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helicase_primase_complex

Euk-Vir

Human_betaherpesvirus_6A

helicase_primase_complex__NP_042967__Human_betaherpesvirus_6A__32603

Identity

Accession:
NP_042967 ↗
Protein ID:
helicase_primase_complex
Kingdom:
euk

Quality

86.8 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Roseolovirus› Human_betaherpesvirus_6A

TaxID: 32603

Cluster

View cluster (7 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 1-127
PDB
Domain cluster: rep: helicase-primase_subunit__YP_004940263__Saimiriine_betaherpesvirus_4__1535247__D1-152
D2 medium residues 128-324
PDB
Domain cluster: rep: ORF31__NP_733884__Callitrichine_gammaherpesvirus_3__106331__D132-145_190-351
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03324.21 best Herpes_HEPA 67.5 1.50e-18 44.2% 98.9%
D3 medium residues 325-509
PDB
Domain cluster: rep: helicase-primase_subunit__YP_073814__Human_betaherpesvirus_7__10372__D324-506
D4 medium residues 510-662
PDB
Domain cluster: rep: E102__YP_007016498__Murid_betaherpesvirus_8__1261657__D578-728
CATH (16)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4fxdA06 1.10.132.60 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain 0.68 59.0 5.85e-01 94.1% 99.4%
4qclA05 1.10.132.60 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain 0.62 55.0 5.33e-01 96.1% 98.2%
1tgoA05 1.10.132.60 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain 0.62 54.0 5.31e-01 95.4% 92.8%
3iayA07 1.10.132.60 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain 0.61 55.0 5.52e-01 96.1% 98.7%
8amzP01 1.25.40.570 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.59 33.0 2.46e-01 94.1% 20.8%
1zk8B02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.59 38.0 4.09e-01 91.5% 74.2%
8fbnB01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.58 36.0 3.18e-01 96.7% 41.9%
6srbA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.55 34.0 3.87e-01 93.5% 84.4%
1q0gA00 1.20.120.400 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nickel-containing superoxide dismutase 0.54 32.0 3.58e-01 73.9% 73.5%
2ce7B03 1.20.58.760 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Peptidase M41 0.53 38.0 3.74e-01 82.4% 67.3%
4ri6A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.53 32.0 3.60e-01 92.8% 77.3%
2ra1A01 1.20.58.790 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.53 33.0 3.96e-01 85.6% 96.9%
4gltA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.52 35.0 3.96e-01 96.1% 91.2%
1b1uA00 1.10.110.10 Mainly Alpha › Orthogonal Bundle › Hydrophobic Seed Protein › Plant lipid-transfer and hydrophobic proteins 0.51 35.0 3.89e-01 100.0% 89.7%
2x64A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.51 35.0 3.95e-01 99.3% 92.9%
1zzpA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.51 32.0 3.69e-01 86.3% 86.2%
ECOD (17)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4961845 4969.1.1.1 ↗ alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.65 57.0 5.79e-01 94.8% 99.3%
5035013 4969.1.1.1 ↗ alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.65 56.0 5.53e-01 92.8% 99.4%
4931233 4969.1.1.1 ↗ alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.65 52.0 5.34e-01 85.0% 100.0%
3705557 4969.1.1.1 ↗ alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.65 56.0 5.58e-01 94.1% 100.0%
4982341 4969.1.1.0 ↗ alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I 0.64 57.0 5.83e-01 98.7% 100.0%
4674133 4969.1.1.1 ↗ alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.63 54.0 5.16e-01 92.2% 94.3%
3169738 4969.1.1.1 ↗ alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.62 56.0 5.55e-01 99.3% 100.0%
3314223 4969.1.1.1 ↗ alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.62 56.0 5.52e-01 98.0% 100.0%
57819 4969.1.1.0 ↗ alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I 0.62 54.0 5.37e-01 96.1% 93.9%
3167790 4969.1.1.1 ↗ alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.61 55.0 5.55e-01 96.7% 100.0%
4865217 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.59 50.0 5.18e-01 90.8% 100.0%
3520104 3121.1.1.0 ↗ a+b duplicates or obligate multimers › Polypeptide transport-associated (POTRA) domain › Polypeptide transport-associated (POTRA) domain › Polypeptide transport-associated (POTRA) domain 0.57 26.0 3.48e-01 100.0% 80.0%
3909630 601.48.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › vWA2 C-terminal domain › vWA2 C-terminal domain 0.52 25.0 3.27e-01 89.5% 85.3%
3782877 3121.1.1.0 ↗ a+b duplicates or obligate multimers › Polypeptide transport-associated (POTRA) domain › Polypeptide transport-associated (POTRA) domain › Polypeptide transport-associated (POTRA) domain 0.52 29.0 3.44e-01 100.0% 80.0%
3968504 632.7.1.4 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › MgtC 0.51 34.0 3.68e-01 81.0% 78.5%
4124115 604.39.1.5 ↗ alpha bundles › Spectrin repeat-like › S-component of energy-coupling factor (ECF) transporters › S-component of energy-coupling factor (ECF) transporters › ECF_trnsprt 0.51 40.0 3.70e-01 83.7% 78.0%
4432233 604.12.1.9 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › ATG1-like_MIT2 0.51 31.0 3.54e-01 86.3% 82.7%