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helicase-primase_subunit

Euk-Vir

Canid_alphaherpesvirus_1

helicase-primase_subunit__YP_009252278__Canid_alphaherpesvirus_1__170325

Identity

Accession:
YP_009252278 ↗
Protein ID:
helicase-primase_subunit
Kingdom:
euk

Quality

90.9 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› Canid_alphaherpesvirus_1

TaxID: 170325

Cluster

View cluster (61 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 400-580
PDB
Domain cluster: rep: NC_004735.1__NP_835679.1__Rm378p092__00092__D1-33_185-289
D2 medium residues 11-152
PDB
Domain cluster: rep: helicase-primase_subunit__YP_004940263__Saimiriine_betaherpesvirus_4__1535247__D1-152
CATH (23)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2lyxA00 3.10.450.390 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › Protein of unknown function DUF3889 0.73 32.0 4.04e-01 87.3% 66.7%
4ec6A00 3.10.450.540 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.69 31.0 3.56e-01 85.9% 55.0%
7pkwA01 3.10.450.540 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.67 29.0 3.36e-01 88.0% 53.4%
3k7cA00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.66 27.0 3.14e-01 72.5% 50.9%
4jbmB01 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.65 39.0 4.70e-01 99.3% 88.5%
2k54A00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.63 29.0 3.15e-01 85.2% 49.6%
2rsxA00 3.10.450.420 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.63 29.0 2.78e-01 73.9% 36.5%
1vqqA01 3.10.450.100 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › NTF2-like; domain 1 0.63 31.0 3.46e-01 86.6% 58.7%
2k4vA00 3.30.160.370 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Domain of unknown function DUF5064 0.62 30.0 3.22e-01 90.8% 50.4%
1o7iB00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.62 39.0 4.33e-01 100.0% 78.9%
3k0zA00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.62 31.0 3.06e-01 91.5% 45.0%
3ub1D02 3.10.450.540 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.61 29.0 3.25e-01 86.6% 54.4%
1fguB01 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.61 40.0 4.56e-01 93.0% 89.5%
2jq5A00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.61 28.0 2.98e-01 85.2% 46.9%
2i9wA00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.60 29.0 2.71e-01 71.8% 35.8%
7r97A02 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.58 27.0 3.87e-01 81.0% 92.6%
5evhA00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.57 29.0 3.09e-01 93.0% 54.5%
3ecfA00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.57 31.0 3.23e-01 95.1% 56.2%
1nu3A00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.56 31.0 3.09e-01 88.7% 51.0%
3bf2A00 3.30.160.150 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Lipoprotein like domain 0.54 34.0 3.62e-01 89.4% 71.2%
5bkaE01 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.52 29.0 3.00e-01 85.2% 56.1%
2g16B00 2.40.155.10 Mainly Beta › Beta Barrel › Green Fluorescent Protein › Green fluorescent protein 0.51 33.0 3.17e-01 93.7% 55.2%
4u13A00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.51 27.0 3.03e-01 90.1% 66.1%
ECOD (37)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3279407 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.69 42.0 4.71e-01 94.4% 77.3%
1807441 243.1.1.37 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like › TcpC-like_C 0.69 31.0 3.56e-01 85.9% 55.0%
3435849 243.3.1.0 ↗ a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin 0.68 31.0 3.87e-01 88.7% 69.3%
4974918 2.1.1.15 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › tRNA_anti-codon 0.68 41.0 4.73e-01 95.8% 81.9%
5041944 2.1.1.15 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › tRNA_anti-codon 0.65 41.0 4.70e-01 100.0% 85.7%
3603237 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.65 41.0 4.69e-01 100.0% 85.7%
5030516 2.1.1.15 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › tRNA_anti-codon 0.65 42.0 4.76e-01 100.0% 87.6%
4943942 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.64 41.0 4.71e-01 100.0% 86.7%
2883156 243.1.1.17 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like › TpcC 0.64 30.0 3.25e-01 85.9% 49.6%
5069581 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.64 41.0 4.58e-01 94.4% 81.8%
5055028 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.64 41.0 4.57e-01 94.4% 81.8%
4978000 243.1.1.18 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like › SnoaL_2 0.64 31.0 3.24e-01 88.7% 49.6%
3214004 243.1.1.0 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.64 30.0 3.56e-01 84.5% 62.0%
4940587 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.63 42.0 4.75e-01 100.0% 87.3%
5030515 2.1.1.76 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › REPA_OB_2 0.63 42.0 4.67e-01 100.0% 83.5%
5046475 2.2.1.0 ↗ beta barrels › OB-fold › Bacterial enterotoxins › Bacterial enterotoxins 0.63 43.0 4.60e-01 93.7% 80.8%
4646070 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.63 42.0 4.68e-01 100.0% 86.4%
1278471 243.1.1.7 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like › MecA_N 0.63 32.0 3.52e-01 88.7% 58.8%
5036293 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.63 38.0 4.46e-01 94.4% 85.0%
5037301 2.1.1.111 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › Ssb-like_OB 0.63 38.0 4.50e-01 93.7% 89.4%
3587653 243.1.1.0 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.61 31.0 3.43e-01 90.1% 59.2%
3789856 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.60 32.0 3.57e-01 95.8% 62.6%
3733907 2.1.1.15 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › tRNA_anti-codon 0.60 42.0 4.33e-01 100.0% 75.6%
3702545 5.1.3.28 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › BNR_3 0.60 42.0 2.97e-01 71.8% 92.6%
3243080 243.5.1.0 ↗ a+b two layers › Cystatin-like › Amine oxidase N-terminal region › Amine oxidase N-terminal region 0.59 32.0 3.73e-01 90.8% 73.0%
4582733 243.1.1.0 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.58 29.0 3.03e-01 83.8% 50.0%
3288868 243.1.1.18 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like › SnoaL_2 0.58 28.0 3.08e-01 87.3% 53.3%
3588474 243.1.1.17 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like › TpcC 0.58 30.0 3.31e-01 88.0% 60.0%
5029238 330.2.1.0 ↗ a+b two layers › dsRBD-like › Ribosome binding protein Y (YfiA homologue) › Ribosome binding protein Y (YfiA homologue) 0.57 29.0 3.35e-01 94.4% 66.0%
4937710 243.1.1.18 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like › SnoaL_2 0.57 27.0 2.98e-01 85.2% 53.0%
3957514 243.1.1.0 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.57 28.0 2.96e-01 88.7% 50.0%
4929844 2.1.1.135 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DUF3592 0.56 35.0 4.24e-01 91.5% 100.0%
4937519 2.1.1.135 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DUF3592 0.55 35.0 3.80e-01 91.5% 75.8%
2617498 243.1.1.18 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like › SnoaL_2 0.54 30.0 3.39e-01 88.0% 69.7%
3613168 5.1.3.28 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › BNR_3 0.53 40.0 2.90e-01 78.9% 85.8%
3958251 243.1.1.0 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like 0.53 27.0 2.69e-01 85.9% 43.5%
3234838 243.1.1.28 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like › DUF4440 0.51 30.0 3.30e-01 90.1% 68.3%
D3 medium residues 243-355
PDB
Domain cluster: rep: ORF40__YP_009173917__Felis_catus_gammaherpesvirus_1__1452540__D204-289
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03324.21 best Herpes_HEPA 88.6 4.00e-25 78.8% 91.2%
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3ij3A01 3.40.220.10 Alpha Beta › 3-Layer(aba) Sandwich › Leucine Aminopeptidase, subunit E; domain 1 › Leucine Aminopeptidase, subunit E, domain 1 0.58 39.0 3.71e-01 83.2% 58.0%
4x00A00 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.55 49.0 3.74e-01 100.0% 75.8%
5y58A01 3.40.50.410 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › von Willebrand factor, type A domain 0.52 41.0 3.36e-01 85.0% 87.9%
4zrlA01 3.30.460.10 Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 0.51 36.0 3.62e-01 74.3% 88.9%
ECOD (6)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3726614 2007.1.1.0 ↗ a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Class I glutamine amidotransferase-like 0.55 41.0 2.80e-01 79.6% 34.1%
2647591 7579.1.1.6 ↗ a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Abhydrolase_1 0.52 47.0 3.63e-01 99.1% 87.0%
3390153 2003.1.2.18 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain 0.52 41.0 2.69e-01 85.8% 48.8%
3249751 2006.1.6.1 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › vWA-like › VWA 0.51 41.0 3.17e-01 89.4% 58.1%
4179872 7579.1.1.44 ↗ a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Abhydrolase_6 0.50 45.0 3.46e-01 100.0% 81.5%
4952259 3397.1.1.0 ↗ a+b complex topology › Tic22 › Tic22 › Tic22 0.50 27.0 3.13e-01 83.2% 73.1%
D4 medium residues 593-754
PDB
Domain cluster: rep: helicase-primase_subunit__YP_009342398__Spheniscid_alphaherpesvirus_1__2560777__D627-772