Orthogonal Bundle › NK-Lysin › Saposin-like 0.61 25.0 3.38e-01 85.7% 70.5%
3hr0B01 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.61 27.0 3.75e-01 74.9% 87.3%
1gaxA05 1.10.287.380 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain 0.60 24.0 3.70e-01 76.0% 87.7%
8ek4A01 1.20.120.20 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein 0.60 41.0 4.57e-01 90.3% 89.5%
6pnjL00 1.20.1240.10 Mainly Alpha › Up-down Bundle › Photosystem 1 Reaction Centre Subunit Xi; Chain: L; › Photosystem I PsaL, reaction centre subunit XI 0.58 38.0 3.98e-01 89.7% 73.1%
1io1A01 1.20.1330.10 Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain 0.57 36.0 3.71e-01 88.0% 64.5%
2d9dA00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.57 28.0 3.74e-01 91.4% 89.9%
3bjdA01 1.10.1240.20 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Lytic transglycosylase, superhelical linker domain 0.56 28.0 3.72e-01 95.4% 90.9%
2odvA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.56 34.0 4.07e-01 88.6% 92.0%
1cunA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.56 32.0 4.06e-01 92.0% 96.1%
4gf0A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.55 34.0 4.06e-01 100.0% 92.0%
3h1nA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.55 34.0 3.98e-01 98.3% 88.3%
3qkxB00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.55 33.0 3.35e-01 99.4% 56.9%
2qvaA01 1.20.58.190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1 0.55 35.0 3.95e-01 99.4% 85.3%
3axjB01 1.20.58.190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1 0.55 38.0 4.00e-01 99.4% 79.4%
5u56A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.54 33.0 3.95e-01 97.7% 92.9%
5z7qA00 1.20.1330.10 Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain 0.54 36.0 3.62e-01 92.0% 65.3%
4mk3A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.53 31.0 3.65e-01 100.0% 83.5%
1zzpA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.53 29.0 3.55e-01 92.6% 82.6%
1orsC00 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.53 29.0 3.30e-01 88.0% 68.9%
3behB01 1.20.120.540 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels 0.53 29.0 3.42e-01 92.0% 76.9%
2kmfA01 1.20.58.810 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Photosystem II Pbs27 0.51 26.0 3.27e-01 87.4% 80.4%
2wauA02 1.20.58.830 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.50 33.0 3.93e-01 92.0% 96.7%
1s2xA00 1.20.190.30 Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › CAG pathogenicity island protein, CagZ 0.50 47.0 4.69e-01 100.0% 100.0%
ECOD (28)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4994765 310.2.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.82 42.0 5.55e-01 89.1% 88.0%
3209632 604.5.1.0 ↗ alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) 0.73 40.0 5.05e-01 88.0% 86.4%
5055960 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.73 40.0 4.82e-01 88.0% 79.2%
3838379 601.53.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Flagellin glycosyltransferase Maf helical bundle domain › Flagellin glycosyltransferase Maf helical bundle domain 0.72 31.0 3.86e-01 89.7% 63.6%
5078792 3684.1.1.0 ↗ alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like 0.69 30.0 3.74e-01 82.3% 63.6%
4940797 605.1.1.0 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.69 33.0 4.56e-01 88.6% 91.8%
4828003 310.2.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.68 44.0 5.16e-01 89.7% 93.4%
3880178 192.8.1.92 ↗ alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › CUPID 0.67 30.0 4.39e-01 83.4% 92.5%
4843090 310.2.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.66 41.0 5.00e-01 88.0% 95.5%
4026671 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.63 35.0 4.29e-01 89.7% 82.6%
3272618 601.1.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.63 33.0 3.53e-01 85.7% 55.5%
3907213 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.62 36.0 4.63e-01 91.4% 100.0%
3560925 604.1.1.20 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › AKNA 0.60 36.0 4.37e-01 89.7% 91.8%
3708344 604.1.1.160 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › DYH2-5-8_CC 0.59 36.0 4.09e-01 89.1% 80.0%
3579154 109.4.1.429 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Sec7-like_HDS 0.59 39.0 3.43e-01 97.1% 43.8%
3413284 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.58 37.0 2.74e-01 100.0% 23.3%
3916831 109.4.1.1198 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Meckelin 0.58 44.0 3.70e-01 89.1% 47.6%
4357799 192.13.1.1 ↗ alpha bundles › Long alpha-hairpin › ISY1 N-terminal domain-like › ISY1 N-terminal domain-like › Isy1 0.58 32.0 3.70e-01 90.3% 72.3%
3952658 2484.1.1.113 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › baeRF_family2 0.56 33.0 3.82e-01 100.0% 79.2%
3484909 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.56 37.0 4.34e-01 92.6% 97.5%
3616669 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.56 35.0 4.20e-01 90.3% 95.7%
143026 109.10.1.1 ↗ alpha superhelices › Repetitive alpha hairpins › Translin › Translin › Translin 0.54 38.0 3.41e-01 100.0% 51.2%
5083938 1075.5.1.0 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.53 41.0 4.07e-01 93.7% 76.3%
4317199 603.5.1.1 ↗ alpha bundles › STAT-like › FlgN-like › FlgN-like › FlgN 0.52 32.0 3.70e-01 90.9% 84.8%
3508392 604.6.1.32 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › Mito_morph_reg 0.51 31.0 3.58e-01 94.9% 83.1%
3713791 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.51 31.0 3.81e-01 83.4% 95.5%
3594516 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.51 31.0 3.06e-01 88.0% 55.1%
3804498 603.1.1.6 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin_2 0.50 33.0 3.94e-01 92.6% 97.5%