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helicase-primase_subunit
Euk-VirFruit_bat_alphaherpesvirus_1
helicase-primase_subunit__YP_009042070__Fruit_bat_alphaherpesvirus_1__1343901
Identity
- Accession:
- YP_009042070 ↗
- Protein ID:
- helicase-primase_subunit
- Kingdom:
- euk
Quality
86.7
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Pteropodid_alphaherpesvirus_1
TaxID: 1343901
Cluster
View cluster (61 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 152-249
Domain cluster:
rep: ORF40__YP_009173917__Felis_catus_gammaherpesvirus_1__1452540__D204-289
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03324.21 best | Herpes_HEPA | 89.5 | 2.00e-25 | 94.9% | 94.5% |
CATH (13)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4mh4A02 | 3.30.300.20 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › K homology (KH) domain | 0.60 | 37.0 | 3.82e-01 | 91.8% | 64.9% |
| 1mixA02 | 2.30.29.30 | Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) | 0.59 | 29.0 | 3.04e-01 | 92.9% | 48.4% |
| 2kdnA00 | 3.30.300.90 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › BolA-like | 0.57 | 35.0 | 3.40e-01 | 93.9% | 53.7% |
| 4e0aA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.55 | 40.0 | 3.49e-01 | 87.8% | 48.7% |
| 4tw1B00 | 2.70.240.10 | Mainly Beta › Distorted Sandwich › Leukocidin-like › Leukocidin/porin MspA | 0.55 | 44.0 | 3.24e-01 | 88.8% | 41.8% |
| 3vb0A01 | 3.10.180.10 | Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 | 0.53 | 32.0 | 2.97e-01 | 71.4% | 45.7% |
| 2o2gA00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.53 | 43.0 | 3.34e-01 | 87.8% | 88.0% |
| 3bdiA00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.53 | 41.0 | 3.21e-01 | 82.7% | 70.5% |
| 1whqA01 | 3.30.160.20 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › | 0.52 | 31.0 | 3.50e-01 | 95.9% | 80.3% |
| 6kd0A01 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.52 | 43.0 | 3.05e-01 | 92.9% | 72.4% |
| 3aimA00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.51 | 43.0 | 3.13e-01 | 92.9% | 76.7% |
| 3licA01 | 3.30.450.20 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain | 0.51 | 39.0 | 3.28e-01 | 82.7% | 80.9% |
| 1bq5A01 | 2.60.40.420 | Mainly Beta › Sandwich › Immunoglobulin-like › Cupredoxins - blue copper proteins | 0.50 | 44.0 | 3.83e-01 | 98.0% | 92.1% |
ECOD (17)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4986717 | 375.1.1.0 ↗ | few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related | 0.66 | 27.0 | 3.38e-01 | 88.8% | 60.0% |
| 3595936 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.58 | 51.0 | 3.56e-01 | 100.0% | 56.2% |
| 3678022 | 2004.1.1.29 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD | 0.57 | 50.0 | 3.99e-01 | 94.9% | 83.7% |
| 3518649 | 327.5.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins › AMP-binding_C | 0.56 | 33.0 | 3.59e-01 | 91.8% | 68.8% |
| 3719951 | 2496.1.1.2 ↗ | a/b three-layered sandwiches › SpoIIaa-like › SpoIIaa-like › SpoIIaa-like › STAS | 0.55 | 47.0 | 4.39e-01 | 94.9% | 81.6% |
| 3612299 | 2496.1.1.0 ↗ | a/b three-layered sandwiches › SpoIIaa-like › SpoIIaa-like › SpoIIaa-like | 0.55 | 45.0 | 4.30e-01 | 92.9% | 82.5% |
| 3410548 | 3615.1.1.0 ↗ | alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain | 0.54 | 40.0 | 3.60e-01 | 79.6% | 78.6% |
| 3997856 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.53 | 43.0 | 2.75e-01 | 87.8% | 20.4% |
| 3969016 | 7579.1.1.3 ↗ | a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Peptidase_S9 | 0.53 | 40.0 | 3.03e-01 | 81.6% | 75.2% |
| 3111967 | 7579.1.1.46 ↗ | a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Chlorophyllase2 | 0.51 | 41.0 | 3.08e-01 | 87.8% | 72.0% |
| 3554460 | 328.1.1.3 ↗ | a+b two layers › IF3-like › AlbA-like › AlbA-like › Rpp20 | 0.51 | 35.0 | 3.43e-01 | 89.8% | 64.8% |
| 3579667 | 2007.2.3.1 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Y_phosphatase | 0.51 | 43.0 | 3.96e-01 | 95.9% | 85.2% |
| 4631930 | 286.1.1.2 ↗ | a+b complex topology › Diaminopimelate epimerase-like › Diaminopimelate epimerase-like › Diaminopimelate epimerase-like › PhzC-PhzF | 0.51 | 33.0 | 3.00e-01 | 88.8% | 48.5% |
| 4334389 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.50 | 42.0 | 3.95e-01 | 92.9% | 100.0% |
| 4012853 | 316.1.1.0 ↗ | a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase | 0.50 | 44.0 | 3.53e-01 | 99.0% | 65.0% |
| 3209732 | 327.5.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins | 0.50 | 43.0 | 3.83e-01 | 90.8% | 72.6% |
| 3997875 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.50 | 38.0 | 2.65e-01 | 80.6% | 32.0% |
D2
medium
residues 250-280_336-389
Domain cluster:
representative
CATH (18)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4gr2A00 | 1.10.1200.210 | Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › Chaperonin-like RbcX | 0.68 | 40.0 | 3.69e-01 | 94.1% | 45.5% |
| 3crjC00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.59 | 50.0 | 3.92e-01 | 91.8% | 46.4% |
| 4kwaB00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.59 | 48.0 | 3.71e-01 | 88.2% | 44.8% |
| 6wm2P02 | 1.25.40.150 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › V-type ATPase, subunit H, C-terminal domain | 0.57 | 38.0 | 3.51e-01 | 90.6% | 52.3% |
| 1hu3A00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.57 | 41.0 | 3.14e-01 | 91.8% | 31.9% |
| 1j1vA00 | 1.10.1750.10 | Mainly Alpha › Orthogonal Bundle › Chromosomal Replication Initiator Protein Dnaa; Chain: A; › DnaA protein, C-terminal DNA-binding domain | 0.56 | 44.0 | 4.31e-01 | 85.9% | 86.2% |
| 2hnhA03 | 1.10.10.1600 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Bacterial DNA polymerase III alpha subunit, thumb domain | 0.53 | 38.0 | 3.99e-01 | 76.5% | 94.9% |
| 8h6rA01 | 1.20.930.10 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0.53 | 38.0 | 3.90e-01 | 90.6% | 77.6% |
| 2j4bB00 | 1.25.40.500 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › TFIID subunit TAF5, NTD2 domain | 0.52 | 44.0 | 3.81e-01 | 92.9% | 94.7% |
| 3lbxB01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.52 | 42.0 | 3.90e-01 | 87.1% | 85.0% |
| 3tu3B03 | 1.20.1050.100 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.52 | 40.0 | 3.26e-01 | 92.9% | 41.8% |
| 1kgqA01 | 1.10.166.10 | Mainly Alpha › Orthogonal Bundle › Tetrahydrodipicolinate-N-succinyltransferase; Chain A, domain 1 › Tetrahydrodipicolinate-N-succinyltransferase, N-terminal domain | 0.52 | 38.0 | 4.10e-01 | 81.2% | 92.9% |
| 4u2xF00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.52 | 36.0 | 2.94e-01 | 91.8% | 35.4% |
| 2guzB00 | 1.10.287.110 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain | 0.52 | 37.0 | 4.16e-01 | 96.5% | 100.0% |
| 4ks9A01 | 1.20.140.90 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Malonyl-CoA decarboxylase, oligemerization domain | 0.51 | 40.0 | 3.54e-01 | 84.7% | 64.3% |
| 3dv8A01 | 2.60.120.10 | Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls | 0.51 | 43.0 | 3.74e-01 | 95.3% | 92.1% |
| 1ia6A00 | 1.50.10.10 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.51 | 40.0 | 2.62e-01 | 87.1% | 91.3% |
| 2ra1A03 | 1.20.58.770 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.51 | 35.0 | 3.87e-01 | 94.1% | 96.8% |
ECOD (18)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3258925 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.67 | 32.0 | 3.50e-01 | 70.6% | 54.3% |
| 3797195 | 109.4.1.2 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Arm | 0.62 | 40.0 | 2.93e-01 | 90.6% | 23.9% |
| 3816065 | 109.4.1.240 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_long | 0.60 | 41.0 | 3.00e-01 | 87.1% | 26.0% |
| 3738396 | 109.4.1.546 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Ecm29 | 0.60 | 42.0 | 4.01e-01 | 92.9% | 62.0% |
| 3739978 | 3444.1.1.0 ↗ | alpha arrays › DP domain › DP domain › DP domain | 0.60 | 41.0 | 4.21e-01 | 97.6% | 75.9% |
| 3297319 | 611.3.1.1 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 | 0.56 | 37.0 | 3.65e-01 | 90.6% | 60.0% |
| 4874432 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.56 | 37.0 | 3.28e-01 | 88.2% | 45.0% |
| 3737968 | 611.3.1.1 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 | 0.55 | 36.0 | 3.77e-01 | 91.8% | 72.5% |
| 3622067 | 611.3.1.1 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 | 0.54 | 36.0 | 3.69e-01 | 91.8% | 71.2% |
| 3471670 | 611.3.1.1 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 | 0.54 | 36.0 | 3.76e-01 | 90.6% | 77.3% |
| 3482665 | 611.3.1.0 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0.53 | 36.0 | 3.66e-01 | 91.8% | 71.8% |
| 3693222 | 2006.1.1.0 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like | 0.53 | 37.0 | 2.78e-01 | 77.6% | 28.6% |
| 4264669 | 563.1.1.1 ↗ | alpha bundles › ATPD N-terminal domain-like › N-terminal domain of the delta subunit of the F1F0-ATP synthase › N-terminal domain of the delta subunit of the F1F0-ATP synthase › OSCP | 0.52 | 44.0 | 3.56e-01 | 97.6% | 81.1% |
| 1806460 | 604.1.1.8 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › SbsC_spectrin-like | 0.51 | 35.0 | 3.86e-01 | 90.6% | 93.7% |
| 3208649 | 604.13.1.1 ↗ | alpha bundles › Spectrin repeat-like › USP8 N-terminal domain-like › USP8 N-terminal domain-like › USP8_dimer | 0.51 | 39.0 | 3.35e-01 | 100.0% | 51.1% |
| 4993505 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.51 | 38.0 | 3.43e-01 | 80.0% | 60.8% |
| 4325839 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.51 | 37.0 | 3.98e-01 | 84.7% | 94.3% |
| 3416261 | 371.1.1.0 ↗ | few secondary structure elements › Phospholipase A2, PLA2 › Phospholipase A2, PLA2 › Phospholipase A2, PLA2 | 0.51 | 43.0 | 4.09e-01 | 95.3% | 98.1% |
D3
medium
residues 281-335_390-502
Domain cluster:
rep: NC_004735.1__NP_835679.1__Rm378p092__00092__D1-33_185-289
D4
medium
residues 503-668