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helicase-primase_subunit

Euk-Vir

Macropodid_alphaherpesvirus_1

helicase-primase_subunit__YP_009227241__Macropodid_alphaherpesvirus_1__137443

Identity

Accession:
YP_009227241 ↗
Protein ID:
helicase-primase_subunit
Kingdom:
euk

Quality

87.7 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 585-747
PDB
CATH (16)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4qclA05 1.10.132.60 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain 0.68 63.0 6.24e-01 99.4% 98.8%
4fxdA06 1.10.132.60 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain 0.67 62.0 6.25e-01 98.8% 100.0%
3onjA00 1.20.58.400 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins 0.60 35.0 4.38e-01 87.7% 95.9%
2oerA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.60 40.0 3.87e-01 96.9% 60.9%
1hlvA02 1.10.10.60 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like 0.59 25.0 3.72e-01 87.7% 100.0%
1aj3A00 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 34.0 4.27e-01 88.3% 96.9%
5f42A02 1.20.1180.10 Mainly Alpha › Up-down Bundle › Udp N-acetylglucosamine O-acyltransferase; Domain 2 › Udp N-acetylglucosamine O-acyltransferase, C-terminal domain 0.57 26.0 3.50e-01 89.6% 81.7%
2c5iT00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.56 32.0 3.97e-01 87.1% 94.7%
4exjA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.55 33.0 3.79e-01 96.9% 80.2%
3v9pB00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.55 38.0 3.53e-01 100.0% 56.4%
1xdxA01 3.30.1140.40 Alpha Beta › 2-Layer Sandwich › Ribosomal protein S3 C-terminal domain › Tctex-1 0.53 32.0 3.97e-01 96.3% 98.0%
4kn7D01 1.10.132.30 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › RNA polymerase Rpb1 funnel domain 0.52 35.0 3.92e-01 92.0% 84.2%
3ppbA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.52 36.0 3.43e-01 98.2% 60.6%
3zheA02 1.25.40.760 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.51 31.0 2.88e-01 95.7% 44.9%
4evxA00 1.10.1740.240 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › 0.51 25.0 3.15e-01 70.6% 77.3%
5uh5D02 1.10.132.30 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › RNA polymerase Rpb1 funnel domain 0.51 36.0 3.93e-01 93.3% 86.2%
ECOD (15)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4223248 621.1.1.3 alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Sey1_3HB 0.77 45.0 5.39e-01 92.6% 85.5%
4346136 605.1.1.108 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › GrpE 0.73 29.0 4.46e-01 73.0% 90.8%
4931503 604.3.1.0 alpha bundles › Spectrin repeat-like › BAG domain › BAG domain 0.66 32.0 4.54e-01 87.7% 100.0%
5007869 601.33.1.0 alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain 0.60 31.0 3.82e-01 92.0% 78.0%
3694137 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.59 36.0 3.27e-01 96.9% 43.6%
3626530 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.58 32.0 3.97e-01 87.1% 88.4%
3786307 109.4.1.228 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Exo84_C 0.57 45.0 3.68e-01 97.5% 44.7%
3281218 3812.1.1.0 alpha bundles › Type III secretion protein YscE › Type III secretion protein YscE › Type III secretion protein YscE 0.56 39.0 4.29e-01 92.0% 86.7%
3390092 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.55 37.0 4.13e-01 92.0% 86.9%
3701966 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.54 45.0 3.32e-01 97.5% 35.1%
3992995 604.12.1.0 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.53 29.0 3.42e-01 90.8% 78.6%
4278611 604.12.1.15 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › Mito_morph_reg 0.51 32.0 3.53e-01 84.7% 76.9%
4091932 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.51 38.0 4.09e-01 89.0% 93.3%
3711528 633.23.1.0 alpha bundles › Bromodomain-like › Claudin › Claudin 0.51 36.0 3.28e-01 73.0% 89.1%
3712221 5050.1.1.1 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr 0.51 34.0 3.62e-01 90.2% 75.9%
D2 medium residues 1-145
PDB
CATH (19)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2lyxA00 3.10.450.390 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › Protein of unknown function DUF3889 0.75 32.0 4.06e-01 87.6% 66.7%
4ec6A00 3.10.450.540 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.68 31.0 3.53e-01 86.2% 55.0%
3en2A00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.66 41.0 5.13e-01 95.2% 100.0%
1vqqA01 3.10.450.100 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › NTF2-like; domain 1 0.63 31.0 3.48e-01 86.9% 58.7%
2i9wA00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.61 29.0 2.77e-01 73.1% 36.4%
1v1qA00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.61 42.0 4.79e-01 96.6% 92.7%
3fhwA00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.61 40.0 4.82e-01 96.6% 99.0%
3ub1D02 3.10.450.540 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.61 29.0 3.26e-01 86.9% 55.3%
3k8aB00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.60 41.0 4.77e-01 96.6% 97.1%
3kojB00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.60 35.0 4.28e-01 92.4% 91.1%
1wnhA02 3.10.450.10 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.60 29.0 3.17e-01 87.6% 54.2%
5dvyA01 3.10.450.100 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › NTF2-like; domain 1 0.59 32.0 3.37e-01 91.7% 57.1%
3eyrA00 3.15.10.40 Alpha Beta › Super Roll › Bactericidal permeability-increasing protein; domain 1 › Uncharacterised protein PF07273 family, DUF1439 0.55 35.0 3.34e-01 90.3% 53.8%
2g2sA00 3.30.1300.40 Alpha Beta › 2-Layer Sandwich › Pantoate--beta-alanine Ligase; Chain: A,domain 2 › 0.53 21.0 3.03e-01 76.6% 78.1%
5aj3Q00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.53 32.0 3.59e-01 95.9% 77.1%
5i97C00 3.10.450.230 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › VirB8 protein 0.53 30.0 3.07e-01 83.4% 56.2%
3mg1B02 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.52 30.0 3.24e-01 88.3% 64.8%
2gtlO02 2.40.128.620 Mainly Beta › Beta Barrel › Lipocalin › 0.52 35.0 3.40e-01 76.6% 60.7%
2gtlN02 2.40.128.620 Mainly Beta › Beta Barrel › Lipocalin › 0.51 35.0 3.30e-01 76.6% 59.4%
ECOD (30)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3672943 330.1.1.0 a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.69 33.0 4.75e-01 86.9% 100.0%
1278471 243.1.1.7 a+b two layers › Cystatin-like › NTF2-like › NTF2-like › MecA_N 0.64 32.0 3.54e-01 88.3% 58.8%
222748 2.1.1.122 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › SSB_1 0.63 39.0 4.84e-01 92.4% 100.0%
5046475 2.2.1.0 beta barrels › OB-fold › Bacterial enterotoxins › Bacterial enterotoxins 0.62 43.0 4.63e-01 97.9% 85.8%
3451025 243.3.1.19 a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin › DUF3615 0.61 33.0 3.89e-01 89.7% 74.0%
5034706 295.1.1.0 a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain 0.61 30.0 4.01e-01 84.1% 89.3%
3965166 2.1.1.0 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.61 38.0 4.75e-01 91.7% 100.0%
3783432 2.1.1.6 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › SSB 0.61 43.0 4.97e-01 95.9% 99.0%
5045679 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.60 31.0 3.35e-01 92.4% 55.2%
4136826 7520.1.1.0 a/b three-layered sandwiches › CinA-like › CinA-like › CinA-like 0.59 29.0 3.02e-01 88.3% 46.4%
3588474 243.1.1.17 a+b two layers › Cystatin-like › NTF2-like › NTF2-like › TpcC 0.59 31.0 3.36e-01 88.3% 59.2%
5040972 295.1.1.0 a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain 0.59 30.0 3.88e-01 83.4% 90.7%
3473720 2.1.1.6 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › SSB 0.58 42.0 4.77e-01 97.2% 97.3%
3616890 2.1.1.6 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › SSB 0.58 42.0 4.73e-01 98.6% 94.8%
3739446 330.4.1.1 a+b two layers › dsRBD-like › Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain › Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain › Porphobil_deamC 0.57 30.0 3.55e-01 91.7% 74.7%
3734807 243.1.1.0 a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.56 31.0 3.01e-01 90.3% 45.3%
3957514 243.1.1.0 a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.56 28.0 3.01e-01 91.0% 52.3%
4807965 2.1.1.4 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › Ribosomal_S17 0.55 32.0 3.81e-01 97.9% 84.7%
3289158 243.1.1.0 a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.54 32.0 3.65e-01 89.7% 77.3%
4259027 9.3.1.3 beta barrels › Lipocalins/Streptavidin › Quinohemoprotein amine dehydrogenase A chain, domain 3-like › Quinohemoprotein amine dehydrogenase A chain, domain 3-like › Eryth_link_C 0.53 35.0 3.83e-01 76.6% 79.7%
3694950 243.1.1.0 a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.53 29.0 2.98e-01 91.0% 51.0%
4097328 9.3.1.3 beta barrels › Lipocalins/Streptavidin › Quinohemoprotein amine dehydrogenase A chain, domain 3-like › Quinohemoprotein amine dehydrogenase A chain, domain 3-like › Eryth_link_C 0.53 36.0 3.84e-01 76.6% 79.2%
3518540 5.1.4.1 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 0.53 41.0 2.89e-01 82.8% 76.3%
3591628 243.3.1.0 a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin 0.52 34.0 3.76e-01 90.3% 81.7%
860 9.3.1.3 beta barrels › Lipocalins/Streptavidin › Quinohemoprotein amine dehydrogenase A chain, domain 3-like › Quinohemoprotein amine dehydrogenase A chain, domain 3-like › Eryth_link_C 0.52 35.0 3.79e-01 76.6% 81.1%
4371290 9.3.1.3 beta barrels › Lipocalins/Streptavidin › Quinohemoprotein amine dehydrogenase A chain, domain 3-like › Quinohemoprotein amine dehydrogenase A chain, domain 3-like › Eryth_link_C 0.51 35.0 3.72e-01 76.6% 79.8%
3307679 243.1.1.2 a+b two layers › Cystatin-like › NTF2-like › NTF2-like › NTF2 0.51 30.0 3.14e-01 89.7% 60.0%
3725005 243.1.1.26 a+b two layers › Cystatin-like › NTF2-like › NTF2-like › SnoaL_4 0.51 30.0 3.14e-01 88.3% 62.2%
3262201 243.1.1.0 a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.51 31.0 3.14e-01 90.3% 59.3%
3967817 243.1.1.34 a+b two layers › Cystatin-like › NTF2-like › NTF2-like › YchJ_M-like 0.50 27.0 2.89e-01 90.3% 57.6%
D3 medium residues 146-228
PDB
D4 medium residues 229-353
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03324.21 best Herpes_HEPA 91.9 3.70e-26 74.4% 95.6%
D5 medium residues 354-388_411-482
PDB
CATH (13)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1x9fA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.58 40.0 3.62e-01 87.9% 51.7%
1zbsA03 1.10.720.160 Mainly Alpha › Orthogonal Bundle › Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1 › 0.56 39.0 4.17e-01 71.0% 87.6%
3u9jA00 1.20.120.520 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › nmb1532 protein domain like 0.56 42.0 3.71e-01 79.4% 70.7%
2c12A01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.55 39.0 3.76e-01 98.1% 63.8%
3umbA02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.54 34.0 3.90e-01 88.8% 86.1%
4x28C01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.54 37.0 3.61e-01 98.1% 63.0%
1orsC00 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.53 38.0 3.64e-01 76.6% 97.0%
2dlrA00 1.10.167.10 Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 0.52 38.0 3.44e-01 76.6% 82.6%
1ivhA01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.52 38.0 3.67e-01 86.0% 67.2%
1g7dA00 1.20.1150.12 Mainly Alpha › Up-down Bundle › Endoplasmic reticulum protein erp29 › Endoplasmic reticulum resident protein 29, C-terminal domain 0.51 35.0 3.56e-01 85.0% 70.8%
3kyiA00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.51 39.0 3.73e-01 82.2% 73.4%
4w8pA02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.50 38.0 3.63e-01 80.4% 90.0%
6nmnA02 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.50 38.0 3.58e-01 79.4% 80.5%
ECOD (9)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3941633 150.1.2.13 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Heme oxygenase/Ribonucleotide reductase › Haem_oxygenas_2 0.57 43.0 3.35e-01 80.4% 91.0%
3641962 101.1.10.36 alpha arrays › HTH › HTH › Cyclin-like › MOM1 0.56 36.0 3.99e-01 78.5% 82.4%
3185106 101.1.2.0 alpha arrays › HTH › HTH › winged helix domain 0.56 32.0 3.67e-01 90.7% 78.7%
3477001 101.1.10.0 alpha arrays › HTH › HTH › Cyclin-like 0.54 40.0 3.58e-01 77.6% 57.3%
4029967 633.1.1.0 alpha bundles › Bromodomain-like › Bromodomain › Bromodomain 0.54 37.0 3.64e-01 70.1% 94.8%
4016106 650.1.1.0 alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain 0.54 33.0 3.73e-01 96.3% 82.5%
3795349 101.1.1.112 alpha arrays › HTH › HTH › Three-helical HTH › MADF_DNA_bdg 0.53 31.0 3.43e-01 92.5% 71.8%
4220561 601.1.1.5 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › CAS_C 0.52 42.0 3.95e-01 86.0% 92.2%
3262410 650.1.1.0 alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain 0.51 30.0 3.50e-01 95.3% 82.7%
D6 medium residues 389-410_483-584
PDB