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helicase-primase_subunit
Euk-VirCervid_alphaherpesvirus_3
helicase-primase_subunit__YP_010087594__Cervid_alphaherpesvirus_3__2115790
Identity
- Accession:
- YP_010087594 ↗
- Protein ID:
- helicase-primase_subunit
- Kingdom:
- euk
Quality
90.5
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Varicellovirus›
Cervid_alphaherpesvirus_3
TaxID: 2115790
Cluster
View cluster (61 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-142
Domain cluster:
rep: helicase-primase_subunit__YP_004940263__Saimiriine_betaherpesvirus_4__1535247__D1-152
CATH (24)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3f14A00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.65 | 29.0 | 3.28e-01 | 85.2% | 51.8% |
| 4gs3A00 | 2.40.50.140 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins | 0.65 | 41.0 | 5.05e-01 | 97.2% | 100.0% |
| 3lygA00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.65 | 30.0 | 3.28e-01 | 93.0% | 50.8% |
| 2jq5A00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.62 | 29.0 | 3.07e-01 | 85.2% | 46.9% |
| 2imjD01 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.61 | 29.0 | 3.00e-01 | 84.5% | 43.7% |
| 3hx8A00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.61 | 31.0 | 3.32e-01 | 83.8% | 53.1% |
| 1fguB02 | 2.40.50.140 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins | 0.61 | 43.0 | 4.59e-01 | 100.0% | 83.1% |
| 3ebtA00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.59 | 31.0 | 3.21e-01 | 92.3% | 51.9% |
| 5aigA00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.58 | 30.0 | 3.26e-01 | 88.7% | 55.6% |
| 3er7B00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.58 | 29.0 | 3.14e-01 | 84.5% | 52.8% |
| 3fhwA00 | 2.40.50.140 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins | 0.58 | 39.0 | 4.62e-01 | 97.9% | 99.0% |
| 5odnC00 | 2.40.50.140 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins | 0.58 | 39.0 | 4.48e-01 | 95.1% | 94.1% |
| 4kz1A00 | 3.10.450.230 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › VirB8 protein | 0.58 | 32.0 | 3.32e-01 | 86.6% | 57.0% |
| 2cc3A00 | 3.10.450.230 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › VirB8 protein | 0.57 | 33.0 | 3.35e-01 | 83.1% | 54.9% |
| 3iayA01 | 2.40.50.730 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › | 0.56 | 38.0 | 4.47e-01 | 99.3% | 99.0% |
| 2vl6A02 | 2.40.50.140 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins | 0.56 | 39.0 | 4.32e-01 | 95.1% | 89.3% |
| 4o3vA00 | 3.10.450.230 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › VirB8 protein | 0.55 | 31.0 | 3.18e-01 | 86.6% | 55.1% |
| 3cqnB00 | 2.40.128.20 | Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain | 0.55 | 35.0 | 3.38e-01 | 73.2% | 55.3% |
| 3u4vA00 | 2.40.50.140 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins | 0.55 | 43.0 | 4.70e-01 | 97.2% | 99.1% |
| 2vw9B00 | 2.40.50.140 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins | 0.54 | 38.0 | 4.38e-01 | 95.1% | 99.0% |
| 3ff0A01 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.52 | 29.0 | 3.01e-01 | 88.0% | 53.9% |
| 4jf8A00 | 3.10.450.230 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › VirB8 protein | 0.51 | 30.0 | 3.08e-01 | 84.5% | 56.2% |
| 3bxoA02 | 2.20.130.10 | Mainly Beta › Single Sheet › S-adenosyl-L-methionine-dependent methyltransferases › CAC2371-like domains | 0.51 | 22.0 | 3.12e-01 | 78.2% | 89.8% |
| 5irbA01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.50 | 32.0 | 3.71e-01 | 93.7% | 88.5% |
ECOD (28)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3317450 | 2.1.1.0 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein | 0.74 | 45.0 | 5.08e-01 | 99.3% | 78.2% |
| 3589048 | 243.1.1.7 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like › MecA_N | 0.67 | 33.0 | 3.41e-01 | 88.7% | 47.9% |
| 3280323 | 243.1.1.7 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like › MecA_N | 0.66 | 31.0 | 3.59e-01 | 86.6% | 60.0% |
| 3978258 | 243.3.1.0 ↗ | a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin | 0.65 | 32.0 | 3.96e-01 | 89.4% | 73.1% |
| 3950757 | 243.1.1.7 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like › MecA_N | 0.64 | 32.0 | 3.57e-01 | 88.7% | 57.4% |
| 4982481 | 2.1.1.0 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein | 0.63 | 38.0 | 4.54e-01 | 93.0% | 89.5% |
| 3225768 | 883.1.1.0 ↗ | a+b complex topology › Aha1/BPI domain-like › Aha1/BPI domain-like › Aha1/BPI domain-like | 0.62 | 35.0 | 3.34e-01 | 90.8% | 45.3% |
| 4593266 | 325.1.7.0 ↗ | a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif | 0.61 | 28.0 | 3.72e-01 | 90.1% | 80.0% |
| 4464528 | 243.1.1.0 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like | 0.60 | 28.0 | 3.14e-01 | 85.9% | 54.1% |
| 3252847 | 2.1.1.0 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein | 0.59 | 35.0 | 4.28e-01 | 92.3% | 96.5% |
| 4026722 | 2.1.1.76 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › REPA_OB_2 | 0.59 | 44.0 | 4.48e-01 | 100.0% | 78.6% |
| 3250428 | 2.1.1.0 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein | 0.58 | 35.0 | 3.57e-01 | 93.0% | 57.9% |
| 4565299 | 243.1.1.6 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like › VirB8 | 0.58 | 33.0 | 3.35e-01 | 85.9% | 55.6% |
| 6403 | 243.1.1.6 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like › VirB8 | 0.57 | 33.0 | 3.38e-01 | 83.1% | 56.4% |
| 3458037 | 243.3.1.19 ↗ | a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin › DUF3615 | 0.57 | 35.0 | 3.23e-01 | 86.6% | 48.6% |
| 4448420 | 2.1.1.0 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein | 0.57 | 52.0 | 4.35e-01 | 99.3% | 81.7% |
| 3238606 | 243.3.1.0 ↗ | a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin | 0.57 | 34.0 | 3.72e-01 | 90.1% | 72.2% |
| 3666655 | 2.1.1.0 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein | 0.57 | 42.0 | 4.51e-01 | 100.0% | 88.0% |
| 4018893 | 243.1.1.0 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like | 0.56 | 30.0 | 3.05e-01 | 90.8% | 49.7% |
| None | — | 0.55 | 51.0 | 3.10e-01 | 99.3% | 24.7% | |
| 3223708 | 243.1.1.0 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like | 0.53 | 30.0 | 3.31e-01 | 90.1% | 66.7% |
| 4956351 | 2.1.1.0 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein | 0.52 | 47.0 | 3.21e-01 | 97.2% | 36.7% |
| 3247589 | 243.1.1.0 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like | 0.52 | 31.0 | 3.24e-01 | 90.8% | 63.2% |
| 3582816 | 243.1.1.0 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like | 0.51 | 31.0 | 3.18e-01 | 90.8% | 62.7% |
| 4978072 | 512.1.1.0 ↗ | a+b two layers › a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) › a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) › a+b domain in putative modulator of DNA gyrase, PmbA/TldD (Pfam 01523) | 0.50 | 29.0 | 3.18e-01 | 89.4% | 69.1% |
| 3828737 | 243.1.1.2 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like › NTF2 | 0.50 | 32.0 | 3.42e-01 | 90.1% | 74.2% |
| 3786132 | 330.1.1.4 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › Rad52_Rad22 | 0.50 | 35.0 | 3.49e-01 | 87.3% | 69.0% |
| 3258019 | 2.1.1.0 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein | 0.50 | 40.0 | 3.95e-01 | 100.0% | 79.3% |
D2
medium
residues 143-255
Domain cluster:
rep: helicase-primase_subunit__YP_001033936__Gallid_alphaherpesvirus_2__10390__D159-238
D3
medium
residues 256-341
Domain cluster:
rep: ORF40__YP_009173917__Felis_catus_gammaherpesvirus_1__1452540__D204-289
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03324.21 best | Herpes_HEPA | 49.7 | 5.40e-13 | 74.4% | 67.0% |
D4
medium
residues 342-387_428-462
Domain cluster:
representative
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3bjdA01 | 1.10.1240.20 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Lytic transglycosylase, superhelical linker domain | 0.58 | 42.0 | 4.14e-01 | 98.8% | 70.5% |
| 3b6hA00 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.57 | 50.0 | 3.16e-01 | 100.0% | 68.7% |
| 1juqC00 | 1.25.40.90 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.52 | 37.0 | 3.06e-01 | 100.0% | 40.9% |
| 1eiaA01 | 1.10.375.10 | Mainly Alpha › Orthogonal Bundle › Human Immunodeficiency Virus Type 1 Capsid Protein › Human Immunodeficiency Virus Type 1 Capsid Protein | 0.51 | 31.0 | 2.65e-01 | 100.0% | 36.8% |
| 3pivA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.51 | 43.0 | 3.58e-01 | 100.0% | 79.5% |
ECOD (1)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3644602 | 5070.1.1.1 ↗ | alpha arrays › 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › UCR_14kD | 0.54 | 33.0 | 3.40e-01 | 71.6% | 62.5% |
D5
medium
residues 388-427_463-576
Domain cluster:
rep: NC_004735.1__NP_835679.1__Rm378p092__00092__D1-33_185-289
D6
medium
residues 644-704
Domain cluster:
representative
CATH (6)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4da2A01 | 2.40.50.580 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › | 0.60 | 48.0 | 4.46e-01 | 90.2% | 93.7% |
| 6lcqA00 | 3.30.30.10 | Alpha Beta › 2-Layer Sandwich › Defensin A-like › Knottin, scorpion toxin-like | 0.57 | 32.0 | 3.41e-01 | 85.2% | 61.1% |
| 3mlqH00 | 2.40.10.170 | Mainly Beta › Beta Barrel › Thrombin, subunit H › | 0.55 | 36.0 | 4.01e-01 | 100.0% | 97.6% |
| 4zpjA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.54 | 42.0 | 3.05e-01 | 85.2% | 85.4% |
| 2eqsA01 | 2.40.50.140 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins | 0.52 | 41.0 | 3.71e-01 | 91.8% | 93.3% |
| 5oomJ01 | 3.30.1550.10 | Alpha Beta › 2-Layer Sandwich › Ribosomal protein L11, N-terminal domain › Ribosomal protein L11/L12, N-terminal domain | 0.50 | 36.0 | 3.60e-01 | 80.3% | 97.0% |
ECOD (16)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3476371 | 1.1.7.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C | 0.61 | 41.0 | 3.15e-01 | 70.5% | 77.9% |
| 4006298 | 284.1.1.0 ↗ | a+b two layers › FKBP-like › FKBP-like › FKBP-like | 0.59 | 33.0 | 3.50e-01 | 88.5% | 60.0% |
| 3594165 | 1.1.7.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C | 0.58 | 39.0 | 2.92e-01 | 70.5% | 70.6% |
| 3511311 | 2.6.1.0 ↗ | beta barrels › OB-fold › Staphylococcal nuclease › Staphylococcal nuclease | 0.58 | 45.0 | 3.99e-01 | 90.2% | 82.7% |
| 2036627 | 284.4.1.0 ↗ | a+b two layers › FKBP-like › Archaeal FKBP insertion domain › Archaeal FKBP insertion domain | 0.57 | 34.0 | 3.32e-01 | 90.2% | 50.7% |
| 1557348 | 4.1.1.32 ↗ | beta barrels › SH3 › SH3 › SH3 › CarD_TRCF_RID | 0.55 | 36.0 | 4.01e-01 | 100.0% | 97.6% |
| 4123274 | 284.4.1.0 ↗ | a+b two layers › FKBP-like › Archaeal FKBP insertion domain › Archaeal FKBP insertion domain | 0.55 | 32.0 | 3.33e-01 | 88.5% | 60.0% |
| 3647911 | 4.1.1.0 ↗ | beta barrels › SH3 › SH3 › SH3 | 0.54 | 29.0 | 3.39e-01 | 96.7% | 82.9% |
| 3579004 | 2.6.1.0 ↗ | beta barrels › OB-fold › Staphylococcal nuclease › Staphylococcal nuclease | 0.54 | 42.0 | 3.54e-01 | 95.1% | 94.4% |
| 3619402 | 2.6.1.0 ↗ | beta barrels › OB-fold › Staphylococcal nuclease › Staphylococcal nuclease | 0.53 | 43.0 | 3.75e-01 | 96.7% | 90.5% |
| 3239431 | 206.1.1.1 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase | 0.53 | 40.0 | 2.60e-01 | 88.5% | 35.7% |
| 3276905 | 221.4.1.1 ↗ | a+b two layers › beta-Grasp › Nudix › Nudix › NUDIX | 0.53 | 45.0 | 3.07e-01 | 95.1% | 28.8% |
| 3999675 | 2.6.1.0 ↗ | beta barrels › OB-fold › Staphylococcal nuclease › Staphylococcal nuclease | 0.51 | 40.0 | 3.43e-01 | 91.8% | 94.5% |
| 3822816 | 387.1.5.1 ↗ | few secondary structure elements › omega toxin-like › omega toxin-related › Scorpion toxin-like › Gamma-thionin | 0.51 | 29.0 | 3.21e-01 | 85.2% | 70.0% |
| 5011625 | 2008.1.1.57 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › VirArc_Nuclease | 0.50 | 43.0 | 3.04e-01 | 98.4% | 84.1% |
| 3669342 | 387.1.5.1 ↗ | few secondary structure elements › omega toxin-like › omega toxin-related › Scorpion toxin-like › Gamma-thionin | 0.50 | 30.0 | 3.06e-01 | 85.2% | 60.0% |