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helicase-primase_subunit
Euk-VirHuman_alphaherpesvirus_1
helicase-primase_subunit__YP_009137082__Human_alphaherpesvirus_1__10298
Identity
- Accession:
- YP_009137082 ↗
- Protein ID:
- helicase-primase_subunit
- Kingdom:
- euk
Quality
81.3
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Human_alphaherpesvirus_1
TaxID: 10298
Cluster
View cluster (61 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-145
D2
medium
residues 146-258
Domain cluster:
representative
CATH (1)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4q28A00 | 3.30.160.780 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › | 0.50 | 34.0 | 3.50e-01 | 70.8% | 70.9% |
D3
medium
residues 259-347
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03324.21 best | Herpes_HEPA | 56.4 | 4.50e-15 | 70.8% | 61.5% |
CATH (23)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3b0xA03 | 3.30.460.10 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 | 0.67 | 45.0 | 4.29e-01 | 91.0% | 58.1% |
| 1nkiA00 | 3.10.180.10 | Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 | 0.65 | 36.0 | 3.16e-01 | 77.5% | 35.1% |
| 1kllA00 | 3.10.180.10 | Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 | 0.59 | 36.0 | 3.22e-01 | 75.3% | 42.2% |
| 3hv8A00 | 3.20.20.450 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › EAL domain | 0.58 | 45.0 | 3.34e-01 | 84.3% | 76.0% |
| 2hc5A01 | 3.30.160.170 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › FlaG-like | 0.58 | 39.0 | 3.85e-01 | 70.8% | 70.4% |
| 2kjzA02 | 3.30.720.110 | Alpha Beta › 2-Layer Sandwich › Signal recognition particle alu RNA binding heterodimer, srp9/1 › | 0.57 | 35.0 | 4.09e-01 | 74.2% | 94.7% |
| 3s1sA01 | 3.90.1570.30 | Alpha Beta › Alpha-Beta Complex › tt1808, chain A › | 0.57 | 50.0 | 4.06e-01 | 96.6% | 51.5% |
| 4m8aA00 | 3.30.720.210 | Alpha Beta › 2-Layer Sandwich › Signal recognition particle alu RNA binding heterodimer, srp9/1 › | 0.57 | 31.0 | 3.40e-01 | 74.2% | 65.7% |
| 6jpaE00 | 1.20.140.150 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › | 0.56 | 42.0 | 3.52e-01 | 82.0% | 97.6% |
| 1gd5A00 | 3.30.1520.10 | Alpha Beta › 2-Layer Sandwich › PX Domain › Phox-like domain | 0.54 | 37.0 | 3.31e-01 | 70.8% | 69.2% |
| 3cb6A01 | 3.40.350.10 | Alpha Beta › 3-Layer(aba) Sandwich › Creatine Amidinohydrolase; Chain A, domain 1 › Creatinase/prolidase N-terminal domain | 0.54 | 35.0 | 2.84e-01 | 98.9% | 34.3% |
| 4z04A00 | 3.10.180.10 | Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 | 0.53 | 34.0 | 3.11e-01 | 74.2% | 46.0% |
| 1hc7A01 | 3.30.930.10 | Alpha Beta › 2-Layer Sandwich › BirA Bifunctional Protein; domain 2 › Bira Bifunctional Protein; Domain 2 | 0.53 | 40.0 | 2.86e-01 | 79.8% | 48.7% |
| 3sluA02 | 3.10.450.350 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.53 | 42.0 | 3.72e-01 | 89.9% | 74.5% |
| 4v0bA00 | 3.30.720.210 | Alpha Beta › 2-Layer Sandwich › Signal recognition particle alu RNA binding heterodimer, srp9/1 › | 0.52 | 27.0 | 3.01e-01 | 70.8% | 61.9% |
| 4zrlA01 | 3.30.460.10 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 | 0.52 | 39.0 | 3.62e-01 | 79.8% | 86.3% |
| 2x0nA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.52 | 38.0 | 3.09e-01 | 87.6% | 38.3% |
| 1o5wA01 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.52 | 41.0 | 3.29e-01 | 98.9% | 40.6% |
| 1dg3A02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.51 | 44.0 | 3.32e-01 | 98.9% | 46.7% |
| 2w9jA00 | 3.30.720.10 | Alpha Beta › 2-Layer Sandwich › Signal recognition particle alu RNA binding heterodimer, srp9/1 › Signal recognition particle alu RNA binding heterodimer, srp9/1 | 0.51 | 28.0 | 3.15e-01 | 97.8% | 67.6% |
| 3opyB01 | 3.10.180.10 | Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 | 0.51 | 31.0 | 2.74e-01 | 77.5% | 37.8% |
| 4py5A01 | 3.30.310.10 | Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › TATA-Binding Protein | 0.51 | 31.0 | 3.34e-01 | 97.8% | 72.2% |
| 3ct8A00 | 3.10.180.10 | Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 | 0.50 | 33.0 | 2.91e-01 | 86.5% | 44.4% |
ECOD (25)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4443386 | 4263.2.1.1 ↗ | a+b two layers › TTHA1528-like › FtsH Periplasmic Domain › FtsH Periplasmic Domain › FtsH_ext | 0.61 | 30.0 | 3.57e-01 | 74.2% | 68.3% |
| 5077512 | 7541.1.1.1 ↗ | a/b three-layered sandwiches › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › Molybdenum cofactor biosynthesis proteins › MoCF_biosynth | 0.61 | 47.0 | 3.96e-01 | 98.9% | 48.4% |
| 4196588 | 211.1.1.1 ↗ | a+b two layers › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase | 0.59 | 33.0 | 2.94e-01 | 77.5% | 34.8% |
| 4407299 | 211.1.1.1 ↗ | a+b two layers › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase | 0.57 | 37.0 | 3.17e-01 | 87.6% | 39.3% |
| 4562140 | 4263.2.1.0 ↗ | a+b two layers › TTHA1528-like › FtsH Periplasmic Domain › FtsH Periplasmic Domain | 0.57 | 29.0 | 3.39e-01 | 73.0% | 68.3% |
| 3738789 | 316.1.1.25 ↗ | a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › Nrap_D4 | 0.56 | 46.0 | 3.63e-01 | 94.4% | 53.0% |
| 3460220 | 314.1.1.2 ↗ | a+b three layers › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › tRNA-synt_2b | 0.55 | 40.0 | 3.39e-01 | 78.7% | 84.5% |
| 4012853 | 316.1.1.0 ↗ | a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase | 0.54 | 45.0 | 3.59e-01 | 95.5% | 58.0% |
| 4115930 | 211.1.1.1 ↗ | a+b two layers › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase | 0.54 | 35.0 | 3.51e-01 | 87.6% | 63.3% |
| 4591781 | 2004.1.1.1117 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DUF2478 | 0.54 | 44.0 | 3.63e-01 | 91.0% | 83.5% |
| 3600840 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.54 | 36.0 | 3.56e-01 | 70.8% | 76.0% |
| 3213425 | 2007.1.2.0 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I | 0.54 | 44.0 | 3.49e-01 | 95.5% | 60.0% |
| 3285978 | 331.2.1.1 ↗ | a+b two layers › TBP-like › Phosphoglucomutase, C-terminal domain › Phosphoglucomutase, C-terminal domain › PGM_PMM_IV | 0.53 | 40.0 | 3.79e-01 | 94.4% | 64.6% |
| 1117795 | 316.1.1.25 ↗ | a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › Nrap_D4 | 0.53 | 44.0 | 3.47e-01 | 94.4% | 54.6% |
| 4888970 | 316.1.1.58 ↗ | a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › Nrap_D4, Nrap_D5 | 0.53 | 40.0 | 3.10e-01 | 80.9% | 38.9% |
| 5042722 | 2004.1.1.175 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ParA | 0.53 | 45.0 | 3.44e-01 | 98.9% | 63.8% |
| 2552720 | 211.1.1.0 ↗ | a+b two layers › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.53 | 37.0 | 3.90e-01 | 83.1% | 85.7% |
| 1388503 | 4263.2.1.1 ↗ | a+b two layers › TTHA1528-like › FtsH Periplasmic Domain › FtsH Periplasmic Domain › FtsH_ext | 0.52 | 29.0 | 3.22e-01 | 74.2% | 66.2% |
| 3174658 | 220.1.1.1 ↗ | beta barrels › PH domain-like › PH domain-like › PH domain-like › PH | 0.52 | 32.0 | 3.24e-01 | 100.0% | 61.1% |
| 4027128 | 896.1.1.2 ↗ | a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › SRP14 | 0.51 | 34.0 | 3.62e-01 | 75.3% | 78.2% |
| 3912274 | 1170.1.1.1 ↗ | beta barrels › IL8-related › IL8-related › IL8 › IL8 | 0.51 | 29.0 | 3.22e-01 | 100.0% | 71.4% |
| 3753697 | 220.1.1.0 ↗ | beta barrels › PH domain-like › PH domain-like › PH domain-like | 0.51 | 30.0 | 3.55e-01 | 97.8% | 86.7% |
| 3998421 | 220.1.1.1 ↗ | beta barrels › PH domain-like › PH domain-like › PH domain-like › PH | 0.51 | 29.0 | 3.31e-01 | 97.8% | 76.9% |
| 357202 | 896.1.1.2 ↗ | a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › SRP14 | 0.51 | 33.0 | 3.46e-01 | 74.2% | 73.2% |
| 3242912 | 7561.1.1.1 ↗ | a/b three-layered sandwiches › Isochorismatase-like hydrolases › Isochorismatase-like hydrolases › Isochorismatase-like hydrolases › Isochorismatase | 0.50 | 42.0 | 3.08e-01 | 96.6% | 73.7% |
D4
medium
residues 365-388_412-480
D5
medium
residues 389-411_481-562
Domain cluster:
rep: NC_004735.1__NP_835679.1__Rm378p092__00092__D1-33_185-289
D6
medium
residues 563-750