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helicase_primase_complex

Euk-Vir

Human_betaherpesvirus_6B

helicase_primase_complex__NP_050253__Human_betaherpesvirus_6B__32604

Identity

Accession:
NP_050253 ↗
Protein ID:
helicase_primase_complex
Kingdom:
euk

Quality

81.3 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Roseolovirus› Human_betaherpesvirus_6B

TaxID: 32604

Cluster

View cluster (7 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 1-127
PDB
Domain cluster: rep: helicase-primase_subunit__YP_004940263__Saimiriine_betaherpesvirus_4__1535247__D1-152
CATH (17)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1iz6A01 2.30.30.30 Mainly Beta › Roll › SH3 type barrels. › 0.72 31.0 4.09e-01 96.9% 72.5%
3kojB00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.71 46.0 5.41e-01 96.1% 92.2%
2k75A01 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.71 45.0 4.94e-01 99.2% 78.6%
1z9fA00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.70 45.0 5.24e-01 97.6% 92.1%
1fguB01 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.68 48.0 5.26e-01 96.1% 87.6%
4dkaC00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.65 42.0 5.11e-01 96.9% 97.7%
3irbA02 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.65 36.0 4.67e-01 94.5% 100.0%
5l37C00 2.40.50.220 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › EutN/Ccml 0.62 39.0 4.61e-01 97.6% 93.0%
4qclA01 2.40.50.730 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › 0.62 41.0 4.85e-01 100.0% 98.8%
4dduA07 2.60.510.20 Mainly Beta › Sandwich › EV matrix protein fold › 0.55 39.0 4.22e-01 85.8% 85.0%
1vqqA01 3.10.450.100 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › NTF2-like; domain 1 0.54 29.0 3.15e-01 90.6% 58.7%
7pkwA01 3.10.450.540 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.53 27.0 2.96e-01 92.9% 55.3%
3en2A00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.53 36.0 4.07e-01 100.0% 97.8%
2g2sA00 3.30.1300.40 Alpha Beta › 2-Layer Sandwich › Pantoate--beta-alanine Ligase; Chain: A,domain 2 › 0.51 23.0 3.09e-01 85.8% 81.2%
2iqiB00 3.40.50.10610 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › ABC-type transport auxiliary lipoprotein component 0.50 34.0 3.15e-01 96.1% 50.9%
2gumB01 2.30.30.1230 Mainly Beta › Roll › SH3 type barrels. › 0.50 30.0 3.32e-01 80.3% 74.0%
4p2iA00 3.30.1520.10 Alpha Beta › 2-Layer Sandwich › PX Domain › Phox-like domain 0.50 42.0 4.40e-01 90.6% 100.0%
ECOD (33)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3268888 2.1.1.44 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › Dna2 0.72 48.0 5.65e-01 98.4% 96.7%
5036293 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.71 47.0 5.25e-01 100.0% 86.0%
3279407 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.69 46.0 4.86e-01 100.0% 77.3%
3666058 2.1.1.44 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › Dna2 0.67 45.0 5.14e-01 98.4% 91.6%
3472467 284.1.3.0 ↗ a+b two layers › FKBP-like › FKBP-like › WNK1 autoinhibitory domain 0.67 35.0 4.40e-01 77.2% 85.3%
4043017 2.1.1.173 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › RADX 0.66 49.0 4.53e-01 100.0% 61.3%
4512226 330.6.1.0 ↗ a+b two layers › dsRBD-like › 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain › 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 0.65 33.0 3.63e-01 92.1% 58.1%
3251381 295.1.1.4 ↗ a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain › COMM_domain 0.65 32.0 4.40e-01 74.0% 93.8%
4003604 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.63 37.0 4.00e-01 100.0% 68.6%
5074460 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.63 43.0 4.69e-01 98.4% 84.8%
3705431 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.59 49.0 5.18e-01 98.4% 97.4%
5051439 2.1.1.42 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › Rep_fac-A_C 0.58 51.0 5.01e-01 95.3% 88.6%
3609098 7575.1.1.0 ↗ a/b three-layered sandwiches › Caspase-like › Caspase-like › Caspase-like 0.58 43.0 2.63e-01 77.2% 16.1%
3435849 243.3.1.0 ↗ a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin 0.57 30.0 3.51e-01 91.3% 70.5%
3940786 2.3.1.1 ↗ beta barrels › OB-fold › TIMP-like › TIMP-like › TIMP 0.57 44.0 4.37e-01 98.4% 77.7%
3645341 2.1.1.76 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › REPA_OB_2 0.57 46.0 4.21e-01 99.2% 66.1%
3931897 69.1.2.1 ↗ beta complex topology › Hedgehog/intein › Hedgehog/intein › AXH › AXH 0.56 38.0 3.85e-01 85.0% 69.6%
3451025 243.3.1.19 ↗ a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin › DUF3615 0.56 34.0 3.82e-01 91.3% 77.0%
3413325 5.1.4.0 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed 0.56 42.0 2.94e-01 92.1% 26.1%
3824401 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.55 42.0 4.35e-01 100.0% 83.7%
3620578 277.1.1.1 ↗ a+b two layers › PX domain › PX domain › PX domain › PX 0.53 45.0 4.14e-01 91.3% 99.4%
3402094 243.3.1.35 ↗ a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin › DUF229 0.53 29.0 3.15e-01 74.8% 62.9%
5031452 2484.1.1.18 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_Tnp_1 0.52 33.0 3.69e-01 100.0% 84.2%
3251342 277.1.1.1 ↗ a+b two layers › PX domain › PX domain › PX domain › PX 0.52 44.0 4.51e-01 92.1% 96.7%
1278471 243.1.1.7 ↗ a+b two layers › Cystatin-like › NTF2-like › NTF2-like › MecA_N 0.52 29.0 3.10e-01 92.1% 58.8%
5079866 11.1.4.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Prealbumin-like 0.51 31.0 3.64e-01 95.3% 86.7%
3916200 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.51 43.0 2.94e-01 91.3% 93.6%
3197234 2.1.1.25 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1 0.51 39.0 4.23e-01 100.0% 95.5%
5079867 11.1.4.23 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Prealbumin-like › CarboxypepD_reg 0.51 31.0 3.61e-01 93.7% 89.4%
4977268 7504.1.1.2 ↗ a/b three-layered sandwiches › ITPase-like › ITPase-like › ITPase-like › NTPase_I-T 0.50 42.0 3.61e-01 89.8% 82.5%
5057162 504.1.1.0 ↗ a+b two layers › Bacterial protein-export protein SecB › Bacterial protein-export protein SecB › Bacterial protein-export protein SecB 0.50 41.0 4.22e-01 99.2% 91.2%
5043294 504.1.1.0 ↗ a+b two layers › Bacterial protein-export protein SecB › Bacterial protein-export protein SecB › Bacterial protein-export protein SecB 0.50 43.0 4.28e-01 96.1% 90.8%
1813813 206.1.1.1 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.50 32.0 3.39e-01 94.5% 73.0%
D2 medium residues 128-322
PDB
Domain cluster: rep: ORF31__NP_733884__Callitrichine_gammaherpesvirus_3__106331__D132-145_190-351
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03324.21 best Herpes_HEPA 65.9 4.90e-18 44.6% 98.9%
CATH (3)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4azpA00 2.40.128.20 Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain 0.59 32.0 3.84e-01 83.6% 76.1%
2a6aB01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.57 35.0 4.32e-01 95.4% 100.0%
2a1rB01 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.54 48.0 4.18e-01 94.9% 93.2%
ECOD (6)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3796352 295.1.1.0 ↗ a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain 0.65 19.0 3.24e-01 79.5% 73.8%
4936812 2484.1.1.49 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Hydant_A_N 0.54 30.0 3.68e-01 95.4% 82.4%
5025208 2484.1.1.34 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.53 49.0 4.67e-01 100.0% 93.0%
4944521 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.53 44.0 4.32e-01 88.7% 100.0%
5031060 2.1.1.32 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › TIP49 0.52 26.0 3.26e-01 91.8% 76.5%
5011572 2.1.1.32 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › TIP49 0.52 25.0 3.28e-01 91.8% 80.0%
D3 medium residues 323-506
PDB
Domain cluster: rep: helicase-primase_subunit__YP_073814__Human_betaherpesvirus_7__10372__D324-506
D4 medium residues 507-662
PDB
Domain cluster: rep: E102__YP_007016498__Murid_betaherpesvirus_8__1261657__D578-728