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helicase-primase_subunit
Euk-VirBeluga_whale_alphaherpesvirus_1
helicase-primase_subunit__YP_010084983__Beluga_whale_alphaherpesvirus_1__1434720
Identity
- Accession:
- YP_010084983 ↗
- Protein ID:
- helicase-primase_subunit
- Kingdom:
- euk
Quality
89.6
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Varicellovirus›
Beluga_whale_alphaherpesvirus_1
TaxID: 1434720
Cluster
View cluster (61 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 14-150_243-254
Domain cluster:
rep: helicase-primase_subunit__YP_068368__Suid_alphaherpesvirus_1__10345__D1-121
D2
medium
residues 151-167_203-242_255-352
Domain cluster:
rep: ORF31__NP_733884__Callitrichine_gammaherpesvirus_3__106331__D132-145_190-351
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03324.21 best | Herpes_HEPA | 70.6 | 1.60e-19 | 60.7% | 80.2% |
D3
medium
residues 381-404_479-575
Domain cluster:
rep: NC_004735.1__NP_835679.1__Rm378p092__00092__D1-33_185-289
CATH (8)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2gv9B04 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.71 | 65.0 | 5.40e-01 | 96.7% | 100.0% |
| 4fxdA05 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.71 | 62.0 | 6.33e-01 | 95.0% | 95.7% |
| 1azsA00 | 3.30.70.1230 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Nucleotide cyclase, GGDEF domain | 0.61 | 51.0 | 4.35e-01 | 88.4% | 70.5% |
| 2py5A02 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.60 | 55.0 | 4.79e-01 | 97.5% | 78.2% |
| 3cu7A05 | 2.60.40.1930 | Mainly Beta › Sandwich › Immunoglobulin-like › Macroglobulin (MG2) domain | 0.58 | 31.0 | 3.34e-01 | 81.8% | 58.5% |
| 2q7nA05 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.58 | 31.0 | 3.41e-01 | 82.6% | 62.2% |
| 7sz8A02 | 2.60.40.60 | Mainly Beta › Sandwich › Immunoglobulin-like › Cadherins | 0.53 | 27.0 | 2.96e-01 | 81.8% | 57.9% |
| 4bluB00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.51 | 34.0 | 2.66e-01 | 87.6% | 30.1% |
ECOD (21)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3684974 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.73 | 68.0 | 4.10e-01 | 96.7% | 39.1% |
| 3784383 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.73 | 67.0 | 4.61e-01 | 96.7% | 70.5% |
| 3801150 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.73 | 68.0 | 4.98e-01 | 99.2% | 82.7% |
| 3466667 | 2484.1.1.161 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.72 | 67.0 | 4.11e-01 | 99.2% | 34.5% |
| 4958554 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.70 | 66.0 | 5.15e-01 | 99.2% | 97.4% |
| 5017083 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.70 | 64.0 | 4.81e-01 | 96.7% | 85.6% |
| 4282509 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.67 | 61.0 | 3.89e-01 | 98.3% | 31.7% |
| 4100823 | 4970.1.1.1 ↗ | alpha bundles › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.67 | 60.0 | 4.69e-01 | 97.5% | 84.0% |
| 4942685 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.66 | 60.0 | 3.87e-01 | 96.7% | 45.4% |
| 4956224 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.66 | 61.0 | 4.75e-01 | 97.5% | 91.5% |
| 3506687 | 304.48.1.17 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_2 | 0.61 | 57.0 | 3.81e-01 | 100.0% | 70.9% |
| 4629102 | 2484.1.1.36 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_2 | 0.60 | 56.0 | 3.67e-01 | 100.0% | 32.4% |
| 4264107 | 304.48.1.17 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_2 | 0.58 | 55.0 | 4.00e-01 | 100.0% | 72.3% |
| 3582653 | 304.48.1.17 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_2 | 0.58 | 54.0 | 4.57e-01 | 100.0% | 64.7% |
| 4243736 | 304.48.1.17 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_2 | 0.57 | 53.0 | 4.75e-01 | 100.0% | 73.9% |
| 4365778 | 304.48.1.17 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_2 | 0.56 | 52.0 | 3.88e-01 | 100.0% | 83.6% |
| 3615693 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.56 | 47.0 | 3.89e-01 | 92.6% | 89.5% |
| 3680878 | 304.48.1.17 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_2 | 0.56 | 52.0 | 3.73e-01 | 100.0% | 85.6% |
| 2396500 | 11.1.1.236 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Mannosidase_ig | 0.54 | 31.0 | 3.35e-01 | 81.8% | 64.7% |
| 3910715 | 10.10.1.0 ↗ | beta sandwiches › jelly-roll › Lipase/lipooxygenase domain (PLAT/LH2 domain) › Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.51 | 39.0 | 3.83e-01 | 81.8% | 100.0% |
| 5034544 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.50 | 26.0 | 2.87e-01 | 80.2% | 60.2% |
D4
medium
residues 405-478
D5
medium
residues 577-729
Domain cluster:
rep: helicase-primase_subunit__YP_009342398__Spheniscid_alphaherpesvirus_1__2560777__D627-772
CATH (25)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4qclA05 | 1.10.132.60 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain | 0.68 | 63.0 | 6.10e-01 | 99.3% | 93.5% |
| 2oerA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.66 | 44.0 | 4.16e-01 | 100.0% | 57.5% |
| 3a11B01 | 1.20.120.420 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1 | 0.64 | 39.0 | 4.32e-01 | 100.0% | 75.2% |
| 4kb2A01 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.63 | 42.0 | 4.84e-01 | 90.8% | 93.6% |
| 1zvzA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.61 | 35.0 | 3.83e-01 | 90.2% | 66.9% |
| 7oq4Z01 | 1.20.120.950 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein DUF5062 | 0.61 | 27.0 | 3.33e-01 | 90.2% | 62.2% |
| 6hj2A00 | 1.10.565.10 | Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor | 0.61 | 32.0 | 2.63e-01 | 88.2% | 27.4% |
| 3nbxX03 | 1.20.58.1510 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 34.0 | 4.02e-01 | 93.5% | 82.2% |
| 1s35A01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.59 | 34.0 | 4.13e-01 | 96.7% | 87.1% |
| 1q0gA00 | 1.20.120.400 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nickel-containing superoxide dismutase | 0.58 | 33.0 | 3.76e-01 | 86.3% | 71.8% |
| 5dukB00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.58 | 24.0 | 3.47e-01 | 91.5% | 85.1% |
| 1vcsA00 | 1.20.58.400 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins | 0.57 | 34.0 | 4.05e-01 | 90.8% | 88.2% |
| 7d3uC01 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.57 | 32.0 | 3.79e-01 | 85.0% | 78.5% |
| 2f07B00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.57 | 41.0 | 3.76e-01 | 100.0% | 57.1% |
| 3edvB01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.56 | 37.0 | 3.87e-01 | 92.8% | 72.8% |
| 3r2qA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.56 | 33.0 | 3.77e-01 | 100.0% | 77.0% |
| 1zeeA01 | 1.20.58.600 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.55 | 36.0 | 3.99e-01 | 100.0% | 83.1% |
| 1wcrA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.55 | 34.0 | 4.01e-01 | 92.2% | 92.2% |
| 3zheA02 | 1.25.40.760 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.54 | 34.0 | 3.10e-01 | 100.0% | 45.4% |
| 2kmfA01 | 1.20.58.810 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Photosystem II Pbs27 | 0.54 | 29.0 | 3.49e-01 | 86.3% | 77.5% |
| 3f1bA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.54 | 37.0 | 3.48e-01 | 99.3% | 57.9% |
| 3r6nB01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.53 | 35.0 | 3.15e-01 | 92.2% | 45.1% |
| 2pmzK00 | 3.90.940.10 | Alpha Beta › Alpha-Beta Complex › Eukaryotic RPB6 RNA polymerase subunit › RNA polymerase subunit, RPB6/omega | 0.53 | 29.0 | 3.70e-01 | 81.7% | 96.3% |
| 1bbnA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.52 | 36.0 | 3.80e-01 | 92.2% | 79.7% |
| 1g2rA00 | 3.30.1230.10 | Alpha Beta › 2-Layer Sandwich › Hypothetical Cytosolic Protein; Chain: A; › YlxR-like | 0.51 | 23.0 | 2.83e-01 | 90.2% | 64.9% |
ECOD (23)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3971428 | 3706.1.1.1 ↗ | alpha bundles › Conserved type six secretion component TssL-related › Conserved type six secretion component TssL-related › Conserved type six secretion component TssL-related › DotU | 0.75 | 44.0 | 4.33e-01 | 96.7% | 54.5% |
| 4929241 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.72 | 61.0 | 6.14e-01 | 98.7% | 88.4% |
| 3715557 | 109.4.1.1341 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › COG3_N, COG3_C | 0.63 | 46.0 | 3.08e-01 | 97.4% | 22.2% |
| 3457663 | 192.29.1.178 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › PF28703 | 0.62 | 37.0 | 4.31e-01 | 94.1% | 84.8% |
| 3062952 | 108.1.1.0 ↗ | alpha arrays › EF-hand › EF-hand-related › EF-hand | 0.61 | 33.0 | 3.88e-01 | 88.9% | 75.0% |
| 3569305 | 109.4.1.1158 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_IPO11 | 0.60 | 36.0 | 2.60e-01 | 100.0% | 21.0% |
| 3400732 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.59 | 38.0 | 4.18e-01 | 91.5% | 80.0% |
| 3220229 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.58 | 37.0 | 4.09e-01 | 92.8% | 80.0% |
| 3808 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.58 | 35.0 | 4.11e-01 | 95.4% | 85.8% |
| 3245545 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.57 | 39.0 | 4.38e-01 | 92.2% | 93.0% |
| 3749998 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.56 | 36.0 | 3.99e-01 | 92.2% | 81.7% |
| 3938862 | 604.1.1.98 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_Anc-1 | 0.56 | 35.0 | 4.03e-01 | 92.8% | 86.4% |
| 3755118 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.56 | 36.0 | 4.06e-01 | 92.8% | 86.1% |
| 3917090 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.56 | 36.0 | 3.84e-01 | 92.2% | 73.3% |
| 3581461 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.54 | 35.0 | 3.81e-01 | 92.8% | 80.0% |
| 3469833 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.54 | 34.0 | 3.80e-01 | 92.2% | 80.0% |
| 3400711 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.52 | 33.0 | 2.64e-01 | 92.2% | 30.0% |
| 3992995 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.51 | 30.0 | 3.50e-01 | 96.7% | 82.5% |
| 3545242 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.51 | 32.0 | 3.57e-01 | 90.8% | 81.7% |
| 3321310 | 603.1.1.5 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin-6_N | 0.51 | 34.0 | 3.74e-01 | 92.8% | 86.7% |
| 3751495 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.50 | 32.0 | 2.95e-01 | 94.8% | 45.2% |
| 3750022 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.50 | 32.0 | 3.69e-01 | 92.2% | 89.1% |
| 3564106 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.50 | 32.0 | 3.71e-01 | 92.8% | 91.4% |