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helicase

Euk-Vir

African_swine_fever_virus

helicase__YP_009702368__African_swine_fever_virus__10497

Identity

Accession:
YP_009702368 ↗
Protein ID:
helicase
Kingdom:
euk

Quality

76.5 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Pokkesviricetes› Asfuvirales› Asfarviridae› Asfivirus› African_swine_fever_virus

TaxID: 10497

Cluster

View cluster (106 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 641-702
PDB
Domain cluster: rep: hypothetical_protein_BNJ_00447__YP_009352839__Kaumoebavirus_Viruses.__X__D733-789
CATH (42)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2af5A01 2.40.128.160 Mainly Beta › Beta Barrel › Lipocalin › C1 set domains (antibody constant domain-like) 0.63 43.0 4.60e-01 87.1% 83.3%
1llnA01 3.40.420.10 Alpha Beta › 3-Layer(aba) Sandwich › Ricin (A subunit); domain 1 › Ricin (A subunit), domain 1 0.63 50.0 3.69e-01 90.3% 72.6%
2cfuA01 3.60.15.30 Alpha Beta › 4-Layer Sandwich › Metallo-beta-lactamase; Chain A › Metallo-beta-lactamase domain 0.62 49.0 3.07e-01 88.7% 67.2%
3a32A02 3.40.50.800 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Anticodon-binding domain 0.61 44.0 3.41e-01 77.4% 73.0%
1y7bA01 2.115.10.20 Mainly Beta › 5 Propeller › Tachylectin-2; Chain A › Glycosyl hydrolase domain; family 43 0.59 50.0 3.16e-01 95.2% 30.2%
3cp2A02 2.40.30.260 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › 0.59 43.0 3.76e-01 79.0% 71.7%
2hesX00 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.58 48.0 3.08e-01 93.5% 32.8%
4uf7B00 2.120.10.10 Mainly Beta › 6 Propeller › Neuraminidase › 0.57 48.0 2.98e-01 100.0% 46.8%
2zylA01 2.102.10.10 Mainly Beta › 3-layer Sandwich › Rieske Iron-sulfur Protein › Rieske [2Fe-2S] iron-sulphur domain 0.56 44.0 3.57e-01 90.3% 67.4%
1rieA00 2.102.10.10 Mainly Beta › 3-layer Sandwich › Rieske Iron-sulfur Protein › Rieske [2Fe-2S] iron-sulphur domain 0.56 43.0 3.50e-01 85.5% 88.2%
2vhfB00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.56 45.0 2.94e-01 96.8% 96.4%
3lxqA01 3.30.1120.80 Alpha Beta › 2-Layer Sandwich › Arylsulfatase, C-terminal domain › 0.55 41.0 3.57e-01 80.6% 72.7%
1jyaB00 3.30.1460.10 Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › 0.55 41.0 3.35e-01 80.6% 69.4%
2e9hA02 2.20.25.350 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › 0.55 35.0 3.78e-01 71.0% 88.6%
2vg9A00 2.60.120.180 Mainly Beta › Sandwich › Jelly Rolls › Glycoside hydrolase family 11/12, catalytic domain 0.55 47.0 3.31e-01 100.0% 43.8%
1r8oB01 2.30.30.480 Mainly Beta › Roll › SH3 type barrels. › 0.55 42.0 4.13e-01 85.5% 93.9%
3wxeA00 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.55 46.0 3.04e-01 98.4% 93.7%
3fgbA00 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.55 45.0 2.84e-01 93.5% 28.7%
7szeB01 2.102.10.10 Mainly Beta › 3-layer Sandwich › Rieske Iron-sulfur Protein › Rieske [2Fe-2S] iron-sulphur domain 0.55 43.0 3.71e-01 90.3% 87.9%
6bhdA03 2.30.30.140 Mainly Beta › Roll › SH3 type barrels. › 0.54 39.0 3.96e-01 90.3% 79.4%
1s4uX00 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.54 45.0 2.83e-01 93.5% 30.6%
3hfqA00 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.54 45.0 2.88e-01 96.8% 47.9%
2eqmA01 2.30.30.140 Mainly Beta › Roll › SH3 type barrels. › 0.53 39.0 4.04e-01 87.1% 94.3%
5os9A00 2.40.330.10 Mainly Beta › Beta Barrel › At1g16640 B3 domain › DNA-binding pseudobarrel domain 0.53 39.0 3.28e-01 80.6% 57.4%
3mazA00 3.30.505.10 Alpha Beta › 2-Layer Sandwich › SHC Adaptor Protein › SH2 domain 0.53 41.0 3.63e-01 88.7% 68.7%
1y96D00 2.30.30.100 Mainly Beta › Roll › SH3 type barrels. › 0.53 40.0 3.72e-01 83.9% 66.3%
3mx7A00 2.40.128.180 Mainly Beta › Beta Barrel › Lipocalin › 0.53 41.0 3.75e-01 90.3% 96.7%
3bs4A00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.53 40.0 2.72e-01 83.9% 98.4%
4rbnA01 3.10.450.330 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.53 41.0 3.36e-01 90.3% 82.2%
2db2A01 3.30.160.20 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.53 37.0 3.31e-01 75.8% 70.2%
2retA00 3.30.1300.30 Alpha Beta › 2-Layer Sandwich › Pantoate--beta-alanine Ligase; Chain: A,domain 2 › GSPII I/J protein-like 0.53 36.0 3.26e-01 71.0% 63.1%
2lezA00 3.30.2450.10 Alpha Beta › 2-Layer Sandwich › Secreted effector protein pipB2 fold › Secreted effector protein pipB2 0.53 38.0 3.14e-01 79.0% 67.5%
2e4mC00 2.80.10.50 Mainly Beta › Trefoil › Trefoil (Acidic Fibroblast Growth Factor, subunit A) › 0.52 40.0 3.23e-01 90.3% 43.4%
3lygA00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.52 37.0 3.12e-01 79.0% 55.8%
4xcmA02 3.90.1720.10 Alpha Beta › Alpha-Beta Complex › endopeptidase fold (from Nostoc punctiforme) › endopeptidase domain like (from Nostoc punctiforme) 0.52 41.0 3.45e-01 95.2% 87.0%
1k32A01 2.120.10.60 Mainly Beta › 6 Propeller › Neuraminidase › Tricorn protease N-terminal domain 0.52 41.0 2.79e-01 93.5% 44.9%
2gu3A02 3.10.450.40 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.51 42.0 4.23e-01 91.9% 95.2%
5iroD00 2.60.40.3530 Mainly Beta › Sandwich › Immunoglobulin-like › 0.51 36.0 3.14e-01 75.8% 73.5%
1qypA00 2.20.25.10 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › 0.51 41.0 4.22e-01 98.4% 100.0%
1a15A00 2.40.50.40 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › 0.50 40.0 3.99e-01 93.5% 86.6%
1vmeB01 3.60.15.10 Alpha Beta › 4-Layer Sandwich › Metallo-beta-lactamase; Chain A › Ribonuclease Z/Hydroxyacylglutathione hydrolase-like 0.50 39.0 2.68e-01 90.3% 51.8%
3kh8A02 3.10.129.10 Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Hotdog Thioesterase 0.50 39.0 3.16e-01 88.7% 93.2%
ECOD (53)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3218417 375.1.1.0 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related 0.70 48.0 4.34e-01 80.6% 52.9%
3211026 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.67 46.0 3.97e-01 71.0% 46.3%
3391302 5.1.4.0 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed 0.66 55.0 3.52e-01 95.2% 19.3%
4029085 11.16.1.1 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › N-terminal domain in A1 cistron-splicing factor AAR2 › N-terminal domain in A1 cistron-splicing factor AAR2 › AAR2_1st 0.64 52.0 3.99e-01 88.7% 56.4%
3829068 5.1.3.65 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › DUF295 0.63 53.0 3.65e-01 96.8% 27.4%
4930465 4294.1.1.0 ↗ few secondary structure elements › Trm112p-like › Trm112p-like › Trm112p-like 0.63 51.0 5.16e-01 90.3% 100.0%
5052205 2004.1.1.198 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 0.63 50.0 2.90e-01 88.7% 9.0%
3430306 5.1.3.118 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › FBA_3 0.62 50.0 3.24e-01 95.2% 37.6%
5058622 5.1.9.0 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › Propeller domain in ABC toxin B component 0.61 52.0 3.46e-01 95.2% 35.6%
3811228 5.1.3.118 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › FBA_3 0.61 51.0 3.31e-01 95.2% 28.7%
2439625 1170.1.1.1 ↗ beta barrels › IL8-related › IL8-related › IL8 › IL8 0.61 49.0 4.28e-01 90.3% 59.2%
3436743 5.1.3.67 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › FBA_1 0.61 51.0 3.27e-01 95.2% 25.9%
4267419 219.1.1.6 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Acetyltransf_2 0.61 51.0 3.45e-01 96.8% 62.2%
3363058 5.1.8.0 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › putative conserved lipoprotein NT01CX_1156 0.60 50.0 3.45e-01 95.2% 40.0%
3322492 5.1.4.550 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › Kelch_FKB95 0.60 49.0 3.21e-01 93.5% 33.7%
3850092 4099.1.1.21 ↗ a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like › RM3_Med14 0.59 41.0 3.62e-01 71.0% 60.0%
3188230 5.1.4.0 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed 0.58 47.0 3.05e-01 91.9% 36.4%
4283257 243.3.1.52 ↗ a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin › UPF0182 0.57 47.0 3.03e-01 95.2% 49.7%
5069567 243.6.1.0 ↗ a+b two layers › Cystatin-like › Pre-PUA domain › Pre-PUA domain 0.57 39.0 3.83e-01 72.6% 84.3%
3831169 5.1.5.66 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 8-bladed › FBA_1 0.57 47.0 3.14e-01 95.2% 29.8%
3211871 2008.1.1.31 ↗ a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › VRR_NUC 0.57 43.0 2.88e-01 80.6% 83.3%
3438347 5.1.5.63 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 8-bladed › DUF1618 0.57 45.0 3.53e-01 88.7% 77.9%
5047049 2004.1.1.198 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 0.57 45.0 2.60e-01 88.7% 21.3%
4952518 881.1.1.0 ↗ a+b three layers › Mog1p/PsbP-like › Mog1p/PsbP-like › Mog1p/PsbP-like 0.56 45.0 3.81e-01 90.3% 74.5%
3485965 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.56 39.0 4.01e-01 88.7% 78.3%
4998939 2003.1.2.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain 0.56 40.0 3.01e-01 79.0% 92.6%
4105193 325.1.7.0 ↗ a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif 0.56 40.0 3.54e-01 77.4% 85.3%
4569026 4041.1.1.1 ↗ a+b complex topology › insertion domain in beta subunit of DNA dependent RNA-polymerase › insertion domain in beta subunit of DNA dependent RNA-polymerase › insertion domain in beta subunit of DNA dependent RNA-polymerase › RNA_pol_Rpb2_2 0.56 38.0 2.92e-01 72.6% 92.5%
3819081 5.1.3.67 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › FBA_1 0.56 47.0 3.07e-01 98.4% 37.7%
3804709 5.1.3.65 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › DUF295 0.55 44.0 2.89e-01 91.9% 19.5%
4481026 4.1.1.407 ↗ beta barrels › SH3 › SH3 › SH3 › PF29661 0.55 39.0 3.97e-01 88.7% 80.0%
3617111 4.1.1.9 ↗ beta barrels › SH3 › SH3 › SH3 › TUDOR 0.55 36.0 3.31e-01 88.7% 47.8%
3494479 5.1.4.6 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40,ANAPC4_WD40 0.54 44.0 2.67e-01 93.5% 24.0%
4181736 4041.1.1.0 ↗ a+b complex topology › insertion domain in beta subunit of DNA dependent RNA-polymerase › insertion domain in beta subunit of DNA dependent RNA-polymerase › insertion domain in beta subunit of DNA dependent RNA-polymerase 0.54 37.0 2.87e-01 74.2% 93.9%
3853654 5.1.3.6 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › Kelch_1 0.54 44.0 2.89e-01 95.2% 24.5%
5040847 5.1.5.0 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 8-bladed 0.54 44.0 2.90e-01 93.5% 47.1%
4030033 331.4.1.0 ↗ a+b two layers › TBP-like › Kinase associated domain 1, KA1 › Kinase associated domain 1, KA1 0.54 37.0 3.57e-01 74.2% 66.7%
3266081 5.1.3.135 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › Kelch_1, Kelch_KLHDC2_KLHL20_DRC7, Beta-prop_ATRN-LZTR1 0.54 45.0 2.91e-01 96.8% 27.0%
3902978 5.1.3.6 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › Kelch_1 0.54 44.0 2.86e-01 95.2% 23.7%
3914746 4.1.1.128 ↗ beta barrels › SH3 › SH3 › SH3 › Tudor_4 0.54 38.0 3.77e-01 90.3% 70.0%
136515 1170.1.1.1 ↗ beta barrels › IL8-related › IL8-related › IL8 › IL8 0.53 44.0 4.33e-01 93.5% 85.3%
4678702 3304.1.1.2 ↗ a+b two layers › Cellular targeting domain in sucrose synthase-1 › Cellular targeting domain in sucrose synthase-1 › Cellular targeting domain in sucrose synthase-1 › SUS_N 0.53 42.0 3.44e-01 90.3% 79.2%
5051418 295.1.1.0 ↗ a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain 0.53 42.0 3.29e-01 87.1% 70.4%
3699899 214.1.1.6 ↗ a+b two layers › SH2 › SH2 › SH2 › SH2_2 0.52 41.0 3.44e-01 90.3% 60.8%
2429397 214.1.1.4 ↗ a+b two layers › SH2 › SH2 › SH2 › MelC1 0.52 40.0 3.69e-01 83.9% 72.5%
3795223 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.52 42.0 3.89e-01 95.2% 91.8%
3922679 4.1.1.154 ↗ beta barrels › SH3 › SH3 › SH3 › DUF4772 0.52 36.0 3.82e-01 85.5% 94.0%
3684267 5.1.10.15 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 12-bladed › RPE65 0.51 38.0 3.16e-01 85.5% 50.0%
3597599 214.1.1.0 ↗ a+b two layers › SH2 › SH2 › SH2 0.51 41.0 3.57e-01 90.3% 73.0%
3937472 214.1.1.1 ↗ a+b two layers › SH2 › SH2 › SH2 › SH2 0.51 39.0 3.35e-01 83.9% 58.1%
3608202 77.3.1.3 ↗ beta meanders › open-sided beta-meander › CPAP G-box domain › CPAP G-box domain › MORN 0.51 36.0 2.89e-01 72.6% 42.4%
4023585 59.1.3.2 ↗ beta complex topology › triple barrel › triple barrel › RNA polymerase I subunits A49/A34.5 dimerization domains › RNA_polI_A34 0.51 36.0 3.02e-01 75.8% 66.1%
3797162 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.51 34.0 3.09e-01 85.5% 48.9%
D2 medium residues 11-65
PDB
Domain cluster: rep: Q706L__YP_009703177__African_swine_fever_virus__10497__D8-63
D3 medium residues 66-232
PDB
Domain cluster: rep: HQ123590.1__ADW08988.1__CN77-20-1__00001__D9-139_144-252
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00176.30 best SNF2-rel_dom 37.3 2.50e-09 98.8% 56.9%
PF04851.22 ResIII 30.5 4.60e-07 87.4% 85.4%
D4 medium residues 233-276_571-639
PDB
Domain cluster: rep: Q706L__YP_009704073__African_swine_fever_virus_Georgia_2007_1__874269__D233-274_573-611
D5 medium residues 277-289_377-444_457-570
PDB
Domain cluster: rep: OQ622096.1__WGH28569.1__13VV501A_gene0073__00071__D542-667
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00271.38 best Helicase_C 35.6 1.30e-08 56.9% 89.1%
D6 medium residues 290-376
PDB
Domain cluster: rep: hypothetical_protein_IM014_gp154__YP_009927245__African_swine_fever_virus__10497__D279-309_332-375